6,309 research outputs found
Penerapan Metode Pembelajaran Writing Estafet untuk Meningkatkan Kemampuan Menulis Pantun Siswa Kelas IV Sdn 006 Raja Bejamu Sinaboi
This study is a Class Action Research (CAR) conducted aims to improve the ability to write rhymes fourth grade students of SDN 006 Raja Bejamu Sinaboi. Research motivated by low yields Indonesian student learning is 56.40 by the number of students as many as 20 people. This study aims to improve students' ability to write rhymes fourth grade 006 Raja bejamu Sinaboi by applying the learning model Writing Relay. This research was conducted using the instrument observation sheets, and a test sheet learning outcomes. Based on the analysis, it is known that the use of learning model can improve activity relay writing teacher from 71.42 in the first cycle of the meeting rose to 82.14 at the end of the cycle two. Furthermore activity students also increased from 67.80 in the first meeting of the cycle, increasing to 71.42 in cycle two. The ability to write poetry students also increased from 56.40 on the score increased at the end of two cycles with an average to 83.33. These research findings could prove the hypothesis of the study with the application model Writing Relay can improve relay pantun writing skills fourth grade students of SDN 006 Raja Bejamu. This means that the research hypothesis is accepted.Key Words ; Writing relay, the ability to write rhyme
A Soluble Phase Field Model
The kinetics of an initially undercooled solid-liquid melt is studied by
means of a generalized Phase Field model, which describes the dynamics of an
ordering non-conserved field phi (e.g. solid-liquid order parameter) coupled to
a conserved field (e.g. thermal field). After obtaining the rules governing the
evolution process, by means of analytical arguments, we present a discussion of
the asymptotic time-dependent solutions. The full solutions of the exact
self-consistent equations for the model are also obtained and compared with
computer simulation results. In addition, in order to check the validity of the
present model we confronted its predictions against those of the standard Phase
field model and found reasonable agreement. Interestingly, we find that the
system relaxes towards a mixed phase, depending on the average value of the
conserved field, i.e. on the initial condition. Such a phase is characterized
by large fluctuations of the phi field.Comment: 13 pages, 8 figures, RevTeX 3.1, submitted to Physical Review
Selection Of A Novel Aptamer Against Vitronectin Using Capillary Electrophoresis And Next Generation Sequencing
Breast cancer (BC) results in ≃40,000 deaths each year in the United States and even among survivors treatment of the disease may have devastating consequences, including increased risk for heart disease and cognitive impairment resulting from the toxic effects of chemotherapy. Aptamer-mediated drug delivery can contribute to improved treatment outcomes through the selective delivery of chemotherapy to BC cells, provided suitable cancer-specific antigens can be identified. We report here the use of capillary electrophoresis in conjunction with next generation sequencing to develop the first vitronectin (VN) binding aptamer (VBA-01; Kd 405 nmol/l, the first aptamer to vitronectin (VN; Kd = 405 nmol/l), a protein that plays an important role in wound healing and that is present at elevated levels in BC tissue and in the blood of BC patients relative to the corresponding nonmalignant tissues. We used VBA-01 to develop DVBA-01, a dimeric aptamer complex, and conjugated doxorubicin (Dox) to DVBA-01 (7:1 ratio) using pH-sensitive, covalent linkages. Dox conjugation enhanced the thermal stability of the complex (60.2 versus 46.5°C) and did not decrease affinity for the VN target. The resulting DVBA-01-Dox complex displayed increased cytotoxicity to MDA-MB-231 BC cells that were cultured on plasticware coated with VN (1.8 × 10⁻⁶mol/l) relative to uncoated plates (2.4 × 10⁻⁶ mol/l), or plates coated with the related protein fibronectin (2.1 × 10⁻⁶ mol/l). The VBA-01 aptamer was evaluated for binding to human BC tissue using immunohistochemistry and displayed tissue specific binding and apparent association with BC cells. In contrast, a monoclonal antibody that preferentially binds to multimeric VN primarily stained extracellular matrix and vessel walls of BC tissue. Our results indicate a strong potential for using VN-targeting aptamers to improve drug delivery to treat BC
Growth Kinetics in a Phase Field Model with Continuous Symmetry
We discuss the static and kinetic properties of a Ginzburg-Landau spherically
symmetric model recently introduced (Phys. Rev. Lett. {\bf 75}, 2176,
(1995)) in order to generalize the so called Phase field model of Langer. The
Hamiltonian contains two invariant fields and bilinearly
coupled. The order parameter field evolves according to a non conserved
dynamics, whereas the diffusive field follows a conserved dynamics. In the
limit we obtain an exact solution, which displays an interesting
kinetic behavior characterized by three different growth regimes. In the early
regime the system displays normal scaling and the average domain size grows as
, in the intermediate regime one observes a finite wavevector
instability, which is related to the Mullins-Sekerka instability; finally, in
the late stage the structure function has a multiscaling behavior, while the
domain size grows as .Comment: 9 pages RevTeX, 9 figures included, files packed with uufiles to
appear on Phy. Rev.
Temperature dependence of the electronic structure of semiconductors and insulators
The renormalization of electronic eigenenergies due to electron-phonon
coupling is sizable in many materials with light atoms. This effect, often
neglected in ab-initio calculations, can be computed using the
perturbation-based Allen-Heine-Cardona theory in the adiabatic or non-adiabatic
harmonic approximation. After a short description of the numerous recent
progresses in this field, and a brief overview of the theory, we focus on the
issue of phonon wavevector sampling convergence, until now poorly understood.
Indeed, the renormalization is obtained numerically through a q-point sampling
inside the BZ. For q-points close to G, we show that a divergence due to
non-zero Born effective charge appears in the electron-phonon matrix elements,
leading to a divergence of the integral over the BZ for band extrema. Although
it should vanish for non-polar materials, unphysical residual Born effective
charges are usually present in ab-initio calculations. Here, we propose a
solution that improves the coupled q-point convergence dramatically. For polar
materials, the problem is more severe: the divergence of the integral does not
disappear in the adiabatic harmonic approximation, but only in the
non-adiabatic harmonic approximation. In all cases, we study in detail the
convergence behavior of the renormalization as the q-point sampling goes to
infinity and the imaginary broadening parameter goes to zero. This allows
extrapolation, thus enabling a systematic way to converge the renormalization
for both polar and non-polar materials. Finally, the adiabatic and
non-adiabatic theory, with corrections for the divergence problem, are applied
to the study of five semiconductors and insulators: a-AlN, b-AlN, BN, diamond
and silicon. For these five materials, we present the zero-point
renormalization, temperature dependence, phonon-induced lifetime broadening and
the renormalized electronic bandstructure.Comment: 27 pages and 26 figure
A high-throughput and open-source platform for embryo phenomics
<div><p>Phenomics has the potential to facilitate significant advances in biology but requires the development of high-throughput technologies capable of generating and analysing high-dimensional data. There are significant challenges associated with building such technologies, not least those required for investigating dynamic processes such as embryonic development, during which high rates of temporal, spatial, and functional change are inherently difficult to capture. Here, we present EmbryoPhenomics, an accessible high-throughput platform for phenomics in aquatic embryos comprising an Open-source Video Microscope (OpenVIM) that produces high-resolution videos of multiple embryos under tightly controlled environmental conditions. These videos are then analysed by the Python package Embryo Computer Vision (EmbryoCV), which extracts phenomic data for morphological, physiological, behavioural, and proxy traits during the process of embryonic development. We demonstrate the broad-scale applicability of EmbryoPhenomics in a series of experiments assessing chronic, acute, and multistressor responses to environmental change (temperature and salinity) in >30 million images of >600 embryos of two species with markedly different patterns of development—the pond snail <i>Radix balthica</i> and the marine amphipod <i>Orchestia gammarellus</i>. The challenge of phenomics is significant but so too are the rewards, and it is particularly relevant to the urgent task of assessing complex organismal responses to current rates of environmental change. EmbryoPhenomics can acquire and process data capturing functional, temporal, and spatial responses in the earliest, most dynamic life stages and is potentially game changing for those interested in studying development and phenomics more widely.</p></div
BCS-Bose Crossover in Color Superconductivity
It is shown that the onset of the color superconducting phase occurs in the
BCS-BE crossover region.Comment: 5 pages, LaTeX, references adde
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