Proposal for the virtual and material reconstruction through anastylosis of the archaeological remains of the Patio of the Renaissance Palace of the Ambassador Vich in Valencia, Spain

[ES] El palacio del Embajador Vich en Valencia (1526-1858) fue una de las primeras muestras de arquitectura renacentista en España. Tras su derribo se conservaron parte de los mármoles del patio, reunidos, tras siglo y medio de peregrinaje, en una intervención unificadora en el Museo de Bellas Artes San Pío V en 2006. La recuperación de la esencia espacial, compositiva y material del monumento queda incompleta por falta de las cornisas y marcos que decoraban la galería baja circundante, restos arqueológicos materializados en caliza gris italiana, Pietra Serena, que junto al mármol blanco Carrara, creaba la bicromía típica de estos juegos compositivos tan "brunelleschianos". La anastilosis virtual permite lanzar una propuesta de recuperación material del emblemático monumento, favoreciendo así la correcta lectura del mismo.[EN] Ambassador Vich’s palace in Valencia (1526-1858) was one of the first examples of renaissance architecture in Spain. After its demolition, part of the courtyard’s marbles was conserved, gathered, after a century and a half of pilgrimage in a unifying intervention in the Museum of Fine Arts of San Pío V in 2006. The recovery of the spatial, composite and material essence of the monument remains incomplete, as the cornices and frames that decorated the surrounding lower gallery are missing; archaeological remains made with grey Italian limestone, Pietra Serena, which together with the white Carrara marble, created the typical two-colour of these, such “Brunelleschian” composite games. The virtual anastylosis allows a proposal to be launched for the material recovery of the emblematic monument, favouring as such the correct reading of the same.Galiana Agulló, M.; Mas Tomas, MDLA.; Lerma Elvira, C.; Conesa Tejada, S. (2013). Propuesta de reconstrucción virtual y material por anastilosis de los restos arqueológicos del patio del palacio renacentista del Embajador Vich en Valencia, España. Virtual Archaeology Review. 4(9):21-27. https://doi.org/10.4995/var.2013.4237OJS212749BENITO, F. (2000): El patio del palacio del Embajador Vich. Elementos para su recuperación. Museo de Bellas Artes de Valencia. Valencia.ESBERT, R.M. et alii. (2003): "Criterios de intervención en materiales pétreos", en Bienes Culturales. Revista del Instituto del Patrimonio Histórico Español, vol. 2, pp. 1-35.GAVARA PRIOR, J. J. (2006): L'Ambaixador Vich. L'home i el seu temps. Museu de Belles Arts de València, Generalitat Valenciana, Valencia

Functional Recovery and Serum Angiogenin Changes According to Intensity of Rehabilitation Therapy After Stroke

Rehabilitation is still the only treatment available to improve functional status after the acute phase of stroke. Most clinical guidelines highlight the need to design rehabilitation treatments considering starting time, intensity, and frequency, according to the tolerance of the patient. However, there are no homogeneous protocols and the biological effects are under investigation. To investigate the impact of rehabilitation intensity (hours) after stroke on functional improvement and serum angiogenin (ANG) in a 6-month follow-up study. A prospective, observational, longitudinal, and multicenter study with three cohorts: strokes in intensive rehabilitation therapy (IRT, minimum 15 h/week) vs. conventional therapy (NO-IRT, <15 h/week), and controls subjects (without known neurological, malignant, or inflammatory diseases). A total of seven centers participated, with functional evaluations and blood sampling during follow-up. The final cohort includes 62 strokes and 43 controls with demographic, clinical, blood samples, and exhaustive functional monitoring. The median (IQR) number of weekly hours of therapy was different: IRT 15 (15-16) vs. NO-IRT 7.5 (5-9), p < 0.01, with progressive and significant improvements in both groups. However, IRT patients showed earlier improvements (within 1 month) on several scales (CAHAI, FMA, and FAC; p < 0.001) and the earliest community ambulation achievements (0.89 m/s at 3 months). There was a significant difference in ANG temporal profile between the IRT and NO-IRT groups (p < 0.01). Additionally, ANG was elevated at 1 month only in the IRT group (p < 0.05) whereas it decreased in the NO-IRT group (p < 0.05). Our results suggest an association of rehabilitation intensity with early functional improvements, and connect the rehabilitation process with blood biomarkers

Dieta vegana en gestantes: requerimientos y recomendaciones nutricionales

Durante el embarazo los requerimientos nutricionales cambian en función del índice de masa corporal, nivel de actividad física, y tasa metabólica de la gestante. Se ha relacionado la cantidad insuficiente de nutrientes esenciales en la dieta vegana con consecuencias en la salud de la gestante como depresión post-parto, parestesias, calambres musculares, anemia ferropénica, diabetes mellitus gestacional. Se hace hincapié en la correcta planificación de la dieta en gestantes veganas para evitar estas complicaciones. Es de suma importancia considerar fuentes ricas en proteínas, vitaminas y minerales en cantidades adecuadas para la gestante. Palabras clave: dieta, veganos, mujeres embarazadas, requerimientos nutricionales. (Fuente: DeCS) DOI: http://dx.doi.org/10.17268/rmt.2021.v16i02.1

Common Breast Cancer Susceptibility Alleles and the Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Implications for Risk Prediction

The known breast cancer (BC) susceptibility polymorphisms in FGFR2, TNRC9/TOX3, MAP3K1,LSP1 and 2q35 confer increased risks of BC for BRCA1 or BRCA2 mutation carriers. We evaluated the associations of three additional SNPs, rs4973768 in SLC4A7/NEK10, rs6504950 in STXBP4/COX11 and rs10941679 at 5p12 and reanalyzed the previous associations using additional carriers in a sample of 12,525 BRCA1 and 7,409 BRCA2 carriers. Additionally, we investigated potential interactions between SNPs and assessed the implications for risk prediction. The minor alleles of rs4973768 and rs10941679 were associated with increased BC risk for BRCA2 carriers (per-allele Hazard Ratio (HR)=1.10, 95%CI:1.03-1.18, p=0.006 and HR=1.09, 95%CI:1.01-1.19, p=0.03, respectively). Neither SNP was associated with BC risk for BRCA1 carriers and rs6504950 was not associated with BC for either BRCA1 or BRCA2 carriers. Of the nine polymorphisms investigated, seven were associated with BC for BRCA2 carriers (FGFR2, TOX3, MAP3K1, LSP1, 2q35, SLC4A7, 5p12, p-values:7×10−11-0.03), but only TOX3 and 2q35 were associated with the risk for BRCA1 carriers (p=0.0049, 0.03 respectively). All risk associated polymorphisms appear to interact multiplicatively on BC risk for mutation carriers. Based on the joint genotype distribution of the seven risk associated SNPs in BRCA2 mutation carriers, the 5% of BRCA2 carriers at highest risk (i.e. between 95th and 100th percentiles) were predicted to have a probability between 80% and 96% of developing BC by age 80, compared with 42-50% for the 5% of carriers at lowest risk. Our findings indicated that these risk differences may be sufficient to influence the clinical management of mutation carriers

Time to Switch to Second-line Antiretroviral Therapy in Children With Human Immunodeficiency Virus in Europe and Thailand.

Background: Data on durability of first-line antiretroviral therapy (ART) in children with human immunodeficiency virus (HIV) are limited. We assessed time to switch to second-line therapy in 16 European countries and Thailand. Methods: Children aged <18 years initiating combination ART (≥2 nucleoside reverse transcriptase inhibitors [NRTIs] plus nonnucleoside reverse transcriptase inhibitor [NNRTI] or boosted protease inhibitor [PI]) were included. Switch to second-line was defined as (i) change across drug class (PI to NNRTI or vice versa) or within PI class plus change of ≥1 NRTI; (ii) change from single to dual PI; or (iii) addition of a new drug class. Cumulative incidence of switch was calculated with death and loss to follow-up as competing risks. Results: Of 3668 children included, median age at ART initiation was 6.1 (interquartile range (IQR), 1.7-10.5) years. Initial regimens were 32% PI based, 34% nevirapine (NVP) based, and 33% efavirenz based. Median duration of follow-up was 5.4 (IQR, 2.9-8.3) years. Cumulative incidence of switch at 5 years was 21% (95% confidence interval, 20%-23%), with significant regional variations. Median time to switch was 30 (IQR, 16-58) months; two-thirds of switches were related to treatment failure. In multivariable analysis, older age, severe immunosuppression and higher viral load (VL) at ART start, and NVP-based initial regimens were associated with increased risk of switch. Conclusions: One in 5 children switched to a second-line regimen by 5 years of ART, with two-thirds failure related. Advanced HIV, older age, and NVP-based regimens were associated with increased risk of switch

Música : contenidos, actividades y recursos

Todas las obras de la colección son libros de hojas cambiables que cuentan con una actualización periódica de tres entregas al añoConjunto de propuestas didácticas para el aprendizaje de la música en educación secundaria obligatoria cuyo objetivo es desarrollar estrategias de sensibilización general ante el hecho sonoro y frente al objeto musical. Con cada unidad se pretenden establecer las vías de acceso e intercambio del alumnado con la música como oyente, como intérprete y como creador. Cada unidad consta de: presentación del tema, selección y secuenciación de contenidos, desarrollo de la propuesta y recursos de intervención. Se ofrece la organización de la actividad y materiales para el profesor y para los alumnos.CataluñaES

Improved darunavir genotypic mutation score predicting treatment response for patients infected with HIRaben-1 subtype B and non-subtype B receiving a salvage regimen

Objectives: The objective of this studywas to improve the prediction of the impact of HIV-1 protease mutations in different viral subtypes on virological response to darunavir. Methods: Darunavir-containing treatment change episodes (TCEs) in patients previously failing PIs were selected from large European databases. HIV-1 subtype B-infected patients were used as the derivation dataset and HIV- 1 non-B-infected patients were used as the validation dataset. The adjusted association of each mutation with week 8 HIV RNA change from baseline was analysed by linear regression. A prediction model was derived based on best subset least squares estimation with mutational weights corresponding to regression coefficients. Virological outcome prediction accuracy was compared with that from existing genotypic resistance interpretation systems (GISs) (ANRS 2013, Rega 9.1.0 and HIVdb 7.0). Results: TCEs were selected from 681 subtype B-infected and 199 non-B-infected adults. Accompanying drugs were NRTIs in 87%, NNRTIs in 27%and raltegravir ormaraviroc or enfuvirtide in 53%. The predictionmodel included weighted protease mutations, HIV RNA, CD4 and activity of accompanying drugs. The model's association with week 8 HIV RNA change in the subtype B (derivation) set was R2=0.47 [average squared error (ASE)=0.67, P>10-6]; in the non-B (validation) set, ASE was 0.91. Accuracy investigated by means of area under the receiver operating characteristic curves with a binary response (above the threshold value of HIV RNA reduction) showed that our finalmodel outperformed models with existing interpretation systems in both training and validation sets. Conclusions: A model with a new darunavir-weighted mutation score outperformed existing GISs in both B and non-B subtypes in predicting virological response to darunavir