Adolescencia y cáncer

Adolescence covers from the 15 to the 19 years of age, is a period of transition in the development from childhood to adult life. The appearance of youth changes as a result of the hormonal events of puberty. At this stage, they incorporate a new look and there is a search for their sense of identity. Adolescent cancer is the leading cause of non-accidental mortality. Adolescence is a significant period of physical and emotional changes and the diagnosis of cancer during this time has an important impact on their psychological and physical development.The aim is to carry out a literature review of 80 most relevant articles published during the last years in the literature associated with adolescents with cancer. The literature review has been made in computerised databases PubMed, PsycINFOs.This review describes the psychosocial issues faced by teens with cancer: problems of development, initial responses to the diagnosis, psychological adjustment, quality of life and adverse cancer sequelae, problems with body image, sexuality and the compliance and treatment adherence.Conclusions: The lack of personal resources or life experiences that might allow them to cope with and make sense of the many potential problems that are inherent to cancer, and sometimes there are not in a period of change and personal development. The article aims to pay attention on the need of making specialised units in treatment of adolescents with multidisciplinary specialists, which ones were specialized in this complex period of development and that include mental health professionals.La adolescencia es un período que abarca los de los 15 a 19 años de edad, es una etapa de transición en el desarrollo desde la infancia hasta la vida adulta. La apariencia de los jóvenes cambia como resultado de los acontecimientos hormonales de la pubertad. En esta etapa, incorporan una nueva apariencia y hay una búsqueda de su sentido de identidad. El cáncer en la adolescencia es la principal causa de mortalidad no accidental. Dado que la adolescencia es un período de cambios físicos y emocionales significativos, un diagnóstico de cáncer durante esta etapa del desarrollo tiene un impacto importante en su desarrollo psicológico y físico.El objetivo es realizar una revisión bibliográfica de los 80 artículos más relevantes publicados durante los últimos años en la literatura asociados con el adolescente con cáncer. La revisión bibliográfica ha sido realizada en las bases computerizadas PubMed, PsycINFOs.En esta revisión se describe los problemas psicosociales que afrontan los adolescentes con cáncer: problemas de desarrollo, respuestas iniciales al diagnóstico, el ajuste psicológico, la calidad de vida y las secuelas adversas del cáncer, los problemas de imagen corporal, la sexualidad y el cumplimiento y adherencia del tratamiento.Conclusiones: La falta de recursos personales o experiencias de vida que podrían capacitarlos para afrontar y dar sentido a los muchos problemas potenciales que pueden acompaña el cáncer, es en ocasiones inexistente en un periodo de cambio y desarrollo personal. El artículo pretende llamar la atención sobre la necesidad de creación de unidades especializadas en el tratamiento para adolescentes y la necesidad de que dichas unidades sean multidisciplinares, formadas por profesionales especialistas en este complejo periodo del desarrollo e incluyan profesionales de la Salud Mental

Chloroplast damage induced by the inhibition of fatty acid synthesis triggers autophagy in chlamydomonas

Fatty acids are synthesized in the stroma of plant and algal chloroplasts by the fatty acid synthase complex. Newly synthesized fatty acids are then used to generate plastidial lipids that are essential for chloroplast structure and function. Here, we show that inhibition of fatty acid synthesis in the model alga Chlamydomonas reinhardtii activates autophagy, a highly conserved catabolic process by which cells degrade intracellular material under adverse conditions to maintain cell homeostasis. Treatment of Chlamydomonas cells with cerulenin, a specific fatty acid synthase inhibitor, stimulated lipidation of the autophagosome protein ATG8 and enhanced autophagic flux. We found that inhibition of fatty acid synthesis decreased monogalactosyldiacylglycerol abundance, increased lutein content, down-regulated photosynthesis, and increased the production of reactive oxygen species. Electron microscopy revealed a high degree of thylakoid membrane stacking in cerulenin-treated cells. Moreover, global transcriptomic analysis of these cells showed an up-regulation of genes encoding chloroplast proteins involved in protein folding and oxidative stress and the induction of major catabolic processes, including autophagy and proteasome pathways. Thus, our results uncovered a link between lipid metabolism, chloroplast integrity, and autophagy through a mechanism that involves the activation of a chloroplast quality control system.Ministerio de Economía y Competitividad BFU2015-68216-PJunta de Andalucía CVI-7336, BIO2015-74432-JI

Root-to-Shoot Hormonal Communication in Contrasting Rootstocks Suggests an Important Role for the Ethylene Precursor Aminocyclopropane-1-carboxylic Acid in Mediating Plant Growth under Low-Potassium Nutrition in Tomato

Selection and breeding of rootstocks that can tolerate low K supply may increase crop productivity in low fertility soils and reduce fertilizer application. However, the underlying physiological traits are still largely unknown. In this study, 16 contrasting recombinant inbred lines (RILs) derived from a cross between domestic and wild tomato species (Solanum lycopersicum × Solanum pimpinellifolium) have been used to analyse traits related to the rootstock-mediated induction of low (L, low shoot fresh weight) or high (H, high shoot fresh weight) vigor to a commercial F1 hybrid grown under control (6 mM, c) and low-K (1 mM, k). Based on hormonal and ionomic composition in the root xylem sap and the leaf nutritional status after long-term (7 weeks) exposure low-K supply, a model can be proposed to explain the rootstocks effects on shoot performance with the ethylene precursor aminocyclopropane-1-carboxylic acid (ACC) playing a pivotal negative role. The concentration of this hormone was higher in the low-vigor Lc and Lk rootstocks under both conditions, increased in the sensitive HcLk plants under low-K while it was reduced in the high-vigor Hk ones. Low ACC levels would promote the transport of K vs. Na in the vigorous Hk grafted plants. Along with K, Ca, and S, micronutrient uptake and transport were also activated in the tolerant Hk combinations under low-K. Additionally, an interconversion of trans-zeatin into trans-zeatin riboside would contribute to decrease ACC in the tolerant LcHk plants. The high vigor induced by the Hk plants can also be explained by an interaction of ACC with other hormones (cytokinins and salicylic, abscisic and jasmonic acids). Therefore, Hk rootstocks convert an elite tomato F1 cultivar into a (micro) nutrient-efficient phenotype, improving growth under reduced K fertilization.This research has received funding from the Spanish MINECO-FEDER (project AGL2014-59728-R) and from the European Union's Seventh Framework Programme for research, technological development and demonstration under grant agreement no 289365 (project ROOTOPOWER).USD 2,116.5 APC fee funded by the EC FP7 Post-Grant Open Access PilotPeer reviewe

Puesta en valor y gestión de los afloramientos del Bajociense (Jurásico medio) de Moscardón (Teruel).

Este proyecto trata de poner en valor a través de la musealización y la gestión unos afloramientos geológicos localizados en la Cordillera Ibérica y ubicados en las inmediaciones del municipio de Moscardón (Teruel). Estos afloramientos ilustran una plataforma carbonatada con desarrollo de grandes biohermos silíceos de edad jurásica (165 millones de años aproximadamente). A través de la puesta en valor de este patrimonio geológico, se pretende vertebrar el territorio de la comarca Sierra de Albarracín con estrategias como la instalación de paneles, mesas informativas y con algunas otras más innovadoras, como la edición de guías de campo, talleres divulgativos, conferencias (en las que intervendrán prestigiosos investigadores) y mediante la celebración de concursos en redes sociales. De esta manera convertiremos la roca en historia y Moscardón en el escenario dónde este patrimonio cobra vida, también pretendemos darlo a conocer en toda la región aragonesa y cuyo objetivo final será que se conozca en toda España.<br /

Adolescence & cancer

Adolescence covers from the 15 to the 19 years of age, is a period of transition in the development from childhood to adult life. The appearance of youth changes as a result of the hormonal events of puberty. At this stage, they incorporate a new look and there is a search for their sense of identity. Adolescent cancer is the leading cause of non-accidental mortality. Adolescence is a significant period of physical and emotional changes and the diagnosis of cancer during this time has an important impact on their psychological and physical development.The aim is to carry out a literature review of 80 most relevant articles published during the last years in the literature associated with adolescents with cancer. The literature review has been made in computerised databases PubMed, PsycINFOs.This review describes the psychosocial issues faced by teens with cancer: problems of development, initial responses to the diagnosis, psychological adjustment, quality of life and adverse cancer sequelae, problems with body image, sexuality and the compliance and treatment adherence.Conclusions: The lack of personal resources or life experiences that might allow them to cope with and make sense of the many potential problems that are inherent to cancer, and sometimes there are not in a period of change and personal development. The article aims to pay attention on the need of making specialised units in treatment of adolescents with multidisciplinary specialists, which ones were specialized in this complex period of development and that include mental health professionals.</p

Aproximación a las restauraciones del Real Monasterio Cisterciense de Santa María de Piedra: las intervenciones del arquitecto Joaquín Soro López

El tema de investigación del presente trabajo se centra en el análisis histórico, crítico y contextualizado de las diferentes restauraciones realizadas por el arquitecto Joaquín Soro López en el conjunto de edificaciones del Monasterio de Piedra. La investigación, por tanto, se centra en un único monumento y en las intervenciones de un arquitecto concreto

ABA-overproduction response under salinity

[SPA] Con el fin de comprender la influencia de la fitohormona ácido abscísico (ABA) en la adaptación al riego salino, dos líneas transgénicas independientes de tomate (Solanum lycopersicum L.), sp12 y sp5, que sobreexpresan constitutivamente el gen NCED1 (codifica para la enzima que cataliza un paso limitante en la biosíntesis de ABA) y la variedad silvestre Ailsa Craig, se han estudiado en experimentos o bien i) como planta entera o ii) como portainjerto bajo condiciones control y de estrés salino. Aunque la expresión constitutiva de NCED disminuye el crecimiento bajo condiciones control, minimiza los efectos producidos por la sal (planta completa) y mejora significativamente el crecimiento cuando se usa como portainjerto. El análisis de la savia xilemática de raíz mostró que los fenotipos resultantes bajo las diferentes condiciones de cultivo eran difíciles de explicar en términos de sobreproducción de ABA. Para intentar explicar estos resultados se llevó a cabo un análisis de expresión de un conjunto de genes relacionados con hormonas y estrés mediante PCR cuantitativa, así como un estudio transcriptómico mediante microarrays en la raíz. Los resultados sugieren que la sobreexpresión de NCED parece alterar diversas rutas de señalización, derivando en una respuesta adaptativa al estrés que podría ayudar a explicar los fenotipos observados. [ENG] With the aim of better understanding the influence of the plan hormone abscisic acid (ABA) in adaptation to saline irrigation, two independent transgenic tomato (Solanum lycopersicum L.) lines, sp12 and sp5, overexpressing constitutively NCED1 (the enzyme that catalyzes a key rate-limiting step in ABA biosynthesis) and the wild type Ailsa Craig, have been studied in experiments either i) as whole plants or ii) as rootstocks under control and salinity conditions. While NCED overexpression penalizes growth under control conditions, it minimized the effect of salinity (whole plants) or significantly improved plant growth and yield when used as rootstocks. The analysis of the root xylem sap revealed that the phenotypes resulting under the different conditions were difficult to explain in terms of ABA overproduction. With the aim of explaining these results, the expression of a set of hormone and stress associated genes (analysed by real time PCR) as well as a transcriptomic analysis (by using one-color microarray) were performed in roots. The results suggest that NCED overexpression seems to alter several signalling pathways leading to stress adaptive responses that could help to explain the observed phenotypes.The authors thank Andrew J. Thompson from Cranfield University, the NCED seeds set. This work was supported by CICYT-FEDER (project AGL2011-27996) and European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 289365(ROOTOPOWER project)

Buenas prácticas en gestión de emergencias

Comunicación presentada en las I Jornadas de Bibliotecas G9 sobre buenas prácticas en atención a espacios y usuarios, organizada por el Servicio de Bibliotecas de la UEx en Jarandilla de la Vera (Cáceres) los días 29 y 30 de septiembre de 2016Se diseña el Plan de emergencia y seguridad de la Biblioteca del País Vasco, Campus Universitario de Vizcaya.Plan emergency and security of the Library of the Basque Country, Campus Universitario de Vizcaya is designed

Buenas prácticas en gestión de emergencias

Comunicación presentada en las I Jornadas de Bibliotecas G9 sobre buenas prácticas en atención a espacios y usuarios, organizada por el Servicio de Bibliotecas de la UEx en Jarandilla de la Vera (Cáceres) los días 29 y 30 de septiembre de 2016Se diseña el Plan de emergencia y seguridad de la Biblioteca del País Vasco, Campus Universitario de Vizcaya.Plan emergency and security of the Library of the Basque Country, Campus Universitario de Vizcaya is designed