Interfaces to Mobile Virtual Reality

In this paper, we describe a project which uses PDAs to provide an interactive experience with a virtual environment. In particular, we focus on the navigational aspects of allowing the users to move through, and view, the environment. As this system will be deployed in a museum, it was crucial that the navigation be as intuitive as possible. To that end, we developed and evaluated two prototypes: one was based purely on gesture, whilst the other used a combination of gesture and keypad. For the purposes of our application, the combination of keypad and gesture provided the most effective

A meta-analysis of sensitivity to grammatical information during self-paced reading: Towards a framework of reference for reading time effect sizes.

Despite extensive theoretical and empirical research, we do not have estimations of the magnitude of sensitivity to grammatical information during L2 online processing. This is largely due to reliance on null hypothesis significance testing (Plonsky, 2015). The current meta-analysis draws on data from one elicitation technique, self-paced reading, across 57 studies (N = 3,052), to estimate sensitivity to L2 morphosyntax and how far L1 background moderates this. Overall, we found a reliable sensitivity to L2 morphosyntax at advanced proficiencies (d =.20, 95% CIs.15,.25), with some evidence that this was reliably lower than for native speakers (NSs). These patterns were not generally moderated by linguistic feature or sentence region. However, effects for anomaly detection were larger among NSs than L2 learners and the effects among L2 learners appeared to show a trend toward L1 influence. Finding smaller effects than in other subdomains, we provide an initial framework of reference for L2 reading time effect sizes

Basal cell carcinoma treated successfully with combined CO2 laser and photodynamic therapy in a renal transplant patient: a case report

Renal transplant recipients are at significantly greater risk of developing skin malignancies due to combination immunosuppressive therapy. A significant number of patients present with lesions needing excision at multiple outpatient follow-up visits. For basal cell carcinoma, we have recently described how combining CO2 laser with Photodynamic therapy greatly increases the efficacy of long-term tumour clearance compared with each modality alone. We present a case of a 66-year-old renal transplant therapy patient who repeatedly presents with new skin malignancies, in whom we treated successfully with Laser-Photodynamic therapy in a see-and-treat setting. This therapy offers patients the possibility of better cosmetic and functional results whilst obviating the need for repeated surgery. Other pre-cancerous lesions such as solar keratoses are prevalent in this patient group and respond extremely well to Photodynamic therapy monotherapy. We propose a regular clinic for renal transplant patients in a laser facility equipped with CO2 laser and Photodynamic therapy, histopathology and punch-biopsy materials. This strategy allows simple and effective treatment of multiple lesions simultaneously, avoidance of numerous operations, avoidance of non-essential outpatient appointments that result in booking furthers visits for treatment, whilst facilitating diagnostic biopsies of potentially malignant lesions. We outline a care pathway for a see-and-treat clinic that implements this novel treatment modality improving the care of this unique patient population

The N-terminal ricin propeptide influences the fate of ricin A-chain in tobacco protoplasts.

The plant toxin ricin is synthesized in castor bean seeds as an endoplasmic reticulum (ER)-targeted precursor. Removal of the signal peptide generates proricin in which the mature A- and B-chains are joined by an intervening propeptide and a 9-residue propeptide persists at the N terminus. The two propeptides are ultimately removed in protein storage vacuoles, where ricin accumulates. Here we have demonstrated that the N-terminal propeptide of proricin acts as a nonspecific spacer to ensure efficient ER import and glycosylation. Indeed, when absent from the N terminus of ricin A-chain, the non-imported material remained tethered to the cytosolic face of the ER membrane, presumably by the signal peptide. This species appeared toxic to ribosomes. The propeptide does not, however, influence catalytic activity per se or the vacuolar targeting of proricin or the rate of retrotranslocation/degradation of A-chain in the cytosol. The likely implications of these findings to the survival of the toxin-producing tissue are discussed

Virtual Window: A Peephole into another World

This project investigates an effective means of streaming and displaying complex 3D scenes over a low-bandwidth wireless network to a remote PDA device, which has limited graphical capabilities. The PDA is also made position-aware, allowing user interaction to occur with a new degree of freedom, mapping real world movements such as rotation to virtual environment changes. Rendering techniques such as silhouetting optimise PDA display rate, but slow PDA processing speed means image compression to reduce network latency is unfeasible. In spite of any technical limitations, however, preliminary user testing shows that the concept and methods of interaction developed are intuitive, with good potential for further system development

Airborne Prokaryotic, Fungal and Eukaryotic Communities of an Urban Environment in the UK

Bioaerosols often contain human pathogens and allergens affecting public health. However, relatively little attention has been given to bioaerosols compared with non-biological aerosols. In this study, we aimed to identify bioaerosol compositions in Manchester, UK by applying high throughput sequencing methods and to find potential sources. Samples were collected at Manchester Air Quality Super Site at the Firs Environmental Research Station in November 2019 and in February 2020. Total DNA has been extracted and sequenced targeting the 16S rRNA gene of prokaryotes, ITS region of fungal DNA and 18S rRNA gene of eukaryotes. We found marine environment-associated bacteria and archaea were relatively more abundant in the February 2020 samples compared with the November 2019 samples, consistent with the North West marine origin based on wind back-trajectory analysis. In contrast, an OTU belonging to Methylobacterium, which includes many species resistant to heavy metals, was relatively more abundant in November 2019 when there were higher metal concentrations. Fungal taxa that fruit all year were relatively more abundant in the February 2020 samples while autumn fruiting species generally had higher relative abundance in the November 2019 samples. There were higher relative abundances of land plants and algae in the February 2020 samples based on 18S rRNA gene sequencing. One of the OTUs belonging to the coniferous yew genus Taxus was more abundant in the February 2020 samples agreeing with the usual pollen season of yews in the UK which is from mid-January until late April. The result from this study suggests a potential application of bioaerosol profiling for tracing the source of atmospheric particles

Evidence of sound production by spawning lake trout (Salvelinus namaycush) in lakes Huron and Champlain

Two sounds associated with spawning lake trout (Salvelinus namaycush) in lakes Huron and Champlain were characterized by comparing sound recordings with behavioral data collected using acoustic telemetry and video. These sounds were named “growls” and “snaps” and were heard on lake trout spawning reefs, but not on a nonspawning reef, and were more common at night than during the day. Growls also occurred more often during the spawning period than the prespawning period, while the trend for snaps was reversed. In a laboratory flume, sounds occurred when male lake trout were displaying spawning behaviors: growls when males were quivering and parallel swimming and snaps when males moved their jaw. Combining our results with the observation of possible sound production by spawning splake (Salvelinus fontinalis × Salvelinus namaycush hybrid) provides rare evidence for spawning-related sound production by a salmonid or any other fish in the superorder Protacanthopterygii. Further characterization of these sounds could be useful for lake trout assessment, restoration, and control

К вопросу подготовки медицинских кадров в условиях реформирования системы здравоохранения

Реформирование системы здравоохранения в Украине вносит серьезные кор­рективы в работу лечебно-профилактических учреждений, и определяет необходимость подготовки, переподготовки, повышения квалификации, как врачей так и среднего медицинского персонала. Система дополнительного профессионального образования должна быть одной из основополагающих систем, обеспечивающих практическое здравоохранение высокопрофессиональными кадрами. Реализация этого возможна при использовании современных, актуальных и апробированных методик обучения, переобучения и повышения квалификации

The Importance of Capturing Local Measurement-Driven Adjustment of Modelled <i>j</i>(NO₂)

Accurate photolysis rate constants are essential for simulation of local air quality but their values can vary substantially with changes in local meteorological and surface conditions. This study demonstrates the use of local radiometer measurements for capturing via hourly measurement-driven adjustment factors (MDAF) the temporal resolution needed to adjust clear-sky or cloud-free model estimates of j(NO2). Measurements simultaneously at two sites in the UK (Auchencorth Moss and Manchester) showed that TUV (v5.3) model estimates of j(NO2)↓ in cloud-free conditions (used as an example of modelled j-values) were, on average, approximately 45% larger than measured j(NO2)↓, which would lead to substantial model bias in the absence of local adjustment. At Auchencorth Moss, MDAF values based on 4π and 2π radiometer inlets generally agreed very well with each other (<6% average difference). However, under conditions of particularly high surface albedo (such as snow cover), increased upwelling local diffuse radiation yielded an MDAF derived using total radiation (sum of ↓ and ↑ components) ~40% larger than the MDAF derived using only ↓ radiation. The study has demonstrated: (1) the magnitude of potential impact of local conditions—principally cloud cover, but also changes in surface albedo—on assumed j-values; (2) that whilst annual mean MDAF values are similar at Auchencorth Moss and Manchester, there is no contemporaneous correlation between them at hourly resolution; hence MDAF values derived at one site cannot readily be applied at another site. These data illustrate the need to routinely deploy long-term radiometer measurements alongside compositional measurements to support atmospheric chemistry modelling