Iterative design of dynamic experiments in modeling for optimization of innovative bioprocesses

Finding optimal operating conditions fast with a scarce budget of experimental runs is a key problem to speed up the development and scaling up of innovative bioprocesses. In this paper, a novel iterative methodology for the model-based design of dynamic experiments in modeling for optimization is developed and successfully applied to the optimization of a fed-batch bioreactor related to the production of r-interleukin-11 (rIL-11) whose DNA sequence has been cloned in an Escherichia coli strain. At each iteration, the proposed methodology resorts to a library of tendency models to increasingly bias bioreactor operating conditions towards an optimum. By selecting the ‘most informative’ tendency model in the sequel, the next dynamic experiment is defined by re-optimizing the input policy and calculating optimal sampling times. Model selection is based on minimizing an error measure which distinguishes between parametric and structural uncertainty to selectively bias data gathering towards improved operating conditions. The parametric uncertainty of tendency models is iteratively reduced using Global Sensitivity Analysis (GSA) to pinpoint which parameters are keys for estimating the objective function. Results obtained after just a few iterations are very promising.Fil: Cristaldi, Mariano Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo y Diseño. Universidad Tecnológica Nacional. Facultad Regional Santa Fe. Instituto de Desarrollo y Diseño; ArgentinaFil: Grau, Ricardo José Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Martínez, Ernesto Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo y Diseño. Universidad Tecnológica Nacional. Facultad Regional Santa Fe. Instituto de Desarrollo y Diseño; Argentin

UNDERSTANDING CRIMINOLOGICAL THEORIES AS A TOOL FOR CRIME PREVENTION

The story of Adam and Eve shows that there was a law (not to eat the fruit from the tree of good and evil). The consequence or punishment would be death as stated by God, while the benefit was ‘to be like God’ according to Satan. Therefore, the choices were either to receive a punishment or a benefit. Eve then chose the latter. This may reflect how one foreign theory of crime causation (rational choice theory) works, especially when it comes to crimes and punishments. A person would weigh the costs and benefits and decides according to his/her belief, judgment and conviction. In the local setting, a recent incident showed a preliminary applicability of one of the theories of crime causation, specifically, the rational choice theory (RCT) in the Philippine setting. It was when a relieved security guard turned into a hostage taker

¿Hacia un modelo sudamericano de política cultural? Singularidades y convergencias en Uruguay, Paraguay y Chile en el siglo XXI

Desde los inicios del estudio de la política cultural en los años ochenta, la dimensión comparativa internacional ha sido uno de sus ejes de análisis. Esto ha revelado la diversidad de enfoques y la existencia de modelos nacionales y regionales, unas diferencias que han sido explicadas por condicionantes históricos y políticos. Asimismo se ha diagnosticado una tendencia a la difusión internacional de estos modelos. En el caso Latinoamericano, se han realizado en los últimos años algunas compilaciones de estudios nacionales, pero raramente estos estudios abordan la tarea comparativa. En este artículo, intentaremos responder a la pregunta de si existe un modelo sudamericano de política cultural. A partir del estudio de tres países (Chile, Paraguay y Uruguay) defenderemos la hipótesis de que si bien no podemos hablar de un modelo propio del sur del continente y existe una multiplicidad debida a diversas genealogías y al desarrollo de políticas culturales diferenciadas por Estado-nación, si existen algunos condicionantes compartidos y una tendencia hacia la convergencia que prefigura un patrón propio

Apresentação

Em setembro de 2005, foram realizadas, na PUCRS, em Porto Alegre, as XIII Jornadas sobre Alternativas Religiosas na América Latina, cujo tema geral foi Religião, poder e política: novos atores e contextos na América Latina. Este número de Ciências Sociales y Religión / Ciências Sociais e Religião contém 9 artigos, sendo sete deles selecionados pelos coordenadores de Mesas-redondas e Grupos de Trabalho das XIII Jornadas, além de uma conferência e do trabalho premiado no Concurso de monografias “Religión, poder y política”, promovido pela Associação de Cientistas Sociais da Religião do Mercosul

MUDANÇAS NO CAMPO RELIGIOSO BRASILEIRO NO CENSO 2010

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