Eksistensi Nilai Moral dan Nilai Hukum dalam Sistem Hukum Nasional

Laws that benefit a community should reflect the moral and legal values ​​of the society in which a law enforced. Likewise with the Indonesian national legal system should reflect the moral and legal values ​​contained in Pancasila. The low legal authority in to day\u27s society due to national legal systems have not fully reflect the value of moral and legal values ​​based on Pancasila. Problems in this paper is why the moral and legal values ​​of Pancasila has not been fully reflected in the current National Legal Systems. The results of the study that cause: (1) Pancasila translated in accordance with the interests of the ruler, (2) national legal reform is deadlocked due to, among others: the struggle of political interests, target orientation, ego-sectoral, bond romanticism of the past, dealing with inferiority superiority. Advice to immediately reorient and reevaluation national legal system based on Pancasila

The Recognition of Traumatic Brain Injuries as a Risk Factor for Dementia in Military Veterans: A Systematic Review

Purpose/Hypothesis: The prevalence of traumatic brain injuries has increased over time. Following a TBI, neurodegeneration occurs which predisposes individuals to other neurological conditions such as dementia. The purpose of this study is to demonstrate the relationship between TBIs and the occurrence of dementia in military veterans. Number of subjects: Not applicable Materials/Methods: CINAHL complete and APA PsychInfo were searched electronically between the years 2000 and 2020 in August of 2020. A second search was conducted in January of 2021 to include any new and updated research. Search terms included concussion, mild traumatic brain injury, mild tbi, mtbi, traumatic brain injury, TBI, dementia, alzheimers, military, veterans, soldiers, armed forces, VA, and veterans affairs. The search was narrowed to include only academic journals in English. Selection of articles were determined by the authors that agreed upon the inclusion of TBI, dementia, and military population. Access to full text articles were gained through the inter-library loan, One Search, and the databases above via Misericordia University. Hand searching occurred to gain access to articles that were identified in the reference of established matrix articles. Results: 172 articles were identified through electronic search. Based on inclusion criteria, 8 articles were included in the systematic review. Two other articles were included following a hand search. All studies were retrospective including cohort and case control studies. Conclusion: Nine of ten articles identified traumatic brian injuries are a risk factor for the development of dementia in military members. Two articles identified there was no relationship between the severity of a TBI and risk factors for developing dementia. Four articles reported an increased risk for dementia when other risk factors combined with TBI were involved. Four articles determine there is a greater risk for late onset dementia than early onset dementia when sustaining a TBI at any age. Clinical Relevance: By understanding the risk factor of dementia following TBIs health care providers can screen for dementia and treat as needed. The better understanding there is of this relationship the better prevention, management, and treatment can be implemented to decrease this silent epidemic.https://digitalcommons.misericordia.edu/research_posters2021/1012/thumbnail.jp

Local structural studies of Ba1−x_{1-x}Kx_xFe2_2As2_2 using atomic pair distribution function analysis

Systematic local structural studies of Ba$_{1-x}$K$_x$Fe$_2$As$_2$ system are undertaken at room temperature using atomic pair distribution function (PDF) analysis. The local structure of the Ba$_{1-x}$K$_x$Fe$_2$As$_2$ is found to be well described by the long-range structure extracted from the diffraction experiments, but with anisotropic atomic vibrations of the constituent atoms ($U_{11}$ = $U_{22} \ne U_{33}$). The crystal unit cell parameters, the FeAs$_4$ tetrahedral angle and the pnictogen height above the Fe-plane are seen to show systematic evolution with K doping, underlining the importance of the structural changes, in addition to the charge doping, in determining the properties of Ba$_{1-x}$K$_x$Fe$_2$As$_2$

A lithium-ion battery based on LiFePO4 and silicon/reduced graphene oxide nanocomposite

In this paper, the preparation and chemical–physical characterization of a composite material made of silicon nanoparticles (nSi) and reduced graphene oxide (RGO) for using as an anode for lithium-ion batteries are report- ed. The nSi/RGO composite was synthesized by microwave irradiation followed by a thermal treatment under reducing atmosphere of a mixture of nSi and graphene oxide, and characterized by XRD, SEM, and TGA. The nano- structured material was used to prepare an electrode, and its electrochemical performance was evaluated in a lithium cell by galvanostatic cycles at various charge rates. The electrode was then coupled with a LiFePO4 cathode to fabricate a full lithium-ion battery cell and the cell performance evaluated as a function of the discharge rate and cycle number

Quantification of asbestos and other mineral phase burden in necroscopic human lung tissues with a new method

Background: A large amount of studies on asbestos exposure reconstruction have been so far conducted digesting the lung tissues with appropriate reagents, separating the powder from the digestion liquid by filtration and analysing the residue by optical or electron microscopy. This analytical approach has good sensitivity but is not yet well standardized, the investigated portion is not representative of the bulk sample, the results are often characterized by lack of reproducibility and repeatability. Moreover, the numeric quantification of asbestos requires a time-consuming particle by particle analysis. Aim: to develop a new method for the complete quantitative characterization of asbestos and other mineral phases in human lung tissue. Methods: The new method is based on sodium hypochlorite digestion, separation and XRPD analysis. The XRPD approach needs moderate lung tissue amounts (at least 20 g of wet tissue), but allows to conduct a complete quantitative characterization of each crystalline phase in the sample giving bulk-representative results with good reproducibility, accuracy and precision. The detection limit of conventional XRPD was considerably improved by a novel instrumental setting and weight concentrations can be obtained, giving additional information to numeric ones, preferable in clinical and pathogenetic studies but probably not for the exposure reconstruction. Results: Among the analysed autoptic lung tissues, ten samples belonged to subjects occupationally exposed to asbestos and six were collected from urban area controls. Asbestos phases were detected in none of controls and in 5 of 10 occupationally exposed subjects (those with highest exposure history) indicating that this method is suitable for the reconstruction of medium and high asbestos exposures. It has been furthermore confirmed the mineral association found in previous studies: mainly composed by quartz, talc, clay minerals, micas, Fe-Al-Ti oxides and bio-minerals such Ca-phosphates, carbonates and oxalates

Kidney transplantation with presymptomatic COVID-19–positive surgeon

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Erodible drug delivery systems for time-controlled release into the gastrointestinal tract

In oral delivery, lag phases of programmable duration that precede drug release may be advantageous in a number of instances, e.g. to meet chronotherapeutic needs or pursue colonic delivery. Systems that give rise to characteristic lag phases in their release profiles, i.e. intended for time-controlled release, are generally composed of a drug-containing core and a functional polymeric barrier. According to the nature of the polymer, the latter may delay the onset of drug release by acting as a rupturable, permeable or erodible boundary layer. Erodible systems are mostly based on water swellable polymers, such as hydrophilic cellulose ethers, and the release of the incorporated drug is deferred through the progressive hydration and erosion of the polymeric barrier upon contact with aqueous fluids. The extent of delay depends on the employed polymer, particularly on its viscosity grade, and on the thickness of the layer applied. The manufacturing technique may also have an impact on the performance of such systems. Double-compression and spray-coating have mainly been used, resulting in differing technical issues and release outcomes. In this article, an update on delivery systems based on erodible polymer barriers (coatings, shells) for time-controlled release is presented

Mechanically induced cis-to-trans isomerization of carbon–carbon double bonds using atomic force microscopy

Cis-to-trans isomerization of carbon–carbon double bonds can be induced by the application of mechanical force. Using single molecule force spectroscopy by means of atomic force microscopy (AFM) we pulled polymer molecules which contained cis double bonds in the backbone. In the force versus extension profiles of these polymers, a sudden extension increase is observed which is due to the conversion of shorter cis isomers into longer trans isomers. The added length to the polymer results in relaxation in probed force. We find that the isomerization occurs at forces of 800 ± 60 pN, independent of AFM tip and solid substrate chemistries. Investigation of similar polymers which exclusively contained single bonds in the backbone showed no evidence of a similar transition

Western Diet in Adulthood, Timing of Menarche, and Economic Status Among Northeast Ohioans

I studied the age at first menstruation as a predictor of Western diet consumption among adults at The University of Akron and in Cleveland. I used stable carbon and nitrogen isotope compositions of human hair, as well as surveyed consumption of foods important to a Western diet (red meat, sugar, and dairy), to understand whether participants aligned with a Western dietary pattern. Age at survey and adult economic status were investigated as potential confounding variables. My data analysis and conclusions for this project has been completed and approved by my advisor and committee. To maintain collaborators\u27 ability to publish a comprehensive analysis of this dataset, I am not at liberty to publish my results here. Broader analyses of diet composition across lifetime, age at menarche, and economic status represent interesting avenues for future study

Non-uniform drug distribution matrix system (NUDDMat) for zero-order release of drugs with different solubility

A decrease in the drug release rate over time typically affects the performance of hydrophilic matrices for oral prolonged release. To address such an issue, a Non-Uniform Drug Distribution Matrix (NUDDMat) based on hypromellose was proposed and demonstrated to yield zero-order release. The system consisted of 5 overlaid layers, applied by powder layering, having drug concentration decreasing from the inside towards the outside of the matrix according to a descending staircase function. In the present study, manufacturing and performance of the described delivery platform were evaluated using drug tracers having different water solubility. Lansoprazole, acetaminophen and losartan potassium were selected as slightly (SST), moderately (MST) and highly (HST) soluble tracers. By halving the thickness of the external layer, which contained no drug, linear release of HST and MST was obtained. The release behavior of the NUDDMat system loaded with a drug having pH-independent solubility was shown to be consistent in pH 1.2, 4.5 and 6.8 media. Based on these results, feasibility of the NUDDMat platform by powder layering was demonstrated using drugs having different physico-technological characteristics. Moreover, its ability to generate zero-order release was proved in the case of drugs with water solubility in a relatively wide range