Nîmes – Hôtel d’Albenas, 7 rue Dorée

La réhabilitation de l’hôtel d’Albenas au 7 rue Dorée est à l’origine d’une opération de diagnostic archéologique. La parcelle étudiée EY733 s’ouvre sur la rue Dorée au sud et couvre une superficie de plus de 800 m2. L’étude archéologique de l’immeuble est complétée par les travaux de Sophie Aspord-Mercier au préalable à la demande de permis de construire et par une étude historique conduite par G. Caillat (Ville de Nîmes, Direction des affaires culturelles). L’intervention archéologique s’es..

Roquemaure – Église collégiale Saint-Jean-Baptiste

Le diagnostic de la nef de la collégiale Saint-Jean-Baptiste de Roquemaure a été réalisé suite à la dépose d’une soixantaine de dalles du sol, afin de permettre l’installation de câbles électriques alimentant un tapis chauffant. L’étude a porté sur l’emprise de 14 dalles limitée à une quarantaine de centimètres de profondeur depuis le sol actuel, le projet n’affectant que peu profondément le sous-sol. Cette étude a été conduite sur le terrain par deux archéologues médiévistes du 23 au 24 nove..

Nîmes – 1 rue Guynemer

Le projet de construction d’une maison individuelle avec piscine au 1 rue Guynemer à Nîmes (parcelle HD 472) est à l’origine d’une opération de diagnostic qui vise à reconnaître la présence d’une part d’une voie antique au nord de la parcelle, ainsi que ses aménagements bordiers, d’autre part de la basilique Sainte-Perpétue installée au xe s. dans le quartier et détruite aux premières années des guerres de Religions, et enfin de la nécropole antique, tardo-antique et alto-médiévale. Le diagno..

Portrait of driving practice following a mild stroke : a secondary analysis of a chart audit

Background: The majority of individuals who have had a mild stroke are discharged home from acute care. Yet, the proportion who are assessed for driving ability and given related recommendations is unknown. Objective: To describe acute care practice related to driving among individuals whose discharge location is home. Methods: A secondary analysis of data from a chart audit was realized in the Province of Quebec, Canada. Data were retrieved from the charts by trained extractors. Evaluation practice was described according to whether the driving assessment was specific or nonspecific to driving (cognitive, perceptual and visual functions). Descriptive statistics were used. Results: The sample consisted of 419 charts of individuals with a mean age of 70.5 ± 13.3 years old. Mean length of hospital stay was 10.3 ± 13.3 days. Specific driving assessment was documented among 26/419 (6.2%) charts while for seven of these, the assessment was considered full. Meanwhile, 92/419 (22.0%) were considered as problematic for driving a vehicle. Nonspecific driving assessment was documented among 70/419 (16.7%), 43/419 (10.3%) and 33/419 (7.9%) of charts for cognitive, perceptual and visual functions, respectively. Charts were characterized by several missing data relating to driving. Conclusion: The proportion of charts documenting driving restriction post-stroke in acute care was very low. Assuming that all driving discussions and referrals were captured in the charts (which may not be the case), our results would indicate an important gap in acute care practice as compared to best practices relating to driving post-stroke

Villæ – Villages du haut Moyen Âge en plaine du Languedoc oriental. Maillage, morphologie et économie

Le village de plaine en Languedoc oriental au premier Moyen Âge était encore, ces dernières années, un grand inconnu. Non qu’il fut rare entre les ve et xiie siècles – c’est au contraire manifestement la forme d’habitat la plus répandue à partir du ixe siècle –, mais parce qu’il n’a laissé que peu de traces, tant dans la documentation écrite et iconographique qu’au sol. Peu d’historiens se sont attachés au sujet, ce que la parcimonie des sources explique en grande partie. Les archéologues, de..

A strategic initiative to facilitate knowledge translation research in rehabilitation

While there is a growing body of literature supporting clinical decision-making for rehabilitation professionals, suboptimal use of evidence-based practices in that field persists. A strategic initiative that ensures the relevance of the research and its implementation in the context of rehabilitation could 1) help improve the coordination of knowledge translation (KT) research and 2) enhance the delivery of evidence-based rehabilitation services offered to patients with physical disabilities. This paper describes the process and methods used to develop a KT strategic initiative aimed at building capacity and coordinating KT research in physical rehabilitation and its strategic plan; it also reports the initial applications of the strategic plan implementation

Translational Control through eIF2alpha Phosphorylation during the Leishmania Differentiation Process

The parasitic protozoan Leishmania alternates between an invertebrate and a mammalian host. Upon their entry to mammalian macrophages, Leishmania promastigotes differentiate into amastigote forms within the harsh environment of the phagolysosomal compartment. Here, we provide evidence for the importance of translational control during the Leishmania differentiation process. We find that exposure of promastigotes to a combined elevated temperature and acidic pH stress, a key signal triggering amastigote differentiation, leads to a marked decrease in global translation initiation, which is associated with eIF2α phosphorylation. Interestingly, we show that amastigotes adapted to grow in a cell-free medium exhibit lower levels of protein synthesis in comparison to promastigotes, suggesting that amastigotes have to enter a slow growth state to adapt to the stressful conditions encountered inside macrophages. Reconversion of amastigotes back to promastigote growth results in upregulation of global translation and a decrease in eIF2α phosphorylation. In addition, we show that while general translation is reduced during amastigote differentiation, translation of amastigote-specific transcripts such as A2 is preferentially upregulated. We find that A2 developmental gene regulation is triggered by temperature changes in the environment and that occurs mainly at the level of translation. Upon elevated temperature, the A2 transcript is stabilized through its association with polyribosomes leading to high levels of translation. When temperature decreases during amastigote to promastigote differentiation, the A2 transcript is not longer associated with translating polyribosomes and is being gradually degraded. Overall, these findings contribute to our better understanding of the adaptive responses of Leishmania to stress during its development and highlight the importance of translational control in promastigote to amastigote differentiation and vice-versa

Imaging and impact of myocardial fibrosis in aortic stenosis

Aortic stenosis is characterized both by progressive valve narrowing and the left ventricular remodeling response that ensues. The only effective treatment is aortic valve replacement, which is usually recommended in patients with severe stenosis and evidence of left ventricular decompensation. At present, left ventricular decompensation is most frequently identified by the development of typical symptoms or a marked reduction in left ventricular ejection fraction <50%. However, there is growing interest in using the assessment of myocardial fibrosis as an earlier and more objective marker of left ventricular decompensation, particularly in asymptomatic patients, where guidelines currently rely on non- randomized data and expert consensus. Myocardial fibrosis has major functional consequences, is the key pathological process driving left ventricular decompensation, and can be divided into 2 categories. Replacement fibrosis is irreversible and identified using late gadolinium enhancement on cardiac magnetic resonance, while diffuse fibrosis occurs earlier, is potentially reversible, and can be quantified with cardiac magnetic resonance T1 mapping techniques. There is a substantial body of observational data in this field, but there is now a need for randomized clinical trials of myocardial imaging in aortic stenosis to optimize patient management. This review will discuss the role that myocardial fibrosis plays in aortic stenosis, how it can be imaged, and how these approaches might be used to track myocardial health and improve the timing of aortic valve replacement