TCT-77 Risk and benefits of triple therapy in patients undergoing percutaneous coronary stent implantation requiring chronic oral anticoagulation: a meta-analysis of 12 trials

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Modelling, additive layer manufacturing and testing of interlocking structures for joined components

Modelling, additive layer manufacturing and testing of interlocking structures for joined component

COMT Val158Met polymorphism and socioeconomic status interact to predict attention deficit/hyperactivity problems in children aged 10–14

The functional Val158Met COMT polymorphism appears to affect a host of behaviours mediated by the pre-frontal cortex, and has been found associated to the risk for disruptive behaviours including ADHD. Parental socioeconomic status (SES) has also been reported as a predictor for the same childhood disorders. In a general population sample of 575 Italian pre-adolescents aged 10–14, we examined the association of the functional Val158Met COMT polymorphism and SES—both as linear and interactive effects—with oppositional defiant problems, conduct problems, and attention deficit/hyperactivity problems, as defined by the newly established Child Behaviour Check-List/6-18 DSM oriented scales. Multivariate- and subsequent univariate-analysis of covariance showed a significant association of COMT × SES interaction with CBCL 6/18 DOS attention deficit/hyperactivity problems (p = 0.004), and revealed higher scores among those children with Val/Val COMT genotype who belonged to low-SES families. We also found a significant association of SES with attention deficit/hyperactivity problems and conduct problems DOS (p = 0.04 and 0.01, respectively). Our data are consistent with a bulk of recent literature suggesting a role of environmental factors in moderating the contribution of specific genetic polymorphisms to human variability in ADHD. While future investigations will refine and better clarify which specific environmental and genetic mechanisms are at work in influencing the individual risk to ADHD in pre-adolescence, these data may contribute to identify/prevent the risk for ADHD problems in childhood

<i>Mycobacterium chelonae</i> associated with tumor-like skin and oral masses in farmed Russian sturgeons (<i>Acipenser gueldenstaedtii</i>)

Background: Non-tuberculous mycobacteria responsible for piscine mycobacteriosis usually produce visceral granulomas in both freshwater and marine species. In this study, the first occurrence of Mycobacterium chelonae associated with tumor-like lesions in the Russian sturgeon (Acipenser gueldenstaedtii) is reported. Fifteen sturgeons from an Italian fish farm showing skin and oral cauliflower-like masses were investigated by histopathology, bacterial culture and molecular analyses. Results: A total of 20 masses different in size located in the mouth and in pectoral and caudal fins (characterized by abundant calcium deposits and by mild to moderate granulomatous inflammation) were observed with a significant different degree of histological severity. All internal organs of the fish were negative for mycobacteria, Ziehl-Neelsen was positive in only one of the oral masses, whereas bacterial and PCR analyses detected the presence of M. chelonae for almost all the skin and oral masses. Based on these results, a calcinosis of dystrophic origin associated with a chronic granulomatous inflammation was considered as a primary diagnosis consequent to tissue injury in areas susceptible to trauma. Conclusions: We hypothesized that the occurrence of M. chelonae in farmed sturgeons was only a secondary event related to its presence in a stressful rearing environment and subsequent to a dystrophic calcinosis occurred in previously damaged tissues

Mycobacterium chelonae associated with tumor-like skin and oral masses in farmed Russian sturgeons (Acipenser gueldenstaedtii)

Peer reviewe

Ubiquitous giant Ly α\alpha nebulae around the brightest quasars at z∼3.5z\sim3.5 revealed with MUSE

Direct Ly $\alpha$ imaging of intergalactic gas at $z\sim2$ has recently revealed giant cosmological structures around quasars, e.g. the Slug Nebula (Cantalupo et al. 2014). Despite their high luminosity, the detection rate of such systems in narrow-band and spectroscopic surveys is less than 10%, possibly encoding crucial information on the distribution of gas around quasars and the quasar emission properties. In this study, we use the MUSE integral-field instrument to perform a blind survey for giant Ly $\alpha$ nebulae around 17 bright radio-quiet quasars at $3<z<4$ that does not suffer from most of the limitations of previous surveys. After data reduction and analysis performed with specifically developed tools, we found that each quasar is surrounded by giant Ly $\alpha$ nebulae with projected sizes larger than 100 physical kpc and, in some cases, extending up to 320 kpc. The circularly averaged surface brightness profiles of the nebulae appear very similar to each other despite their different morphologies and are consistent with power laws with slopes $\approx-1.8$. The similarity between the properties of all these nebulae and the Slug Nebula suggests a similar origin for all systems and that a large fraction of gas around bright quasars could be in a relatively "cold" (T$\sim$10$^4$K) and dense phase. In addition, our results imply that such gas is ubiquitous within at least 50 kpc from bright quasars at $3<z<4$ independently of the quasar emission opening angle, or extending up to 200 kpc for quasar isotropic emission.Comment: 19 pages, 9 figures, 3 Tables, accepted to Ap

Montagne, comunità e lavoro tra 14. e 18. secolo

Il tema del volume è la definizione del rapporto tra comunità e lavoro in ambito alpino e prealpino. L’ambiente delle Alpi, infatti, ha determinato forme specifiche di organizzazione del lavoro e della proprietà, per esempio enfatizzando il ruolo della gestione collettiva dei beni fondiari, ma, al tempo stesso, l’organizzazione del lavoro ha modificato e connotato diversamente la vita delle comunità montane rispetto a quella delle comunità di pianura. Le aree alpine fornivano opportunità non sempre presenti altrove: attività di sfruttamento dei boschi e delle acque, di guida e di someggiatura legate ai passi e ai transiti di viaggiatori, erano solo alcuni degli ambiti di lavoro possibili in queste zone. I testi che il lettore troverà nel volume sono stati organizzati in cinque sezioni: la prima dedicata alle necessità collettive e alle risorse locali, la seconda all’organizzazione del lavoro, la terza agli scambi e al commercio, la quarta alle infrastrutture e, infine, in funzione comparativa e di confronto, una quinta sezione rivolta ad “altre montagne”

Festuca alta (Lolium arundinaceum) expuesta a sequía: re-determinación de su status nitrogenado teniendo en cuenta su menor nitrógeno crítico

EEA BalcarceFil: Errecart, Pedro Manuel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; ArgentinaFil: Durand, J.L. Institut National de la Recherche Agronomique Lusignan; FranciaFil: Agnusdei, Monica Graciela. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; ArgentinaFil: Marino, María Alejandra. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentin