Arcsine Laws in Stochastic Thermodynamics

We show that the fraction of time a thermodynamic current spends above its average value follows the arcsine law, a prominent result obtained by L\'evy for Brownian motion. Stochastic currents with long streaks above or below their average are much more likely than those that spend similar fractions of time above and below their average. Our result is confirmed with experimental data from a Brownian Carnot engine. We also conjecture that two other random times associated with currents obey the arcsine law: the time a current reaches its maximum value and the last time a current crosses its average value. These results apply to, inter alia, molecular motors, quantum dots and colloidal systems.Comment: 11 pages, 11 figure

Multidimensional Fixed-Point Theorems in Partially Ordered Complete Partial Metric Spaces under ()-Contractivity Conditions

We study the existence and uniqueness of coincidence point for nonlinear mappings of any number of arguments under a weak ()-contractivity condition in partial metric spaces. The results we obtain generalize, extend, and unify several classical and very recent related results in the literature in metric spaces (see Aydi et al. (2011), Berinde and Borcut (2011), Gnana Bhaskar and Lakshmikantham (2006), Berzig and Samet (2012), Borcut and Berinde (2012), Choudhury et al. (2011), Karapınar and Luong (2012), Lakshmikantham and Ćirić (2009), Luong and Thuan (2011), and Roldán et al. (2012)) and in partial metric spaces (see Shatanawi et al. (2012))

Accessible lifelong learning at higher education:outcomes and lessons Learned at two different PilotSites in the EU4ALL Project

[EN] The EU4ALL project (IST-FP6-034778) has developed a general framework to address the needs of accessible lifelong learning at Higher Education level consisting of several standards-based interoperable components integrated into an open web service architecture aimed at supporting adapted interaction to guarantee students' accessibility needs. Its flexibility has supported the project implementation at several sites with different settings and various learning management systems. Large-scale evaluations involving hundreds of users, considering diverse disability types, and key staff roles have allowed obtaining valuable lessons with respect to "how to adopt or enhance eLearning accessibility" at university. The project was evaluated at four higher education institutions, two of the largest in Europe and two mediumsized. In this paper, we focus on describing the implementation and main conclusions at the largest project evaluation site (UNED), which was involved in the project from the beginning, and thus, in the design process, and a medium-sized university that adopted the EU4ALL approach (UPV). This implies dealing with two well-known open source learning environments (i.e. dotLRN and Sakai), and considering a wide variety of stakeholders and requirements. Thus the results of this evaluation serve to illustrate the coverage of both the approach and developments.The authors would like to thank the European Commission for the financial support of the EU4ALL project (IST-2006-034478). The work at aDeNu is also supported by the Spanish Ministry of Science and Innovation (TIN2008-06862-C04-01/TSI “A2UN@”). Authors would also like to thank all the EU4ALL partners for their collaboration.Boticario, JG.; Rodriguez-Ascaso, A.; Santos, OC.; Raffenne, E.; Montandon, L.; Roldán Martínez, D.; Buendía García, F. (2012). Accessible lifelong learning at higher education:outcomes and lessons Learned at two different PilotSites in the EU4ALL Project. Journal of Universal Computer Science. 18(1):62-85. http://hdl.handle.net/10251/37117628518

Physics demos for all UVEG degrees: a unique project in Spain

The Physics Demo Project at the University of Valencia (www.uv.es/fisicademos) has developed a collection of physics demonstrations to be used during lectures. It consists of more than 130 experimental demos about different physics topics. More than 30 professors borrow them whenever they lecture on physics in any of our 40 courses in 17 different science or technical degrees, involving 246 ECTS and more than 3500 students. Each demo kit with a simple experimental set displays a particular physics phenomenon. An on-line user guide highlights the main physics principles involved, instructions on how to use it and advices of how to link it to the theoretical concepts or to technical applications. Demo lectures (and collections) are a usual and widespread practice in many countries but not in Spain. This unique initiative aims at the recovery of this practice by involving a growing collaborative team of users and with the aid of educational innovation projects. Here we explain the project content, organization and recent developments. Our experience, together with the positive students comments, allows us to draw the following conclusions: demos introduce the real sensible world in the lecture hall, providing the necessary link between concepts and everyday life, and becoming, again, something more than "chalk and talk"

Antibody response in patients admitted to the hospital with suspected SARS-CoV-2 infection: results from a multicenter study across Spain

Aim: To evaluate the serological response against SARS-CoV-2 in a multicenter study representative of the Spanish COVID pandemic. Methods: IgG and IgM + IgA responses were measured on 1466 samples from 1236 Spanish COVID-19 patients admitted to the hospital, two commercial ELISA kits (Vircell SL, Spain) based on the detection of antibodies against the viral spike protein and nucleoprotein, were used. Results: Approximately half of the patients presented antibodies (56.8% were IgM + IgA positive and 43.0% were IgG positive) as soon as 2 days after the first positive PCR result. Serological test positivity increased with time from the PCR test, and 10 days after the first PCR result, 91.5% and 88.0% of the patients presented IgM + IgA and IgG antibodies, respectively. Conclusion: The high values of sensitivity attained in the present study from a relatively early period of time after hospitalization support the use of the evaluated serological assays as supplementary diagnostic tests for the clinical management of COVID-19

Molecular organization and effective energy transfer in iridium metallosurfactant-prophyrin assemblies embedded in Langmuir-Schaefer films

III Encuentro sobre Nanociencia y Nanotecnología de Investigadores y Tecnólogos Andaluce

Meaning-making from wordless (or nearly wordless) picturebooks: what educational research expects and what readers have to say

Wordless (or nearly wordless) picturebooks are intriguing in terms of how readers make meaning from them. This article offers a conceptualization of existing studies in the field of education that use wordless picturebooks with young readers. While some of these studies contribute to understanding meaning-making, the pragmatic use of wordless picturebooks often does not take account of their particular nature and of the heightened role of the reader, leading to a mismatch between what the picturebook expects from the implied reader and the researchers’ expectations of what ‘real’ readers must do with these books. By highlighting observations from children’s literature scholarship and reader-response studies, this article aims to encourage a more interdisciplinary understanding of meaning-making. It also seeks to persuade educational researchers and mediators to consider investigative approaches that are not based on verbalization but are more in tune with the invitations that wordless picturebooks extend to young readers

A PR-1-like Protein of Fusarium oxysporum Functions in Virulence on Mammalian Hosts

The pathogenesis-related PR-1-like protein family comprises secreted proteins from the animal, plant, and fungal kingdoms whose biological function remains poorly understood. Here we have characterized a PR-1-like protein, Fpr1, from Fusarium oxysporum, an ubiquitous fungal pathogen that causes vascular wilt disease on a wide range of plant species and can produce life-threatening infections in immunocompromised humans. Fpr1 is secreted and proteolytically processed by the fungus. The fpr1 gene is required for virulence in a disseminated immunodepressed mouse model, and its function depends on the integrity of the proposed active site of PR-1-like proteins. Fpr1 belongs to a gene family that has expanded in plant pathogenic Sordariomycetes. These results suggest that secreted PR-1-like proteins play important roles in fungal pathogenicit