HIV-associated Cutaneous Dissemination of Visceral Leishmaniasis, Despite Negligible Immunodeficiency. Failure of Liposomal Amphotericin B Administration, Followed by Successful Pentamidine-Paromomycin Administration

and post hoc Tukey test. Statistical analysis of survival time was carried out with Kaplan-Meier (Log-Rank) test. Results: The immunized mice with this DNA vaccine presented an important reduction in diameter of lesion and increasing of weight compared to the control mice and was indicated a significant difference between the immunized group and the control groups (p < 0.05). The survival time of the immunized mice was significantly higher than the control groups (p < 0.05) after challenge with Leishmania major. The immunized mice had significantly lower parasite load compared to the control mice (p < 0.05). Conclusion: The findings of this study, indicated that the TSA encoded DNA vaccine induced protection against infection with Leishmania major in mice. In this study, we demonstrated that, the TSA -encoded DNA vaccine may be an excellent candidate for futher vaccine development

The Supersonic Project: SIGOs, A Proposed Progenitor to Globular Clusters, and Their Connections to Gravitational-wave Anisotropies

Supersonically induced gas objects (SIGOs), are structures with little to no dark-matter component predicted to exist in regions of the universe with large relative velocities between baryons and dark matter at the time of recombination. They have been suggested to be the progenitors of present-day globular clusters. Using simulations, SIGOs have been studied on small scales (around 2 Mpc) where these relative velocities are coherent. However, it is challenging to study SIGOs using simulations on large scales due to the varying relative velocities at scales larger than a few Mpc. Here, we study SIGO abundances semi-analytically: using perturbation theory, we predict the number density of SIGOs analytically, and compare these results to small-box numerical simulations. We use the agreement between the numerical and analytic calculations to extrapolate the large-scale variation of SIGO abundances over different stream velocities. As a result, we predict similar large-scale variations of objects with high gas densities before reionization that could possibly be observed by JWST. If indeed SIGOs are progenitors of globular clusters, then we expect a similar variation of globular cluster abundances over large scales. Significantly, we find that the expected number density of SIGOs is consistent with observed globular cluster number densities. As a proof-of-concept, and because globular clusters were proposed to be natural formation sites for gravitational wave sources from binary black-hole mergers, we show that SIGOs should imprint an anisotropy on the gravitational wave signal on the sky, consistent with their distribution

Optimal strategies for a game on amenable semigroups

The semigroup game is a two-person zero-sum game defined on a semigroup S as follows: Players 1 and 2 choose elements x and y in S, respectively, and player 1 receives a payoff f(xy) defined by a function f from S to [-1,1]. If the semigroup is amenable in the sense of Day and von Neumann, one can extend the set of classical strategies, namely countably additive probability measures on S, to include some finitely additive measures in a natural way. This extended game has a value and the players have optimal strategies. This theorem extends previous results for the multiplication game on a compact group or on the positive integers with a specific payoff. We also prove that the procedure of extending the set of allowed strategies preserves classical solutions: if a semigroup game has a classical solution, this solution solves also the extended game.Comment: 17 pages. To appear in International Journal of Game Theor

Machine Learning for Galactic Archaeology: A chemistry-based neural network method for identification of accreted disc stars

We develop a method ('Galactic Archaeology Neural Network', GANN) based on neural network models (NNMs) to identify accreted stars in galactic discs by only their chemical fingerprint and age, using a suite of simulated galaxies from the Auriga Project. We train the network on the target galaxy's own local environment defined by the stellar halo and the surviving satellites. We demonstrate that this approach allows the detection of accreted stars that are spatially mixed into the disc. Two performance measures are defined - recovery fraction of accreted stars, and the probability that a star with a positive (accreted) classification is a true-positive result, P(TP). As the NNM output is akin to an assigned probability, we are able to determine positivity based on flexible threshold values that can be adjusted easily to refine the selection of presumed-accreted stars. We find that GANN identifies accreted disc stars within simulated galaxies, with high recovery fraction and/or high P(TP). We also find that stars in Gaia-Enceladus-Sausage (GES) mass systems are over 50% recovered by our NNMs in the majority (18/24) of cases. Additionally, nearly every individual source of accreted stars is detected at 10% or more of its peak stellar mass in the disc. We also demonstrate that a conglomerated NNM, trained on the halo and satellite stars from all of the Auriga galaxies provides the most consistent results, and could prove to be an intriguing future approach as our observational capabilities expand.Comment: 19 pages, 12 figure

Molecular hydrogen in IllustrisTNG galaxies: Carefully comparing signatures of environment with local CO and SFR data

We examine how the post-processed content of molecular hydrogen (H2) in galaxies from the TNG100 cosmological, hydrodynamic simulation changes with environment at z = 0, assessing central/satellite status and host halo mass. We make close comparisons with the carbon monoxide (CO) emission survey xCOLD GASS where possible, having mock-observed TNG100 galaxies to match the survey's specifications. For a representative sample of host haloes across 1011 ≲ M200c/M· &lt; 1014.6, TNG100 predicts that satellites with $m∗ ≥ 109, M⊙ should have a median deficit in their H2 fractions of ∼0.6 dex relative to centrals of the same stellar mass. Once observational and group-finding uncertainties are accounted for, the signature of this deficit decreases to ∼0.2 dex. Remarkably, we calculate a deficit in xCOLD GASS satellites' H2 content relative to centrals of 0.2-0.3 dex, in line with our prediction. We further show that TNG100 and SDSS data exhibit continuous declines in the average star formation rates of galaxies at fixed stellar mass in denser environments, in quantitative agreement with each other. By tracking satellites from their moment of infall in TNG100, we directly show that atomic hydrogen (H i) is depleted at fractionally higher rates than H2 on average. Supporting this picture, we find that the H2/H i mass ratios of satellites are elevated relative to centrals in xCOLD GASS. We provide additional predictions for the effect of environment on H2-both absolute and relative to H i-that can be tested with spectral stacking in future CO surveys

Antimicrobial and Antibiofilm Activities of Carvacrol, Amoxicillin and Salicylhydroxamic Acid Alone and in Combination vs. Helicobacter pylori: Towards a New Multi-Targeted Therapy

The World Health Organization has indicated Helicobacter pylori as a high-priority pathogen whose infections urgently require an update of the antibacterial treatments pipeline. Recently, bacterial ureases and carbonic anhydrases (CAs) were found to represent valuable pharmacological targets to inhibit bacterial growth. Hence, we explored the underexploited possibility of developing a multiple-targeted anti-H. pylori therapy by assessing the antimicrobial and antibiofilm activities of a CA inhibitor, carvacrol (CAR), amoxicillin (AMX) and a urease inhibitor (SHA), alone and in combination. Minimal Inhibitory (MIC) and Minimal Bactericidal (MBC) Concentrations of their different combinations were evaluated by checkerboard assay and three different methods were employed to assess their capability to eradicate H. pylori biofilm. Through Transmission Electron Microscopy (TEM) analysis, the mechanism of action of the three compounds alone and together was determined. Interestingly, most combinations were found to strongly inhibit H. pylori growth, resulting in an additive FIC index for both CAR-AMX and CAR-SHA associations, while an indifferent value was recorded for the AMX-SHA association. Greater antimicrobial and antibiofilm efficacy of the combinations CAR-AMX, SHA-AMX and CAR-SHA against H. pylori were found with respect to the same compounds used alone, thereby representing an innovative and promising strategy to counteract H. pylori infections

MaGICC baryon cycle: the enrichment history of simulated disc galaxies

Using cosmological galaxy formation simulations from the MaGICC (Making Galaxies in a Cosmological Context) project, spanning stellar mass from ∼107 to 3 × 1010 M⊙, we trace the baryonic cycle of infalling gas from the virial radius through to its eventual participation in the star formation process. An emphasis is placed upon the temporal history of chemical enrichment during its passage through the corona and circumgalactic medium. We derive the distributions of time between gas crossing the virial radius and being accreted to the star-forming region (which allows for mixing within the corona), as well as the time between gas being accreted to the star-forming region and then ultimately forming stars (which allows for mixing within the disc). Significant numbers of stars are formed from gas that cycles back through the hot halo after first accreting to the star-forming region. Gas entering high-mass galaxies is pre-enriched in low-mass proto-galaxies prior to entering the virial radius of the central progenitor, with only small amounts of primordial gas accreted, even at high redshift (z ∼ 5). After entering the virial radius, significant further enrichment occurs prior to the accretion of the gas to the star-forming region, with gas that is feeding the star-forming region surpassing 0.1 Z⊙ by z = 0. Mixing with halo gas, itself enriched via galactic fountains, is thus crucial in determining the metallicity at which gas is accreted to the disc. The lowest mass simulated galaxy (Mvir ∼ 2 × 1010 M⊙, with M⋆ ∼ 107 M⊙), by contrast, accretes primordial gas through the virial radius and on to the disc, throughout its history. Much like the case for classical analytical solutions to the so-called ‘G-dwarf problem’, overproduction of low-metallicity stars is ameliorated by the interplay between the time of accretion on to the disc and the subsequent involvement in star formation – i.e. due to the inefficiency of star formation. Finally, gas outflow/metal removal rates from star-forming regions as a function of galactic mass are presented

The Supersonic Project: The Early Evolutionary Path of Supersonically Induced Gas Objects

Supersonically induced gas objects (SIGOs) are a class of early universe objects that have gained attention as a potential formation route for globular clusters. SIGOs have recently begun to be studied in the context of molecular hydrogen cooling, which is key to characterizing their structure and evolution. Studying the population-level properties of SIGOs with molecular cooling is important for understanding their potential for collapse and star formation, and for addressing whether SIGOs can survive to the present epoch. Here, we investigate the evolution of SIGOs before they form stars, using a combination of numerical and analytical analysis. We study timescales important to the evolution of SIGOs at a population level in the presence of molecular cooling. Revising the previous formulation for the critical density of collapse for SIGOs allows us to show that their prolateness tends to act as an inhibiting factor to collapse. We find that simulated SIGOs are limited by artificial two-body relaxation effects that tend to disperse them. We expect that SIGOs in nature will be longer lived compared to our simulations. Further, the fall-back timescale on which SIGOs fall into nearby dark matter halos, potentially producing a globular-cluster-like system, is frequently longer than their cooling timescale and the collapse timescale on which they shrink through gravity. Therefore, some SIGOs have time to cool and collapse outside of halos despite initially failing to exceed the critical density. From this analysis we conclude that SIGOs should form stars outside of halos in nonnegligible stream velocity patches in the universe

The illustris simulation: Public data release

We present the full public release of all data from the Illustris simulation project. Illustris is a suite of large volume, cosmological hydrodynamical simulations run with the moving-mesh code Arepo and including a comprehensive set of physical models critical for following the formation and evolution of galaxies across cosmic time. Each simulates a volume of (106.5 Mpc)3and self-consistently evolves five different types of resolution elements from a starting redshift of z=127 to the present day, z=0. These components are: dark matter particles, gas cells, passive gas tracers, stars and stellar wind particles, and supermassive black holes. This data release includes the snapshots at all 136 available redshifts, halo and subhalo catalogs at each snapshot, and two distinct merger trees. Six primary realizations of the Illustris volume are released, including the flagship Illustris-1 run. These include three resolution levels with the fiducial "full" baryonic physics model, and a dark matter only analog for each. In addition, we provide four distinct, high time resolution, smaller volume "subboxes". The total data volume is ~265 TB, including ~800 full volume snapshots and ~30,000 subbox snapshots. We describe the released data products as well as tools we have developed for their analysis. All data may be directly downloaded in its native HDF5 format. Additionally, we release a comprehensive, web-based API which allows programmatic access to search and data processing tasks. In both cases we provide example scripts and a getting-started guide in several languages: currently, IDL, Python, and Matlab. This paper addresses scientific issues relevant for the interpretation of the simulations, serves as a pointer to published and on-line documentation of the project, describes planned future additional data releases, and discusses technical aspects of the release

Gaseous Galaxy Halos

Galactic halo gas traces inflowing star formation fuel and feedback from a galaxy's disk and is therefore crucial to our understanding of galaxy evolution. In this review, we summarize the multi-wavelength observational properties and origin models of Galactic and low redshift spiral galaxy halo gas. Galactic halos contain multiphase gas flows that are dominated in mass by the ionized component and extend to large radii. The densest, coldest halo gas observed in neutral hydrogen (HI) is generally closest to the disk (< 20 kpc), and absorption line results indicate warm and warm-hot diffuse halo gas is present throughout a galaxy's halo. The hot halo gas detected is not a significant fraction of a galaxy's baryons. The disk-halo interface is where the multiphase flows are integrated into the star forming disk, and there is evidence for both feedback and fueling at this interface from the temperature and kinematic gradient of the gas and HI structures. The origin and fate of halo gas is considered in the context of cosmological and idealized local simulations. Accretion along cosmic filaments occurs in both a hot (> 10^5.5 K) and cold mode in simulations, with the compressed material close to the disk the coldest and densest, in agreement with observations. There is evidence in halo gas observations for radiative and mechanical feedback mechanisms, including escaping photons from the disk, supernova-driven winds, and a galactic fountain. Satellite accretion also leaves behind abundant halo gas. This satellite gas interacts with the existing halo medium, and much of this gas will become part of the diffuse halo before it can reach the disk. The accretion rate from cold and warm halo gas is generally below a galaxy disk's star formation rate, but gas at the disk-halo interface and stellar feedback may be important additional fuel sources.Comment: 50 pages, 9 figures (1 in 3D, view with a current version of Adobe), to appear in ARA&A, 50, 49