67 research outputs found
Ozone Therapy for Tumor Oxygenation: a Pilot Study
Tumor hypoxia is an adverse factor for chemotherapy and radiotherapy. Ozone therapy is a non-conventional form of medicine that has been used successfully in the treatment of ischemic disorders. This prospective study was designed to assess the effect of ozone therapy on tumor oxygenation. Eighteen subjects were recruited for the study. Systemic ozone therapy was administered by autohemotransfusion on three alternate days over one week. Tumor oxygenation levels were measured using polarographic needle probes before and after the first and the third ozone therapy session. Overall, no statistically significant change was observed in the tumor oxygenation in the 18 patients. However, a significant decrease was observed in hypoxic values â€10 and â€5âmmHg of pO(2). When individually assessed, a significant and inverse non-linear correlation was observed between increase in oxygenation and the initial tumor pO(2) values at each measuring time-point, thus indicating that the more poorly-oxygenated tumors benefited most (rho = â0.725; P = 0.001). Additionally, the effect of ozone therapy was found to be lower in patients with higher hemoglobin concentrations (rho = â0.531; P < 0.034). Despite being administered over a very short period, ozone therapy improved oxygenation in the most hypoxic tumors. Ozone therapy as adjuvant in chemo-radiotherapy warrants further research
Adjuvant Ozonetherapy in Advanced Head and Neck Tumors: A Comparative Study
Advanced head and neck (H&N) tumors have a poor prognosis, and this is worsened by the occurrence of hypoxia and ischemia in the tumors. Ozonetherapy has proved useful in the treatment of ischemic syndromes, and several studies have described a potential increase of oxygenation in tissues and tumors. The aim of this prospective study was to evaluate the clinical effect of ozonetherapy in patients with advanced H&N cancer in the course of their scheduled radiotherapy. Over a period of 3 years, 19 patients with advanced H&N tumors who were undergoing treatment in our department with non-standard fractionated radiotherapy plus oral tegafur. A group of 12 patients was additionally treated with intravenous chemotherapy before and/or during radiotherapy. In the other group of seven patients, systemic ozonetherapy was administered twice weekly during radiotherapy. The ozonetherapy group was older (64 versus 54 years old, P = 0.006), with a higher percentage of lymph node involvement (71% versus 8%, P = 0.019) and with a trend to more unfavorable tumor stage (57% versus 8% IVb + IVc stages, P = 0.073). However, there was no significant difference in overall survival between the chemotherapy (median 6 months) and ozonetherapy (8 months) groups. Although these results have to be viewed with caution because of the limited number of patients, they suggest that ozonetherapy could have had some positive effect during the treatment of our patients with advanced H&N tumors. The adjuvant administration of ozonetherapy during the chemoâradiotherapy for these tumors merits further research
RevisiĂłn de los aspectos mĂĄs importantes de la leptospirosis equina con mayor atenciĂłn en su epidemiologĂa y diagnĂłstico
La leptospirosis es una infecciĂłn zoonĂłtica comĂșn que afecta a la mayorĂa de los animales, incluso a aves, reptiles anfibios y artrĂłpodos. Teniendo en cuenta lo mencionado se puede decir que la Leptospirosis es una enfermedad epidemiolĂłgicamente importante para la especie equina, donde los caballos contribuyen a la permanencia de la bacteria dentro de la poblaciĂłn de animales domĂ©sticos y silvestres convirtiĂ©ndose en un factor de control dentro de la salud pĂșblica teniendo en cuenta la importancia zoonĂłtica de esta enfermedad.Facultad de Ciencias Veterinaria
Increasing stratification as observed by satellite sea surface salinity measurements
9 pages, 4 figures, supplementary information https://doi.org/10.1038/s41598-022-10265-1.-- This work is a contribution to CSIC PTI TeledetectChanges in the Earthâs water cycle can be estimated by analyzing sea surface salinity. This variable reflects the balance between precipitation and evaporation over the ocean, since the upper layers of the ocean are the most sensitive to atmosphereâocean interactions. In situ measurements lack spatial and temporal synopticity and are typically acquired at few meters below the surface. Satellite measurements, on the contrary, are synoptic, repetitive and acquired at the surface. Here we show that the satellite-derived sea surface salinity measurements evidence an intensification of the water cycle (the freshest waters become fresher and vice-versa) which is not observed at the in-situ near-surface salinity measurements. The largest positive differences between surface and near-surface salinity trends are located over regions characterized by a decrease in the mixed layer depth and the sea surface wind speed, and an increase in sea surface temperature, which is consistent with an increased stratification of the water column due to global warming. These results highlight the crucial importance of using satellites to unveil critical changes on oceanâatmosphere fluxesThis work was supported in part by the Spanish R&D project L-BAND (ESP2017-89463-C3-1-R), which is funded by MCIN/AEI/10.13039/501100011033 and âERDF A way of making Europeâ, and project INTERACT (PID2020-114623RB-C31), which is funded by MCIN/AEI/10.13039/501100011033. , and in part by the European Space Agency by means of the Contract SMOS ESL L2OS. We also acknowledge funding from the Spanish government through the âSevero Ochoa Centre of Excellenceâ accreditation (CEX2019-000928-S)Peer reviewe
Role of age and comorbidities in mortality of patients with infective endocarditis
[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality.
[Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65âŻyears,65 to 80âŻyears,andâŻâ„âŻ80âŻyears.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk.
[Results]: A total of 3120 patients with IE (1327âŻ<âŻ65âŻyears;1291 65-80âŻyears;502âŻâ„âŻ80âŻyears) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients â„80âŻyears who underwent surgery were significantly lower compared with other age groups (14.3%,65âŻyears; 20.5%,65-79âŻyears; 31.3%,â„80âŻyears). In-hospital mortality was lower in the <65-year group (20.3%,<65âŻyears;30.1%,65-79âŻyears;34.7%,â„80âŻyears;pâŻ<âŻ0.001) as well as 1-year mortality (3.2%, <65âŻyears; 5.5%, 65-80âŻyears;7.6%,â„80âŻyears; pâŻ=âŻ0.003).Independent predictors of mortality were ageâŻâ„âŻ80âŻyears (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32â3.34), CCIâŻâ„âŻ3 (HR:1.62; 95% CI:1.39â1.88),and non-performed surgery (HR:1.64;95% CI:11.16â1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65âŻyears(pâŻ<âŻ0.001) for both in-hospital and 1-year mortality.
[Conclusion]: There were no differences in the clinical presentation of IE between the groups. AgeâŻâ„âŻ80âŻyears, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group
Recommended from our members
Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9â27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6â16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2â1.8), stage II (OR 1.6; 95% CI 1.4â1.9), and stage III or worse (OR 2.8; 95% CI 2.3â3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
Recommended from our members
Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
The original version of this article unfortunately contained a mistake
Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9â27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6â16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2â1.8), stage II (OR 1.6; 95% CI 1.4â1.9), and stage III or worse (OR 2.8; 95% CI 2.3â3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
Synthesis and structural characterisation of new mono and dinuclear pyrazolatopalladium (II) complexes self-assembled through robust hydrogen-bonds
11 pages, 6 tables, 9 figures.This work describes the reactivity of compounds [Pd(dmpz)2(Hdmpz)2] (A) (dmpz = 3,5-dimethylpyrazolate, Hdmpz = 3,5-dimethylpyrazol) and [Pd2(ÎŒ-dmpz)2(dmpz)2(Hdmpz)2] (B) towards several dicarboxylic acids and also towards perchloric acid. The compounds [Pd(Hdmpz)4](O2Câ(CH2)nâCO2H)2 [n = 1 (1), 3 (2)] have been obtained by treatment of [Pd(dmpz)2(Hdmpz)2] (A) with two equivalents of malonic (HO2CâCH2âCO2H) and glutaric (HO2Câ(CH2)3âCO2H) acids. The X-ray study on a crystal of [Pd(Hdmpz)4](O2Câ(CH2)3âCO2H)2 (2) revealed that the glutarate anions link to the cationic complex [Pd(Hdmpz)4]2+ through the carboxylate group by charge-assisted NâH(+)cdots, three dots, centeredO(â) hydrogen bonds. Additionally, the carboxylate anions View the MathML source form uncommon dimeric rings on both sides of the metal complex via a pair of OâHcdots, three dots, centeredO hydrogen bonds, yielding a hydrogen bonded polymeric chain with alternating inorganic [Pd(Hdmpz)4]2+ and organic View the MathML source fragments. The dinuclear complexes [Pd2(ÎŒ-dmpz)2(O2Câ(CH2)nâCO2)(Hdmpz)2] [n = 0 (5), 1 (6)] were obtained from equimolar amounts of [Pd2(ÎŒ-dmpz)2(dmpz)2(Hdmpz)2] (B) and the corresponding dicarboxylic acid, HO2Câ(CH2)nâCO2H (n = 0, 1). However, the synthesis of 5 and 6 requires two steps, the protonation of both terminal dmpz groups in B with HClO4 to give [Pd2(ÎŒ-dmpz)2(Hdmpz)4](ClO4)2 (4) and the subsequent treatment of this cationic palladium complex with salts of the corresponding dicarboxylic acids. The X-ray structures of compounds 5 and 6 are reported. Both in 5 and 6, the Pd2N4 ring shows a typical boat-like conformation and the metal atoms are separated in about 3.3 Ă
. Both 5 and 6 are asymmetric and contain two Hdmpz groups â H-bond donors â at one end, and two Cdouble bond; length as m-dashO groups from the dicarboxylate anion â H-bond acceptors â at the other, in such a way that the donor end of one molecule links with the acceptor end of its neighbour forming a hydrogen-bonded polymeric chain. The synthesis and X-ray study of compounds [Pd(Hdmpz)4](ClO4)2 (3) and [Pd2(ÎŒ-dmpz)2(Hdmpz)4](ClO4)2 (4), obtained by reaction of [Pd(dmpz)2(Hdmpz)2] (A) and [Pd2(ÎŒ-dmpz)2(dmpz)2(Hdmpz)2] (B) with two equivalents of perchloric acid, are also reported.This work was supported by the Spanish Ministerio de EducaciĂłn y Ciencia (Projects CTQ2005-08606-C02-01 and CTQ2005-03141) and the Gobierno de AragĂłn (Grupo de Excelencia: QuĂmica InorgĂĄnica y de los Compuestos OrganometĂĄlicos).Peer reviewe
Seawater carbonate chemistry and nutritional characteristics of mussels
Ocean Acidification (OA) has become one of the most studied global stressors in marine science during the last fifteen years. Despite the variety of studies on the biological effects of OA with marine commercial species, estimations of these impacts over consumers' preferences have not been studied in detail, compromising our ability to undertake an assessment of market and economic impacts resulting from OA at local scales. Here, we use a novel and interdisciplinary approach to fill this gap. We experimentally test the impact of OA on commercially relevant physical and nutritional attributes of mussels, and then we use economic discrete choice models to assess the marginal effects of these impacts over consumers' preferences and wellbeing. Results showed that attributes, which were significantly affected by OA, are also those preferred by consumers. Consumers are willing to pay on average 52% less for mussels with evidences of OA and are willing to increase the price they pay to avoid negative changes in attributes due to OA. The interdisciplinary approach developed here, complements research conducted on OA by effectively informing how OA economic impacts can be analyzed under the lens of marginal changes in market price and consumer' welfare. Thereby, linking global phenomena to consumers' wellbeing, and shifting the focus of OA impacts to assess the effects of local vulnerabilities in a wider context of people and businesses
- âŠ