790 research outputs found
Guest Editor\u27s Introduction
Guest editor\u27s introduction for 54.3/
Preheating in Derivatively-Coupled Inflation Models
We study preheating in theories where the inflaton couples derivatively to
scalar and gauge fields. Such couplings may dominate in natural models of
inflation, in which the flatness of the inflaton potential is related to an
approximate shift symmetry of the inflaton. We compare our results with
previously studied models with non-derivative couplings. For sufficiently heavy
scalar matter, parametric resonance is ineffective in reheating the universe,
because the couplings of the inflaton to matter are very weak. If scalar matter
fields are light, derivative couplings lead to a mild long-wavelength
instability that drives matter fields to non-zero expectation values. In this
case however, long-wavelength fluctuations of the light scalar are produced
during inflation, leading to a host of cosmological problems. In contrast,
axion-like couplings of the inflaton to a gauge field do not lead to production
of long-wavelength fluctuations during inflation. However, again because of the
weakness of the couplings to the inflaton, parametric resonance is not
effective in producing gauge field quanta.Comment: 10 pages, 9 figure
Cheiradone: a vascular endothelial cell growth factor receptor antagonist
<p>Abstract</p> <p>Background</p> <p>Angiogenesis, the growth of new blood vessels from the pre-existing vasculature is associated with physiological (for example wound healing) and pathological conditions (tumour development). Vascular endothelial growth factor (VEGF), fibroblast growth factor-2 (FGF-2) and epidermal growth factor (EGF) are the major angiogenic regulators. We have identified a natural product (cheiradone) isolated from a <it>Euphorbia </it>species which inhibited <it>in vivo </it>and <it>in vitro </it>VEGF- stimulated angiogenesis but had no effect on FGF-2 or EGF activity. Two primary cultures, bovine aortic and human dermal endothelial cells were used in <it>in vitro </it>(proliferation, wound healing, invasion in Matrigel and tube formation) and <it>in vivo </it>(the chick chorioallantoic membrane) models of angiogenesis in the presence of growth factors and cheiradone. In all cases, the concentration of cheiradone which caused 50% inhibition (IC<sub>50</sub>) was determined. The effect of cheiradone on the binding of growth factors to their receptors was also investigated.</p> <p>Results</p> <p>Cheiradone inhibited all stages of VEGF-induced angiogenesis with IC<sub>50 </sub>values in the range 5.20–7.50 μM but did not inhibit FGF-2 or EGF-induced angiogenesis. It also inhibited VEGF binding to VEGF receptor-1 and 2 with IC<sub>50 </sub>values of 2.9 and 0.61 μM respectively.</p> <p>Conclusion</p> <p>Cheiradone inhibited VEGF-induced angiogenesis by binding to VEGF receptors -1 and -2 and may be a useful investigative tool to study the specific contribution of VEGF to angiogenesis and may have therapeutic potential.</p
Massive Ellipticals at High Redshift: NICMOS Imaging of Z~1 Radio Galaxies
We present deep, continuum images of eleven high-redshift (0.811 < z < 1.875)
3CR radio galaxies observed with NICMOS. Our images probe the rest-frame
optical light where stars are expected to dominate the galaxy luminosity. The
rest-frame UV light of eight of these galaxies demonstrates the well-known
``alignment effect''. Most of the radio galaxies have rounder, more symmetric
morphologies at rest-frame optical wavelengths. Here we show the most direct
evidence that in most cases the stellar hosts are normal elliptical galaxies
with de Vaucouleurs law light profiles. For a few galaxies very faint traces of
the UV-bright aligned component are also visible in the infrared images. We
derive both the effective radius and surface-brightness for nine of eleven
sample galaxies by fitting surface-brightness models to them. We find their
sizes are similar to those of local FRII radio source hosts and are in general
larger than other local galaxies. The derived host galaxy luminosities are very
high and lie at the bright end of luminosity functions constructed at similar
redshifts. The galaxies in our sample are also brighter than the rest-frame
size--surface-brightness locus defined by the low-redshift sources. Passive
evolution roughly aligns the z ~ 1 galaxies with the low-redshift samples. The
optical host is sometimes centered on a local minimum in the rest-frame UV
emission, suggesting the presence of substantial dust obscuration. We also see
good evidence of nuclear point sources in three galaxies. Overall, our results
are consistent with the hypothesis that these galaxies have already formed the
bulk of their stars at redshifts greater than z >~ 2, and that the AGN
phenomenon takes place within otherwise normal, perhaps passively evolving,
galaxies. (abridged)Comment: 28 pages, 14 figures, accepted to ApJ. Uses AASTEX and emulateapj
Limits from the Hubble Space Telescope on a Point Source in SN 1987A
We observed supernova 1987A (SN 1987A) with the Space Telescope Imaging
Spectrograph (STIS) on the Hubble Space Telescope (HST) in 1999 September, and
again with the Advanced Camera for Surveys (ACS) on the HST in 2003 November.
No point source is observed in the remnant. We obtain a limiting flux of F_opt
< 1.6 x 10^{-14} ergs/s/cm^2 in the wavelength range 2900-9650 Angstroms for
any continuum emitter at the center of the supernova remnant (SNR). It is
likely that the SNR contains opaque dust that absorbs UV and optical emission,
resulting in an attenuation of ~35% due to dust absorption in the SNR. Taking
into account dust absorption in the remnant, we find a limit of L_opt < 8 x
10^{33} ergs/s. We compare this upper bound with empirical evidence from point
sources in other supernova remnants, and with theoretical models for possible
compact sources. Bright young pulsars such as Kes 75 or the Crab pulsar are
excluded by optical and X-ray limits on SN 1987A. Of the young pulsars known to
be associated with SNRs, those with ages < 5000 years are all too bright in
X-rays to be compatible with the limits on SN 1987A. Examining theoretical
models for accretion onto a compact object, we find that spherical accretion
onto a neutron star is firmly ruled out, and that spherical accretion onto a
black hole is possible only if there is a larger amount of dust absorption in
the remnant than predicted. In the case of thin-disk accretion, our flux limit
requires a small disk, no larger than 10^{10} cm, with an accretion rate no
more than 0.3 times the Eddington accretion rate. Possible ways to hide a
surviving compact object include the removal of all surrounding material at
early times by a photon-driven wind, a small accretion disk, or very high
levels of dust absorption in the remnant.Comment: 40 pages, 5 figures. AAStex. Accepted, ApJ 04/28/200
Evaluation of a national universal coverage campaign of long-lasting insecticidal nets in a rural district in north-west Tanzania.
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Insecticide-treated nets (ITN) are one of the most effective measures for preventing malaria. Mass distribution campaigns are being used to rapidly increase net coverage in at-risk populations. This study had two purposes: to evaluate the impact of a universal coverage campaign (UCC) of long-lasting insecticidal nets (LLINs) on LLIN ownership and usage, and to identify factors that may be associated with inadequate coverage. In 2011 two cross-sectional household surveys were conducted in 50 clusters in Muleba district, north-west Tanzania. Prior to the UCC 3,246 households were surveyed and 2,499 afterwards. Data on bed net ownership and usage, demographics of household members and household characteristics including factors related to socio-economic status were gathered, using an adapted version of the standard Malaria Indicator Survey. Specific questions relating to the UCC process were asked. The proportion of households with at least one ITN increased from 62.6% (95% Confidence Interval (CI) = 60.9-64.2) before the UCC to 90.8% (95% CI = 89.0-92.3) afterwards. ITN usage in all residents rose from 40.8% to 55.7%. After the UCC 58.4% (95% CI = 54.7-62.1) of households had sufficient ITNs to cover all their sleeping places. Households with children under five years (OR = 2.4, 95% CI = 1.9-2.9) and small households (OR = 1.9, 95% CI = 1.5-2.4) were most likely to reach universal coverage. Poverty was not associated with net coverage. Eighty percent of households surveyed received LLINs from the campaign. The UCC in Muleba district of Tanzania was equitable, greatly improving LLIN ownership and, more moderately, usage. However, the goal of universal coverage in terms of the adequate provision of nets was not achieved. Multiple, continuous delivery systems and education activities are required to maintain and improve bed net ownership and usage.\ud
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Indoor Residual Spraying in Combination with Insecticide-Treated Nets Compared to Insecticide-Treated Nets Alone for Protection against Malaria: A Cluster Randomised Trial in Tanzania.
Insecticide-treated nets (ITNs) and indoor residual spraying (IRS) of houses provide effective malaria transmission control. There is conflicting evidence about whether it is more beneficial to provide both interventions in combination. A cluster randomised controlled trial was conducted to investigate whether the combination provides added protection compared to ITNs alone. In northwest Tanzania, 50 clusters (village areas) were randomly allocated to ITNs only or ITNs and IRS. Dwellings in the ITN+IRS arm were sprayed with two rounds of bendiocarb in 2012. Plasmodium falciparum prevalence rate (PfPR) in children 0.5-14 y old (primary outcome) and anaemia in children <5 y old (secondary outcome) were compared between study arms using three cross-sectional household surveys in 2012. Entomological inoculation rate (secondary outcome) was compared between study arms. IRS coverage was approximately 90%. ITN use ranged from 36% to 50%. In intention-to-treat analysis, mean PfPR was 13% in the ITN+IRS arm and 26% in the ITN only arm, odds ratio = 0.43 (95% CI 0.19-0.97, n = 13,146). The strongest effect was observed in the peak transmission season, 6 mo after the first IRS. Subgroup analysis showed that ITN users were additionally protected if their houses were sprayed. Mean monthly entomological inoculation rate was non-significantly lower in the ITN+IRS arm than in the ITN only arm, rate ratio = 0.17 (95% CI 0.03-1.08). This is the first randomised trial to our knowledge that reports significant added protection from combining IRS and ITNs compared to ITNs alone. The effect is likely to be attributable to IRS providing added protection to ITN users as well as compensating for inadequate ITN use. Policy makers should consider deploying IRS in combination with ITNs to control transmission if local ITN strategies on their own are insufficiently effective. Given the uncertain generalisability of these findings, it would be prudent for malaria control programmes to evaluate the cost-effectiveness of deploying the combination.\ud
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Intra- and inter-individual genetic differences in gene expression
Genetic variation is known to influence the amount of mRNA produced by a gene. Given that the molecular machines control mRNA levels of multiple genes, we expect genetic variation in the components of these machines would influence multiple genes in a similar fashion. In this study we show that this assumption is correct by using correlation of mRNA levels measured independently in the brain, kidney or liver of multiple, genetically typed, mice strains to detect shared genetic influences. These correlating groups of genes (CGG) have collective properties that account for 40-90% of the variability of their constituent genes and in some cases, but not all, contain genes encoding functionally related proteins. Critically, we show that the genetic influences are essentially tissue specific and consequently the same genetic variations in the one animal may up-regulate a CGG in one tissue but down-regulate the same CGG in a second tissue. We further show similarly paradoxical behaviour of CGGs within the same tissues of different individuals. The implication of this study is that this class of genetic variation can result in complex inter- and intra-individual and tissue differences and that this will create substantial challenges to the investigation of phenotypic outcomes, particularly in humans where multiple tissues are not readily available.


Galileons as Wess-Zumino Terms
We show that the galileons can be thought of as Wess-Zumino terms for the
spontaneous breaking of space-time symmetries. Wess-Zumino terms are terms
which are not captured by the coset construction for phenomenological
Lagrangians with broken symmetries. Rather they are, in d space-time
dimensions, d-form potentials for (d+1)-forms which are non-trivial co-cycles
in Lie algebra cohomology of the full symmetry group relative to the unbroken
symmetry group. We introduce the galileon algebras and construct the
non-trivial (d+1)-form co-cycles, showing that the presence of galileons and
multi-galileons in all dimensions is counted by the dimensions of particular
Lie algebra cohomology groups. We also discuss the DBI and conformal galileons
from this point of view, showing that they are not Wess-Zumino terms, with one
exception in each case.Comment: 49 pages. v2 minor changes, version appearing in JHE
Infrared nanoscopy of Dirac plasmons at the graphene-SiO2 interface
We report on infrared (IR) nanoscopy of 2D plasmon excitations of Dirac
fermions in graphene. This is achieved by confining mid-IR radiation at the
apex of a nanoscale tip: an approach yielding two orders of magnitude increase
in the value of in-plane component of incident wavevector q compared to free
space propagation. At these high wavevectors, the Dirac plasmon is found to
dramatically enhance the near-field interaction with mid-IR surface phonons of
SiO2 substrate. Our data augmented by detailed modeling establish graphene as a
new medium supporting plasmonic effects that can be controlled by gate voltage.Comment: 12 pages, 4 figure
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