ESBOZO HISTÓRICO DEL PROCESO DE SUPERVISIÓN EN EL SISTEMA EDUCATIVO VENEZOLANO

The purpose of the present paper is make public the main characteristics, stages and legal regulations that constitute landmarks in the historical course of the supervision process in the Bolivarian Educational System, so it becomes an important reference for the study and the research of the Venezuelan education in general and of the educational supervision process in particular. The carried out analysis shows that the supervision process has moved from the concept of autocratic inspection throughout the liberal inspection to democratic supervision. In the last years, the Bolivarian government has granted authority to the supervision service, with enough concepts and precisions that convert it in a permanent and indispensable activity for the improvement of the new educational system. The operated changes in the legal framework and official standards state the supervision as a political and strategic process in order to increase the quality of the Venezuelan education.El objetivo del presente trabajo es socializar las principales características, así como los momentos y reglamentaciones legales que resultan hitos en el devenir histórico del proceso supervisivo en el Sistema Educativo Bolivariano, lo cual constituye un importante referente para el estudio y la investigación de la educación venezolana en general y de la supervisión educativa en particular. El análisis realizado muestra que se ha transitado desde el concepto de inspección autocrática al de supervisión democrática, pasando por la inspección liberal. En los últimos años el gobierno bolivariano le ha otorgado autoridad al servicio de la supervisión, con conceptos y precisiones suficientes, para convertirla en una actividad permanente e indispensable para el funcionamiento del nuevo sistema educativo. Los cambios operados en la normatividad oficial y el marco legal reafirman a la supervisión como un proceso político y estratégico para elevar la calidad de la educación venezolana

Cumplimiento de la norma técnica obligatoria Nicaragüense 03 026-10 en el comedor de una casa hogar de la ciudad de Managua, Marzo-Octubre

El presente estudio es descriptivo, prospectivo y de corte transversal enfocado en la Norma Técnica Obligatoria Nicaragüense, NTON O3 O26-10. Investigación dirigida a los manipuladores de alimentos de una Casa Hogar de la Ciudad de Managua, con el objetivo de verificar el cumplimiento de dicha norma. En este estudio participaron voluntariamente los 6 manipuladores de alimentos que laboran en el comedor de la Casa Hogar. La recolección de los datos se obtuvo por medio de encuesta y guía de observación, instrumentos que permitieron conocer las características socio demográficas de los manipuladores en cuanto a sexo predominando el 90% femenino, en edad 90% 21-40 años y el 100% afirmaron haber cursado un nivel de educación básica. Asimismo, se verificó los requisitos sanitarios para los manipuladores de alimentos donde el 52% cumple debidamente y para la manipulación de los alimentos establecidos en la norma un 61% cumple correctamente datos que permitieron identificar las deficiencias y fortalezas en cuanto al cumplimiento de los requisitos. Por otra parte, se les realizó los siguientes exámenes de laboratorio: EGH, VRDL, BAAR, Examen de piel y Exudado faríngeo, obteniendo en el EGH el 50% de los manipuladores parasitados. Por consiguiente, se decidió identificar la presencia de microorganismos indicadores de higiene en los manipuladores debido a que los exámenes estipulados por la norma no conllevan a determinar estos grupos que se utilizan para controlar la presencia y condiciones higiénicas en la manipulación directa de los alimentos, se aisló: Staphylococcus aureus coagulasa positiva (50%), hongos y levaduras (50%), y coliformes totales (83%), lo cual nos indicó que existe una contaminación ambiental, presente en las manos de los manipuladores y proveniente del entorno con las que estas entran en contacto constantemente. En consideración, es necesario dar seguimiento a futuras investigaciones que aborden la higiene en la manipulación donde analicen las prácticas y condiciones higiénicas sanitarias dentro de las áreas de cocina

Outcomes and prognostic factors of adults with refractory or relapsed T-cell acute lymphoblastic leukemia included in measurable residual disease-oriented trials

Despite high complete remission (CR) rates with frontline therapy, relapses are frequent in adults with T-cell acute lymphoblastic leukemia (T-ALL) with limited salvage options. We analyzed the outcomes and prognostic factors for CR to salvage therapy and overall survival (OS) of patients with R/R T-ALL included in two prospective measurable residual disease-oriented trials. Seventy-five patients (70 relapsed, 5 refractory) were identified. Relapses occurred in bone marrow, isolated or combined in 50 patients, and in the central nervous system (CNS; isolated or combined) in 20. Second CR was attained in 30/75 patients (40%). Treatment with FLAG-Ida and isolated CNS relapse were independently associated with a higher CR rate after first salvage therapy. The median OS was 6.2 (95% confidence interval [CI], 3.9–8.6) months, with a 4-year OS probability of 18% (95% CI, 9%–27%). No differences in survival were observed according to the treatment with hematopoietic stem cell transplantation in patients in CR after first salvage therapy. Multivariable analysis showed a ≥12-month interval between first CR and relapse, CR after first salvage therapy and isolated CNS relapse as favorable prognostic factors for OS with hazard ratios (HR) (95% CI) of 1.931 (1.109–3.362), 2.958 (1.640–5.334), and 2.976 (1.157–7.655), respectively. This study confirms the poor outcomes of adults with R/R T-ALL among whom FLAG-Ida was the best of the rescue therapies evaluated. Late relapse, CR after first rescue therapy and isolated CNS relapse showed prognostic impact on survival. More effective rescue therapies are needed in adults with R/R T-ALL.La Caixa" Foundation and ISCIII, Grant/ Award Number: PI19/01828; Generalitat de Catalunya (GRC), Grant/Award Number: 2017 SGR28

The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structure

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) allele groups and alleles by PCR-SSP based typing in a total of 15,318 mixed ancestry Mexicans from all the states of the country divided into 78 sample sets, providing information regarding allelic and haplotypic frequencies and their linkage disequilibrium, as well as admixture estimates and genetic substructure. We identified the presence of 4268 unique HLA extended haplotypes across Mexico and find that the ten most frequent (HF > 1%) HLA haplotypes with significant linkage disequilibrium (Δ’≥0.1) in Mexico (accounting for 20% of the haplotypic diversity of the country) are of primarily Native American ancestry (A*02~B*39~DRB1*04~DQB1*03:02, A*02~B*35~DRB1*08~DQB1*04, A*68~B*39~DRB1*04~DQB1*03:02, A*02~B*35~DRB1*04~DQB1*03:02, A*24~B*39~DRB1*14~DQB1*03:01, A*24~B*35~DRB1*04~DQB1*03:02, A*24~B*39~DRB1*04~DQB1*03:02, A*02~B*40:02~DRB1*04~DQB1*03:02, A*68~B*35~DRB1*04~DQB1*03:02, A*02~B*15:01~DRB1*04~DQB1*03:02). Admixture estimates obtained by a maximum likelihood method using HLA-A/-B/-DRB1 as genetic estimators revealed that the main genetic components in Mexico as a whole are Native American (ranging from 37.8% in the northern part of the country to 81.5% in the southeastern region) and European (ranging from 11.5% in the southeast to 62.6% in northern Mexico). African admixture ranged from 0.0 to 12.7% not following any specific pattern. We were able to detect three major immunogenetic clusters correlating with genetic diversity and differential admixture within Mexico: North, Central and Southeast, which is in accordance with previous reports using genome-wide data. Our findings provide insights into the population immunogenetic substructure of the whole country and add to the knowledge of mixed ancestry Latin American population genetics, important for disease association studies, detection of demographic signatures on population variation and improved allocation of public health resources.Fil: Barquera, Rodrigo. Max Planck Institute For The Science Of Human History; Alemania. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: Hernández Zaragoza, Diana Iraíz. Técnicas Genéticas Aplicadas A la Clínica (tgac); México. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: Bravo Acevedo, Alicia. Instituto Mexicano del Seguro Social; MéxicoFil: Arrieta Bolaños, Esteban. Universitat Essen; AlemaniaFil: Clayton, Stephen. Max Planck Institute For The Science Of Human History; AlemaniaFil: Acuña Alonzo, Víctor. Instituto Nacional de Antropología E Historia, Mexico; MéxicoFil: Martínez Álvarez, Julio César. Instituto Mexicano del Seguro Social; MéxicoFil: López Gil, Concepción. Instituto Mexicano del Seguro Social; MéxicoFil: Adalid Sáinz, Carmen. Instituto Mexicano del Seguro Social; MéxicoFil: Vega Martínez, María del Rosario. Hospital Central Sur de Alta Especialidad; MéxicoFil: Escobedo Ruíz, Araceli. Instituto Mexicano del Seguro Social; MéxicoFil: Juárez Cortés, Eva Dolores. Instituto Mexicano del Seguro Social; MéxicoFil: Immel, Alexander. Max Planck Institute For The Science Of Human History; Alemania. Christian Albrechts Universitat Zu Kiel; AlemaniaFil: Pacheco Ubaldo, Hanna. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: González Medina, Liliana. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: Lona Sánchez, Abraham. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: Lara Riegos, Julio. Universidad Autónoma de Yucatán; MéxicoFil: Sánchez Fernández, María Guadalupe de Jesús. Instituto Mexicano del Seguro Social; MéxicoFil: Díaz López, Rosario. Hospital Central Militar, Mexico City; MéxicoFil: Guizar López, Gregorio Ulises. Hospital Central Militar, Mexico City; MéxicoFil: Medina Escobedo, Carolina Elizabeth. Instituto Mexicano del Seguro Social; MéxicoFil: Arrazola García, María Araceli. Instituto Mexicano del Seguro Social; MéxicoFil: Montiel Hernández, Gustavo Daniel. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: Hernández Hernández, Ofelia. Técnicas Genéticas Aplicadas a la Clínica ; MéxicoFil: Ramos de la Cruz, Flor del Rocío. Instituto Mexicano del Seguro Social; MéxicoFil: Juárez Nicolás, Francisco. Instituto Nacional de Pediatría; MéxicoFil: Pantoja Torres, Jorge Arturo. Instituto Mexicano del Seguro Social; MéxicoFil: Rodríguez Munguía, Tirzo Jesús. Hospital General Norberto Treviño Zapata; MéxicoFil: Juárez Barreto, Vicencio. Hospital Infantil de Mexico Federico Gomez; MéxicoFil: Gonzalez-Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentin

Implementation of hydroponic crops as a pedagogical strategy for the promotion of research

En el presente proyecto se desarrollaron actividades pedagógicas para el fortalecimiento de los procesos educativos en la población estudiantil de la institución: Centro de Educación Básica San Valentín, en el departamento del Magdalena, a través de implementación de cultivos hidropónicos, como estrategias pedagógicas que desarrollan habilidades investigativas en infantes y jóvenes de la institución. Se trabajó bajo la metodología cualitativa con modelo de investigación acción participativa. La población estuvo conformada por estudiantes de esa institución. Se recogió la información por medio de las técnicas como relatorías individuales, institucionales, diario de campo, encuestas y observación directa. Se identificaron los contenidos curriculares del área de Biología para aplicar en los cultivos como un recurso generador de aprendizaje, con base en los cuales se realizó la planeación para las clases y el trabajo en los cultivos.In the present project, pedagogical activities were developed for the strengthening of educational processes in the student population of the San Valentín Basic Education Center, in the department of Magdalena, through the implementation of hydroponic crops as pedagogical strategies that develop investigative skills in infants and young people of the institution. We worked under the qualitative methodology with participatory action research model. The population was conformed by students of the San Valentín Basic Education Center, in Magdalena. The information was collected by means of techniques such as individual and institutional rapporteurships, field journals, surveys and direct observation. The curricular contents of the Biology area to be applied in the crops were identified as a learning instrument, based on which the planning for the classes and the work in the crops was carried out

Challenge B: Human sciences in transition scenarios

Coordinators: Josep Martí Pérez (IMF, CSIC), Idoia Murga Castro (IH, CSIC).This challenge is formulated in terms of “humanities in transition,” that is, their approach and articulation in the face of the changes they must undergo to achieve the social weight that, due to their intrinsic relevance, should correspond to them. Faced with these situations that would demand a reinforcement in research and dissemination in diverse aspects of the humanities, from multiple perspectives, paradoxically an adverse panorama is drawn for the development and dissemination of humanistic knowledge, which concerns different factors. Some are related to the consideration of the area of knowledge itself, its organization within the scientific system, the questioning of its own limits, and the interaction with another knowledge. Considering current transition scenarios does not mean having to abandon old objectives, but it adds to the work conducted new objects of study closely related to current reality, such as: the informational revolution; the relations with the ecosystem and the environmental crisis; globalization; the intensification of human mobility and migration flows; the growing economic and social inequality; the frictions derived from the articulation of collective identities; the decolonization of discourses; demographic dynamics; integration of technological advances; and viability and support for alternative models of society.Peer reviewe

Gestión del conocimiento. Perspectiva multidisciplinaria. Volumen 8

El libro “Gestión del Conocimiento. Perspectiva Multidisciplinaria”, volumen 8, de la Colección Unión Global, es resultado de investigaciones. Los capítulos del libro, son resultados de investigaciones desarrolladas por sus autores. El libro es una publicación internacional, seriada, continua, arbitrada de acceso abierto a todas las áreas del conocimiento, que cuenta con el esfuerzo de investigadores de varios países del mundo, orientada a contribuir con procesos de gestión del conocimiento científico, tecnológico y humanístico que consoliden la transformación del conocimiento en diferentes escenarios, tanto organizacionales como universitarios, para el desarrollo de habilidades cognitivas del quehacer diario. La gestión del conocimiento es un camino para consolidar una plataforma en las empresas públicas o privadas, entidades educativas, organizaciones no gubernamentales, ya sea generando políticas para todas las jerarquías o un modelo de gestión para la administración, donde es fundamental articular el conocimiento, los trabajadores, directivos, el espacio de trabajo, hacia la creación de ambientes propicios para el desarrollo integral de las instituciones

Esbozo histórico del proceso de supervisión en el sistema educativo venezolano

The purpose of the present paper is make public the main characteristics, stages and legal regulations that constitute landmarks in the historical course of the supervision process in the Bolivarian Educational System, so it becomes an important reference for the study and the research of the Venezuelan education in general and of the educational supervision process in particular. The carried out analysis shows that the supervision process has moved from the concept of autocratic inspection throughout the liberal inspection to democratic supervision. In the last years, the Bolivarian government has granted authority to the supervision service, with enough concepts and precisions that convert it in a permanent and indispensable activity for the improvement of the new educational system. The operated changes in the legal framework and official standards state the supervision as a political and strategic process in order to increase the quality of the Venezuelan education.El objetivo del presente trabajo es socializar las principales características, así como los momentos y reglamentaciones legales que resultan hitos en el devenir histórico del proceso supervisivo en el Sistema Educativo Bolivariano, lo cual constituye un importante referente para el estudio y la investigación de la educación venezolana en general y de la supervisión educativa en particular. El análisis realizado muestra que se ha transitado desde el concepto de inspección autocrática al de supervisión democrática, pasando por la inspección liberal. En los últimos años el gobierno bolivariano le ha otorgado autoridad al servicio de la supervisión, con conceptos y precisiones suficientes, para convertirla en una actividad permanente e indispensable para el funcionamiento del nuevo sistema educativo. Los cambios operados en la normatividad oficial y el marco legal reafirman a la supervisión como un proceso político y estratégico para elevar la calidad de la educación venezolana

Silver Nanoparticles and Chitosan Oligomers Composites as Poplar Wood Protective Treatments against Wood-Decay Fungi and Termites

This study focuses on Populus ×euramericana (Dode) Guinier, a globally distributed fast-growing tree. Despite its valuable wood, it exhibits low durability. The aim of this study was to assess the efficacy of a binary composite comprising silver nanoparticles (AgNPs) and chitosan oligomers (COS) in protecting P. ×euramericana ‘I-214’ wood against degradation caused by xylophagous fungi and termites through vacuum-pressure impregnation. The test material was carefully selected and conditioned following the guidelines of EN 350:2016, and impregnation was carried out in accordance with EN 113-1:2021. Five concentrations of AgNPs–COS composites were utilized. Biodeterioration resistance was evaluated based on EN 350:2016 for white (Trametes versicolor (L.) Lloyd) and brown (Coniophora puteana (Schumach.) P.Karst.) rot fungi, and EN 117:2012 for subterranean termites (Reticulitermis grassei Clément). The durability class and use class were assigned following EN 350:2016 and EN 335:2013, respectively. In comparison to the untreated control, the binary solution at its highest concentration (AgNPs 4 ppm + COS 20 g·L−1) demonstrated a notable reduction in weight loss, decreasing from 41.96 ± 4.49% to 30.15 ± 3.08% for white-rot fungi and from 41.93 ± 4.33% to 27.22 ± 0.66% for brown rot fungi. Furthermore, the observed termite infestation shifted from “heavy” to “attempted attack”, resulting in a decrease in the survival rate from 53.98 ± 10.40% to 26.62 ± 8.63%. Consequently, the durability classification of P. ×euramericana I-214 witnessed an enhancement from “Not durable” to “Slightly” and “Moderately durable” concerning decay fungi and termites, respectively. These findings expand the potential applications of this wood and substantiate the advantages of employing this environmentally friendly treatment

Prospective nonrandomized study of diagnostic accuracy comparing prostate cancer detection by transrectal ultrasound-guided biopsy to magnetic resonance imaging with subsequent MRI-guided biopsy in biopsy-naïve patients

Background: To evaluate the diagnostic efficacy in cancer prostate (PCa) of Multiparametric prostate magnetic resonance imaging (mp-MRI) targeted biopsy compared to standard systematic transrectal ultrasound-guided biopsy (TRUSGB) in biopsy-naïve patients. Methods: A total of 168 biopsy-naïve men with clinical suspicion of PCa due to elevated PSA levels and/or an abnormal digital rectal examination were consecutively enrolled from July 2011 to July 2014. All patients underwent TRUSGB. Patients with equivocal (Pi-rads 3) or suspicious lesion (Pi-rads 4-5), were additionally biopsied using two cores, by the same operator (cognitive technique). Results: Among the 168 cases, mp-MRI was equivocal for PCa (Pi-rads 3) in 46 subjects (27.4%) and suspicious (Pi-rads 4, 5) in 40 cases (23.8%). Of the 69 patients with PCa, standard TRUSGB showed Gleason ≥7 in 75% of patients with Pirads 3 and 77.8% in cases with Pirads 4-5 on mp-MRI. Among the 40 patients with Pi-rads 4-5 lesion on the MRI, cognitive mp-MRI-guided biopsy (MRCGB) detected a higher number of cases of PCa with a Gleason score equal or superior to 7 (90%) with a higher negative predictive value (97.5%) than cases with Pi-rads 3 lesion or subjects with TRUSGB alone. Conclusions: mp-MRI followed by selective biopsy seems to be a valuable tool to improve the diagnosis of intermediate and high risk PCa compared to standard TRUSGB.Sin financiación1.449 JCR (2017) Q3, 56/76 Urology & Nephrology0.439 SJR (2017) Q3, 43/66 NephrologyNo data IDR 2017UE