182 research outputs found
Colocação de implantes curtos em zonas com pouca disponibilidade óssea
Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas MonizNa região posterior dos maxilares frequentemente existem limitações em termos de altura óssea o que condiciona a colocação de implantes standard.
Nesses casos recorre-se muitas vezes à realização intervenções cirúrgicas tais como o aumento do osso reabsorvido da crista óssea com recurso a regeneração óssea guiada, enxertos ósseos, distração osteogénica, elevação do seio maxilar, reposicionamento do nervo alveolar inferior ou colocação de implantes angulados. Não há dados suficientes que indiquem qual o melhor procedimento cirúrgico a seguir já que dependem do caso em questão, do seu custo, tempo de intervenção e do tempo de recuperação.
Uma alternativa a estes procedimentos cirúrgicos mais invasivos, nos casos de rebordos ósseos muito reabsorvidos, é a utilização de implantes curtos (IC). Os implantes curtos são cada vez mais utilizados ou indicados como uma opção válida de tratamento em casos em que o uso de implantes convencionais está limitado. O termo implante curto é subjetivo, sem um consenso na literatura em relação à sua definição, isto porque alguns autores defendem a definição como um implante que não seja maior que 7mm enquanto outros defendem que um implante de 10mm ainda é considerado um implante curto.
Quanto às taxas de sucesso dos implantes curtos, apesar de anteriormente estarem associados a uma menor taxa de sucesso/sobrevivência, apontando-se como possíveis razões uma reduzida estabilidade primária e um reduzido contacto osso-implante bem como um rácio coroa-implante desfavorável, os avanços a nível de design e superfícies dos implantes possibilitaram compensar estas mesmas situações, permitindo atualmente apresentarem taxas de sucesso similares aos dos implantes standard
Efeito da convergência das perspetivas do terapeuta e do cliente sobre as sessões para a evolução dos resultados da terapia
Os estudos atuais tendem a considerar a psicoterapia como um processo diádico, de partilha, negociação de significados e encontro entre terapeuta e cliente. Quanto maior a concordância e convergência de perspetivas do terapeuta e cliente sobre a própria terapia melhores serão os resultados. Neste estudo pretendemos descrever a convergência no que diz respeito à avaliação que terapeuta e cliente fazem das sessões terapêuticas e avaliar o seu contributo para os resultados da terapia.
A amostra foi composta por 24 sujeitos que realizaram acompanhamento psicoterapêutico no Serviço de Psicologia da Escola de Psicologia da Universidade do Minho. Após as sessões, terapeutas e clientes preencheram o Questionário de Avaliação da Sessão, enquanto apenas os clientes responderam ao Outcome Questionnaire no final de todas as sessões. Os dados foram analisados com recurso a um procedimento de Modelagem Linear Hierárquica Polinomial em combinação com a Análise de Resposta de Superfície.
Os resultados sugerem que a concordância na suavidade e a convergência na positividade, aspetos que definem qualidades relacionais e emocionais da relação terapêutica, em fases mais avançadas da terapia, se associam à obtenção de resultados. Havendo discordância, em particular no fator positividade, que ocorreu tipicamente na fase inicial da terapia, para a obtenção de resultados é mais importante que o cliente se sinta melhor do que o terapeuta.
Este estudo permitiu estabelecer hipóteses relativamente ao modo como a experiência partilhada pelo terapeuta e cliente nas sessões poderá contribuir para os resultados terapêuticos numa população clínica.Current studies tend to consider psychotherapy as a dyadic process of sharing, meaning negotiation and meeting between therapist and client. The greater the agreement and convergence of the therapist and client's perspectives on the therapy itself, the better will be the outcome. In this study we intended to describe the convergence with regard to the therapist and client evaluation of the therapeutic sessions and to assess their contribution to the outcome.
The sample consisted of 24 subjects who underwent psychotherapeutic follow-up at the Psychology Service of the School of Psychology at the University of Minho. After the sessions, therapists and clients completed the Session Evaluation Questionnaire, while only the clients answered the Outcome Questionnaire at the end of all sessions. The data were analyzed using a Polynomial Hierarchical Linear Modeling procedure in combination with the Surface Response Analysis.
The results suggest that the agreement on smoothness and the convergence on positivity, aspects that define the relational and emotional qualities of the therapeutic relationship are associated to the outcome, in more advanced stages of the therapy. If there is disagreement, particularly in the positivity factor, which typically occurred in the initial stage of the therapy, it is more important for the client to feel better, than for the therapist.
This study made it possible to establish hypotheses as to how the experience shared by therapist and client in the sessions could contribute to the therapeutic results in a clinical population
A flexible online apparatus for projectile launch experiments
In order to provide a more flexible learning environment in physics, the developed projectile launch apparatus enables students to determine the acceleration of gravity and the dependence of a set of parameters in the projectile movement. This apparatus is remotely operated and accessed via web, by first scheduling an access time slot. This machine has a number of configuration parameters that support different learning scenarios with different complexities
Validation of a Portuguese version of the Groningen radiotherapy-induced xerostomia questionnaire
The aim of this study was to validate and determine at pretest level the reliability of the Portuguese version of the Groningen radiotherapy-induced xerostomia questionnaire. This study employed 37 head and neck cancer patients. Each patient signed an informed consent and responded to the Portuguese version of the questionnaire in the form of an interview. This was repeated again after 2 weeks. A standard single question provided a validity check. Data were analyzed using Cronbach?s ? to test its reliability and total and interitem correlation, and intraclass correlation to determine its internal consistency and test-retest reliability. Construct validity supported by objective measurements as salivary secretion was also investigated. Significance was set at .05. Cronbach?s ? was 0.91 and 0.89 for the first and second test administrations, respectively, which indicates that the internal consistency was excellent. The intraclass correlation coefficient value for the test-retest reliability was 0.70. The correlation between the total score of the questionnaire and standard single dry mouth question was 0.72 for the first round, indicating a good correlation. Demonstrating very good psychometric properties, the Portuguese version of the Groningen radiotherapy-induced xerostomia questionnaire is a valid tool and can be considered a reliable instrument to measure xerostomia in head and neck cancer patients
Natural Stones from Portugal : Proposal for harmonizing Commercial Names
ABSTRACT: Over the years, the Portuguese Geological Survey – LNEG, has been dedicated to the characterization of Portuguese natural stones. Today, a newly updated LNEG web portal contains information on 149 natural stones, which are known by their unique trade names. Many of these names integrate the EN 12440 - Natural Stone - Denomination Criteria standard, but others do not. Furthermore, there many other names used to identify natural stones that are traded today and that do not integrate the LNEG web Portal or the EN 12440. This work presents a harmonization proposal for the commercial denomination of the Portuguese natural stones. It is a working basis for a final list that must be submitted to ISO/Technical Committee 118 – Natural Stones.info:eu-repo/semantics/publishedVersio
Cancer Theranostic Dyes
Funding Information: This work was financed by national funds from FCT—Fundação para a Ciência e a Tecnologia, I.P., within the scope of the projects of the Ministry of Science Technology and Higher Education: UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences—UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB and, in part, by the Jeanne and J.-Louis Lévesque foundation, Montreal, QC, Canada (J.E.v.L.). J.E.v.L. is a member of the Research Center of the CHUS (CRCHUS), Sherbrooke, QC, Canada, supported by the Fonds de la Recherche du Québec—Santé. C.R.R., A.L. and R.V. were funded by FCT/MCTES, grant numbers SFRH/BPD/124612/2016, SFRH/BD/12161/2022, and SFRH/BD/09845/2022, respectively. Publisher Copyright: © 2023 by the authors.Estradiol-BODIPY linked via an 8-carbon spacer chain and 19-nortestosterone- and testosterone-BODIPY linked via an ethynyl spacer group were evaluated for cell uptake in the breast cancer cell lines MCF-7 and MDA-MB-231 and prostate cancer cell lines PC-3 and LNCaP, as well as in normal dermal fibroblasts, using fluorescence microscopy. The highest level of internalization was observed with 11β-OMe-estradiol-BODIPY 2 and 7α-Me-19-nortestosterone-BODIPY 4 towards cells expressing their specific receptors. Blocking experiments showed changes in non-specific cell uptake in the cancer and normal cells, which likely reflect differences in the lipophilicity of the conjugates. The internalization of the conjugates was shown to be an energy-dependent process that is likely mediated by clathrin- and caveolae-endocytosis. Studies using 2D co-cultures of cancer cells and normal fibroblasts showed that the conjugates are more selective towards cancer cells. Cell viability assays showed that the conjugates are non-toxic for cancer and/or normal cells. Visible light irradiation of cells incubated with estradiol-BODIPYs 1 and 2 and 7α-Me-19-nortestosterone-BODIPY 4 induced cell death, suggesting their potential for use as PDT agents.publishersversionpublishe
The TOSCA Registry for Tuberous Sclerosis-Lessons Learnt for Future Registry Development in Rare and Complex Diseases.
Introduction: The TuberOus SClerosis registry to increase disease Awareness (TOSCA) is an international disease registry designed to provide insights into the clinical characteristics of patients with Tuberous Sclerosis Complex (TSC). The aims of this study were to identify issues that arose during the design, execution, and publication phases of TOSCA, and to reflect on lessons learnt that may guide future registries in rare and complex diseases. Methods: A questionnaire was designed to identify the strengths, weaknesses, and issues that arose at any stage of development and implementation of the TOSCA registry. The questionnaire contained 225 questions distributed in 7 sections (identification of issues during registry planning, during the operation of the registry, during data analysis, during the publication of the results, other issues, assessment of lessons learnt, and additional comments), and was sent by e-mail to 511 people involved in the registry, including 28 members of the Scientific Advisory Board (SAB), 162 principal investigators (PIs), and 321 employees of the sponsor belonging to the medical department or that were clinical research associate (CRA). Questionnaires received within the 2 months from the initial mailing were included in the analysis. Results: A total of 53 (10.4%) questionnaires were received (64.3% for SAB members, 12.3% for PIs and 4.7% for employees of the sponsor), and the overall completeness rate for closed questions was 87.6%. The most common issues identified were the limited duration of the registry (38%) and issues related to handling of missing data (32%). In addition, 25% of the respondents commented that biases might have compromised the validity of the results. More than 80% of the respondents reported that the registry improved the knowledge on the natural history and manifestations of TSC, increased disease awareness and helped to identify relevant information for clinical research in TSC. Conclusions: This analysis shows the importance of registries as a powerful tool to increase disease awareness, to produce real-world evidence, and to generate questions for future research. However, there is a need to implement strategies to ensure patient retention and long-term sustainability of patient registries, to improve data quality, and to reduce biases
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