On the heating of source of the Orion KL hot core

We present images of the J=10-9 rotational lines of HC3N in the vibrationally excited levels 1v7, 1v6 and 1v5 of the hot core (HC) in Orion KL. The images show that the spatial distribution and the size emission from the 1v7 and 1v5 levels are different. While the J=10-9 1v7 line has a size of 4''x 6'' and peaks 1.1'' NE of the 3 mm continuum peak, the J=10--9 1v5 line emission is unresolved (<3'') and peaks 1.3'' south of the 3 mm peak. This is a clear indication that the HC is composed of condensations with very different temperatures (170 K for the 1v7 peak and $>230$ K for the 1v5 peak). The temperature derived from the 1v7 and 1v5 lines increases with the projected distance to the suspected main heating source I. Projection effects along the line of sight could explain the temperature gradient as produced by source I. However, the large luminosity required for source I, >5 10^5 Lsolar, to explain the 1v5 line suggests that external heating by this source may not dominate the heating of the HC. Simple model calculations of the vibrationally excited emission indicate that the HC can be internally heated by a source with a luminosity of 10^5 Lsolar, located 1.2'' SW of the 1v5 line peak (1.8'' south of source I). We also report the first detection of high-velocity gas from vibrationally excited HC3N emission. Based on excitation arguments we conclude that the main heating source is also driving the molecular outflow. We speculate that all the data presented in this letter and the IR images are consistent with a young massive protostar embedded in an edge-on disk.Comment: 13 pages, 3 figures, To be published in Ap.J. Letter

Procesos geomorfológicos activos en cárcavas del borde del piedemonte norte de la Sierra de Guadarrama (Provincia de Segovia, España)

Dos localizaciones situadas cerca del borde del piedemonte norte de la Sierra de Guadarrama (provincia de Segovia) ofrecen formas erosivas en cárcavas bien desarrolladas: (a) un conjunto de barrancos encajados sobre arenas arcósicas del Mioceno, en un relieve de lomas y vaguadas del suroeste provincial; (b) cárcavas sobre arenas silíceas del Cretácico Superior, en un relieve de laderas de mesas y cuestas de la zona centro sur de la Provincia. En este trabajo se caracteriza la actividad geomorfológica de esos barrancos y cárcavas, y se inicia su cuantificación. El objetivo está encaminado a conocer qué procesos movilizan sedimentos, y a evaluar sus tasas de actuación, intensidad, frecuencia de ocurrencia y conectividad entre los mismos. Los procesos de erosión hídrica por salpicadura, arroyada laminar y concentrada en rills, junto con la actividad gravitacional observada, movilizan materiales desde las cabeceras de las cárcavas hasta los colectores, rellenándolos; éstos son evacuados mediante procesos de encajamiento en los canales efímeros, y sedimentados en pequeños conos aluviales. En los barrancos sobre arcosas, los eventos de precipitación poco intensos y de alta frecuencia tienden a rellenar los lechos arenosos, mientras que la fusión nival y las precipitaciones de alta intensidad y baja frecuencia vacían los canales, sedimentando en zonas apicales de los conos aluviales. En las cárcavas sobre arenas silíceas, los primeros datos obtenidos apuntan a unas tasas de erosión y producción de sedimentos muy elevadas, ya que sobre ellas se produce escorrentía y erosión hídrica de manera casi instantánea; por ello, los eventos de precipitación de baja intensidad son capaces de sedimentar en las zonas apicales de los conos, mientras que los eventos de alta intensidad originan lóbulos telescópicos sobre conos aluviales existentes en pedimentos. [ABSTRACT] Two areas located at the edge of the North piedmont of the Guadarrama Mountains (province of Segovia) show a conspicuous development of gullies. A series of valley side gullies, or ravines, cut on arkosic sand sediments of Miocene age at the Río Chico Valley (southwest of the Segovia province); and slope gullies, cut on silica sand, shale and gravel sediments of Upper Cretaceous age, on the slopes of a set of mesas and cuestas at the río Cega piedmont (Pedraza region, south centre of the Segovia province). This paper characterizes the geomorphic activity of both types of gullies. In addition, the quantification of their current activity is initiated. The objectives are: to know which processes are eroding and mobilizing the sediments within the gullies, and to evaluate their rates, intensity, frequency and connectivity. A detailed field survey shows that weathering processes (sandstone sheeting, and the formation of popcorn structures on shale layers), and splash, sheet and rill erosion, along with sand and mud falls, slides and flows move sediment from the gully slopes and internal divides to the dry washes. These materials are temporary stored in ephemeral stream channels (filled with sandy bed material), evacuated by stream-bed scour and fill processes, and deposited in alluvial cones. In order to get a first approximation of the amount of erosion and sediment movement, a set of field methods have been applied to these areas. These methods include: erosion pins, measurement of pedestals, system of rods and washers, pit traps (box and gabion check-dam types), and topographic surveys after extensive sedimentation on alluvial cones, along with the installation of pluviographs. The results show how on the arkosic valley side gullies, the precipitation events of low intensity and high frequency tend to fill the sandy stream-beds, whereas the snowmelt and the high intensity and low frequency precipitation events scour the sandy stream-beds. The sedimentation occurs here at the apex part of the alluvial cones, which rest directly on the nearby floodplain of the Chico River. On the silica sand slope gullies, the first gathered data point at very high rates of erosion and sedimentation (44.1 tons/ha for a single event), which is interpreted due to the fact that runoff and water erosion occurs here almost instantaneously after precipitation. Here, the precipitation events of low intensity and high frequency produce sedimentation at the apex part of the alluvial cones, whereas the high intensity and low frequency precipitation events sediment in the form of telescopic lobes, on existing alluvial cones, which rest on pediments

Tracing shocks and photodissociation in the Galactic center region

We present a systematic study of the HNCO, C18O, 13CS, and C34S emission towards 13 selected molecular clouds in the Galactic center region. The molecular emission in these positions are used as templates of the different physical and chemical processes claimed to be dominant in the circumnuclear molecular gas of galaxies. The relative abundance of HNCO shows a variation of more than a factor of 20 amo ng the observed sources. The HNCO/13CS abundance ratio is highly contrasted (up to a factor of 30) between the shielded molecular clouds mostly affected by shocks, where HNCO is released to gas-phase from grain mantles, and those pervaded by an intense UV radiation field, where HNCO is photo-dissociated and CS production favored via ion reactions. We propose the relative HNCO to CS abundance ratio as a highly contrasted diagnostic tool to distinguish between the influence of shocks and/or the radiation field in the nuclear regions of galaxies and their relation to the evolutionary state of their nuclear star formation bursts.Comment: 25 pages, 5 figures, Accepted for publication in Ap

ISO observations toward the reflection nebula NGC 7023: A nonequilibrium ortho- to para-H2 ratio

We have observed the S(0), S(1), S(2), S(3), S(4) and S(5) rotational lines of molecular hydrogen (H2) towards the peak of the photodissociation region (PDR) associated with the reflection nebula NGC 7023. The observed H2 line ratios show that they arise in warm gas with kinetic temperatures ~300 - 700 K. However, the data cannot be fitted by an ortho- to para- (OTP) ratio of 3. An OTP ratio in the range ~1.5 - 2 is necessary to explain our observations. This is the first detection of a non-equilibrium OTP ratio measured from the H2 pure-rotational lines in a PDR. The existence of a dynamical PDR is discussed as the most likely explanation for this low OTP ratio.Comment: 4 pages, 3 figure

Robust ASR using Support Vector Machines

The improved theoretical properties of Support Vector Machines with respect to other machine learning alternatives due to their max-margin training paradigm have led us to suggest them as a good technique for robust speech recognition. However, important shortcomings have had to be circumvented, the most important being the normalisation of the time duration of different realisations of the acoustic speech units. In this paper, we have compared two approaches in noisy environments: first, a hybrid HMM–SVM solution where a fixed number of frames is selected by means of an HMM segmentation and second, a normalisation kernel called Dynamic Time Alignment Kernel (DTAK) first introduced in Shimodaira et al. [Shimodaira, H., Noma, K., Nakai, M., Sagayama, S., 2001. Support vector machine with dynamic time-alignment kernel for speech recognition. In: Proc. Eurospeech, Aalborg, Denmark, pp. 1841–1844] and based on DTW (Dynamic Time Warping). Special attention has been paid to the adaptation of both alternatives to noisy environments, comparing two types of parameterisations and performing suitable feature normalisation operations. The results show that the DTA Kernel provides important advantages over the baseline HMM system in medium to bad noise conditions, also outperforming the results of the hybrid system.Publicad

Decontamination of filtering facepiece respirators using a low-temperature-steam–2%-formaldehyde sterilization process during a pandemic: a safe alternative for re-use

Background The coronavirus disease 2019 pandemic has caused problems with respirator supplies. Re-use may minimize the impact of the shortage, but requires the availability of an efficient and safe decontamination method. Aim To determine whether low-temperature-steam–2%-formaldehyde (LTSF) sterilization is effective, preserves the properties of filtering facepiece (FFP) respirators and allows safe re-use. Methods Fourteen unused FFP2, FFP3 and N95 respirator models were subjected to two cycles of decontamination cycles. After the second cycle, each model was inspected visually and accumulated residual formaldehyde levels were analysed according to EN 14180. After one and two decontamination cycles, the fit factor (FF) of each model was tested, and penetration tests with sodium chloride aerosols were performed on five models. Findings Decontamination physically altered three of the 14 models. All of the residual formaldehyde values were below the permissible threshold. Irregular decreases and increases in FF were observed after each decontamination cycle. In the sodium chloride aerosol penetration test, three models obtained equivalent or superior results to those of the FFP classification with which they were marketed, both at baseline and after one and two cycles of decontamination, and two models had lower filtering capacity. Conclusion One and two decontamination cycles using LTSF did not alter the structure of most (11/14) respirators tested, and did not degrade the fit or filtration capacity of any of the analysed respirators. The residual formaldehyde levels complied with EN 14180. This reprocessing method could be used in times of shortage of personal protective equipment

Large scale grain mantle disruption in the Galactic Center

We present observations of C2H5OH toward molecular clouds in Sgr A, Sgr B2 and associated with thermal and non-thermal features in the Galactic center. C2H5OH emission in Sgr A and Sgr B2 is widespread, but not uniform. C2H5OH emission is much weaker or it is not detected in some molecular clouds in both complexes, in particular those with radial velocities between 70 and 120 km/s. While most of the clouds associated with the thermal features do not show C2H5OH emission, that associated with the Non-Thermal Radio Arc shows emission. The fractional abundance of C2H5OH in most of the clouds with radial velocities between 0 and 70 km/s in Sgr A and Sgr B2 is relatively high, of few 1e-8. The C2H5OH abundance decreases by more than one order of magnitude (aprox. 1e-9) in the clouds associated with the thermal features. The large abundance of C2H5OH in the gas-phase indicates that C2H5OH has formed in grains and released to gas-phase by shocks in the last aprox. 1e5 years.Comment: In press in Astrophysical Journal Letters 7 pages, 1 table, 1 figur

Bioactivities and extract dereplication of actinomycetales isolated from marine sponges

In the beginning of the twenty-first century, humanity faces great challenges regarding diseases and health-related quality of life. A drastic rise in bacterial antibiotic resistance, in the number of cancer patients, in the obesity epidemics and in chronic diseases due to life expectation extension are some of these challenges. The discovery of novel therapeutics is fundamental and it may come from underexplored environments, like marine habitats, and microbial origin. Actinobacteria are well-known as treasure chests for the discovery of novel natural compounds. In this study, eighteen Actinomycetales isolated from marine sponges of three Erylus genera collected in Portuguese waters were tested for bioactivities with the main goal of isolating and characterizing the responsible bioactive metabolites. The screening comprehended antimicrobial, anti-fungal, anti-parasitic, anti-cancer and anti-obesity properties. Fermentations of the selected strains were prepared using ten different culturing media. Several bioactivities against the fungus Aspergillus fumigatus, the bacteria Staphylococcus aureus methicillin-resistant (MRSA) and the human liver cancer cell line HepG2 were obtained in small volume cultures. Screening in higher volumes showed consistent anti-fungal activity by strain Dermacoccus sp. #91-17 and Micrococcus luteus Berg02-26. Gordonia sp. Berg02-22.2 showed anti-parasitic (Trypanosoma cruzi) and anti-cancer activity against several cell lines (melanoma A2058, liver HepG2, colon HT29, breast MCF7 and pancreatic MiaPaca). For the anti-obesity assay, Microbacterium foliorum #91-29 and #91-40 induced lipid reduction on the larvae of zebrafish (Danio rerio). Dereplication of the extracts from several bacteria showed the existence of a variety of secondary metabolites, with some undiscovered molecules. This work showed that Actinomycetales are indeed good candidates for drug discovery.This research was partially supported by the Strategic Funding UID/Multi/04423/2013 through national funds provided by FCT – Foundation for Science and Technology and European Regional Development Fund (ERDF), in the framework of the programme PT2020, the EU H2020-TWINN-2015, BLUEandGREEN – Boosting scientific excellence and innovation capacity in biorefineries based on marine resources (Project No. 692419) and the European ERA-NET Marine Biotechnology project CYANOBESITY (ERA-MBT/0001/2015), financed by national funds through FCT (Foundation for Science and Technology, Portugal). Ralph Urbatzka was supported by a FCT postdoc grant (SFRH/BPD/112287/2015). The MEDINA authors disclosed the receipt of financial support from Fundación MEDINA, a public-private partnership of Merck Sharp & Dohme de España S.A./Universidad de Granada/Junta de Andalucía. Moreover, some of the equipment used in this work was supported by the Ministerio de Ciencia e Innovación and the European Union (Grant INP-2011-0016-PCT-010000-ACT6)

Clinical and laboratory features of anti-MAG neuropathy without monoclonal gammopathy

Antibodies against myelin-associated glycoprotein (MAG) almost invariably appear in the context of an IgM monoclonal gammopathy associated neuropathy. Very few cases of anti-MAG neuropathy lacking IgM-monoclonal gammopathy have been reported. We investigated the presence of anti-MAG antibodies in 69 patients fulfilling diagnostic criteria for CIDP. Anti-MAG antibodies were tested by ELISA and confirmed by immunohistochemistry. We identified four (5.8%) anti-MAG positive patients without detectable IgM-monoclonal gammopathy. In two of them, IgM-monoclonal gammopathy was detected at 3 and 4-year follow-up coinciding with an increase in anti-MAG antibodies titers. In conclusion, anti-MAG antibody testing should be considered in chronic demyelinating neuropathies, even if IgM-monoclonal gammopathy is not detectable

The detection of the (J,K)=(18,18) line of NH3

The first astronomical detection of the metastable ($J,K$) = (18,18) line of NH3 is reported. With 3130 K above the ground state, this is the NH3 line with by far the highest energy detected in interstellar space. It is observed in absorption toward the galactic center star forming region Sgr B2. There is a clear detection toward Sgr B2(M) and a likely one toward SgrB2(N). An upper limit for emission is determined for Orion-KL. If we combine the (18,18) line results from Sgr B2(M) with the previously measured (12,12) absorption line, we find a rotation temperature of >1300 K for the absorbing cloud. This is at least a factor of two higher than previously derived values from less highly excited ammonia lines, giving a lower limit to the kinetic temperature. There is a hot low density gas component in the envelope of SgrB2. It is possible that the (18,18) line arises in this region. The radial velocity of the low density, hot envelope is the same as that of the dense hot cores, so the (18,18) line could also arise in the dense hot cores where non-metastable (J>K) absorption lines from energy levels of up to 1350 K above the ground state have been observed. A discussion of scenarios is presented.Comment: 6 pages, 2 figures, 2 Tables, accepted for publication in A&A Main Journa