FONDEMENTS NON RATIONNELS ET CONTENUS NON CONCEPTUELS

The phenomenological tradition has long contended that natural perception is neither conceptually articulated nor governed by deterministic laws, but rather organized according to the practically articulated structure of bodily being-in-the-world. But this leaves the problem of explaining how perception can provide justificatory support to thought. The phenomenologists’ answer is to say that the meaningful (but not conceptual) structure of natural perception makes it possible for us to think about objects by motivating particular thoughts about the objects as they present themselves in perception. I show how this view provides a way out of worries that plague contemporary philosophy of mind.Die phänomenologische Tradition war lange Zeit der Auffassung, dass die natürliche Perzeption weder konzeptuell artikuliert ist noch von deterministischen Gesetzen beherrscht wird, sondern dass sie eher nach der praktisch artikulierten Struktur des körperlichen In-der-Welt-Seins organisiert ist. Dabei bleibt die Erklärung dafür problematisch, auf welche Art und Weise die Perzeption dem Denken eine rechtfertigende Unterstützung bieten kann. Die Antwort der Phänomenologen lautet, dass es die bedeutungstragende (nicht aber konzeptuelle) Struktur der natürlichen Perzeption ist, die uns ermöglicht, über Objekte nachzudenken, indem sie die einzelnen Gedanken über die Objekte motiviert, wie sie sich in der Perzeption darstellen. Der Autor zeigt, welchen Ausweg aus den Sorgen der modernen Philosophie des Geistes dieser Standpunkt weist.La tradition phénoménologique a longtemps considéré que la perception naturelle n’était ni actualisée conceptuellement ni régie par des lois déterministes, mais qu’elle était plutôt organisée d’après la strcture pratiquement articulée de l’être-dans-le-monde physique. Or, cela laisse entier le problème d’explication de la façon dont la perception peut assurer un support justificatif à la pensée. La réponse de la phénoménologie est que c’est la structure significative (et non conceptuelle) de la perception naturelle qui nous permet de penser des objets en motivant nons pensées sur ces objets par la manière dont ils se présente à notre perception. Ce pont de vue permet de sortir des problèmes qui tourmentent la philosophie de l’esprit contemporaine

Non-rational Grounds and Non-conceptual Content

Fenomenološka tradicija dugo je smatrala da prirodna percepcija nije ni konceptualno artikulirana niti upravljana determinističkim zakonima, već je radije organizirana prema praktično artikuliranoj strukturi tjelesnog bitka-u-svijetu. Ali to ostavlja problem objašnjavanja kako percepcija može omogućiti opravdavajuću podršku mišljenju. Odgovor fenomenologa jest taj da nam značenjska (ali ne konceptualna) struktura prirodne percepcije omogućuje da mislimo o objektima motivirajući pojedinačne misli o objektima kakvima se oni predstavljaju u percepciji. Pokazujem kako takvo gledište omogućuje izlaz iz briga koje more suvremenu filozofiju uma.The phenomenological tradition has long contended that natural perception is neither conceptually articulated nor governed by deterministic laws, but rather organized according to the practically articulated structure of bodily being-in-the-world. But this leaves the problem of explaining how perception can provide justificatory support to thought. The phenomenologists’ answer is to say that the meaningful (but not conceptual) structure of natural perception makes it possible for us to think about objects by motivating particular thoughts about the objects as they present themselves in perception. I show how this view provides a way out of worries that plague contemporary philosophy of mind

Trivial Tasks that Consume a Lifetime: Kierkegaard on Immortality and Becoming Subjective

S. Kierkegaard argued that our highest task as humans is to realize an “intensified” or “developed” form of subjectivity—his name for self-responsible agency. A self-responsible agent is not only responsible for her actions. She also bears responsibility for the individual that she is. In this paper, I review Kierkegaard’s account of the role that our capacity for reflective self-evaluation plays in making us responsible for ourselves. It is in the exercise of this capacity that we can go from being subjective in a degraded sense—merely being an idiosyncratic jumble of accidental and arbitrary attitudes and affects—to being a subject in the ideal or eminent sense. The latter requires the exercise of my capacity for reflective self-evaluation, since it involves recognizing, identifying with, and reinforcing those aspects of my overall make-up that allow me to express successfully a coherent way of being in the world. Kierkegaard argues that taking immortality seriously is one way to achieve the right kind of reflective stance on one’s own character or personality. Thus, Kierkegaard argues that immortality as a theoretical posit can contribute to one’s effort to own or assume responsibility for being the person one is

Spatio-Temporal Progression of Grey and White Matter Damage Following Contusion Injury in Rat Spinal Cord

Cellular mechanisms of secondary damage progression following spinal cord injury remain unclear. We have studied the extent of tissue damage from 15 min to 10 weeks after injury using morphological and biochemical estimates of lesion volume and surviving grey and white matter. This has been achieved by semi-quantitative immunocytochemical methods for a range of cellular markers, quantitative counts of white matter axonal profiles in semi-thin sections and semi-quantitative Western blot analysis, together with behavioural tests (BBB scores, ledged beam, random rung horizontal ladder and DigiGait™ analysis). We have developed a new computer-controlled electronic impactor based on a linear motor that allows specification of the precise nature, extent and timing of the impact. Initial (15 min) lesion volumes showed very low variance (1.92±0.23 mm3, mean±SD, n = 5). Although substantial tissue clearance continued for weeks after injury, loss of grey matter was rapid and complete by 24 hours, whereas loss of white matter extended up to one week. No change was found between one and 10 weeks after injury for almost all morphological and biochemical estimates of lesion size or behavioural methods. These results suggest that previously reported apparent ongoing injury progression is likely to be due, to a large extent, to clearance of tissue damaged by the primary impact rather than continuing cell death. The low variance of the impactor and the comprehensive assessment methods described in this paper provide an improved basis on which the effects of potential treatment regimes for spinal cord injury can be assessed

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe

Increasing frailty is associated with higher prevalence and reduced recognition of delirium in older hospitalised inpatients: results of a multi-centre study

Purpose: Delirium is a neuropsychiatric disorder delineated by an acute change in cognition, attention, and consciousness. It is common, particularly in older adults, but poorly recognised. Frailty is the accumulation of deficits conferring an increased risk of adverse outcomes. We set out to determine how severity of frailty, as measured using the CFS, affected delirium rates, and recognition in hospitalised older people in the United Kingdom. Methods: Adults over 65 years were included in an observational multi-centre audit across UK hospitals, two prospective rounds, and one retrospective note review. Clinical Frailty Scale (CFS), delirium status, and 30-day outcomes were recorded. Results: The overall prevalence of delirium was 16.3% (483). Patients with delirium were more frail than patients without delirium (median CFS 6 vs 4). The risk of delirium was greater with increasing frailty [OR 2.9 (1.8–4.6) in CFS 4 vs 1–3; OR 12.4 (6.2–24.5) in CFS 8 vs 1–3]. Higher CFS was associated with reduced recognition of delirium (OR of 0.7 (0.3–1.9) in CFS 4 compared to 0.2 (0.1–0.7) in CFS 8). These risks were both independent of age and dementia. Conclusion: We have demonstrated an incremental increase in risk of delirium with increasing frailty. This has important clinical implications, suggesting that frailty may provide a more nuanced measure of vulnerability to delirium and poor outcomes. However, the most frail patients are least likely to have their delirium diagnosed and there is a significant lack of research into the underlying pathophysiology of both of these common geriatric syndromes

Non-rational Grounds and Non-conceptual Content

Fenomenološka tradicija dugo je smatrala da prirodna percepcija nije ni konceptualno artikulirana niti upravljana determinističkim zakonima, već je radije organizirana prema praktično artikuliranoj strukturi tjelesnog bitka-u-svijetu. Ali to ostavlja problem objašnjavanja kako percepcija može omogućiti opravdavajuću podršku mišljenju. Odgovor fenomenologa jest taj da nam značenjska (ali ne konceptualna) struktura prirodne percepcije omogućuje da mislimo o objektima motivirajući pojedinačne misli o objektima kakvima se oni predstavljaju u percepciji. Pokazujem kako takvo gledište omogućuje izlaz iz briga koje more suvremenu filozofiju uma.The phenomenological tradition has long contended that natural perception is neither conceptually articulated nor governed by deterministic laws, but rather organized according to the practically articulated structure of bodily being-in-the-world. But this leaves the problem of explaining how perception can provide justificatory support to thought. The phenomenologists’ answer is to say that the meaningful (but not conceptual) structure of natural perception makes it possible for us to think about objects by motivating particular thoughts about the objects as they present themselves in perception. I show how this view provides a way out of worries that plague contemporary philosophy of mind