DESCRIPTION AND INTERPRETATION OF A MEGATHERIUM AMERICANUM ATLAS WITH EVIDENCE OF HUMAN INTERVENTION

This paper discusses a Megatherium americanum atlas from the Pampas region of Argentina, which is currently housed at the Museo di Storia Naturale di Firenze, Italy. Traces of anthropic cut marks were found on the dorsal and ventral faces of the posterior part, in articulation with the axis. This is the first time that this type of evidence has been documented on this element of this species. The position of these marks suggests that they resulted from the act of separating the head from the postcranial skeleton. They were therefore most likely made in an effort to exploit the contents of the head. Current research focusing on museum collections employing modern methods can provide new and valuable information, despite the general lack of contextualization of these pieces. In the case studied here, these methods have allowed us to delve deeper into the first dispersal of Homo sapiens and their interaction with the native fauna in the South American Southern Cone.&nbsp

NO2-controlled cargo delivery from gated silica mesoporous nanoparticles

[EN] Cargo delivery from mesoporous silica nanoparticles loaded with sulforhodamine B and capped with a difluoroboron-dipyrromethene (BODIPY) derivative was triggered by a NO2-induced oxidative process.The authors thank the financial support from the Spanish Government (project MAT2015-64139-C4-R) and the Generalitat Valenciana (project GVA/2014/13).Juarez, LA.; Costero, AM.; Parra Alvarez, M.; Gaviña, P.; Gil Grau, S.; Martínez-Máñez, R.; Sancenón Galarza, F. (2017). NO2-controlled cargo delivery from gated silica mesoporous nanoparticles. Chemical Communications. 53(3):585-588. https://doi.org/10.1039/c6cc08885fS585588533ARIGA, K., VINU, A., HILL, J., & MORI, T. (2007). Coordination chemistry and supramolecular chemistry in mesoporous nanospace. Coordination Chemistry Reviews, 251(21-24), 2562-2591. doi:10.1016/j.ccr.2007.02.024Katz, E., & Willner, I. (2004). Integrated Nanoparticle-Biomolecule Hybrid Systems: Synthesis, Properties, and Applications. Angewandte Chemie International Edition, 43(45), 6042-6108. doi:10.1002/anie.200400651Descalzo, A. B., Martínez-Máñez, R., Sancenón, F., Hoffmann, K., & Rurack, K. (2006). The Supramolecular Chemistry of Organic–Inorganic Hybrid Materials. Angewandte Chemie International Edition, 45(36), 5924-5948. doi:10.1002/anie.200600734Puoci, F., Iemma, F., & Picci, N. (2008). Stimuli-Responsive Molecularly Imprinted Polymers for Drug Delivery: A Review. Current Drug Delivery, 5(2), 85-96. doi:10.2174/156720108783954888Siepmann, F., Siepmann, J., Walther, M., MacRae, R. J., & Bodmeier, R. (2008). Polymer blends for controlled release coatings. Journal of Controlled Release, 125(1), 1-15. doi:10.1016/j.jconrel.2007.09.012Hamidi, M., Azadi, A., & Rafiei, P. (2008). Hydrogel nanoparticles in drug delivery. Advanced Drug Delivery Reviews, 60(15), 1638-1649. doi:10.1016/j.addr.2008.08.002Pouton, C. W., & Porter, C. J. H. (2008). Formulation of lipid-based delivery systems for oral administration: Materials, methods and strategies. Advanced Drug Delivery Reviews, 60(6), 625-637. doi:10.1016/j.addr.2007.10.010Rijcken, C. J. F., Soga, O., Hennink, W. E., & Nostrum, C. F. van. (2007). Triggered destabilisation of polymeric micelles and vesicles by changing polymers polarity: An attractive tool for drug delivery. Journal of Controlled Release, 120(3), 131-148. doi:10.1016/j.jconrel.2007.03.023Andresen, T. L., Jensen, S. S., & Jørgensen, K. (2005). Advanced strategies in liposomal cancer therapy: Problems and prospects of active and tumor specific drug release. Progress in Lipid Research, 44(1), 68-97. doi:10.1016/j.plipres.2004.12.001Beck, J. S., Vartuli, J. C., Roth, W. J., Leonowicz, M. E., Kresge, C. T., Schmitt, K. D., … Schlenker, J. L. (1992). A new family of mesoporous molecular sieves prepared with liquid crystal templates. Journal of the American Chemical Society, 114(27), 10834-10843. doi:10.1021/ja00053a020Wight, A. P., & Davis, M. E. (2002). Design and Preparation of Organic−Inorganic Hybrid Catalysts. Chemical Reviews, 102(10), 3589-3614. doi:10.1021/cr010334mKickelbick, G. (2004). Hybrid Inorganic–Organic Mesoporous Materials. Angewandte Chemie International Edition, 43(24), 3102-3104. doi:10.1002/anie.200301751Stein, A. (2003). Advances in Microporous and Mesoporous Solids—Highlights of Recent Progress. Advanced Materials, 15(10), 763-775. doi:10.1002/adma.200300007Aznar, E., Oroval, M., Pascual, L., Murguía, J. R., Martínez-Máñez, R., & Sancenón, F. (2016). Gated Materials for On-Command Release of Guest Molecules. Chemical Reviews, 116(2), 561-718. doi:10.1021/acs.chemrev.5b00456Soler-Illia, G. J. A. A., & Azzaroni, O. (2011). Multifunctional hybrids by combining ordered mesoporous materials and macromolecular building blocks. Chemical Society Reviews, 40(2), 1107. doi:10.1039/c0cs00208aSaha, S., Leung, K. C.-F., Nguyen, T. D., Stoddart, J. F., & Zink, J. I. (2007). Nanovalves. Advanced Functional Materials, 17(5), 685-693. doi:10.1002/adfm.200600989Wang, F., Liu, X., & Willner, I. (2014). DNA Switches: From Principles to Applications. Angewandte Chemie International Edition, 54(4), 1098-1129. doi:10.1002/anie.201404652Song, N., & Yang, Y.-W. (2015). Molecular and supramolecular switches on mesoporous silica nanoparticles. Chemical Society Reviews, 44(11), 3474-3504. doi:10.1039/c5cs00243eTrewyn, B. G., Giri, S., Slowing, I. I., & Lin, V. S.-Y. (2007). Mesoporous silica nanoparticle based controlled release, drug delivery, and biosensor systems. Chemical Communications, (31), 3236. doi:10.1039/b701744hSancenón, F., Pascual, L., Oroval, M., Aznar, E., & Martínez-Máñez, R. (2015). Gated Silica Mesoporous Materials in Sensing Applications. ChemistryOpen, 4(4), 418-437. doi:10.1002/open.201500053Casasús, R., Aznar, E., Marcos, M. D., Martínez-Máñez, R., Sancenón, F., Soto, J., & Amorós, P. (2006). New Methods for Anion Recognition and Signaling Using Nanoscopic Gatelike Scaffoldings. Angewandte Chemie International Edition, 45(40), 6661-6664. doi:10.1002/anie.200602045Coll, C., Casasús, R., Aznar, E., Marcos, M. D., Martínez-Máñez, R., Sancenón, F., … Amorós, P. (2007). Nanoscopic hybrid systems with a polarity-controlled gate-like scaffolding for the colorimetric signalling of long-chain carboxylates. Chem. Commun., (19), 1957-1959. doi:10.1039/b617703dÖzalp, V. C., & Schäfer, T. (2011). Aptamer-Based Switchable Nanovalves for Stimuli-Responsive Drug Delivery. Chemistry - A European Journal, 17(36), 9893-9896. doi:10.1002/chem.201101403Climent, E., Marcos, M. D., Martínez-Máñez, R., Sancenón, F., Soto, J., Rurack, K., & Amorós, P. (2009). The Determination of Methylmercury in Real Samples Using Organically Capped Mesoporous Inorganic Materials Capable of Signal Amplification. Angewandte Chemie International Edition, 48(45), 8519-8522. doi:10.1002/anie.200904243Wen, Y., Xu, L., Li, C., Du, H., Chen, L., Su, B., … Song, Y. (2012). DNA-based intelligent logic controlled release systems. Chemical Communications, 48(67), 8410. doi:10.1039/c2cc34501cZhang, Z., Balogh, D., Wang, F., & Willner, I. (2013). Smart Mesoporous SiO2 Nanoparticles for the DNAzyme-Induced Multiplexed Release of Substrates. Journal of the American Chemical Society, 135(5), 1934-1940. doi:10.1021/ja311385yZhou, Y., Tan, L.-L., Li, Q.-L., Qiu, X.-L., Qi, A.-D., Tao, Y., & Yang, Y.-W. (2014). Acetylcholine-Triggered Cargo Release from Supramolecular Nanovalves Based on Different Macrocyclic Receptors. Chemistry - A European Journal, 20(11), 2998-3004. doi:10.1002/chem.201304864Chen, M., Huang, C., He, C., Zhu, W., Xu, Y., & Lu, Y. (2012). A glucose-responsive controlled release system using glucose oxidase-gated mesoporous silica nanocontainers. Chemical Communications, 48(76), 9522. doi:10.1039/c2cc34290aCliment, E., Bernardos, A., Martínez-Máñez, R., Maquieira, A., Marcos, M. D., Pastor-Navarro, N., … Amorós, P. (2009). Controlled Delivery Systems Using Antibody-Capped Mesoporous Nanocontainers. Journal of the American Chemical Society, 131(39), 14075-14080. doi:10.1021/ja904456dYang, S., Li, N., Liu, Z., Sha, W., Chen, D., Xu, Q., & Lu, J. (2014). Amphiphilic copolymer coated upconversion nanoparticles for near-infrared light-triggered dual anticancer treatment. Nanoscale, 6(24), 14903-14910. doi:10.1039/c4nr05305bSchloßbauer, A., Sauer, A. M., Cauda, V., Schmidt, A., Engelke, H., Rothbauer, U., … Bein, T. (2012). Cascaded Photoinduced Drug Delivery to Cells from Multifunctional Core-Shell Mesoporous Silica. Advanced Healthcare Materials, 1(3), 316-320. doi:10.1002/adhm.201100033Mackowiak, S. A., Schmidt, A., Weiss, V., Argyo, C., von Schirnding, C., Bein, T., & Bräuchle, C. (2013). Targeted Drug Delivery in Cancer Cells with Red-Light Photoactivated Mesoporous Silica Nanoparticles. Nano Letters, 13(6), 2576-2583. doi:10.1021/nl400681fSilveira, G. Q., Vargas, M. D., & Ronconi, C. M. (2011). Nanoreservoir operated by ferrocenyl linker oxidation with molecular oxygen. Journal of Materials Chemistry, 21(16), 6034. doi:10.1039/c0jm03738aColl, C., Bernardos, A., Martínez-Máñez, R., & Sancenón, F. (2012). Gated Silica Mesoporous Supports for Controlled Release and Signaling Applications. Accounts of Chemical Research, 46(2), 339-349. doi:10.1021/ar3001469El Sayed, S., Milani, M., Milanese, C., Licchelli, M., Martínez-Máñez, R., & Sancenón, F. (2016). Anions as Triggers in Controlled Release Protocols from Mesoporous Silica Nanoparticles Functionalized with Macrocyclic Copper(II) Complexes. Chemistry - A European Journal, 22(39), 13935-13945. doi:10.1002/chem.201601024De la Torre, C., Casanova, I., Acosta, G., Coll, C., Moreno, M. J., Albericio, F., … Martínez-Máñez, R. (2014). Gated Mesoporous Silica Nanoparticles Using a Double-Role Circular Peptide for the Controlled and Target-Preferential Release of Doxorubicin in CXCR4-Expresing Lymphoma Cells. Advanced Functional Materials, 25(5), 687-695. doi:10.1002/adfm.201403822Climent, E., Mondragón, L., Martínez-Máñez, R., Sancenón, F., Marcos, M. D., Murguía, J. R., … Pérez-Payá, E. (2013). Selective, Highly Sensitive, and Rapid Detection of Genomic DNA by Using Gated Materials:MycoplasmaDetection. Angewandte Chemie International Edition, 52(34), 8938-8942. doi:10.1002/anie.201302954Li, H., Chen, L., Guo, Z., Sang, N., & Li, G. (2012). In vivo screening to determine neurological hazards of nitrogen dioxide (NO2) using Wistar rats. Journal of Hazardous Materials, 225-226, 46-53. doi:10.1016/j.jhazmat.2012.04.063Folinsbee, L. J. (1993). Human health effects of air pollution. Environmental Health Perspectives, 100, 45-56. doi:10.1289/ehp.9310045Melia, R. J., Florey, C. D., Altman, D. G., & Swan, A. V. (1977). Association between gas cooking and respiratory disease in children. BMJ, 2(6080), 149-152. doi:10.1136/bmj.2.6080.149Neas, L. M., Dockery, D. W., Ware, J. H., Spengler, J. D., Speizer, F. E., & Ferris, B. G. (1991). Association of Indoor Nitrogen Dioxide with Respiratory Symptoms and Pulmonary Function in Children. American Journal of Epidemiology, 134(2), 204-219. doi:10.1093/oxfordjournals.aje.a116073Meng, X., Wang, C., Cao, D., Wong, C.-M., & Kan, H. (2013). Short-term effect of ambient air pollution on COPD mortality in four Chinese cities. Atmospheric Environment, 77, 149-154. doi:10.1016/j.atmosenv.2013.05.001Shim, S. B., Kim, K., & Kim, Y. H. (1987). Direct conversion of oximes and hydrazones into their ketones with dinitrogen tetroxide. Tetrahedron Letters, 28(6), 645-648. doi:10.1016/s0040-4039(00)95802-7Mokhtari, J., Naimi-Jamal, M. R., Hamzeali, H., Dekamin, M. G., & Kaupp, G. (2009). Kneading Ball-Milling and Stoichiometric Melts for the Quantitative Derivatization of Carbonyl Compounds with Gas-Solid Recovery. ChemSusChem, 2(3), 248-254. doi:10.1002/cssc.200800258Cabrera, S., El Haskouri, J., Guillem, C., Latorre, J., Beltrán-Porter, A., Beltrán-Porter, D., … Amorós *, P. (2000). Generalised syntheses of ordered mesoporous oxides: the atrane route. Solid State Sciences, 2(4), 405-420. doi:10.1016/s1293-2558(00)00152-7Radu, D. R., Lai, C.-Y., Jeftinija, K., Rowe, E. W., Jeftinija, S., & Lin, V. S.-Y. (2004). A Polyamidoamine Dendrimer-Capped Mesoporous Silica Nanosphere-Based Gene Transfection Reagent. Journal of the American Chemical Society, 126(41), 13216-13217. doi:10.1021/ja046275mJuárez, L. A., Costero, A. M., Parra, M., Gaviña, P., & Gil, S. (2016). 3-Formyl-BODIPY Phenylhydrazone as a Chromo-Fluorogenic Probe for Selective Detection of NO2(g). Chemistry - A European Journal, 22(25), 8448-8451. doi:10.1002/chem.20160092

Application of Vegetation Indices to Estimate Acorn Production at Iberian

The Iberian pig valued natural resources of the pasture when fattened in mountain. The variability of acorn production is not contained in any line of Spanish agricultural insurance. However, the production of arable pasture is covered by line insurance number 133 for loss of pasture compensation. This scenario is only contemplated for breeding cows and brave bulls, sheep, goats and horses, although pigs are not included. This insurance is established by monitoring ten-day composites Normalized Difference Vegetation Index (NDVI) measured by satellite over treeless pastures, using MODIS TERRA satellite. The aim of this work is to check if we can use a satellite vegetation index to estimate the production of acorns

Strategies to establish the structure and the evaluation system of the student projects in the bachelor engineering in industrial design and product development at Universitat Politècnica de València campus of Alcoi

[EN] The Bachelor Engineering in Industrial Design and Product Development is a multidisciplinary degree, in which a wide range of disciplines have a key role in the final projects developed by the students of the fourth grade. At Universitat Politècnica de València ¿ Campus d¿Alcoi, a number of lecturers are involved in an Education Project in order to change and adapt the evaluation system of the student projects. The current model is based on developing the work with the help of a supervisor and the evaluation carried out by other three teachers, who form the panel. In the frame of the Education Project, some teachers are trying to apply new strategies to improve both the supervising process and the evaluation system of the projects. First of all, an index is provided to the students to adapt the structure of their work. Then, it is intended that a number of teachers, each one from a different specialization, supervise the progress of the students weekly. Finally, the same teachers will take part in the evaluation as examiners. All this work must be integrated in the 120 attendance hours established to develop the project, which correspond to the 12 ECTS. In the frame of the new teaching-learning methodologies, the aim of this Education Project is to provide a system to develop and evaluate the student final projects, taking into account the role of students, supervisors and examiners in every stage of the work.Juliá Sanchis, E.; Jorda-Vilaplana, A.; Valor Valor, M.; Pla-Ferrando, L.; Sempere Ripoll, S.; Picó Silvestre, JF.; Bonet-Aracil, M.... (2017). Strategies to establish the structure and the evaluation system of the student projects in the bachelor engineering in industrial design and product development at Universitat Politècnica de València campus of Alcoi. EDULEARN Proceedings (Internet). 249-255. doi:10.21125/edulearn.2017.0106S24925

DEFINITION OF THE MAIN FEATURES OF THE STUDENT PROJECTS FOR THEIR DEVELOPMENT AND ASSESSMENT IN THE BACHELOR ENGINEERING IN INDUSTRIAL DESIGN AND PRODUCT DEVELOPMENT AT UNIVERSITAT POLITÈCNICA DE VALÈNCIA CAMPUS OF ALCOI

[EN] The Bachelor Engineering in Industrial Design and Product Development establishes the final project as a compulsory stage to achieve the degree. Due to the wide range of industrial products that can be designed, there is an extensive number of topics. The students can choose their final project according to the specialization they have studied all along the fourth academic year. At Universitat Politècnica de València ¿ Campus d¿Alcoi, three specializations can be studied: a) Product Design; b) Production and Innovation, and c) Textile and Fashion Design. Due to the multidisciplinary approach, there is a need to define a general index, both for students and lecturers, which contains the minimum contents of every type of project. Part of the work consists of analysing the three types of projects and the basic structure for each one, depending on the specialization. In addition, there is a particular project based on communication issues. A team of lecturers are involved in an education project at Universitat Politècnica de València. There is, at least, one representative for each specialization. The team has been working based on the last five years presented final projects and with a National Standard UNE 157001:2014: general criteria for the formal preparation of the documents constituting a technical project. The aim of this part of the project is to define the main structure for the minimum contents that these projects must include for their assessment. Finally, a document has been prepared as a basic guideline for students and lecturers, with definitions and instructions. Despite being four different topics, results show a common part which must be fulfilled by every project. Apart from the common part, every specialization has defined the particular features to be included. This document is useful for every part in the process: students to focus on the tasks to develop, lecturers to guide the students and introduce the process and the panel of teachers to obtain the basis for the evaluation.Bonet-Aracil, M.; Valor Valor, M.; Jorda-Vilaplana, A.; Sempere Ripoll, S.; Juliá Sanchis, E.; Pla-Ferrando, L.; Picó Silvestre, JF.... (2017). DEFINITION OF THE MAIN FEATURES OF THE STUDENT PROJECTS FOR THEIR DEVELOPMENT AND ASSESSMENT IN THE BACHELOR ENGINEERING IN INDUSTRIAL DESIGN AND PRODUCT DEVELOPMENT AT UNIVERSITAT POLITÈCNICA DE VALÈNCIA CAMPUS OF ALCOI. EDULEARN Proceedings (Internet). 9471-9474. doi:10.21125/edulearn.2017.0789S9471947

Carotenoides en agroalimentación y salud

Los carotenoides son compuestos especiales; si bien es común referirse a ellos como pigmentos, lo cierto es que son compuestos de gran versatilidad e importancia en la naturaleza. Más específicamente, son de gran interés en agroalimentación y salud. Así, por ejemplo, son pigmentos naturales y por lo tanto tienen un importante papel en la elección de alimentos por parte de los consumidores. Asimismo, algunos de ellos son precursores de la vitamina A. Sin embargo, que cada vez exista más interés en los carotenoides en este contexto se debe en gran parte a muchos estudios de distinta naturaleza que indican que pueden proporcionar beneficios para la salud. Su interés en alimentación funcional es por lo tanto indudable. En este libro se refleja la experiencia en carotenoides de un gran número de profesionales de la región iberoamericana. En conjunto, se ofrece una visión general de la investigación sobre estos compuestos en agroalimentación y salud. Los autores son miembros de la red IBERCAROT (http://carotenoides.us.es), que tiene entre sus objetivos conformar una red estable y funcional de profesionales que aúnen esfuerzos en pos de identificar nuevas fuentes de carotenoides de interés nutricional, mejorar su producción y aumentar el valor de los productos que los contengan

High-resolution genome screen for bone mineral density in heterogeneous stock rat

We previously demonstrated that skeletal mass, structure, and biomechanical properties vary considerably in heterogeneous stock (HS) rat strains. In addition, we observed strong heritability for several of these skeletal phenotypes in the HS rat model, suggesting that it represents a unique genetic resource for dissecting the complex genetics underlying bone fragility. The purpose of this study was to identify and localize genes associated with bone mineral density in HS rats. We measured bone phenotypes from 1524 adult male and female HS rats between 17 and 20 weeks of age. Phenotypes included dual-energy X-ray absorptiometry (DXA) measurements for bone mineral content and areal bone mineral density (aBMD) for femur and lumbar spine (L3-L5), and volumetric BMD measurements by CT for the midshaft and distal femur, femur neck, and fifth lumbar vertebra (L5). A total of 70,000 polymorphic single-nucleotide polymorphisms (SNPs) distributed throughout the genome were selected from genotypes obtained from the Affymetrix rat custom SNPs array for the HS rat population. These SNPs spanned the HS rat genome with a mean linkage disequilibrium coefficient between neighboring SNPs of 0.95. Haplotypes were estimated across the entire genome for each rat using a multipoint haplotype reconstruction method, which calculates the probability of descent for each genotyped locus from each of the eight founder HS strains. The haplotypes were tested for association with each bone density phenotype via a mixed model with covariate adjustment. We identified quantitative trait loci (QTLs) for BMD phenotypes on chromosomes 2, 9, 10, and 13 meeting a conservative genomewide empiric significance threshold (false discovery rate [FDR] = 5%; p < 3 × 10(-6)). Importantly, most QTLs were localized to very small genomic regions (1-3 megabases [Mb]), allowing us to identify a narrow set of potential candidate genes including both novel genes and genes previously shown to have roles in skeletal development and homeostasis

Fine mapping of bone structure and strength QTLs in heterogeneous stock rat

We previously demonstrated that skeletal structure and strength phenotypes vary considerably in heterogeneous stock (HS) rats. These phenotypes were found to be strongly heritable, suggesting that the HS rat model represents a unique genetic resource for dissecting the complex genetic etiology underlying bone fragility. The purpose of this study was to identify and localize genes associated with bone structure and strength phenotypes using 1524 adult male and female HS rats between 17 to 20 weeks of age. Structure measures included femur length, neck width, head width; femur and lumbar spine (L3-5) areas obtained by DXA; and cross-sectional areas (CSA) at the midshaft, distal femur and femoral neck, and the 5th lumbar vertebra measured by CT. In addition, measures of strength of the whole femur and femoral neck were obtained. Approximately 70,000 polymorphic SNPs distributed throughout the rat genome were selected for genotyping, with a mean linkage disequilibrium coefficient between neighboring SNPs of 0.95. Haplotypes were estimated across the entire genome for each rat using a multipoint haplotype reconstruction method, which calculates the probability of descent at each locus from each of the 8 HS founder strains. The haplotypes were then tested for association with each structure and strength phenotype via a mixed model with covariate adjustment. We identified quantitative trait loci (QTLs) for structure phenotypes on chromosomes 3, 8, 10, 12, 17 and 20, and QTLs for strength phenotypes on chromosomes 5, 10 and 11 that met a conservative genome-wide empiric significance threshold (FDR=5%; P<3×10(-6)). Importantly, most QTLs were localized to very narrow genomic regions (as small as 0.3 Mb and up to 3 Mb), each harboring a small set of candidate genes, both novel and previously shown to have roles in skeletal development and homeostasis

Hacia la creación de la especialidad sanitaria de Psicología Clínica de la Infancia y la Adolescencia

En España aún no existe un título oficial de especialista sanitario en Psicología Clínica de la Infancia y la Adolescencia, sin embargo, son muchos los argumentos que evidencian la necesidad de su creación. Entre los principales están la urgente necesidad de mejorar la calidad de la atención a la salud mental de la infancia y la adolescencia; el hecho de que esta especialidad sanitaria ya existe como rama científica diferenciada y consolidada; la necesidad de un programa de formación reglada propio para esta área de la psicología clínica, dada la especificidad y extensión de los conocimientos científicos y competencias profesionales necesarios para su ejercicio; o que la Psicología Clínica de la Infancia y la Adolescencia ya existe de facto como especialidad sanitaria diferenciada en algunos sistemas sanitarios públicos autonómicos. En este artículo se exponen y desarrollan estos y otros argumentos con el objetivo de impulsar la creación de esta nueva especialidad sanitaria en nuestro país