The large grey area between ‘bona fide’ and ‘rogue’ stem cell interventions — ethical acceptability and the need to include local variability

This article aims to put into perspective the binary opposition between ‘scientific’ clinical research trials and ‘rogue’ experimental stem cell therapies, and to show why the ethics criteria used by the dominant science community are not suitable for distinguishing between adequate and inadequate treatments. By focusing on the grey area between clinical stem cell trials and stem cell experimentation, the experimental space where patients, medical professionals and life scientists negotiate for diverging reasons and aims, I show why idealised notions of ethics are not feasible for many stem cell scientists in low- and middle-income countries. Drawing on fieldwork in China from 2012 to 2013, the article asks why ‘the unethical’ according to some is acceptable to Chinese life scientists. The case study of stem cell service provider Beike Biotech illustrates how stem cell interventions take place in a large grey area, where narrow notions of ethics are blurred with and supplanted by broader notions of ethics, co-determined by estimations of socio-economic, political and cultural understandings of risk, opportunity and benefit. I borrow the term ‘bionetworking’, understood as the entrepreneurial aspects of scientific networks that engage in creating biomedical products, to analyse various forms of medical experimentation. I speak of the ‘externalisation’ and ‘internalisation’ of local factors to elucidate how features of patient populations and their environments are subsumed in clinical research applications. Compared to polarised views of stem cell therapy, this approach increases the transparency of clinical interventions and broadens our understanding of why ‘stem cell tourism’ to some is ‘stem cell therapy’ to others

Comparing national home-keeping and the regulation of translational stem cell applications: an international perspective

A very large grey area exists between translational stem cell research and applications that comply with the ideals of randomised control trials and good laboratory and clinical practice and what is often referred to as snake-oil trade. We identify a discrepancy between international research and ethics regulation and the ways in which regulatory instruments in the stem cell field are developed in practice. We examine this discrepancy using the notion of ‘national home-keeping’, referring to the way governments articulate international standards and regulation with conflicting demands on local players at home. Identifying particular dimensions of regulatory tools – authority, permissions, space and acceleration – as crucial to national home-keeping in Asia, Europe and the USA, we show how local regulation works to enable development of the field, notwithstanding international (i.e. principally ‘western’) regulation. Triangulating regulation with empirical data and archival research between 2012 and 2015 has helped us to shed light on how countries and organisations adapt and resist internationally dominant regulation through the manipulation of regulatory tools (contingent upon country size, the state's ability to accumulate resources, healthcare demands, established traditions of scientific governance, and economic and scientific ambitions)

Developing policies for the end-of-life of energy infrastructure: Coming to terms with the challenges of decommissioning

Energy sector policies have focused historically on the planning, design and construction of energy infrastructures, while typically overlooking the processes required for the management of their end-of-life, and particularly their decommissioning. However, decommissioning of existing and future energy infrastructures is constrained by a plethora of technical, economic, social and environmental challenges that must be understood and addressed if such infrastructures are to make a net-positive contribution over their whole life. Here, we introduce the magnitude and variety of these challenges to raise awareness and stimulate debate on the development of reasonable policies for current and future decommissioning projects. Focusing on power plants, the paper provides the foundations for the interdisciplinary thinking required to deliver an integrated decommissioning policy that incorporates circular economy principles to maximise value throughout the lifecycle of energy infrastructures. We conclude by suggesting new research paths that will promote more sustainable management of energy infrastructures at the end of their life

COVID-19 Lockdown Brings Fresher Air, Cleaner Rivers in India

This article focuses on the Hindu holy site of the Ganges River and the decrease in pollution of the river due to the COVID-19 lockdown. The article discusses issues such as bathing in the river. It also looks at other places in India that have seen a decrease in pollution since the beginning of the pandemic. The article features Executive Director Anumita Roychowdhury of the Center for Science and Environment in India, environmentalists Vimlendu Jha, founder of the NGO, Swechha, and Ashok Mandal, a New Delhi rickshaw driver