Incidencia de la Gestión en el Área Financiera de “Comisión Nacional Ganadera” en el Municipio de Matagalpa, en el I Semestre del año 2014

La presente investigación trata de las Incidencias de la Gestión Financiera en el Área Financiera de “Comisión Nacional Ganadera” en el Municipio de Matagalpa en el I Semestre del año 2014, el cual tiene como finalidad evaluar todos los hallazgos sobre las incidencias de la gestión financiera, relacionado a los análisis, decisiones y acciones respecto a los medios financieros necesarios a la actividad de dicha organización. Así, la función financiera integra todas las tareas relacionadas con el logro, utilización y control de recursos financieros. Además este tema es de suma importancia dado que profundizará los conocimientos de los estudiantes de la UNAN-FAREM-MATAGALPA y servirá de guía a los ejecutivos de la empresa de estudio, ya que los orientará a convertir los recursos disponibles en recursos productivos, rentables y generadores de valor, permitiendo al mismo tiempo el despliegue de los objetivos estratégicos de la empresa. En síntesis la Gestión Financiera está directamente relacionada con la rama de las finanzas, dado que sin este elemento de importancia no se llevaría un buen control de los recursos financieros, los cuales por medio de esta se trata de maximizar los beneficios, teniendo una buena organización, planificación, control y evaluación de los recursos que posea una entidad, dado que se hace uso de las funciones integrales de la gestión a través de la determinación de las necesidades de recursos, consecución de financiamiento, la aplicación de los recursos financieros y el debido análisis financiero teniendo como énfasis la viabilidad económica y financiera de las inversione

Incidencia de la Gestión en el Área Financiera de “Comisión Nacional Ganadera” en el Municipio de Matagalpa, en el I Semestre del año 2014

La presente investigación trata de las Incidencias de la Gestión Financiera en el Área Financiera de “Comisión Nacional Ganadera” en el Municipio de Matagalpa en el I Semestre del año 2014, el cual tiene como finalidad evaluar todos los hallazgos sobre las incidencias de la gestión financiera, relacionado a los análisis, decisiones y acciones respecto a los medios financieros necesarios a la actividad de dicha organización. Así, la función financiera integra todas las tareas relacionadas con el logro, utilización y control de recursos financieros. Además este tema es de suma importancia dado que profundizará los conocimientos de los estudiantes de la UNAN-FAREM-MATAGALPA y servirá de guía a los ejecutivos de la empresa de estudio, ya que los orientará a convertir los recursos disponibles en recursos productivos, rentables y generadores de valor, permitiendo al mismo tiempo el despliegue de los objetivos estratégicos de la empresa. En síntesis la Gestión Financiera está directamente relacionada con la rama de las finanzas, dado que sin este elemento de importancia no se llevaría un buen control de los recursos financieros, los cuales por medio de esta se trata de maximizar los beneficios, teniendo una buena organización, planificación, control y evaluación de los recursos que posea una entidad, dado que se hace uso de las funciones integrales de la gestión a través de la determinación de las necesidades de recursos, consecución de financiamiento, la aplicación de los recursos financieros y el debido análisis financiero teniendo como énfasis la viabilidad económica y financiera de las inversione

Prevalence and molecular typing of rotavirus in children with acute diarrhoea in Northeastern Colombia

After the introduction of the rotavirus vaccine, the number of rotavirus-associated deaths and the predicted annual rotavirus detection rate had slightly declined worldwide. Taking in account that in Colombia, Rotarix vaccine was introduced in 2009, the purpose of this study was to evaluate the presence of rotavirus A in children under five years who were treated for acute diarrhoea in Bucaramanga, Colombia and, moreover, to determine the genotypes of rotavirus present in those children. We performed an analytical cross-sectional study of rotavirus A in faecal samples from children up to five years of age. Stool samples were screened for rotavirus A using a lateral-flow immunochromatographic assay and confirmed using a VP6 sandwich ELISA. Genotyping of rotavirus A-positive samples was performed by PCR and sequencing of VP7 and VP4 genes. The overall prevalence of rotavirus was 30.53% (95% confidence interval [CI] 21.2 - 39.7). Most of the children with rotavirus (86.2%) had received two doses of the rotavirus vaccine. G3 strains accounted for the vast majority of cases (82.8%), followed by G12 strains (13.8%) and G3/G9 coinfections (3.4%). Among the P genotypes, P[8] was the most prevalent (69%), followed by P[9] (31%). The most common G[P] genotype combination was G3P[8], followed by G3P[9]. The main finding in this study was that rotavirus, in a Colombian region, is still an important pathogen in children under five years old, previously vaccinated. The results showed that different factors, such as kindergarten attendance, could explain the epidemiology and transmission of rotavirus in Bucaramanga

The antiviral and virucidal activities of voacangine and structural analogs extracted from Tabernaemontana cymosa depend on the Dengue virus strain

Currently, no specific licensed antiviral exists for treating the illness caused by dengue virus (DENV). Therefore, the search for compounds of natural origin with antiviral activity is an important area of research. In the present study, three compounds were isolated and identified from seeds of Tabernaemontana cymosa plants. The in vitro antiviral effect of those compounds and voacangine against different DENV strains was assessed using different experimental approaches: compounds added before the infection (Pre), at the same time with the virus (Trans), after the infection (Post) or compounds present in all moments of the experiment (Pre-Trans-Post, Combined treatment). In silico studies (docking and molecular dynamics) were also performed to explain the possible antiviral mechanisms. The identified compounds were three structural analogs of voacangine (voacangine-7-hydroxyindolenine, rupicoline and 3-oxo-voacangine). In the Pre-treatment, only voacangine-7-hydroxyindolenine and rupicoline inhibited the infection caused by the DENV-2/NG strain (16.4% and 29.6% infection, respectively). In the Trans-treatment approach, voacangine, voacangine-7-hydroxyindolenine and rupicoline inhibited the infection in both DENV-2/NG (11.2%, 80.4% and 75.7% infection, respectively) and DENV-2/16681 infection models (73.7%, 74.0% and 75.3% infection, respectively). The latter strain was also inhibited by 3-oxo-voacangine (82.8% infection). Moreover, voacangine (most effective virucidal agent) was also effective against one strain of DENV-1 (DENV-1/WestPac/74) and against the third strain of DENV-2 (DENV-2/S16803) (48.5% and 32.4% infection, respectively). Conversely, no inhibition was observed in the post-treatment approach. The last approach (combined) showed that voacangine, voacangine-7-hydroxyindolenine and rupicoline inhibited over 90% of infections (3.5%, 6.9% and 3.5% infection, respectively) of both strains (DENV-2/NG and DENV-2/16681). The free energy of binding obtained with an in silico approach was favorable for the E protein and compounds, which ranged between −5.1 and −6.3 kcal/mol. Finally, the complex formed between DENV-2 E protein and the best virucidal compound was stable for 50 ns. Our results show that the antiviral effect of indole alkaloids derived from T. cymose depends on the serotype and the virus strain.https://scienti.colciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000213748https://scholar.google.es/citations?user=flSrsSIAAAAJ&hl=eshttps://scienti.minciencias.gov.co/gruplac/jsp/visualiza/visualizagr.jsp?nro=00000000000695https://orcid.org/0000-0002-9429-005

Articulación de las áreas del conocimiento mediado por un AVA para el desarrollo de competencias comunicativas

Se realiza una investigación con estudiantes grado quinto de básica primaria, con el propósito de desarrollar y fortalecer competencias comunicativas a través de la interacción en un AVA, validando el proceso comunicativo como el fundamento de todo proceso social, educativo y formativo, A partir del uso de herramientas desde una dimensión práctica e interdisciplinaria. La importancia en la educación es innovar utilizando herramientas y conocimientos necesarios donde interviene la comunicación, la creatividad, el análisis, uso adecuado de las TIC, donde los estudiantes aprenden y articulan las diferentes áreas del conocimiento. Con los nuevos retos que se deben enfrentar producto de los cambios de la sociedad actual, se representa cambios de paradigmas en la educación que interactúan en procesos de enseñanza

Articulación de las áreas del conocimiento mediado por un AVA para el desarrollo de competencias comunicativas

Se realiza una investigación con estudiantes grado quinto de básica primaria, con el propósito de desarrollar y fortalecer competencias comunicativas a través de la interacción en un AVA, validando el proceso comunicativo como el fundamento de todo proceso social, educativo y formativo, A partir del uso de herramientas desde una dimensión práctica e interdisciplinaria. La importancia en la educación es innovar utilizando herramientas y conocimientos necesarios donde interviene la comunicación, la creatividad, el análisis, uso adecuado de las TIC, donde los estudiantes aprenden y articulan las diferentes áreas del conocimiento. Con los nuevos retos que se deben enfrentar producto de los cambios de la sociedad actual, se representa cambios de paradigmas en la educación que interactúan en procesos de enseñanza

Lovastatin delays infection and increases survival rates in AG129 mice infected with dengue virus serotype 2

ABSTARCT: It has been reported that treatment of DENV-infected cultures with Lovastatin (LOV), can affect viral assembly. The objective of this study was to evaluate the effect of LOV on the survival rate and viremia levels of DENV-2-infected AG129 mice. Methodology/Principal Findings: Mice were inoculated with 16106 plaque-forming units (PFU/ml) of DENV-2 and treated with LOV (200 mg/kg/day). Pre-treatment with one or three doses of LOV increased the survival rate compared to untreated mice (7.3 and 7.1 days, respectively, compared to 4.8 days). Viremia levels also decreased by 21.8% compared to untreated mice, but only in the group administered three doses prior to inoculation. When LOV was administered after viral inoculation, the survival rate increased (7.3 days in the group treated at 24 hpi, 6.8 days in the group treated at 48 hpi and 6.5 days in the group treated with two doses) compared to the untreated group (4.8 days). Interestingly, the serum viral titer increased by 24.6% in mice treated at 48 hpi with a single dose of LOV and by 21.7% in mice treated with two doses (at 24 and 48 hpi) of LOV compared to untreated mice. Finally histopathological changes in the liver and spleen in infected and untreated mice included massive extramedullary erythropoiesis foci and inflammatory filtration, and these characteristics were decreased or absent in LOV-treated mice. Conclusions/Significance: Our results suggest that the effect of LOV on viremia depends on the timing of treatment and on the number of doses administered. We observed a significant increase in the survival rate in both schemes due to a delay in the progression of the disease. However, the results obtained in the post-treatment scheme must be handled carefully because this treatment scheme increases viremia and we do not know how this increase could affect disease progression in humans

Zero by 2030 and OneHealth: The multidisciplinary challenges of rabies control and elimination

"Rabies, caused by a negative strand RNA-virus belonging to the genus Lyssavirus (family Rhabdoviridae of the order Mononegavirales), remains of global concern [1]. This vaccine-preventable viral zoonotic disease is present in more than 150 countries and territories [2]. Ac- cording to the World Health Organization (WHO), rabies is estimated to cause ~59,000 human deaths annually, with 95% of cases occurring in Africa and Asia [3,4]. However, rabies still occurs in other regions, such as Latin America and the Caribbean [5–8], Central Asia and the Middle East [9,10]. Whilst a number of animals can host the rabies virus, dogs are the main source of human rabies deaths, contributing up to 99% of all rabies transmissions to humans. Dog-mediated rabies has been eliminated from Western Europe, Canada, the United States of America (USA), Japan and some Latin American countries [11]. Nevertheless, the risk of reintroduction and disease among travellers to risk areas is a matter of concern [12–15]. As occurred with many other communicable and non-communicable diseases, the 2020–2022 COVID-19 pandemic negatively impacted the efforts of control and reemergence of rabies in certain countries [7,16,17]. Post-pandemic challenges to enhance con- trol and prevention are multiple and need urgent actions to achieve the goal in eight years by 2030 [16].

Infectious Diseases, Social, Economic and Political Crises, Anthropogenic Disasters and Beyond: Venezuela 2019 – Implications for Public Health and Travel Medicine

During last months, there have been a significant increase in the evidences showing the catastrophic health situation in Venezuela. There are multiple epidemics, increase in emerging and reemerging infectious, tropical and parasitic diseases as consequences of the social, economic and political crises, which would be considered today a clearly anthropogenic disaster. Venezuela is facing in 2019, the worse sanitary conditions, with multiple implications for public health and travel medicine. So far, from a global perspective, this situation will be an impediment for the achievement of the sustainable development goals (SDG) in 2030. In this multiauthor review, there is a comprehensive analysis of the situation for infectious diseases, non-communicable diseases, their impact in the Americas region, given the migration crisis as well as the comparative status of the SDG 2030. This discussion can provide input for prioritizing emerging health problems and establish a future agenda