SW for signal generation simulating rotary system faults

Tato diplomová práce se věnuje návrhu a tvorbě algoritmu pro generování simulovaného signálu z vibrodiagnostického zařízení. První část je zaměřená na teoretické seznámení se s vibrodiagnostikou a charakteristikou jednotlivých závad rotačních strojů. Další část se zabývá možnostmi matematických a kinematických simulací za pomocí počítačových programů. Hlavní část této práce se věnuje tvorbě programu pro generování simulovaného signálu. V poslední části je názorně předveden princip simulace konkrétních závad rotačních strojů.This diploma thesis deals with the design and creation of an algorithm for generating simulated signal data from a vibration diagnostics device. The first part is focused on theoretical acquaintance with vibration diagnostics and characteristics of individual defects of rotary machines. The next part deals with the possibilities of mathematical and kinematic simulations using a computer software. The main part of this work is dedicated to design and creation of software for generating simulated signal data. In the last part, the principle of simulation of specific defects of rotary machines is clearly demonstrated.

Home security system

Úvodní kapitoly této práce se věnují druhům ochrany objektů, popisují prvky zabezpečovacích systémů a druhy čidel, které se v systémech vyskytují. Další kapitoly se věnují detektorům jiných nebezpečí než je trestná činnost a řeší problematiku přenosu signálu. V závěru práce je prakticky řešen zabezpečovací systém pro dům či byt založený na open-sourcovém řešení ve vývojovém prostředí ARMmbed.The introductory chapters of this work are dedicated to types of object protection, describe the elements of the security systems and the types of sensors that are present in the security systems. The next chapters deal with detectors of other hazards rather than crime and deal with the problem of signal transmission. At the end of the thesis, security system for house or apartment is solved, based on open-source solution in development environment ARMmbed.

Photochemistry of a 9-Dithianyl-Pyronin Derivative: A Cornucopia of Reaction Intermediates Lead to Common Photoproducts

Leaving groups attached to themeso-methyl position of many common dyes, such as xanthene, BODIPY, or pyronin derivatives, can be liberated upon irradiation with visible light. However, the course of phototransformations of such photoactivatable systems can be quite complex and the identification of reaction intermediates or even products is often neglected. This paper exemplifies the photochemistry of a 9-dithianyl-pyronin derivative, which undergoes an oxidative transformation at themeso-position to give a 3,6-diamino-9H-xanthen-9-one derivative, formic acid, and carbon monoxide as the main photoproducts. The course of this multi-photon multi-step reaction was studied under various conditions by steady-state and time-resolved optical spectroscopy, mass spectrometry and NMR spectroscopy to understand the effects of solvents and molecular oxygen on individual steps. Our analyses have revealed the existence of many intermediates and their interrelationships to provide a complete picture of the transformation, which can bring new inputs to a rational design of new photoactivatable pyronin or xanthene derivatives

Colorectal cancer liver metastases: laparoscopic and open radiofrequency-assisted surgery

Introduction: The liver is the most common site of colorectal metastases (colorectal liver metastases – CLM). Surgical treatment in combination with oncological therapy is the only potentially curative method. Unfortunately, only 10–25% of patients are suitable for surgery. Traditionally, open liver resection (OLR) is usually performed. However, laparoscopic liver resection (LLR) has become popular worldwide in the last two decades. Aim: To evaluate the effectiveness and benefits of radiofrequency minor LLR of CLM in comparison with OLR. Material and methods: The indication for surgery was CLM and the possibility to perform minor laparoscopic or OLR not exceeding two hepatic segments according to Couinaud’s classification. Results: Sixty-six minor liver resections for CLM were performed. Twenty-five (37.9%) patients underwent a laparoscopic approach and 41 (62.1%) patients underwent OLR. The mean operative time was 166.4 min for LLR and 166.8 min for OLR. Average blood loss was 132.3 ±218.0 ml during LLR and 149.5 ±277.5 ml during OLR. Length of hospital stay was 8.4 ±2.0 days for LLR and 10.5 ±5.8 days for OLR. All resections were R0. There was no case of mortality. Postoperative complications were recognized in 9 (13.6%) patients: 8 in the group of OLR patients and 1 in the LLR group. The median survival time for LLR was 70.5 months and for OLR 61.9 months. The 5-year overall survival rate was higher for LLR vs. OLR – 82.1% vs. 69.8%. The average length of disease-free interval after LLR was greater (52.2 months) in comparison with OLR (49.4%). The 5-year disease-free interval was 63.2% for LLR and 58% for OLR. Conclusions: Outcomes and oncological radicality of minor laparoscopic liver resections of CLM are comparable to outcomes of OLR.Web of Science10221220

Cross-coupling reactions of organosulfur compounds

Cross-coupling reactions are one of the most utilitzed and investigated methods for carbon-carbon bond formation. In this diploma thesis the transition metal catalyzed cross-coupling protocol of organosulfur compounds and boronic acids has been studied. The first part of the thesis is aimed at developing a synthesis of a new heterocyclic compounds, which have been used in the cross-coupling reaction. The second part describes the study of the Liebeskind-Šrogl coupling-inspired reaction itself. Various reaction conditions, catalysts and the influence of the structure of starting materials have been examined

Cross-coupling reactions of organosulfur compounds

Cross-coupling reactions are one of the most utilitzed and investigated methods for carbon-carbon bond formation. In this diploma thesis the transition metal catalyzed cross-coupling protocol of organosulfur compounds and boronic acids has been studied. The first part of the thesis is aimed at developing a synthesis of a new heterocyclic compounds, which have been used in the cross-coupling reaction. The second part describes the study of the Liebeskind-Šrogl coupling-inspired reaction itself. Various reaction conditions, catalysts and the influence of the structure of starting materials have been examined

Data přechodu na gregoriánský kalendář

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Novel signal gate solution suitable for implementation in audio and recording technologies

The paper deals with the design and construction of signal gate standardly used in audio technology. The presented signal gate solution uses relatively unusual structural elements in the circuit structure. There are not therefore employed circuit elements by THAT Corporation Audio Technology or by Analog Devices SSM well-known and widely used in audio technology, but conventionally used operational amplifiers. The aim of the study was to develop a comprehensive box including four signal gates and to verify that its parameters can be compared with the commercially available devices

Fluorescenční sondy pro detekci CO založené na modifikované nilské červeni: mechanismus účinku a aplikace

Carbon monoxide (CO) is a cell-signaling molecule (gasotransmitter) produced endogenously by oxidative catabolism of heme, and the understanding of its spatial and temporal sensing at the cellular level is still an open challenge. Synthesis, optical properties, and study of the sensing mechanism of Nile red Pd-based CO chemosensors, structurally modified by core and bridge substituents, in methanol and aqueous solutions are reported in this work. The sensing fluorescence "off-on" response of palladacycle-based sensors possessing low-background fluorescence arises from their reaction with CO to release the corresponding highly fluorescent Nile red derivatives in the final step. Our mechanistic study showed that electron-withdrawing and electron-donating core substituents affect the rate-determining step of the reaction. More importantly, the substituents were found to have a substantial effect on the Nile red sensor fluorescence quantum yields, hereby defining the sensing detection limit. The highest overall fluorescence and sensing rate enhancements were found for a 2-hydroxy palladacycle derivative, which was used in subsequent biological studies on mouse hepatoma cells as it easily crosses the cell membrane and qualitatively traces the localization of CO within the intracellular compartment with the linear quantitative response to increasing CO concentrations.Oxid uhelnatý funguje jako buněčná signalizační molekula (gasotransmitter) produkovaná oxidativním katabolysmem hemu. Pochopení jeho záchytu pomocí senzorů v buňce je stále velkou výzvou. V této práci je popsána syntéza, optické vlastnosti a studium mechanismu účinku chemosenzorů odvozených od substituované (jádro, můstkové ligandy) nilské červeně ve vodě a methanolu. Principem detekce je velký nárůst fluorescence produktů vzniklých reakcí CO s palladacyklickým senzorem, který před reakcí fluorescenci prakticky nevykazuje. Naše mechanistická práce ukazuje, že elektron-akceptorní i elektron-donorní substituenty na jádře ovlivňují rychlost určující krok reakce. Navíc, tyto substituenty mají velký vliv na kvantové-výtěžky fluorescence, čímž určují limity detekce. Jako nejvýhodnější se ukázal 2-hydroxy derivát, který byl použit v následné biologické studii. Studie ukázala, že senzor snadno prostupuje buněčnou membránou myších hepatomických buněk a kvalitativně mapuje rozložení CO v buněčné tekutině s lineární odezvou