A Grid Portal for an Undergraduate Parallel Programming Course

[Abstract] This paper describes an experience of designing and implementing a portal to support transparent remote access to supercomputing facilities to students enrolled in an undergraduate parallel programming course. As these facilities are heterogeneous, are located at different sites, and belong to different institutions, grid computing technologies have been used to overcome these issues. The result is a grid portal based on a modular and easily extensible software architecture that provides a uniform and user-friendly interface for students to work on their programming laboratory assignments.Universidade da Coruña; UDC-TIC03-057Xunta de Galicia; PGIDIT02TIC00103CTXunta de Galicia; PGIDIT04TIC105004PREuropean Commission; IST-2001-3224

Magmatism and early-Variscan continental subduction in the northern Gondwana margin recorded in zircons from the basal units of Galicia, NW Spain

In situ uranium-lead dating (LA-SF-ICPMS and SIMS) and Lu-Hf isotope analyses (LA-MC-ICP-MS) of zircon from eclogite facies rocks from the basal units of the Variscan Belt in Galicia constrain their magmatic and metamorphic evolution and give some clues about the nature and origin of the involved basement. The samples studied are two felsic gneisses, two eclogites, and one eclogitic gneiss of intermediate composition (metatonalite). Oscillatory-zoned zircon cores from the felsic samples gave a main clustering of U-Pb ages at 493 ± 2 and 494 ± 2 Ma, and some older ages that represent inherited cores. Zircon grains from the intermediate and one of the mafi c rocks show no inherited cores and yielded ages of 494 ± 3 and 498 ± 6 Ma, respectively, interpreted as time of protolith crystallization. Variably developed homogeneous zircon rims in one felsic gneiss yielded an age of 372 ± 3 Ma, and very tiny zircons of one eclogite gave 350 ± 2 Ma, both of which we interpret as metamorphic ages. The new age data demonstrate that the calc-alkaline magmatic suite described in the basal unit is ca. 20 Ma older than the alkaline to peralkaline plutonic suite of the same unit (dated at 472 ± 2 Ma; Rodríguez et al., 2007), and thus probably represents a distinct geologic event. Overgrowth rims are interpreted as metamorphic on the basis of their Lu/Hf and Th/U ratios. The 372 ± 3 age is considered as dating the high-pressure (high-P) metamorphism, and is essentially in agreement with previous Ar-Ar and Rb-Sr data. This high-P metamorphism marks the initial early-Variscan subduction of the Gondwana margin. The inherited zircon ages and Hf isotopic composition of zircons point to a considerable input of crustal material with West African Craton provenance to the felsic magma

The development of selective stopping: qualitative and quantitative changes from childhood to early adulthood

Although progress has been made in elucidating the behavioral and neural development of global stopping across the lifespan, little is known about the development of selective stopping. This more complex form of inhibitory control is required in real-world situations where ongoing responses must be inhibited to certain stimuli but not others, and can be assessed in laboratory settings using a stimulus selective stopping task. Here we used this task to investigate the qualitative and quantitative developmental changes in selective stopping in a large-scale cross-sectional study with three different age groups (children, preadolescents, and young adults). We found that the ability to stop a response selectively to some stimuli (i.e., use a selective strategy) rather than non-selectively to all presented stimuli (i.e., use a global, non-selective strategy) is fully mature by early preadolescence, and remains stable afterwards at least until young adulthood. By contrast, the efficiency or speed of stopping (indexed by a shorter stop-signal reaction time or SSRT) continues to mature throughout adolescence until young adulthood, both for global and selective implementations of stopping. We also provide some preliminary findings regarding which other task variables beyond the strategy and SSRT predicted age group status. Premature responding (an index of “waiting impulsivity”) and post-ignore slowing (an index of cognitive control) were among the most relevant predictors in discriminating between developmental age groups. Although present results need to be confirmed and extended in longitudinal studies, they provide new insights into the development of a relevant form of inhibitory controlThis work was supported by grants PSI2017-84922-R (Ministerio de Economía y Competitividad (MINECO, Spain) and SI1/PJI/2019-00061 (Comunidad de Madrid, Spain; V PRICIT

GUANIN: an all-in-one GUi-driven analyzer for NanoString interactive normalization

GUANIN can be installed with pip install GUANIN and it is available at https://pypi.org/project/guanin/. Source code, documentation, and case studies are available at https://github.com/julimontoto/guanin under the GPLv3 license.[Abstract]: Most tools for normalizing NanoString gene expression data, apart from the default NanoString nCounter software, are R packages that focus on technical normalization and lack configurable parameters. However, content normalization is the most sensitive, experiment-specific, and relevant step to preprocess NanoString data. Currently this step requires the use of multiple tools and a deep understanding of data management by the researcher. We present GUANIN, a comprehensive normalization tool that integrates both new and well-established methods, offering a wide variety of options to introduce, filter, choose, and evaluate reference genes for content normalization. GUANIN allows the introduction of genes from an endogenous subset as reference genes, addressing housekeeping-related selection problems. It performs a specific and straightforward normalization approach for each experiment, using a wide variety of parameters with suggested default values. GUANIN provides a large number of informative output files that enable the iterative refinement of the normalization process. In terms of normalization, GUANIN matches or outperforms other available methods. Importantly, it allows researchers to interact comprehensively with the data preprocessing step without programming knowledge, thanks to its easy-to-use Graphical User Interface (GUI).The supercomputer FinisTerrae III and its permanent data storage system have been funded by the Spanish Ministry of Science and Innovation, the Galician Government, and the European Regional Development Fund (ERDF). This study also received support by (i) ISCIII: TRINEO: PI22/00162; DIAVIR: DTS19/00049; Resvi-Omics: PI19/01039 (A.S.), ReSVinext: PI16/01569, Enterogen: PI19/01090 (F.M.-T.), cofinanciados FEDER, (ii) GAIN: IN607B 2020/08 and IN607A 2023/02 (A.S.), GEN-COVID: IN845D 2020/23 (F.M.-T.), IIN607A2021/05 (F.M.-T.); (iii) ACIS: BI-BACVIR (PRIS-3, to A.S.), CovidPhy (SA 304 C, to A.S.); and (iv) consorcio Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CB21/06/00103; to A.S. and F.M.-T.). In addition, this study has been funded by ISCIII through the project “CP23/00080” and co-funded by the European Union. The funders were not involved in the study design, collection, analysis, interpretation of data, the writing of this article, or the decision to submit it for publication.Xunta de Galicia; IN607B 2020/08Xunta de Galicia; IN607A 2023/02Xunta de Galicia; IN845D 2020/23Xunta de Galicia; IIN607A2021/05Centro de Investigación Biomédica en Red de Enfermedades Respiratorias; CB21/06/0010

Measurement of activity produced by low energy proton beam in metals using off-line PET imaging

Proceeding of: 2011 Nuclear Science Symposium and Medical Imaging Conference, Valencia, España, 23-29 October, 2011In this work, we investigate PET imaging with 68Ga and 66Ga after proton irradiation on a natural zinc foil. The nuclides 68Ga and 66Ga are ideally suited for off line PET monitoring of proton radiotherapy due to their beta decay halflives of 67.71(9) minutes and 9.49(3) hours, respectively, and suitable fl end point energy. The purpose of this work is to explore the feasibility of PET monitoring in hadrontherapy treatments, and to study how the amount of activity and the positron range affect the PET image reconstruction. Profiting from the low energy reaction threshold for production via (p,n) reactions, both 68Ga and 66Ga gallium isotopes have been produced by activation on a natural zinc target by a proton pencil beam. In this way, it is possible to create detailed patterns, such as the Derenzo inspired one employed here. The proton beam was produced by the 5 MV tandetron accelerator at CMAM in Madrid. The energy of this beam (up to 10 MeV) is similar to the residual energy of the protons used for therapy at the distal edge of their path. The activated target was imaged in an ARGUS small animal PETtCT scanner and reconstructed with a fully 3D iterative algorithm, with and without positron range corrections.This work was supported in part by Comunidad de Madrid (ARTEMIS S2009/DPI 1802), Spanish Ministry of Science and Innovation (grants FPA2010 17142 and ENTEPRASE, PSE 300000 2009 5), by European Regional Funds, by CDTI under the CENIT Programme (AMIT Project), UCM (grupos UCM, 910059) and by CPAN, CSPD 2007 [email protected]

Derecho penal económico y de la empresa

Presentación (pp. 37 - 38). -- Tema 1: Introducción al derecho penal económico y de la empresa / Adán Nieto Martín (pp. 39 - 60). -- Tema 2: Derecho penal de la empresa y económico europeo e internacional / Adán Nieto Martín (pp. 61 - 85). -- Tema 3: La responsabilidad penal individual en los delitos de empresa / Juan Antonio Lascuraín Sánchez (pp. 87 - 128). -- Tema 4: La responsabilidad penal de las personas jurídicas / Jacobo Dopico Gómez-Aller (pp. 129 - 168). -- Tema 5: Estafas y otros fraudes en el ámbito empresarial / Jacobo Dopico Gómez-Aller (pp. 169 - 235). -- Tema 6: Administración desleal y apropiación indebida / Adán Nieto Martín (pp. 237 - 284). -- Tema 7: Delitos de frustación de la ejecución y delitos de insolvencia / Norberto J. de la Mata Barranco (pp. 285 - 325). -- Tema 8: Delitos contra la propiedad intelectual e industrial y violación de secretos de empresa / Norberto J. de la Mata Barranco (pp. 327 - 366). -- Tema 9: Protección penal de la competencia y del mercado de valores / Adán Nieto Martín (pp. 367 - 414). -- Tema 10: Corrupción en los negocios / Adán Nieto Martín (pp. 415 - 445). -- Tema 11: Delitos contra los consumidores (publicidad engañosa y facturación automática fraudulenta). Piratería de servicios de comunicación / Jacobo Dopico Gómez-Aller y Juan Antonio Lascuraín Sánchez (pp. 447 - 467). -- Tema 12: Delitos societarios / Juan Antonio Lascuraín Sánchez (pp. 469 - 492). -- Tema 13: Blanqueo de capitales / Juan Antonio Lascuraín Sánchez (pp. 493 - 527). -- Tema 14: Delitos contra la Hacienda Pública y la Seguridad Social / Norberto J. de la Mata Barranco (pp. 529 - 591). -- Tema 15: Delitos contra los derechos de los trabajadores / Juan Antonio Lascuraín Sánchez (pp. 593 - 628). -- Tema 16: Delitos contra el urbanismo y la ordenación del territorio y delitos contra el ambiente / Norberto J. de la Mata Barranco (pp. 629 - 684). -- Tema 17: Falsedades en la empresa / Adán Nieto Martín (pp. 685 - 726). -- Tema 18: Delitos contra los sistemas de información / Norberto J. de la Mata Barranco (pp. 727 - 759

The impact of ADHD on reading

Más allá de la frecuente coexistencia del trastorno por déficit de atención con hiperactividad (TDAH) y el trastorno específico del aprendizaje de la lectura, la presente revisión pretende examinar la evidencia empírica disponible sobre cómo el TDAH impacta negativamente sobre el aprendizaje de la lectura. Los datos existentes apuntan a que la presencia del trastorno (especialmente los síntomas de falta de atención), puede afectar a i) la correcta adquisición de lectura, ya sea de manera directa o a través de su influencia sobre los precursores de la lectura; ii) las propias habilidades de decodificación (precisión y fluidez lectora), tanto de manera directa como indirecta a través de su influencia sobre procesos cognitivos como la distracción o las funciones ejecutivas; y ii) la comprensión lectora, probablemente de manera indirecta por las dificultades ejecutivas y en la memoria de trabajo verbal características del TDAH. Estas conclusiones presentan importantes implicaciones para caracterizar e intervenir mejor sobre las dificultades lectoras en el TDAH, ya sean clínicas o subclínicasBeyond the frequent coexistence of attention deficit hyperactivity disorder (ADHD) and reading disorder (dyslexia), the present review aims to examine the available empirical evidence on how ADHD negatively impacts on learning to read. Existing data suggest that the presence of the disorder (especially inattention symptoms), may affect i) the correct acquisition of reading, either directly or through its influence on the precursors to reading; ii) decoding skills themselves (reading accuracy and fluency), both directly and indirectly through its influence on cognitive processes such as distractibility or executive functions; and iii) reading comprehension, probably indirectly through the executive and verbal memory difficulties characteristic of ADHD. These findings have important implications for better characterizing and intervening on reading difficulties in ADHD, whether clinical or subclinica

Subduction and syn-collisional exhumation of a Paleozoic continental margin: an integrated study based on structures and P-T paths of the Basal Units in the Ordenes Complex (Galicia, Spain)

According to their metamorphic evolution, the Basal Units of the Galician Allochthonous Complexes are thought to represent a part of the margin of the Paleozoic Gondwana, subducted at the onset of the Variscan Orogeny. Variations in the P-T conditions of the first HP metamorphic event along the units suggest an important westward component for the direction of sucduction. Subsequent underthrusting of more continental material blocked the subduction and triggered the ascent and exhumation of the Basal Units whereas the convergence continued. Compressional and extensional structures were synchronous or alternated in time and, together, induced the thinning and tapering of the orogenic wedge. The unroofing took place locally under an inverted temperature gradient, caused by a detachment which carried a part of the hot mantle wedge, above the subduction zone, over the subducted units

Variscan exhumation of a subducted Paleozoic continental margin: The basal units of the Ordenes Complex, Galicia, NW Spain

A structural and metamorphic study was carried out in the basal units of the Ordenes Complex in Spain, thought to represent a subducted part of the Paleozoic margin of Gondwana. According to their metamorphic evolution, this part of the margin was subducted at the onset of the Variscan Orogeny, becoming part of an accretionary complex developed below a colliding element built previously. Variations in the PT conditions of the first high-pressure metamorphic event along the units indicate a polarity of the subduction to the west. Subsequent underthrusting of more continental material blocked the subduction and triggered the ascent and exhumation of the basal units, whereas the convergence continued. Recumbent folds and thrusts de ve loped along with successive normal detachments. Compressional and extensional structures were synchronous or alternated in time and together induced the thinning and tapering of the orogenic wedge and its lateral spreading. The unroofing took place locally under an inverted temperature gradient caused by a detachment which carried a part of the hot mantle wedge above the subduction zone over the subducted units