Acute upper airway obstruction due to retropharyngeal hematoma in a dog with Anaplasma species: a case study

Antecedentes: El hematoma retro-faríngeo es una rara afección que es difícil de diagnosticar y puede progresar rápidamente a la obstrucción de las vías respiratorias. Los autores reportan el primer caso conocido de la obstrucción aguda de la vía aérea superior resultante de hematoma retro-faríngeo en un perro. Causas documentadas en medicina humana han incluido coagulopatía, trauma, infección, adenoma paratiroideo ruptura, y la ingestión de cuerpo extraño. Síntomas vagos en los seres humanos como dolor de garganta, disfonía, disnea, disfagia y la hinchazón del cuello puede preceder a la obstrucción de las vías aéreas letales. Presentación de casos: Los autores presentan el caso de una paciente hembra Spaniel de agua, de 18 meses de edad, con trombocitopenia que desarrolló un gran hematoma retro-faríngeo y síntomas de compromiso de la vía aérea. El perro requiere intubación traqueal, seguida por la traque-ostomía quirúrgica. Radiografía cervical lateral y la resonancia magnética del cuello fue compatible con un hematoma retro-faríngeo comprometer la vía respiratoria. El hematoma retro-faríngeo fue gestionado de forma conservadora. Conclusión: El hematoma retrofaríngeo debe ser considerada en pacientes con dificultad respiratoria brusca. La resonancia magnética permite el diagnóstico específico de una rara afección que de otro modo es difícil de diagnosticar.Background: Retropharyngeal hematoma is a rare condition that is difficult to diagnose and may progress rapidly to airway obstruction. The authors report the first known case of acute upper airway obstruction resulting from retropharyngeal hematoma in a dog. Documented causes in human medicine have included coagulopathic states, trauma, infection, parathyroid adenoma rupture, and foreign body ingestion. Vague symptoms in humans such as sore throat, shortness of breath, dysphonia, dysphagia, and neck swelling may precede lethal airway obstruction. Case presentation: The authors report a case of an 18-month-old, intact female water spaniel with thrombocytopenia that developed a massive retropharyngeal hematoma and symptoms of airway compromise. The dog required tracheal intubation followed by surgical tracheostomy. Lateral cervical radiography and magnetic resonance imaging of the neck was consistent with a retropharyngeal hematoma compromising the airway. The retropharyngeal hematoma was managed conservatively. Conclusion: Retropharyngeal hematoma should be considered in patients presenting with abrupt respiratory distress.Magnetic resonance imaging allowed specific diagnosis of a rare condition that is otherwise difficult to diagnose

Teaching performativity in the digital environment of schools: the redefinition of teaching work

M. Isabel Pardo-Baldoví - Universitat de València - 0000-0002-8630-0818Ángel San Martín Alonso - Universitat de València - 0000-0003-3565-4250Edisson Cuervo Montoya - Universidad del Valle - 0000-0001-7793-6825Recepción: 25/11/2019 | Aceptado: 02/12/2019Correspondencia a través de ORCID: M. Isabel Pardo-Baldoví - 0000-0002-8630-0818La presencia de materiales didácticos y dispositivos digitales en las aulas de Educación Primaria es una tendencia creciente. Las tecnologías digitales provocan transformaciones en la vida del aula, y en los roles desempeñados por alumnado y profesorado, quienes deben adoptar estrategias distintas para afrontar nuevas situaciones de aprendizaje. Objetivos: En el presente trabajo abordamos los mecanismos y estrategias didácticas puestas en práctica en el aula, así como las visiones y representaciones simbólicas de alumnado y profesorado frente a los dispositivos digitales, partiendo del concepto de performatividad. Método: Para ello se desarrolla una investigación cualitativa de estudio de casos múltiples en dos centros de Educación Primaria de la Comunitat Valenciana. Resultados: Los resultados obtenidos apuntan que la incorporación de estos medios digitales en el quehacer escolar ha requerido la adopción de cambios relevantes en las tareas de profesorado y alumnado y la adopción de modos de actuar performativos. Discusión/Conclusiones: En conclusión, se observa el desarrollo de estrategias docentes/discentes en un doble plano (analógico-digital) que contribuyen a redefinir el trabajo pedagógico en el aula modificando las relaciones con el tiempo y los espacios de aprendizaje.Abstract: The presence of digital devices in Primary Education classrooms is a growing trend. Digital technologies induce transformations in classroom’s life, and in the roles played by students and teachers, who must adopt different strategies to face new learning situations. Objectives: In this paper we address the mechanisms and teaching strategies implemented in the classroom, as well as the visions and symbolic representations of students and teachers in front of digital devices, based on the concept of performativity. Method: To achieve these objectives, is developed a qualitative research through a multiple cases study in two schools of the Comunitat Valenciana. Results: The results obtained indicate that the incorporation of these digital media in the school work has required the adoption of relevant changes in the tasks of teachers and students and the adoption of performative ways of acting. Discussion/Conclusions: In conclusion, we observe the development of teaching / learning strategies in a double plane (analog-digital) that help to redefine the pedagogical work in the classroom by modifying the relationships with time and learning spaces.Este trabajo se basa en los resultados de la tercera fase del proyecto de investigación emergente con referencia GV/2018/074, financiado por la Conselleria d’Educació, Investigació, Cultura i Esport de la Comunitat Valenciana

Evaluation of Eosinopenia as a SIRS Biomarker in Critically Ill Horses

Systemic inflammatory response syndrome (SIRS) is a very common finding in critically ill patients. To accurately identify patients with SIRS and those who need intensive care, several markers have been evaluated, including cortisol, WBC or lactate. It is widely known that a stress leukogram includes eosinopenia as one of its main markers (neutrophilia, eosinopenia, lymphopenia and mild monocytes). It is known that cortisol concentration in plasma is the main stress biomarker and is strongly correlated with the severity of disease in horses. However, it is not possible to measure this parameter routinely in clinical conditions. Hence, in this study it was hypothesized that the eosinophil count could be a reliable parameter to identify critically ill horses. Horses included in this study were divided into three groups: Group A (sick horses received at the Emergency Unit which did not fulfil the criteria for SIRS), Group B (horses that meet two or more criteria for inclusion in the definition of SIRS) and a control group of healthy horses. In this study, horses with SIRS showed lower eosinophil counts than healthy horses. Moreover, non-surviving horses exhibited lower eosinophil counts than survivors. Eosinopenia could be used to identify horses with SIRS and can be useful as a prognostic marker

Motivación hacia el estudio de la Química en estudiantes de Bachillerato Tecnológico

Este trabajo utilizó una metodología cuantitativa con el objetivo de comparar la motivación de logro, extrínseca e intrínseca y el tipo de atribuciones hacia el estudio de la Química en estudiantes de bachillerato tecnológico con bajo y alto rendimiento académico en esta materia. La muestra final estuvo constituida por 36 estudiantes de alto y 36 de bajo desempeño. Se encontraron diferencias significativas en la motivación de logro en los factores de maestría y trabajo. Con relación a los otros tipos de motivación (atribuciones y motivación extrínseca o intrínseca) no se encontraron diferencias significativas entre ambos grupos de estudiantes

La performatividad docente en el entorno digital de los centros escolares: redefinición del trabajo didáctico

La presencia de materiales didácticos y dispositivos digitales en las aulas de Educación Primaria es una tendencia creciente. Las tecnologías digitales provocantransformaciones en la vida del aula, y en los roles desempeñados por alumnado y profesorado, quienes deben adoptar estrategias distintas para afrontar nuevas situaciones de aprendizaje.Objetivos: En el presente trabajoabordamos los mecanismos y estrategias didácticas puestas en práctica en el aula, así como las visiones y representaciones simbólicas de alumnado y profesorado frente a los dispositivos digitales, partiendo del concepto de performatividad. Método: Para ello se desarrollauna investigación cualitativa de estudio de casos múltiples en dos centros de Educación Primariade la Comunitat Valenciana. Resultados: Los resultados obtenidos apuntan que la incorporación de estos medios digitales en el quehacer escolarha requerido la adopción de cambios relevantes en las tareas de profesorado y alumnadoy la adopción de modos de actuar performativos. Discusión/Conclusiones: En conclusión, se observa el desarrollo de estrategias docentes/discentes en undoble plano(analógico-digital)que contribuyen a redefinir eltrabajo pedagógico en el aula modificando las relaciones con el tiempo y los espacios de aprendizaje. The presence of digital devices in Primary Education classrooms is a growing trend. Digital technologies induce transformations in classroom's life, and in the roles played by students and teachers, who must adopt different strategies to face new learning situations.Objectives: In this paper we address the mechanisms and teaching strategies implemented in the classroom, as well as the visions and symbolic representations of students and teachers in front of digital devices, based on the concept of performativity.Method: To achieve these objectives, is developed a qualitative research through a multiple cases study in two schools of the Comunitat Valenciana.Results: The results obtained indicate that the incorporation of these digital media in the school work has required the adoption of relevant changes in the tasks of teachers and students and the adoption of performative ways of acting.Discussion/Conclusions: In conclusion, we observe the development of teaching / learningstrategies in a doubleplane (analog-digital) that help to redefine the pedagogical work in the classroom by modifying the relationships with time and learning spaces

Fission yeast Cdc14-like phosphatase Flp1/Clp1 modulates the transcriptional response to oxidative stress

[EN]Reactive oxygen species (ROS) are an important source of cellular damage. When ROS intracellular levels increase, oxidative stress takes place affecting DNA stability and metabolic functions. To prevent these effects, stress-activated protein kinases (SAPKs) delay cell cycle progression and induce a transcriptional response that activates antioxidant mechanisms ensuring cell adaptation and survival. Fission yeast Cdc14-like phosphatase Flp1 (also known as Clp1) has a well-established role in cell cycle regulation. Moreover, Flp1 contributes to checkpoint activation during replication stress. Here, we show that Flp1 has a role in fine-tuning the cellular oxidative stress response. Rad24-dependent nucleolar release of Flp1 in response to oxidative stress conditions plays a role in the cellular transcriptional response. Thus, Flp1 ablation increases the transcriptional response to oxidative stress, in both intensity and duration, upregulating Atf1/Pcr1 transcription factors and, consequently, genes such as ctt1+, hsp9+, gpd1+ and pyp2+. Remarkably, we found that Flp1 interacts with the Atf1/Pcr1 complex with Pcr1 acting as a direct substrate. Our results provide evidence that Flp1 modulates the oxidative stress response by limiting the Atf1/Pcr1-mediated transcription

Osteomielitis maxilar debido a Halicephalobus gingivalis y diseminación fatal en un caballo

En la presente comunicación se expone un caso de infestación parasitaria poco habitual causada por Halicephalobus gingivalis, cuya manifestación principal fue osteomielitis del hueso maxilar. El caballo mostraba inicialmente inflamación y dolor en la región de la cresta facial derecha. Las radiografías demostraron la presencia de osteolisis y ensanchamiento de la cresta facial. La biopsia del hueso mostraba inflamación granulomatosa y un gran número de larvas del nematodo. El caballo fue tratado con ivermectina. Inicialmente mejoraron los signos clínicos, pero dos meses y medio después el caballo desarrollo uveitis y fallo renal, por lo que fue eutanasiado. El estudio anatómico-patológico mostro múltiples granulomas parasitarios en los riñones y en la uvea. La infección por Halicephalobus gingivalis es poco frecuente en caballos y personas aunque presenta una distribución mundial. De acuerdo con los autores esta es la primera vez que se describe dicha infestación en un équido en España.This study reports a rare case of maxillary osteomyelitis in a horse caused by Halicephalobus gingivalis. The horse presented inflammation and pain in the region of the right facial crest and the radiographs detected osteolysis and widening of the facial crest. The biopsy revealed a granulomatous inflammation and a large amount of parasite larvae. The horse was treated with ivermectin but it developed uveitis and renal insufficiency 2.5 months later and was euthanised. The anatomopathological study found multiple parasitic granulomas in the kidneys and uveal tract. H. gingivalis is an infrequent infection in horses and people, and it has a worldwide distribution. To the best of our knowledge this is the first report of H. gingivalis infection in an equid to be diagnosed in Spain.peerReviewe

Changes in Oxidative Status Biomarkers in Saliva and Serum in the Equine Gastric Ulcer Syndrome and Colic of Intestinal Aetiology : a Pilot Study

Altres ajuts: Gobierno Regional Murcia, programa Séneca 19894/GERM/15Changes in the oxidative status of the blood of horses suffering from gastric ulcers and colic of intestinal aetiology (CIE) have been reported. However, saliva can also be a source of biomarkers of oxidative status. Therefore, this study aims to validate automated assays for the measurement of oxidative status biomarkers (ferric reducing ability of saliva/serum-FRAS/FRAP, cupric reducing antioxidant capacity-CUPRAC, the Trolox equivalent antioxidant capacity-TEAC, uric acid, and advanced oxidation protein products-AOPP) in the saliva and serum of horses, to assess their changes in the different ulcer gastric diseases (squamous-ESGD and glandular-EGGD) and CIE, and to evaluate their relationship with serum amyloid A (SAA), adenosine deaminase (ADA), and the systemic inflammatory response syndrome (SIRS) status. The assays showed a low imprecision and good linearity with enough sensitivity in both fluids. In EGGD, higher levels of FRAS, uric acid, and AOPP in saliva were observed compared to the healthy group, correlating with the salivary ADA levels. Horses with CIE showed increases in uric acid concentrations in serum associated with their SIRS status and outcome of the disease. In conclusion, analytes related to the oxidative status can be measured in the saliva and serum from horses by automated assays, and some of them can potentially be assessed as biomarkers in horses with gastric ulcers and CIE

Mobilized memories: deployments of the past in the present and the future

Coordinators: Francisco Ferrándiz Martín, (ILLA, CSIC), Reyes Mate Rupérez (IFS, CSIC).Memory processes —as selective displays of the past in the present— are an essential component of the configuration and development of all human societies and affect areas that range from everyday gestures to high-level politics. The unfolding of memory is especially important in the constitution of individual and collective identities, and its enormous potential for cohesion is only comparable to its great capacity to generate exclusion, difference, and dispute. It is impossible to understand historical or contemporary conflicts in depth without analyzing the memory processes in which they are or have been immersed. Hence the strategic importance of this challenge for an institution such as CSIC. The approach to memory and memory processes is necessarily interdisciplinary, as it can be analyzed through the scientific fields of neurobiology, philosophy, sociology, political science, psychology, literary studies, religious studies, cultural studies, historiography, social anthropology, archeology, or cultural geography, among others. By reviewing the main historical, theoretical and thematic anchors of memory studies –with a special emphasis on CSIC-based research–, as well as their prospects for the future, this challenge proposes to proactively foster this interdisciplinarity to build a common analytical language substantially richer and more sophisticated than each of its individual parts

Applying reflective multicriteria decision analysis to understand the value of therapeutic alternatives in the management of gestational and peripartum anaemia in Spain

The objective of the FeminFER project was to assess the value of ferric carboxymaltose following a multicriteria decision analysis in obstetrics and gynaecology in Spain. Methods Ferric carboxymaltose (FCM) and ferrous sulphate were evaluated using the EVIDEM framework. Ten stakeholders participated to collect different perspectives. The framework was adapted considering evidence retrieved with a PICO-S search strategy and grey literature. Criteria/subcriteria were weighted by level of relevance and an evidence-based decision-making exercise was developed in each criterion; weights and scores were combined to obtain the value of intervention relative to each criterion/subcriterion, that were further combined into the Modulated Relative Benefit-Risk Balance (MRBRB). Results The most important criterion favouring FCM was Compared Efficacy/Effectiveness (0.183 +/- 0.07), followed by Patient Preferences (0.059 +/- 0.10). Only Direct medical costs criterion favoured FS (-0.003 +/- 0.03). MRBRB favoured FCM; 0.45 +/- 0.19; in a scale from -1 to + 1. Conclusions In conclusion, considering the several criteria involved in the decision-making process, participants agreed with the use of FCM according to its MRBRB