Poisson relation applied to the Navarrete Plutonic Complex, northeast North-Patagonian Massif, Argentina

Se realizó un estudio gravimétrico y magnetométrico en los afloramientos graníticos del Complejo Plutónico Navarrete, ubicado al noreste del Macizo Norpatagónico. Se analizó el grado de correlación entre ambos campos potenciales utilizando la relación de Poisson. Para ello, 1) se preparó un mapa de gradiente vertical de gravedad, que se comparó con el mapa de anomalías magnéticas reducidas al polo, 2) se calculó la relación magnetización - densidad encontrándose un notorio cambio de polaridad entre ambos campos potenciales. Cálculos complementarios como las soluciones de la señal analítica, en una sección transversal al Complejo Plutónico Navarrete, muestran la existencia de una falla geológica central que lo divide en dos bloques. La geometría inferida a partir de un modelo gravimétrico, y los cambios de polaridad en ambos lados del Complejo Plutónico Navarrete, indican diferencias de composición mineralógica y génesis, entre el Complejo Plutónico Navarrete Oriental y el Occidental.A gravimetric study was carried out in the granite outcrops of the Navarrete Plutonic Complex (NPC), located to the northeast of the Northpatagonian Massive (NPM). The degree of correlation between the gravimetric and magnetometric fields was analyzed using the Poisson relation. In order to do this 1) a vertical gradient map of gravity was compared to the map of magnetic anomalies reduced at the pole, 2) the magnetization-density relation between the two potential fields was analyzed showing a distinct change in polarity. Complementary calculations (the analytic signal in one transverse sector of the NPC) have shown the existence of a central geological fault dividing it into two blocks. Based on the gravimetric model and the polarity changes, the inferred geometry encountered on both sides of the NPC leads to the intuition of mineralogical differences between the composition and origin of the Eastern and Western NPC.Fil: Lince Klinger, Federico Gustavo. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto Geofísico Sismológico Volponi; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; ArgentinaFil: Gimenez, Mario Ernesto. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto Geofísico Sismológico Volponi; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; ArgentinaFil: Martínez, Myriam Patricia. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto Geofísico Sismológico Volponi; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; ArgentinaFil: Rapalini, Augusto Ernesto. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias Geológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Novara, Ivan Lionel. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto Geofísico Sismológico Volponi; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentin

Immunosuppresive effects of the methanolic extract of Chrysophyllum cainito leaves on macrophage functions

Background: The aim of this work was to evaluate the immunomodulatory effect of the methanol extract (MeOH) from Chrysophyllum cainito leaves on the MΦs functions.Material and Methods: Peritoneal murine MΦs isolated from Balb/c mice were treated with the MeOH extract and stimulated with LPS. The effect on the phagocytosis was evaluated by flow cytometry assay. The nitric oxide (NO) and hydrogen peroxide (H2O2) production was measured by the Griess reagent and phenol red reaction, respectively. Levels of IL-6 and TNF-α was measured using an ELISA kit. Viability of MΦs and Vero cells was determined by the MTT method.Results: The MeOH extract of C. cainito leaves inhibited significantly the phagocytosis, and decreased IL-6 and TNF-α production as well as NO and H2O2 released by the MΦs, in a concentration-dependent manner. In addition, MeOH extract of C. cainito showed low cytotoxicity effect against the cells.Conclusion: These results suggest that MeOH extract of C. cainito leaves has an immunosuppressive effect on murine MΦs, without effects on cell viability. GC-MS chromatogram analysis of MeOH extract showed that lupeol acetate and alpha-amyrin acetate are the principal compounds.Keywords: Macrophages, Immunomodulation, Chrysophyllum cainito, Sapotaceae, Phagocytosi

Large-Area, Flexible, Lead-Free Sn-Perovskite Solar Modules

For the first time, large-area, flexible organic–inorganic tin perovskite solar modules are fabricated by means of an industry-compatible and scalable blade-coating technique. An 8-cell interconnected mini module with dimensions of 25 cm2 (active area = 8 × 1.5 cm2) reached 5.7% power conversion efficiency under 1000 W/m2 (AM 1.5G) and 9.4% under 2000 lx (white-LED).This project received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement no. 862656 (project DROP-IT) and of Generalitat Valenciana under the Print-P (MFA/2022/020) project

Intervención educativa en farmacovigilancia dirigida al personal de salud de una clínica de medicina familiar

Pharmacovigilance (FV) has helped to detect and prevent drug-related adverse reactions (ADRs). However, some factors, such as poor knowledge of VF and lack of interest among health personnel, limit its application and favor underreporting of ADRs. In the present study, an educational intervention on FV was carried out aimed at health personnel who work in a family medicine clinic of the ISSSTE and to evaluate its effects in terms of knowledge, attitude, practice and experience. A questionnaire was applied before and after the intervention, consisting of 11 questions related to knowledge, 4 related to the attitude towards FV and 6 questions related to the practice and experience in FV. 60 professionals participated. There were significant improvements in knowledge about FV, while in terms of attitude towards the practice of FV there were no significant changes, although the results showed a good attitude of the participants from before the intervention. Regarding practice and experience in FV, the majority have detected an ADR in the patients they care for, but have not reported it to the respective FV center mainly due to lack of time.La farmacovigilancia (FV) ha ayudado a detectar y prevenir reacciones adversas relacionadas a los medicamentos (RAMs). Sin embargo, algunos factores, como conocimientos deficientes en FV y falta de interés del personal de salud, limitan su aplicación y favorece la subnotificación de las RAMs. En el presente estudio se realizó una intervención educativa sobre FV dirigida al personal de salud que labora en una clínica de medicina familiar del ISSSTE y evaluar sus efectos en términos de conocimientos, actitud, práctica y experiencia. Se aplicó un cuestionario, antes y después de la intervención, constituido por 11 preguntas relacionadas con los conocimientos, 4 relacionadas con la actitud hacia la FV y 6 preguntas relacionadas con la práctica y experiencia en FV. Participaron 60 profesionales. Hubo mejoras significativas en conocimientos sobre FV, mientras que en términos de actitud hacia la práctica de la FV no hubo cambios significativos, aunque los resultados mostraron una buena actitud de los participantes desde antes de la intervención. Respecto a la práctica y experiencia en FV, la mayoría ha detectado una RAM en los pacientes que atiende, pero no la ha reportado al respectivo centro de FV principalmente debido a la falta de tiempo

Sloan Digital Sky Survey Imaging of Low Galactic Latitude Fields: Technical Summary and Data Release

The Sloan Digital Sky Survey (SDSS) mosaic camera and telescope have obtained five-band optical-wavelength imaging near the Galactic plane outside of the nominal survey boundaries. These additional data were obtained during commissioning and subsequent testing of the SDSS observing system, and they provide unique wide-area imaging data in regions of high obscuration and star formation, including numerous young stellar objects, Herbig-Haro objects and young star clusters. Because these data are outside the Survey regions in the Galactic caps, they are not part of the standard SDSS data releases. This paper presents imaging data for 832 square degrees of sky (including repeats), in the star-forming regions of Orion, Taurus, and Cygnus. About 470 square degrees are now released to the public, with the remainder to follow at the time of SDSS Data Release 4. The public data in Orion include the star-forming region NGC 2068/NGC 2071/HH24 and a large part of Barnard's loop.Comment: 31 pages, 9 figures (3 missing to save space), accepted by AJ, in press, see http://photo.astro.princeton.edu/oriondatarelease for data and paper with all figure

Measurement of the cosmic ray spectrum above 4×10184{\times}10^{18} eV using inclined events detected with the Pierre Auger Observatory

A measurement of the cosmic-ray spectrum for energies exceeding $4{\times}10^{18}$ eV is presented, which is based on the analysis of showers with zenith angles greater than $60^{\circ}$ detected with the Pierre Auger Observatory between 1 January 2004 and 31 December 2013. The measured spectrum confirms a flux suppression at the highest energies. Above $5.3{\times}10^{18}$ eV, the "ankle", the flux can be described by a power law $E^{-\gamma}$ with index $\gamma=2.70 \pm 0.02 \,\text{(stat)} \pm 0.1\,\text{(sys)}$ followed by a smooth suppression region. For the energy ($E_\text{s}$) at which the spectral flux has fallen to one-half of its extrapolated value in the absence of suppression, we find $E_\text{s}=(5.12\pm0.25\,\text{(stat)}^{+1.0}_{-1.2}\,\text{(sys)}){\times}10^{19}$ eV.Comment: Replaced with published version. Added journal reference and DO

Energy Estimation of Cosmic Rays with the Engineering Radio Array of the Pierre Auger Observatory

The Auger Engineering Radio Array (AERA) is part of the Pierre Auger Observatory and is used to detect the radio emission of cosmic-ray air showers. These observations are compared to the data of the surface detector stations of the Observatory, which provide well-calibrated information on the cosmic-ray energies and arrival directions. The response of the radio stations in the 30 to 80 MHz regime has been thoroughly calibrated to enable the reconstruction of the incoming electric field. For the latter, the energy deposit per area is determined from the radio pulses at each observer position and is interpolated using a two-dimensional function that takes into account signal asymmetries due to interference between the geomagnetic and charge-excess emission components. The spatial integral over the signal distribution gives a direct measurement of the energy transferred from the primary cosmic ray into radio emission in the AERA frequency range. We measure 15.8 MeV of radiation energy for a 1 EeV air shower arriving perpendicularly to the geomagnetic field. This radiation energy -- corrected for geometrical effects -- is used as a cosmic-ray energy estimator. Performing an absolute energy calibration against the surface-detector information, we observe that this radio-energy estimator scales quadratically with the cosmic-ray energy as expected for coherent emission. We find an energy resolution of the radio reconstruction of 22% for the data set and 17% for a high-quality subset containing only events with at least five radio stations with signal.Comment: Replaced with published version. Added journal reference and DO

Measurement of the Radiation Energy in the Radio Signal of Extensive Air Showers as a Universal Estimator of Cosmic-Ray Energy

We measure the energy emitted by extensive air showers in the form of radio emission in the frequency range from 30 to 80 MHz. Exploiting the accurate energy scale of the Pierre Auger Observatory, we obtain a radiation energy of 15.8 \pm 0.7 (stat) \pm 6.7 (sys) MeV for cosmic rays with an energy of 1 EeV arriving perpendicularly to a geomagnetic field of 0.24 G, scaling quadratically with the cosmic-ray energy. A comparison with predictions from state-of-the-art first-principle calculations shows agreement with our measurement. The radiation energy provides direct access to the calorimetric energy in the electromagnetic cascade of extensive air showers. Comparison with our result thus allows the direct calibration of any cosmic-ray radio detector against the well-established energy scale of the Pierre Auger Observatory.Comment: Replaced with published version. Added journal reference and DOI. Supplemental material in the ancillary file