The Deliberative Value Formation model

It is increasingly argued that preferences and values for complex goods such as ecosystem services are not pre-formed but need to be generated through a process of deliberation and learning. While the number of studies incorporating deliberation in monetary and non-monetary valuation of ecosystem services is increasing, there is a limited theoretical basis to how values are influenced and shaped in social valuation processes. In this paper we present the Deliberative Value Formation (DVF) model, a new theoretical model for deliberative valuation informed by social-psychological theory. Anchored within a broader theoretical framework around shared and plural values, the DVF model identifies a range of potential positive (e.g. learning) and negative (e.g. social desirability bias) outcomes of deliberation and key factors that influence outcomes (e.g. ability to deliberate, institutional factors, power dynamics). It also conceptualises how values may be formed by ‘translating’ transcendental values, our principles and life goals, into more specific contextual values. Underpinned by this theoretical model, we present a six-step template for designing deliberative valuation processes. The DVF provides a theoretical and methodological framework for more rigorous monetary and non-monetary deliberative valuation, and enables more effective integration of social learning and plural knowledges and values in valuation and decision-making

Second generation Robo-AO instruments and systems

The prototype Robo-AO system at the Palomar Observatory 1.5-m telescope is the world's first fully automated laser adaptive optics instrument. Scientific operations commenced in June 2012 and more than 12,000 observations have since been performed at the ~0.12" visible-light diffraction limit. Two new infrared cameras providing high-speed tip-tilt sensing and a 2' field-of-view will be integrated in 2014. In addition to a Robo-AO clone for the 2-m IGO and the natural guide star variant KAPAO at the 1-m Table Mountain telescope, a second generation of facility-class Robo-AO systems are in development for the 2.2-m University of Hawai'i and 3-m IRTF telescopes which will provide higher Strehl ratios, sharper imaging, ~0.07", and correction to {\lambda} = 400 nm.Comment: 11 pages, 4 figures, 3 table

Framing of sustainable agricultural practices by the farming press and its effect on adoption

There is growing political pressure for farmers to use more sustainable agricultural practices to protect people and the planet. The farming press could encourage farmers to adopt sustainable practices through its ability to manipulate discourse and spread awareness by changing the salience of issues or framing topics in specific ways. We sought to understand how the UK farming press framed sustainable agricultural practices and how the salience of these practices changed over time. We combined a media content analysis of the farming press alongside 60 qualitative interviews with farmers and agricultural advisors to understand whether the farming press influenced farmers to try more sustainable practices. Salience of sustainable agricultural practices grew between 2009 and 2020. Many of the practices studied were framed by the press around economic and agronomic aspects, and farmer respondents said the most common reasons for trying sustainable agricultural practices were for economic and agronomic reasons. The farming press tended to use more positive rather than negative tones when covering sustainable agricultural practices. Respondents used the farming press as a source of information, though many did not fully trust these outlets as they believed the farming press were mouthpieces for agribusinesses. Whilst a minority of farmers stated they were motivated to try a new sustainable agricultural practice after learning about it in the farming press, this was rare. Instead, the farming press was used by respondents to raise their awareness about wider agricultural topics. We reflect on the role and power given to agribusinesses by the farming press and what this means for agricultural sustainability.</p

Rethinking Appropriateness of Actions in Environmental Decisions: Connecting Interest and Identity Negotiation with Plural Valuation

Issues of interest, identity and values intertwine in environmental conflicts, creating challenges that cannot generally be overcome using rationalities grounded in generalised argumentation and abstraction. To address the growing need to engage interests and identities along with plural values in the conservation of biodiversity and ecological systems, we introduce the concept of ‘appropriateness of actions’ and ground it in a relational understanding of environmental ethics. A determination of appropriateness for actions comes from combining outputs from value elicitation with those of interest and identity negotiation in ways that are salient to specific people and their relationships to specific places. Drawing on the Blue Mountain Forest Partnership in the Pacific Northwest, we propose factors of success for supporting appropriate actions: 1) understanding context and identifying key stakeholders; 2) surfacing a diversity of interests and building system-level trust; 3) building empathy for different identities grounded in specific places; 4) eliciting diverse values and seeking to understand their links to worldviews and knowledge systems and; 5) seeking out appropriate actions

Star Formation in Isolated Disk Galaxies. I. Models and Characteristics of Nonlinear Gravitational Collapse

We model gravitational collapse leading to star formation in a wide range of isolated disk galaxies using a three-dimensional, smoothed particle hydrodynamics code. The model galaxies include a dark matter halo and a disk of stars and isothermal gas. Absorbing sink particles are used to directly measure the mass of gravitationally collapsing gas. They reach masses characteristic of stellar clusters. In this paper, we describe our galaxy models and numerical methods, followed by an investigation of the gravitational instability in these galaxies. Gravitational collapse forms star clusters with correlated positions and ages, as observed, for example, in the Large Magellanic Cloud. Gravitational instability alone acting in unperturbed galaxies appears sufficient to produce flocculent spiral arms, though not more organized patterns. Unstable galaxies show collapse in thin layers in the galactic plane; associated dust will form thin dust lanes in those galaxies, in agreement with observations. (abridged)Comment: 49 pages, 22 figures, to appear in ApJ (July, 2005), version with high quality color images can be fond in http://research.amnh.org/~yuexing/astro-ph/0501022.pd

Discovery of macrocyclic inhibitors of apurinic/apyrimidinic endonuclease 1

Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential base excision repair enzyme that is upregulated in a number of cancers, contributes to resistance of tumors treated with DNA-alkylating or -oxidizing agents, and has recently been identified as an important therapeutic target. In this work, we identified hot spots for binding of small organic molecules experimentally in high resolution crystal structures of APE1 and computationally through the use of FTMAP analysis (http://ftmap.bu.edu/). Guided by these hot spots, a library of drug-like macrocycles was docked and then screened for inhibition of APE1 endonuclease activity. In an iterative process, hot-spot-guided docking, characterization of inhibition of APE1 endonuclease, and cytotoxicity of cancer cells were used to design next generation macrocycles. To assess target selectivity in cells, selected macrocycles were analyzed for modulation of DNA damage. Taken together, our studies suggest that macrocycles represent a promising class of compounds for inhibition of APE1 in cancer cells.This work was supported by grants from the National Institutes of Health (Grant R01CA205166 to M.R.K. and M.M.G. and Grant R01CA167291 to M.R.K.) and by the Earl and Betty Herr Professor in Pediatric Oncology Research, Jeff Gordon Children's Foundation, and the Riley Children's Foundation (M.R.K.). Work at the BU-CMD (J.A.P., L.E.B., R.T.) is supported by the National Institutes of Health, Grant R24 GM111625. D.B. and S.V. were supported by the National Institutes of Health, Grant R35 GM118078. (R35 GM118078 - National Institutes of Health; R01CA205166 - National Institutes of Health; R01CA167291 - National Institutes of Health; R24 GM111625 - National Institutes of Health; Earl and Betty Herr Professor in Pediatric Oncology Research; Jeff Gordon Children's Foundation; Riley Children's Foundation)Accepted manuscriptSupporting documentatio

Sodium Bicarbonate Ingestion Improves Time-to-Exhaustion Cycling Performance and Alters Estimated Energy System Contribution:A Dose-Response Investigation

This study investigated the effects of two sodium bicarbonate (NaHCO3) doses on estimated energy system contribution and performance during an intermittent high-intensity cycling test (HICT), and time-to-exhaustion (TTE) exercise. Twelve healthy males (stature: 1.75 ± 0.08 m; body mass: 67.5 ± 6.3 kg; age: 21.0 ± 1.4 years; maximal oxygen consumption: 45.1 ± 7.0 ml.kg.min-1) attended four separate laboratory visits. Maximal aerobic power (MAP) was identified from an incremental exercise test. During the three experimental visits, participants ingested either 0.2 g.kg-1 BM NaHCO3 (SBC2), 0.3 g.kg-1 BM NaHCO3 (SBC3), or 0.07 g.kg-1 BM sodium chloride (placebo; PLA), 60 minutes pre-exercise. The HICT involved 3 x 60 s cycling bouts (90%, 95%, 100% MAP) interspersed with 90 s recovery, followed by TTE cycling at 105% MAP. Blood lactate was sampled after each cycling bout to calculate estimates for glycolytic contribution to exercise. Gastrointestinal (GI) upset was quantified at baseline, 30 minutes and 60 minutes post-ingestion, and 5 minutes post-exercise. Cycling TTE increased for SBC2 (+20.2 s; p =0.045) and SBC3 (+31.9 s; p =0.004) compared to PLA. Glycolytic contribution increased during the TTE protocol for SBC2 (+7.77 kJ; p =0.10) and SBC3 (+7.95 kJ; p =0.07) compared to PLA. GI upset was exacerbated post-exercise after SBC3 for nausea compared to SBC2 and PLA (p 0.05). Both NaHCO3 doses enhanced cycling performance and glycolytic contribution, however, higher doses may maximise ergogenic benefits

U–Pb Zircon Ages, Mapping, and Biostratigraphy of the Payette Formation and Idaho Group North of the Western Snake River Plain, Idaho: Implications for Hydrocarbon System Correlation

Sedimentary deposits north of the western Snake River Plain host Idaho’s first and only producing oil and gas field. They consist of the lower to middle Miocene Payette Formation, the middle to upper Miocene Poison Creek and Chalk Hills Formations, and the Pliocene to lower Pleistocene Glenns Ferry Formation. Using new geochronology, palynomorph biostratigraphy, and geologic mapping, we connect updip surface features to subsurface petroleum play elements. The Payette Formation is a likely main source of the hydrocarbons, and acts as one of the reservoirs in the unnamed basin. Here, we redefine the Payette Formation as 0 to ~3,500 ft (0 to ~1,000 m) of mudstone, with lesser amounts of sandstone overlying and interbedded with the Columbia River Basalt Group and Weiser volcanic field. Index palynomorphs, including Liquidambar and Pterocarya, present in Idaho during and immediately after the middle Miocene climatic optimum, and new U–Pb ages of 16.39 and 15.88 Ma, help establish the thickness and extent of the formation. For the first time, these biostratigraphic markers have been defined for the oil and gas wells. The Poison Creek Formation is sandstone interbedded with mudstone that is ~800–1,800 ft (250–550 m) thick. The Chalk Hills Formation is a tuffaceous siltstone, claystone, and sandstone that is as much as ~4,200 ft (1,280 m) thick. New U–Pb ages are 10.1, 9.04, and 9.00 for the Poison Creek Formation, along with maximum depositional ages of 10.7 to 9.9 Ma for four samples from the Poison Creek Formation. A single U–Pb age of 7.78 Ma was determined from pumice low in the Chalk Hills Formation. Like the Payette Formation, the Poison Creek Formation can be a reservoir, whereas the Chalk Hills Formation acts as a sealing mudstone facies. The overlying sandstone, siltstone, and conglomerate of the Glenns Ferry Formation act as the overburden to the petroleum system in the subsurface, and were important for burial and hydrocarbon maturation. The Glenns Ferry Formation is up to 500 ft (150 m) thick in the study area, as much has been eroded. Whereas the Payette and Poison Creek Formations were deposited during the mid-Miocene climatic optimum amongst and above volcanic flows, the Chalk Hills and Glenns Ferry Formations were deposited within ancient Lake Idaho during an overall increase in aridity and cooling after the mid-Miocene climatic optimum