40 research outputs found
Ionizable lipid nanoparticles for in utero mRNA delivery.
- Author
- Publication venue
- Rowan Digital Works
- Publication date
- 01/01/2021
- Field of study
Clinical advances enable the prenatal diagnosis of genetic diseases that are candidates for gene and enzyme therapies such as messenger RNA (mRNA)-mediated protein replacement. Prenatal mRNA therapies can treat disease before the onset of irreversible pathology with high therapeutic efficacy and safety due to the small fetal size, immature immune system, and abundance of progenitor cells. However, the development of nonviral platforms for prenatal delivery is nascent. We developed a library of ionizable lipid nanoparticles (LNPs) for in utero mRNA delivery to mouse fetuses. We screened LNPs for luciferase mRNA delivery and identified formulations that accumulate within fetal livers, lungs, and intestines with higher efficiency and safety compared to benchmark delivery systems, DLin-MC3-DMA and jetPEI. We demonstrate that LNPs can deliver mRNAs to induce hepatic production of therapeutic secreted proteins. These LNPs may provide a platform for in utero mRNA delivery for protein replacement and gene editing
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
- Author
- Adarmes-Gómez Astrid D
- Agee Michelle
- Aguilar Miquel
- Aitkulova Akbota
- Akhmetzhanov Vadim
- Alcalay Roy N
- Alipanahi Babak
- Alvarez Ignacio
- Alvarez Victoria
- Anderson Tim
- Andreassen Ole A
- Auton Adam
- Bandres-Ciga Sara
- Bandres-Ciga Sara
- Bangale Tushar
- Barrero Francisco Javier
- Bell Robert K
- Bentley Steven
- Bergareche Yarza Jesús Alberto
- Bernal-Bernal Inmaculada
- Billingsley Kimberley
- Blauwendraat Cornelis
- Blauwendraat Cornelis
- Blazquez Marta
- Bonilla-Toribio Marta
- Botia Juan A
- Botía Juan A
- Boungiorno María Teresa
- Bras Jose
- Bras Jose
- Brice Alexis
- Brice Alexis
- Brockmann Kathrin
- Bryc Katarzyna
- Bubb Vivien
- Buiza-Rueda Dolores
- Carrillo Fátima
- Carrión-Claro Mario
- Cerdan Debora
- Chang Diana
- Chelban Viorica
- Clarimón Jordi
- Clarke Carl
- Compta Yaroslau
- Cookson Mark R
- Corvol Jean-Christophe
- Corvol Jean-Christophe
- Craig David W
- Cámara Ana
- Dalrymple-Alford John
- Danjou Fabrice
- Diez-Fairen Monica
- Dols-Icardo Oriol
- Duarte Jacinto
- Duran Raquel
- Elson Sarah L
- Escamilla-Sevilla Francisco
- Escott-Price Valentina
- Ezquerra Mario
- Faghri Faraz
- Faghri Faraz
- Feliz Cici
- Fernández Manel
- Fernández-Santiago Rubén
- Finkbeiner Steven
- Foltynie Thomas
- Fontanillas Pierre
- Fowdar Javed
- Furlotte Nicholas A
- Gan-Or Ziv
- Gan-Or Ziv
- Garcia Ciara
- García-Ruiz Pedro
- Gasser Thomas
- Gasser Thomas
- Gibbs J Raphael
- Gibbs J Raphael
- Gomez Heredia Maria Jose
- Gonzalez-Aramburu Isabel
- González Manuel Menéndez
- Graham Robert R
- Gratten Jacob
- Gratten Jacob
- Guelfi Sebastian
- Guerreiro Rita
- Gómez-Garre Pilar
- Halliday Glenda
- Hardy John
- Hardy John A
- Hassin-Baer Sharon
- Heilbron Karl
- Henders Anjali K
- Hernandez Dena G
- Hernandez Dena G
- Heutink Peter
- Heutink Peter
- Hickie Ian
- Hicks Barry
- Hinds David A
- Hoenicka Janet
- Holmans Peter
- Houlden Henry
- Huber Karen E
- Infante Jon
- Iwaki Hirotaka
- Iwaki Hirotaka
- Jankovic Joseph
- Jesús Silvia
- Jewett Ethan M
- Jiang Yunxuan
- Jimenez-Escrig Adriano
- Kaishybayeva Gulnaz
- Kaiyrzhanov Rauan
- Karimova Altynay
- Kassam Irfahan
- Kennedy Martin
- Kia Demis A
- Kia Demis A
- Kinghorn Kerri J
- Kleinman Aaron
- Koks Sulev
- Krohn Lynne
- Krohn Lynne
- Kulisevsky Jaime
- Kwok John
- Labrador-Espinosa Miguel A
- Leonard Hampton
- Leonard Hampton L
- Lesage Suzanne
- Lesage Suzanne
- Lewis Patrick
- Lewis Simon
- Lin Keng-Han
- Litterman Nadia K
- Lopez-Sendon Jose Luis
- Lovering Ruth
- Lubbe Steven
- Lungu Codrin
- Macias Daniel
- Majamaa Kari
- Majamaa Kari
- Manzoni Claudia
- Marinus Johan
- Marti Maria Jose
- Martinez Maria
- Martinez Maria
- Martínez Torres Irene
- Martínez-Castrillo Juan Carlos
- Marín Juan
- Mata Marina
- McCreight Jennifer C
- McIntyre Matthew H
- McManus Kimberly F
- Mellick George
- Mencacci Niccolo E
- Middlehurst Ben
- Mir Pablo
- Mok Kin Y
- Montgomery Grant
- Morris Huw R
- Morris Huw R
- Mountain Joanna L
- Muñoz Esteban
- Méndez-del-Barrio Carlota
- Mínguez Adolfo
- Nalls Mike A
- Nalls Mike A
- Narendra Derek
- Noblin Elizabeth S
- Northover Carrie AM
- Noyce Alastair J
- Noyce Alastair J
- Ojo Oluwadamilola O
- Okubadejo Njideka U
- Pagola Ana Gorostidi
- Pastor Pau
- Pearson John
- Perez Errazquin Francisco
- Periñán-Tocino Teresa
- Pihlstrom Lasse
- Pihlstrøm Lasse
- Pitcher Toni
- Pitts Steven J
- Plun-Favreau Helene
- Poznik G David
- Quinn John
- R'Bibo Lea
- Reed Xylena
- Reich Stephen
- Rezola Elisabet Mondragon
- Rizig Mie
- Rizzu Patrizia
- Robak Laurie
- Rodriguez Antonio Sanchez
- Rouleau Guy A
- Ruiz-Martínez Javier
- Ruz Clara
- Ryten Mina
- Sadykova Dinara
- Sathirapongsasuti J Fah
- Savitt Joseph
- Scholz Sonja W
- Scholz Sonja W
- Schreglmann Sebastian
- Schulte Claudia
- Schulte Claudia
- Sharma Manu
- Sharma Manu
- Shashkin Chingiz
- Shelton Janie F
- Shringarpure Suyash
- Shulman Joshua M
- Shulman Joshua M
- Shulman Lisa M
- Shulman Lisa M
- Sidorenko Julia
- Sierra María
- Siitonen Ari
- Siitonen Ari
- Silburn Peter A
- Simón-Sánchez Javier
- Simón-Sánchez Javier
- Singleton Andrew B
- Singleton Andrew B
- Suarez-Sanmartin Esther
- Sutherland Margaret
- Taba Pille
- Tabernero Cesar
- Tan Manuela
- Tan Manuela X
- Tartari Juan Pablo
- Tejera-Parrado Cristina
- Tian Chao
- Tienari Pentti
- Toft Mathias
- Toft Mathias
- Tolosa Eduard
- Trabzuni Daniah
- Tung Joyce
- Vacic Vladimir
- Valldeoriola Francesc
- Vallerga Costanza L
- Vallerga Costanza L
- van Hilten Jacobus J
- Van Keuren-Jensen Kendall
- Vargas-González Laura
- Vela Lydia
- Visscher Peter M
- Visscher Peter M
- Vives Francisco
- von Coelln Rainer
- von Coelln Rainer
- Wallace Leanne
- Wang Xin
- Williams Nigel
- Wilson Catherine H
- Wood Nicholas W
- Wood Nicholas W
- Wray Naomi R
- Xue Angli
- Xue Angli
- Yang Jian
- Yang Jian
- Ylikotila Pauli
- Young Emily
- Zhang Futao
- Zharkinbekova Nazira
- Zharmukhanov Zharkyn
- Zholdybayeva Elena
- Zimprich Alexander
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/12/2019
- Field of study
Background Genome-wide association studies (GWAS) in Parkinson's disease have increased the scope of biological knowledge about the disease over the past decade. We aimed to use the largest aggregate of GWAS data to identify novel risk loci and gain further insight into the causes of Parkinson's disease. Methods We did a meta-analysis of 17 datasets from Parkinson's disease GWAS available from European ancestry samples to nominate novel loci for disease risk. These datasets incorporated all available data. We then used these data to estimate heritable risk and develop predictive models of this heritability. We also used large gene expression and methylation resources to examine possible functional consequences as well as tissue, cell type, and biological pathway enrichments for the identified risk factors. Additionally, we examined shared genetic risk between Parkinson's disease and other phenotypes of interest via genetic correlations followed by Mendelian randomisation. Findings Between Oct 1, 2017, and Aug 9, 2018, we analysed 7·8 million single nucleotide polymorphisms in 37 688 cases, 18 618 UK Biobank proxy-cases (ie, individuals who do not have Parkinson's disease but have a first degree relative that does), and 1·4 million controls. We identified 90 independent genome-wide significant risk signals across 78 genomic regions, including 38 novel independent risk signals in 37 loci. These 90 variants explained 16–36% of the heritable risk of Parkinson's disease depending on prevalence. Integrating methylation and expression data within a Mendelian randomisation framework identified putatively associated genes at 70 risk signals underlying GWAS loci for follow-up functional studies. Tissue-specific expression enrichment analyses suggested Parkinson's disease loci were heavily brain-enriched, with specific neuronal cell types being implicated from single cell data. We found significant genetic correlations with brain volumes (false discovery rate-adjusted p=0·0035 for intracranial volume, p=0·024 for putamen volume), smoking status (p=0·024), and educational attainment (p=0·038). Mendelian randomisation between cognitive performance and Parkinson's disease risk showed a robust association (p=8·00 × 10−7). Interpretation These data provide the most comprehensive survey of genetic risk within Parkinson's disease to date, to the best of our knowledge, by revealing many additional Parkinson's disease risk loci, providing a biological context for these risk factors, and showing that a considerable genetic component of this disease remains unidentified. These associations derived from European ancestry datasets will need to be followed-up with more diverse data. Funding The National Institute on Aging at the National Institutes of Health (USA), The Michael J Fox Foundation, and The Parkinson's Foundation (see appendix for full list of funding sources)
Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
- Author
- Aali Amirali
- Abate Yohannes Habtegiorgis
- Abbafati Cristiana
- Abbastabar Hedayat
- Abd ElHafeez Samar
- Abd-Elsalam Sherief
- Abdelmasseh Michael
- Abdollahi Arash
- Abdullahi Auwal
- Abegaz Kedir Hussein
- Abeldaño Zuñiga Roberto Ariel
- Aboagye Richard Gyan
- Abolhassani Hassan
- Abreu Lucas Guimarães
- Abu-Gharbieh Eman
- Abu-Rmeileh Niveen ME
- Abualruz Hasan
- Ackerman Ilana N
- Addo Isaac Yeboah
- Addolorato Giovanni
- Adebiyi Akindele Olupelumi
- Adepoju Abiola Victor
- Adewuyi Habeeb Omoponle
- Afyouni Shadi
- Afzal Saira
- Afzal Sina
- Agodi Antonella
- Ahmad Aqeel
- Ahmad Danish
- Ahmad Firdos
- Ahmad Shahzaib
- Ahmed Ali
- Ahmed Luai A
- Ahmed Muktar Beshir
- Ajami Marjan
- Akinosoglou Karolina
- Akkaif Mohammed Ahmed
- Al Hasan Syed Mahfuz
- Al-Aly Ziyad
- Al-Gheethi Adel Ali Saeed
- Al-Marwani Sabah
- Al-Omari Basem
- Al-Wardat Mohammad Sami
- Al-Worafi Yaser Mohammed
- Alalalmeh Samer O
- Albashtawy Mohammed
- Aldridge Robert W
- Alemu Meseret Desalegn
- Alemu Yihun Mulugeta
- Alene Kefyalew Addis
- Alharrasi Maryam
- Alhassan Robert Kaba
- Ali Mohammed Usman
- Ali Rafat
- Ali Syed Shujait Shujait
- Alif Sheikh Mohammad
- Aljunid Syed Mohamed
- Almazan Joseph Uy
- Alomari Mahmoud A
- Altaany Zaid
- Alvis-Guzman Nelson
- Alvis-Zakzuk Nelson J
- Alwafi Hassan
- Aly Safwat
- Alzoubi Karem H
- Amare Azmeraw T
- Amegbor Prince M
- Ameyaw Edward Kwabena
- Amin Tarek Tawfik
- Amindarolzarbi Alireza
- Amiri Sohrab
- Amugsi Dickson A
- Ancuceanu Robert
- Anderlini Deanna
- Anderson David B
- Andrade Pedro Prata
- Andrei Catalina Liliana
- Ansari Hossein
- Antony Catherine M
- Anwar Saleha
- Anwar Sumadi Lukman
- Anwer Razique
- Anyanwu Philip Emeka
- Arab Juan Pablo
- Arabloo Jalal
- Arafat Mosab
- Araki Daniel T
- Aravkin Aleksandr Y
- Arkew Mesay
- Armocida Benedetta
- Arndt Michael Benjamin
- Arooj Mahwish
- Artamonov Anton A
- Aruleba Raphael Taiwo
- Arumugam Ashokan
- Ashbaugh Charlie
- Ashemo Mubarek Yesse
- Ashraf Muhammad
- Asika Marvellous O
- Askari Elaheh
- Astell-Burt Thomas
- Athari Seyyed Shamsadin
- Atorkey Prince
- Atout Maha Moh'd Wahbi
- Atreya Alok
- Aujayeb Avinash
- Ausloos Marcel
- Avan Abolfazl
- Awotidebe Adedapo Wasiu
- Awuviry-Newton Kofi
- Ayala Quintanilla Beatriz Paulina
- Ayuso-Mateos Jose L
- Azadnajafabad Sina
- Azevedo Rui M S
- Babu Abraham Samuel
- Badar Muhammad
- Badiye Ashish D
- Baghdadi Soroush
- Bagheri Nasser
- Bah Sulaiman
- Bai Ruhai
- Baker Jennifer L
- Bakkannavar Shankar M
- Bako Abdulaziz T
- Balakrishnan Senthilkumar
- Bam Kiran
- Banik Palash Chandra
- Barchitta Martina
- Bardhan Mainak
- Bardideh Erfan
- Barker-Collo Suzanne Lyn
- Barqawi Hiba Jawdat
- Barrow Amadou
- Barteit Sandra
- Barua Lingkan
- Bashiri Aliabadi Somaye
- Basiru Afisu
- Basu Sanjay
- Basu Saurav
- Bathini Prapthi Persis
- Batra Kavita
- Baune Bernhard T
- Bayileyegn Nebiyou Simegnew
- Behnam Babak
- Behnoush Amir Hossein
- Beiranvand Maryam
- Bejarano Ramirez Diana Fernanda
- Bell Michelle L
- Bello Olorunjuwon Omolaja
- Beloukas Apostolos
- Bensenor Isabela M
- Berezvai Zombor
- Bernabe Eduardo
- Bernstein Robert S
- Bettencourt Paulo J G
- Bhagavathula Akshaya Srikanth
- Bhala Neeraj
- Bhandari Dinesh
- Bhargava Ashish
- Bhaskar Sonu
- Bhat Vivek
- Bhatti Gurjit Kaur
- Bhatti Jasvinder Singh
- Bhatti Manpreet S
- Bhatti Rajbir
- Bhutta Zulfiqar A
- Bikbov Boris
- Bishai Jessica Devin
- Bisignano Catherine
- Bitra Veera R
- Bjørge Tone
- Bodolica Virginia
- Bodunrin Aadam Olalekan
- Bogale Eyob Ketema
- Bonakdar Hashemi Milad
- Bonny Aime
- Bora Basara Berrak
- Borhany Hamed
- Boxe Christopher
- Brady Oliver J
- Bragazzi Nicola Luigi
- Braithwaite Dejana
- Brant Luisa C
- Brauer Michael
- Breitner Susanne
- Brenner Hermann
- Brown Julie
- Brugha Traolach
- Bulamu Norma B
- Buonsenso Danilo
- Burkart Katrin
- Burns Richard A
- Busse Reinhard
- Bustanji Yasser
- Butt Zahid A
- Byun Justin
- Caetano dos Santos Florentino Luciano
- Calina Daniela
- Campos-Nonato Ismael R
- Cao Chao
- Capodici Angelo
- Carr Sinclair
- Carreras Giulia
- Carugno Andrea
- Carvalho Márcia
- Castaldelli-Maia Joao Mauricio
- Castañeda-Orjuela Carlos A
- Castelpietra Giulio
- Catapano Alberico L
- Cattaruzza Maria Sofia
- Caye Arthur
- Cámera Luis Alberto
- Cegolon Luca
- Cembranel Francieli
- Cenderadewi Muthia
- Cerin Ester
- Chakraborty Promit Ananyo
- Chan Jeffrey Shi Kai
- Chan Raymond N C
- Chandika Rama Mohan
- Chandrasekar Eeshwar K
- Charalampous Periklis
- Chattu Vijay Kumar
- Chatzimavridou-Grigoriadou Victoria
- Chen An-Tian
- Chen Angela W
- Chen Catherine S
- Chen Haowei
- Chen Nathalie M
- Cheng Esther T W
- Chimed-Ochir Odgerel
- Chimoriya Ritesh
- Ching Patrick R
- Cho William C S
- Choi Sungchul
- Chong Bryan
- Chong Yuen Yu
- Choudhari Sonali Gajanan
- Chowdhury Rajiv
- Christensen Steffan Wittrup McPhee
- Chu Dinh-Toi
- Chukwu Isaac Sunday
- Chung Eric
- Chung Eunice
- Chutiyami Muhammad
- Claassens Mareli M
- Cogen Rebecca M
- Columbus Alyssa
- Conde Joao
- Cortesi Paolo Angelo
- Cousin Ewerton
- Criqui Michael H
- Cruz-Martins Natália
- D'Oria Mario
- Dadras Omid
- Dai Siyu
- Dai Xiaochen
- Dai Zhaoli
- Dalaba Maxwell Ayindenaba
- Damiani Giovanni
- Das Jai K
- Das Saswati
- Dashti Mohsen
- Davletov Kairat
- Dávila-Cervantes Claudio Alberto
- De Leo Diego
- Debele Aklilu Tamire
- Debopadhaya Shayom
- DeCleene Nicole K
- Deeba Farah
- Degenhardt Louisa
- Del Bo' Cristian
- Delgado-Enciso Ivan
- Demetriades Andreas K
- Denova-Gutiérrez Edgar
- Dervenis Nikolaos
- Desai Hardik Dineshbhai
- Desai Rupak
- Deuba Keshab
- Dhama Kuldeep
- Dharmaratne Samath Dhamminda
- Dhingra Sameer
- Dias da Silva Diana
- Diaz Daniel
- Diaz Luis Antonio
- Diaz Michael J
- Dima Adriana
- Ding Delaney D
- Dirac M Ashworth
- do Prado Camila Bruneli
- Do Thao Huynh Phuong
- Dohare Sushil
- Dominguez Regina-Mae Villanueva
- Dong Wanyue
- Dongarwar Deepa
- Dorsey E Ray
- Doshmangir Leila
- Dowou Robert Kokou
- Driscoll Tim Robert
- Dsouza Haneil Larson
- Dsouza Viola
- Dube John
- Dumith Samuel C
- Duncan Bruce B
- Duraes Andre Rodrigues
- Duraisamy Senbagam
- Durojaiye Oyewole Christopher
- Dzianach Paulina Agnieszka
- Dziedzic Arkadiusz Marian
- Eboreime Ejemai
- Ebrahimi Alireza
- Edinur Hisham Atan
- Edvardsson David
- Eikemo Terje Andreas
- Eini Ebrahim
- Ekholuenetale Michael
- Ekundayo Temitope Cyrus
- El Sayed Iman
- El Tantawi Maha
- Elbarazi Iffat
- Elemam Noha Mousaad
- ElGohary Ghada Metwally Tawfik
- Elhadi Muhammed
- Elmeligy Omar Abdelsadek Abdou
- ELNahas Gihan
- Elshaer Mohammed
- Elsohaby Ibrahim
- Engelbert Bain Luchuo
- Erkhembayar Ryenchindorj
- Eshrati Babak
- Estep Kara
- Fabin Natalia
- Fagbamigbe Adeniyi Francis
- Falzone Luca
- Fareed Mohammad
- Farinha Carla Sofia e Sá
- Faris MoezAlIslam Ezzat Mahmoud
- Faro Andre
- Farrokhi Pegah
- Fatehizadeh Ali
- Fauk Nelsensius Klau
- Feigin Valery L
- Feng Xiaoqi
- Fereshtehnejad Seyed-Mohammad
- Feroze Abdullah Hamid
- Ferrari Alize J
- Ferreira Nuno
- Ferreira Paulo H
- Fischer Florian
- Flavel Joanne
- Flood David
- Flor Luisa S
- Foigt Nataliya A
- Folayan Morenike Oluwatoyin
- Force Lisa M
- Fortuna Daniela
- Foschi Matteo
- Franklin Richard Charles
- Freitas Alberto
- Fukumoto Takeshi
- Furtado João M
- Gaal Peter Andras
- Gadanya Muktar A
- Gaidhane Abhay Motiramji
- Gaihre Santosh
- Galali Yaseen
- Ganbat Mandukhai
- Gandhi Aravind P
- Ganesan Balasankar
- Ganie Mohd Ashraf
- Ganiyani Mohammad Arfat
- Gardner William M
- Gebi Tilaye Gebru
- Gebregergis Miglas W
- Gebrehiwot Mesfin
- Gebremariam Tesfay B B
- Gebremeskel Teferi Gebru
- Gela Yibeltal Yismaw
- Georgescu Simona Roxana
- Getachew Obsa Abera
- Gething Peter W
- Getie Molla
- Ghadiri Keyghobad
- Ghadirian Fataneh
- Ghailan Khalid Yaser
- Ghajar Alireza
- Ghasemi MohammadReza
- Ghasempour Dabaghi Ghazal
- Ghasemzadeh Afsaneh
- Ghazy Ramy Mohamed
- Gholamrezanezhad Ali
- Ghorbani Mahsa
- Ghotbi Elena
- Gibson Ruth Margaret
- Gill Tiffany K
- Ginindza Themba G
- Girmay Alem
- Glasbey James C
- Godinho Myron Anthony
- Goharinezhad Salime
- Goldust Mohamad
- Golechha Mahaveer
- Goleij Pouya
- Gona Philimon N
- Gorini Giuseppe
- Goulart Alessandra C
- Göbölös Laszlo
- Grada Ayman
- Grivna Michal
- Guan Shi-Yang
- Guarducci Giovanni
- Gubari Mohammed Ibrahim Mohialdeen
- Gudeta Mesay Dechasa
- Guha Avirup
- Guicciardi Stefano
- Gulati Snigdha
- Gulisashvili David
- Gunawardane Damitha Asanga
- Guo Cui
- Gupta Anish Kumar
- Gupta Bhawna
- Gupta Ishita
- Gupta Mohak
- Gupta Rajeev
- Gupta Veer Bala
- Gupta Vijai Kumar
- Gupta Vivek Kumar
- Gutiérrez Reyna Alma
- Habibzadeh Farrokh
- Habibzadeh Parham
- Haddadi Rasool
- Hadi Najah R
- Haep Nils
- Hafezi-Nejad Nima
- Hafiz Abdul
- Hagins Hailey
- Halboub Esam S
- Halimi Aram
- Haller Sebastian
- Halwani Rabih
- Hamilton Erin B
- Hankey Graeme J
- Hannan Md Abdul
- Haque Md Nuruzzaman
- Harapan Harapan
- Haro Josep Maria
- Hartvigsen Jan
- Hasaballah Ahmed I
- Hasan Ikramul
- Hasanian Mohammad
- Hasnain Md Saquib
- Hassan Amr
- Haubold Johannes
- Havmoeller Rasmus J
- Hay Simon I
- Hayat Khezar
- Hebert Jeffrey J
- Hegazi Omar E
- Heidari Golnaz
- Helfer Bartosz
- Hemmati Mehdi
- Hendrie Delia
- Henson Claire A
- Hezam Kamal
- Hiraike Yuta
- Hoan Nguyen Quoc
- Holla Ramesh
- Hon Julia
- Hossain Md Mahbub
- Hosseinzadeh Hassan
- Hosseinzadeh Mehdi
- Hostiuc Mihaela
- Hostiuc Sorin
- Hsu Johnathan M
- Huang Junjie
- Hugo Fernando N
- Hushmandi Kiavash
- Hussain Javid
- Hussein Nawfal R
- Huynh Chantal K
- Huynh Hong-Han
- Hwang Bing-Fang
- Iannucci Vincent C
- Ihler Audrey L
- Ikiroma Adalia I
- Ikuta Kevin S
- Ilesanmi Olayinka Stephen
- Ilic Irena M
- Ilic Milena D
- Imam Mohammad Tarique
- Immurana Mustapha
- Irham Lalu Muhammad
- Islam Md Rabiul
- Islam Sheikh Mohammed Shariful
- Islami Farhad
- Ismail Faisal
- Ismail Nahlah Elkudssiah
- Isola Gaetano
- Iwagami Masao
- Iwu Chidozie C D
- Iyer Mahalaxmi
- Jaafari Jalil
- Jacobsen Kathryn H
- Jadidi-Niaragh Farhad
- Jafarinia Morteza
- Jaggi Khushleen
- Jahankhani Kasra
- Jahanmehr Nader
- Jahrami Haitham
- Jain Akhil
- Jain Nityanand
- Jairoun Ammar Abdulrahman
- Jaiswal Abhishek
- Jakovljevic Mihajlo
- Jatau Abubakar Ibrahim
- Javadov Sabzali
- Javaheri Tahereh
- Jayapal Sathish Kumar
- Jayaram Shubha
- Jee Sun Ha
- Jeganathan Jayakumar
- Jeyakumar Angeline
- Jha Anil K
- Jiang Heng
- Jin Yinzi
- Jonas Jost B
- Joo Tamas
- Joseph Abel
- Joseph Nitin
- Joshua Charity Ehimwenma
- Jozwiak Jacek Jerzy
- Jürisson Mikk
- K Vaishali
- Kaambwa Billingsley
- Kabir Ali
- Kabir Zubair
- Kadashetti Vidya
- Kalani Rizwan
- Kalankesh Leila R
- Kaliyadan Feroze
- Kalra Sanjay
- Kamenov Kaloyan
- Kamyari Naser
- Kanagasabai Thanigaivelan
- Kandel Himal
- Kanmanthareddy Arun R
- Kanmodi Kehinde Kazeem
- Kantar Rami S
- Karaye Ibraheem M
- Karim Asima
- Karimi Salah Eddin
- Karimi Yeganeh
- Kasraei Hengameh
- Kassel Molly B
- Kauppila Joonas H
- Kawakami Norito
- Kayode Gbenga A
- Kazemi Foad
- Kazemian Sina
- Keikavoosi-Arani Leila
- Keller Cathleen
- Kempen John H
- Kerr Jessica A
- Keshtkar Kamyab
- Kesse-Guyot Emmanuelle
- Keykhaei Mohammad
- Khajuria Himanshu
- Khalaji Amirmohammad
- Khalid Asaad
- Khalid Nauman
- Khalilian Alireza
- Khamesipour Faham
- Khan Asaduzzaman
- Khan Ikramullah
- Khan Maseer
- Khan Moien AB
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- Xia Yanjie
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- Xu Yvonne Yiru
- Yadav Lalit
- Yadollahpour Ali
- Yaghoubi Sajad
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- Yang Lin
- Yano Yuichiro
- Yao Yao
- Yaribeygi Habib
- Yazdanpanah Mohammad Hosein
- Ye Pengpeng
- Yehualashet Sisay Shewasinad
- Yesuf Subah Abderehim
- Yezli Saber
- Yigzaw Zeamanuel Anteneh
- Yiğit Arzu
- Yiğit Vahit
- Yismaw Yazachew
- Yon Dong Keon
- Yonemoto Naohiro
- Younis Mustafa Z
- Yu Chuanhua
- Yu Yong
- Yusuf Hadiza
- Zahid Mondal Hasan
- Zakham Fathiah
- Zaki Leila
- Zaki Nazar
- Zaman Burhan Abdullah
- Zamora Nelson
- Zand Ramin
- Zandieh Ghazal G Z
- Zar Heather J
- Zarrintan Armin
- Zastrozhin Mikhail Sergeevich
- Zhang Haijun
- Zhang Ning
- Zhang Yunquan
- Zhao Hanqing
- Zhong Chenwen
- Zhong Panliang
- Zhou Juexiao
- Zhu Zhaohua
- Ziafati Makan
- Zielińska Magdalena
- Zimsen Stephanie R M
- Zoladl Mohammad
- Zumla Alimuddin
- Zyoud Samer H
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Detailed, comprehensive, and timely reporting on population health by underlying causes of disability and premature death is crucial to understanding and responding to complex patterns of disease and injury burden over time and across age groups, sexes, and locations. The availability of disease burden estimates can promote evidence-based interventions that enable public health researchers, policy makers, and other professionals to implement strategies that can mitigate diseases. It can also facilitate more rigorous monitoring of progress towards national and international health targets, such as the Sustainable Development Goals. For three decades, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) has filled that need. A global network of collaborators contributed to the production of GBD 2021 by providing, reviewing, and analysing all available data. GBD estimates are updated routinely with additional data and refined analytical methods. GBD 2021 presents, for the first time, estimates of health loss due to the COVID-19 pandemic. Methods: The GBD 2021 disease and injury burden analysis estimated years lived with disability (YLDs), years of life lost (YLLs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries using 100 983 data sources. Data were extracted from vital registration systems, verbal autopsies, censuses, household surveys, disease-specific registries, health service contact data, and other sources. YLDs were calculated by multiplying cause-age-sex-location-year-specific prevalence of sequelae by their respective disability weights, for each disease and injury. YLLs were calculated by multiplying cause-age-sex-location-year-specific deaths by the standard life expectancy at the age that death occurred. DALYs were calculated by summing YLDs and YLLs. HALE estimates were produced using YLDs per capita and age-specific mortality rates by location, age, sex, year, and cause. 95% uncertainty intervals (UIs) were generated for all final estimates as the 2·5th and 97·5th percentiles values of 500 draws. Uncertainty was propagated at each step of the estimation process. Counts and age-standardised rates were calculated globally, for seven super-regions, 21 regions, 204 countries and territories (including 21 countries with subnational locations), and 811 subnational locations, from 1990 to 2021. Here we report data for 2010 to 2021 to highlight trends in disease burden over the past decade and through the first 2 years of the COVID-19 pandemic. Findings: Global DALYs increased from 2·63 billion (95% UI 2·44–2·85) in 2010 to 2·88 billion (2·64–3·15) in 2021 for all causes combined. Much of this increase in the number of DALYs was due to population growth and ageing, as indicated by a decrease in global age-standardised all-cause DALY rates of 14·2% (95% UI 10·7–17·3) between 2010 and 2019. Notably, however, this decrease in rates reversed during the first 2 years of the COVID-19 pandemic, with increases in global age-standardised all-cause DALY rates since 2019 of 4·1% (1·8–6·3) in 2020 and 7·2% (4·7–10·0) in 2021. In 2021, COVID-19 was the leading cause of DALYs globally (212·0 million [198·0–234·5] DALYs), followed by ischaemic heart disease (188·3 million [176·7–198·3]), neonatal disorders (186·3 million [162·3–214·9]), and stroke (160·4 million [148·0–171·7]). However, notable health gains were seen among other leading communicable, maternal, neonatal, and nutritional (CMNN) diseases. Globally between 2010 and 2021, the age-standardised DALY rates for HIV/AIDS decreased by 47·8% (43·3–51·7) and for diarrhoeal diseases decreased by 47·0% (39·9–52·9). Non-communicable diseases contributed 1·73 billion (95% UI 1·54–1·94) DALYs in 2021, with a decrease in age-standardised DALY rates since 2010 of 6·4% (95% UI 3·5–9·5). Between 2010 and 2021, among the 25 leading Level 3 causes, age-standardised DALY rates increased most substantially for anxiety disorders (16·7% [14·0–19·8]), depressive disorders (16·4% [11·9–21·3]), and diabetes (14·0% [10·0–17·4]). Age-standardised DALY rates due to injuries decreased globally by 24·0% (20·7–27·2) between 2010 and 2021, although improvements were not uniform across locations, ages, and sexes. Globally, HALE at birth improved slightly, from 61·3 years (58·6–63·6) in 2010 to 62·2 years (59·4–64·7) in 2021. However, despite this overall increase, HALE decreased by 2·2% (1·6–2·9) between 2019 and 2021. Interpretation: Putting the COVID-19 pandemic in the context of a mutually exclusive and collectively exhaustive list of causes of health loss is crucial to understanding its impact and ensuring that health funding and policy address needs at both local and global levels through cost-effective and evidence-based interventions. A global epidemiological transition remains underway. Our findings suggest that prioritising non-communicable disease prevention and treatment policies, as well as strengthening health systems, continues to be crucially important. The progress on reducing the burden of CMNN diseases must not stall; although global trends are improving, the burden of CMNN diseases remains unacceptably high. Evidence-based interventions will help save the lives of young children and mothers and improve the overall health and economic conditions of societies across the world. Governments and multilateral organisations should prioritise pandemic preparedness planning alongside efforts to reduce the burden of diseases and injuries that will strain resources in the coming decades. Funding: Bill & Melinda Gates Foundation
Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
- Author
- Aali Amirali
- Abbafati Cristiana
- Abbas Jaffar
- Abbasgholizadeh Rouzbeh
- Abbasi Madineh Akram
- Abbasian Mohammadreza
- Abd ElHafeez Samar
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- Abdelmasseh Michael
- Abdelwahab Ahmed
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- Adetunji Charles Oluwaseun
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- Al Qadire Mohammad
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- Al-Gheethi Adel Ali Saeed
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- Alanzi Turki M
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- AlBataineh Mohammad T
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- Alhabib Khalid F
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- Zhu Zhaohua
- Ziaeefar Pardis
- Zielińska Magdalena
- Zou Zhiyong
- Zumla Alimuddin
- Zweck Elric
- Zyoud Samer H
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides new demographic estimates for 204 countries and territories and 811 additional subnational locations from 1950 to 2021, with a particular emphasis on changes in mortality and life expectancy that occurred during the 2020–21 COVID-19 pandemic period. Methods: 22 223 data sources from vital registration, sample registration, surveys, censuses, and other sources were used to estimate mortality, with a subset of these sources used exclusively to estimate excess mortality due to the COVID-19 pandemic. 2026 data sources were used for population estimation. Additional sources were used to estimate migration; the effects of the HIV epidemic; and demographic discontinuities due to conflicts, famines, natural disasters, and pandemics, which are used as inputs for estimating mortality and population. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate under-5 mortality rates, which synthesised 30 763 location-years of vital registration and sample registration data, 1365 surveys and censuses, and 80 other sources. ST-GPR was also used to estimate adult mortality (between ages 15 and 59 years) based on information from 31 642 location-years of vital registration and sample registration data, 355 surveys and censuses, and 24 other sources. Estimates of child and adult mortality rates were then used to generate life tables with a relational model life table system. For countries with large HIV epidemics, life tables were adjusted using independent estimates of HIV-specific mortality generated via an epidemiological analysis of HIV prevalence surveys, antenatal clinic serosurveillance, and other data sources. Excess mortality due to the COVID-19 pandemic in 2020 and 2021 was determined by subtracting observed all-cause mortality (adjusted for late registration and mortality anomalies) from the mortality expected in the absence of the pandemic. Expected mortality was calculated based on historical trends using an ensemble of models. In location-years where all-cause mortality data were unavailable, we estimated excess mortality rates using a regression model with covariates pertaining to the pandemic. Population size was computed using a Bayesian hierarchical cohort component model. Life expectancy was calculated using age-specific mortality rates and standard demographic methods. Uncertainty intervals (UIs) were calculated for every metric using the 25th and 975th ordered values from a 1000-draw posterior distribution. Findings: Global all-cause mortality followed two distinct patterns over the study period: age-standardised mortality rates declined between 1950 and 2019 (a 62·8% [95% UI 60·5–65·1] decline), and increased during the COVID-19 pandemic period (2020–21; 5·1% [0·9–9·6] increase). In contrast with the overall reverse in mortality trends during the pandemic period, child mortality continued to decline, with 4·66 million (3·98–5·50) global deaths in children younger than 5 years in 2021 compared with 5·21 million (4·50–6·01) in 2019. An estimated 131 million (126–137) people died globally from all causes in 2020 and 2021 combined, of which 15·9 million (14·7–17·2) were due to the COVID-19 pandemic (measured by excess mortality, which includes deaths directly due to SARS-CoV-2 infection and those indirectly due to other social, economic, or behavioural changes associated with the pandemic). Excess mortality rates exceeded 150 deaths per 100 000 population during at least one year of the pandemic in 80 countries and territories, whereas 20 nations had a negative excess mortality rate in 2020 or 2021, indicating that all-cause mortality in these countries was lower during the pandemic than expected based on historical trends. Between 1950 and 2021, global life expectancy at birth increased by 22·7 years (20·8–24·8), from 49·0 years (46·7–51·3) to 71·7 years (70·9–72·5). Global life expectancy at birth declined by 1·6 years (1·0–2·2) between 2019 and 2021, reversing historical trends. An increase in life expectancy was only observed in 32 (15·7%) of 204 countries and territories between 2019 and 2021. The global population reached 7·89 billion (7·67–8·13) people in 2021, by which time 56 of 204 countries and territories had peaked and subsequently populations have declined. The largest proportion of population growth between 2020 and 2021 was in sub-Saharan Africa (39·5% [28·4–52·7]) and south Asia (26·3% [9·0–44·7]). From 2000 to 2021, the ratio of the population aged 65 years and older to the population aged younger than 15 years increased in 188 (92·2%) of 204 nations. Interpretation: Global adult mortality rates markedly increased during the COVID-19 pandemic in 2020 and 2021, reversing past decreasing trends, while child mortality rates continued to decline, albeit more slowly than in earlier years. Although COVID-19 had a substantial impact on many demographic indicators during the first 2 years of the pandemic, overall global health progress over the 72 years evaluated has been profound, with considerable improvements in mortality and life expectancy. Additionally, we observed a deceleration of global population growth since 2017, despite steady or increasing growth in lower-income countries, combined with a continued global shift of population age structures towards older ages. These demographic changes will likely present future challenges to health systems, economies, and societies. The comprehensive demographic estimates reported here will enable researchers, policy makers, health practitioners, and other key stakeholders to better understand and address the profound changes that have occurred in the global health landscape following the first 2 years of the COVID-19 pandemic, and longer-term trends beyond the pandemic
Genome-wide structural variant analysis identifies risk loci for non-Alzheimer’s dementias
- Author
- Aarsland Dag
- Adeleye Adelani
- Al-Sarraj Safa
- Alba Camille
- Albert Marilyn S.
- Albert Marilyn S.
- Alcolea Daniel
- Alvarez Jerez Pilar
- Attems Johannes
- Bacikova Dagmar
- Baloh Robert H.
- Barrett Matthew J.
- Beach Thomas G.
- Beach Thomas G.
- Bekris Lynn M.
- Bennett David A.
- Bennett David A.
- Billingsley Kimberley
- Black Sandra E.
- Black Sandra E.
- Boeve Bradley F.
- Boeve Bradley F.
- Bowser Robert
- Brand Harrison
- Brett Francesca
- Brice Alexis
- Brice Alexis
- Broach James
- Calvo Andrea
- Calvo Andrea
- Camu William
- Canosa Antonio
- Chia Ruth
- Chio Adriano
- Chiò Adriano
- Chiò Adriano
- Clarimon Jordi
- Collins Ryan L.
- Cooper-Knock John
- D'Alfonso Sandra
- Dalgard Clifton L.
- Dalgard Clifton L.
- Dalgard Clifton L.
- Dawson Ted M.
- Dawson Ted M.
- De Jager Philip L.
- Dewan Ramita
- Dickson Dennis W.
- Dickson Dennis W.
- Ding Jinhui
- Drepper Carsten
- Drory Vivian E.
- Dunckley Travis L.
- Faber Kelley
- Feldman Eva
- Ferman Tanis
- Ferman Tanis
- Ferrucci Luigi
- Ferrucci Luigi
- Flanagan Margaret E.
- Foroud Tatiana M.
- Foroud Tatiana M.
- Fortea Juan
- Fratta Pietro
- Fujita Masashi
- Gan-Or Ziv
- Gentleman Steve
- Gerhard Glenn
- Ghetti Bernardino
- Ghetti Bernardino
- Gibbs J. Raphael
- Gibbs J. Raphael
- Gibson Summer B.
- Glass Jonathan D.
- Goate Alison
- Goldstein David S.
- Gonzalez-Aramburu Isabel
- Graff-Radford Neill R.
- Graff-Radford Neill R.
- Hardy John A.
- Hardy John A.
- Hardy John A.
- Harms Matthew B.
- Heiman-Patterson Terry D.
- Hodges Angela K.
- Hupalo Daniel N.
- Infante Jon
- Jansson Lilja
- Kaivola Karri
- Kaufmann Horacio
- Keith Julia
- Keith Julia
- Kirby Janine
- Krüger Rejko
- Kukull Walter A.
- Kwan Justin
- Laaksovirta Hannu
- Lage Carmen
- Landers John E.
- Landers John E.
- Landi Francesco
- Le Ber Isabelle
- Lesage Suzanne
- Leverenz James B.
- Lleó Alberto
- Logroscino Giancarlo
- Lopez Grisel
- Lott Nathaniel
- Love Seth
- Lumbroso Serge
- MacGowan Daniel J. L.
- Malik Laksh
- Mao Qinwen
- Maragakis Nicholas J.
- Masellis Mario
- Masellis Mario
- Masliah Eliezer
- May Patrick
- Mazzini Letizia
- McGrath Martinez Elisa
- McKeith Ian G.
- Menon Vilas
- Moglia Cristina
- Monuki Edwin
- Mora Gabriele
- Morris Christopher M.
- Morris Huw R.
- Morris Huw R.
- Mouzat Kevin
- Myllykangas Liisa
- Newell Kathy L.
- Orrell Richard W.
- Ostrow Lyle W.
- Palma Jose-Alberto
- Palmer Laura
- Pamphlett Roger
- Pastor Pau
- Perkins Matthew
- Pickering-Brown Stuart
- Pioro Erik
- Pletnikova Olga
- Pletnikova Olga
- Pollard Harvey B.
- Pulst Stefan M.
- Rasheed Memoona
- Ravits John M.
- Ray Anindita
- Renton Alan E.
- Resnick Susan M.
- Resnick Susan M.
- Robberecht Wim
- Rogaeva Ekaterina
- Rogaeva Ekaterina
- Rosenthal Liana S.
- Rosenthal Liana S.
- Ross Owen A.
- Ross Owen A.
- Rothstein Jeffrey D.
- Ryten Mina
- Ryten Mina
- Sanchez-Juan Pascual
- Scherzer Clemens R.
- Scholz Sonja W.
- Scholz Sonja W.
- Sendtner Michael
- Serrano Geidy E.
- Serrano Geidy E.
- Shakkottai Vikram G.
- Shaw Pamela J.
- Sidle Katie C.
- Sidransky Ellen
- Simmons Zachary
- Singh Jatinder
- Solaiman Sultana
- Soltis Anthony R.
- Stark Ali
- Stein Thor
- Stone David J.
- Sukumar Gauthaman
- Talkowski Michael
- Tanaka Toshiko
- Tanaka Toshiko
- Tayebi Nahid
- Thomas Alan J.
- Tienari Pentti
- Tienari Pentti J.
- Topol Eric
- Topol Eric
- Torkamani Ali
- Torkamani Ali
- Traynor Bryan J.
- Traynor Bryan J.
- Troakes Claire
- Troncoso Juan C.
- Troncoso Juan C.
- Troncoso Juan C.
- Tuck Meila
- Valori Miko
- Van Damme Philip
- Van Deerlin Vivianna M.
- Van Den Bosch Ludo
- Viollet Coralie
- Walton Ronald L.
- Wilkerson Matthew D.
- Woltjer Randy
- Wszolek Zbigniew K.
- Wszolek Zbigniew K.
- Xiromerisiou Georgia
- Zhang Xijun
- Zhao Xuefang
- Zinman Lorne
- Publication venue
- Publication date
- 04/05/2023
- Field of study
We characterized the role of structural variants, a largely unexplored type of genetic variation, in two non-Alzheimer’s dementias, namely Lewy body dementia (LBD) and frontotemporal dementia (FTD)/amyotrophic lateral sclerosis (ALS). To do this, we applied an advanced structural variant calling pipeline (GATK-SV) to short-read whole-genome sequence data from 5,213 European-ancestry cases and 4,132 controls. We discovered, replicated, and validated a deletion in TPCN1 as a novel risk locus for LBD and detected the known structural variants at the C9orf72 and MAPT loci as associated with FTD/ALS. We also identified rare pathogenic structural variants in both LBD and FTD/ALS. Finally, we assembled a catalog of structural variants that can be mined for new insights into the pathogenesis of these understudied forms of dementia
Observation of gravitational waves from the coalescence of a 2.5−4.5 M⊙ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L.
- Arif Shaikh Md
- Aritomi N.
- Armato Federico
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Attadio Francesca
- Aubin Florian
- AVALLONE Guerino
- Azrad D.
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bagui E.
- Baier Jeremy
- Baiotti Luca
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Baral Pratyusava
- Barayoga J. C.
- Barish B. C.
- Barker D.
- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta Dániel
- Bartoletti A. M.
- Barton Mark Andrew
- Bartos I.
- Basak Soummyadip
- Basalaev Artem
- Bassiri Riccardo
- Basti Andrea
- Bates D. E.
- Bawaj Mateusz
- Baxi P.
- Bayley Joseph
- Baylor Amanda
- Baynard II. P. A.
- Bazzan M.
- Bedakihale V. M.
- Beirnaert Freija
- Bejger Michał
- Belardinelli Daniele
- Bell Angus
- Benedetto V.
- Benoit William
- Bentley Joe
- Bera Sayantani
- Berbel Marina
- Bergamin Fabio
- Berger Beverly
- Bernuzzi Sebastiano
- Beroiz Martin
- Berry Christopher P. L.
- Bersanetti Diego
- Bertolini A.
- Betzwieser Joseph
- Beveridge Damon
- Bevins Nathaniel
- Bhandare R.
- Bhardwaj Uddipta
- Bhatt R.
- Bhattacharjee Dripta
- Bhaumik Shubhagata
- Bhowmick S.
- Bianchi A.
- Bilenko I. A.
- Billingsley GariLynn
- Binetti Alberto
- Bini Sophie
- Birnholtz Ofek
- Bisht A.
- Bitossi Massimiliano
- Blackburn Kent
- Blagg L. A.
- Blair C. D.
- Blair D. G.
- Bobba F.
- Bode Nina
- Boileau Guillaume
- Boldrini Mattia
- Bolingbroke Georgia
- Bolliand A.
- Bondarescu Ruxandra
- Bondu François
- Bonilla Carrasquel Edgard
- Bonino A.
- Bonnand Romain
- Booker P.
- Borchers A.
- Boschi Valerio
- Bose S.
- Bossilkov V.
- Boudart Vincent
- Boudon A.
- Bozzi A.
- Bradaschia C.
- Brady Patrick R.
- Braglia Matteo
- Branch A.
- BRANCHESI Marica
- Brandt J.
- Braun I.
- Breschi Matteo
- Briant Tristan
- Brillet A.
- Brinkmann M.
- Brockill P.
- Brockmüller Eike
- Brooks Aidan
- Brown B. C.
- Brown D. D.
- Brunett S.
- Bruno G.
- Bruntz Robert
- Bryant J.
- Bucci F.
- Buchanan J.
- Bulashenko Oleg
- Bulik T.
- Bulten H. J.
- Buonanno Alessandra
- Burtnyk K.
- Buscicchio Riccardo
- Buskulic D.
- Bustillo J. Calderón
- Buy Christelle
- Byer R. L.
- Cabourn Davies Gareth
- Cabras Giuseppe
- Cabrita Ricardo
- Cadonati Laura
- Cagnoli Gianpietro
- Cahillane Craig
- Callister T. A.
- Calloni E.
- Camp J. B.
- Canepa M.
- Caneva Santoro Giada
- Cannon Kipp C.
- Cao H.
- Capistran L. A.
- Capocasa Eleonora
- Capote Elenna
- Carapella G.
- Carbognani F.
- Carlassara M.
- Carlin Julian
- Carolina Silva Oliveira Ana
- Carpinelli Massimo
- Carrillo G.
- Carter Jonathan
- Carullo Gregorio
- Casentini Claudio
- Castro-Lucas S. Y.
- Caudill S.
- Cavaglia Marco
- Cavalieri Roberto
- Cella Giancarlo
- Cerdá-Durán Pablo
- Cesarini Elisabetta
- Chaibi W.
- Chakraborty Pratik
- Chalathadka Subrahmanya Shreevathsa
- Chan M.
- Chandra K.
- Chang R. -J.
- Chao Shiuh
- Char Prasanta
- Charlton E. L.
- Charlton Philip
- Chassande-Mottin Eric
- Chatterjee Chayan
- Chatterjee Debarati
- Chatterjee Deep
- Chattopadhyay Debatri
- Chaturvedi M.
- Chaty Sylvain
- Chatziioannou Katerina
- Chen A.
- Chen A. H. -Y.
- Chen Dan
- Chen H.
- Chen Hsin-Yu
- Chen Junxin
- Chen K. H.
- Chen Y.
- Chen Yanbei
- Chen Yitian
- Cheng H. P.
- Chessa Piero
- Cheung H. T.
- Cheung S. Y.
- Chiadini Francesco
- Chiarini G.
- Chierici R.
- Chincarini Andrea
- Chiofalo Maria Luisa
- Chiummo Antonino
- Chou C.
- Choudhary Sunil
- Christensen Nelson
- Chua Sheon S. Y.
- Chugh P.
- Chun Lung Chan Juno
- Ciani Giacomo
- Ciecieląg Paweł
- Cieślar Marek
- Cifaldi Maria
- Ciolfi Riccardo
- Clara F.
- Clark James
- Clarke J.
- Clarke Teagan
- Clasey Essick Reed
- Claudio Diaz Mario
- Clearwater P.
- Clesse S.
- Coccia E.
- Codazzo Elena
- Cohadon Pierre-François
- Colace Stefano
- Colleoni Marta
- Collette C. G.
- Collins J.
- Colloms S.
- Colombo Alberto
- Colpi Monica
- Compton C. M.
- Concetta Tringali Maria
- Connolly G.
- Conti Livia
- Corbitt Thomas
- Cordero-Carrión Isabel
- Corezzi S.
- Cornish Neil
- Corsi Alessandra
- Cortese Stefano
- Costa C. A.
- Cottingham R.
- Coughlin Michael
- Couineaux A.
- Coulon J. -P.
- Countryman Stefan
- Coupechoux J. -F.
- Couvares Peter
- Coward D. M.
- Cowart M. J.
- Coyne Dennis
- Coyne Robert
- Craig K.
- Creed R.
- Creighton Jolien
- Creighton T. D.
- Cremonese Paolo
- Criswell Alexander
- Crockett-Gray J. C. G.
- Crook S.
- Crouch R.
- Csizmazia J.
- Cudell Jean-René
- Cullen Torrey
- Cumming Alan
- Cuoco E.
- Cusinato Marco
- Cáceres-Barbosa V.
- César Martins Julio
- D'Angelo Beatrice
- D'Antonio Sabrina
- d'Emilio V.
- D'Onofrio Luca
- D'Urso D.
- Dabadie P.
- Dal Canton Tito
- Dal Pra Stefano
- DALL'OSSO Simone
- Danilishin Stefan
- Danzmann K.
- Darroch K. E.
- Dartez L. P.
- Dasgupta A.
- Datta Sayantani
- Dattilo V.
- Daumas A.
- Davari N.
- Dave I.
- Davenport A.
- Davier M.
- Davies T. F.
- Davis Derek
- Davis L.
- Davis Michael C.
- Davis Philip J.
- Dax Maximilian
- De Bolle Jorden
- De Laurentis Martina
- De Lillo Federico
- de Lluc Planas Maria
- De Marco F.
- De Matteis Fabio
- De Pietri Roberto
- De Rosa Rosario
- de rossi camilla
- De Simone R.
- de Souza Melo S. Assis
- Deenadayalan M.
- Degallaix Jerome
- Del Pozzo Walter
- Dell'Aquila Daniele
- Deléglise Samuel
- Demos N.
- Dent Thomas
- Depasse Antoine
- DePergola N.
- DeSalvo Riccardo
- Dhani A.
- Di Cesare Martina
- Di Fiore L.
- Di Fronzo Chiara
- Di Giovanni Matteo
- Di Girolamo Tristano
- Di Michele Alessandro
- Di Palma Irene
- Di Renzo Francesco
- Diab R.
- Diaz J. Casanueva
- Dideron G.
- Didio N. A.
- Diego Bonavena Luis
- Dietrich Tim
- Diksha D.
- Ding Jacques
- Divyajyoti
- Dmitriev Artemiy
- Doctor Zoheyr
- Dohmen E.
- Doleva P. P.
- Dominguez D.
- Donovan F.
- Dooley Katherine L.
- Dooney T.
- Doravari Suresh
- Dorosh O.
- Drago Marco
- Driggers Jennifer C.
- Ducoin J. -G.
- Dunn Liam
- Dupletsa U.
- Duval Hannah
- Duverne P. -A.
- Dwyer S. E.
- Dálya Gergely
- Eassa C.
- Ebersold Michael
- Eckhardt Tobias
- Eddolls Graeme
- Edelman Bruce
- Edo T. B.
- Edy Oliver
- Effler Anamaria
- Eichholz Johannes
- Einsle H.
- Eisenmann M.
- Eisenstein R. A.
- Ejlli Aldo
- Eleveld R. M.
- Elizabeth Ramirez Guevara Karla
- Emma Mattia
- Endo K.
- enea romano antonio
- Engl A. J.
- Enloe E.
- Erasmo Peña Arellano Fabián
- Errico Luciano
- error error
- error error
- Estellés Estrella Héctor
- Estevez Dimitri
- Etzel T.
- Evans Matthew J.
- Evstafyeva T.
- Ewing B. E.
- Fabrizi Federica
- Faedi F.
- Fafone Viviana
- Fairhurst Stephen
- Farah Amanda M.
- Farr Ben
- Farr Will M.
- Favaro Giulio
- Favata Marc
- Fays Maxime
- Fazio M.
- Feicht J.
- Fejer M. M.
- felicetti riccardo
- Fenyvesi Edit
- Ferguson Deborah
- ferraiuolo sarah
- Ferrante Isidoro
- Ferreira T. A.
- Fidecaro Francesco
- Figura Przemysław
- Fiori Alessio
- Fiori Irene
- Fishbach Maya
- Fisher R. P.
- Fittipaldi R.
- FIUMARA VINCENZO.
- Flaminio R.
- Fleischer Svenja
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- Foley E. M.
- Fong H.
- Fornal Bartosz
- Forsyth P. W. F.
- Franceschetti K.
- Franchini N.
- Francisco Nuño Siles José
- Frasca S.
- Frasconi Franco
- Frei Zsolt
- Freise Andreas
- Freitas Osvaldo
- Frey Raymond
- Frischhertz W.
- Fritschel P.
- Frolov V. V.
- Fuentes-Garcia Melina
- Fujii S.
- Fujimori T.
- Fulda P.
- Fung Wong Chun
- Fyffe M.
- Gadre Bhooshan
- Gaetano Fronzé Gabriele
- Gair Jonathan
- Galaudage Shanika
- Galdi V.
- Gallagher H.
- Gallardo S.
- Gallego B.
- Gamba Rossella
- Gamboa Aldo
- Ganapathy Dhruva
- Ganguly Apratim
- Garaventa Barbara
- Garcia-Bellido Juan
- García Quirós Cecilio
- Gardner James W.
- Gardner K. A.
- Gargiulo Julien
- Garrón Ángel
- Garufi Fabio
- Gasbarra Claudio
- Gateley B.
- Gayathri V.
- Gemme Gianluca
- Gennai Alberto
- Gennari Vasco
- George J.
- George Richard
- Gerberding Oliver
- Ghonge Sudarshan
- Ghosh Archisman
- Ghosh Sayantan
- Ghosh Shaon
- Ghosh Shrobana
- Ghosh Suprovo
- Ghosh Tathagata
- Giacoppo L.
- Giaime Joseph
- Giardina K. D.
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- Gier Chalisa
- Giri Priyanka
- Gissi F.
- Gkaitatzis Stamatios
- Glanzer J.
- Glotin F.
- Godfrey J.
- Godwin P.
- Goetz Evan
- Golomb J.
- Gomez Lopez Sebastian
- Goncharov Boris
- Gong Y.
- Gonzalez Gabriela
- Goodarzi P.
- Goode S.
- Goodwin-Jones Aaron W.
- Gosselin M.
- Gouaty Romain
- Gould D. W.
- Govorkova K.
- Goyal Srashti
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- Grado Aniello
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- Granados A.
- Granata Massimo
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- Griffiths William
- Griggs Hannah
- Grignani G.
- Grimaldi Andrea
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- Grote Hartmut
- Guerra Davide
- guetta dafne
- Guidi Gianluca
- Guimaraes A. R.
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- Gulminelli Francesca
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- Guo Huaike
- Guo Weichangfeng
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- Wu Chien-Ming
- Wu David S.
- Wu Hsun-Chung
- Wuchner E.
- Wysocki Daniel
- Xu Victoria
- Xu Yumeng
- Yaala M. Ben
- Yadav Nikesh
- Yamamoto Hiroaki
- Yamamoto Kazuhiro
- Yamamoto Takahiro
- Yamamoto Takahiro S.
- Yamamura S.
- Yamazaki Ryo
- Yan S.
- Yan T.
- Yang F.
- Yang Fengwei
- Yang Kate Z.
- Yang Yi
- Yarbrough Zach
- Yasui H.
- Yeh S. -W.
- Yelikar A. B.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuan S.
- Yuzurihara Hirotaka
- Zadrożny A.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zeoli M.
- Zerrad M.
- Zevin Michael
- Zhang A. C.
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 都丸 隆行
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Almualla M.
- Altin Paul
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Anand S.
- Ananyeva A.
- Andersen R.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Aoumi M.
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- Babak Stanislav
- Badalyan A.
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bai Y.
- Baier Jeremy
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
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- Baltus Grégory
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- de rossi camilla
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- Degallaix Jerome
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- Dell'Aquila Daniele
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- di giovanni Fabrizio
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- Estevez Dimitri
- Etzel T.
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- Fabrizi Federica
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- Fenyvesi Edit
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- Fidecaro Francesco
- Fiori Alessio
- Fiori Irene
- Fishbach Maya
- Fisher R. P.
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- Fiumara V.
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- Fleischer Svenja
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- Fornal Bartosz
- Forsyth P. W. F.
- Franceschetti K.
- Francisco Nuño Siles José
- Franke A.
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- Fukunaga I.
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- Gaetano Fronzé Gabriele
- Gair Jonathan
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- Galaudage S.
- Gallardo S.
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- Garcia-Bellido Juan
- García Quirós Cecilio
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- Gardner James W.
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- Gasbarra Claudio
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- Yokozawa T.
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- Yu Hang
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- Zahoor Jan Aasim
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- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Álvarez-López S.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L. Granda
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- AVALLONE Guerino
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
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- Massaro L.
- Masserot A.
- Masso Reid Mariela
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- MORALES ESTER. RUIZ.
- Morales M.
- Moraru D.
- Morawski F.
- More Anupreeta
- More Surhud
- Moreno Claudia
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- Mukherjee Subroto
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- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
Antibody-nanoparticle conjugates to enhance the sensitivity of ELISA-based detection methods
- Publication venue
- Publication date
- 01/01/2017
- Field of study
<div><p>Accurate antigen detection is imperative for clinicians to diagnose disease, assess treatment success, and predict patient prognosis. The most common technique used for the detection of disease-associated biomarkers is the enzyme linked immunosorbent assay (ELISA). In an ELISA, primary antibodies are incubated with biological samples containing the biomarker of interest. Then, detectible secondary antibodies conjugated with horseradish peroxidase (HRP) bind the primary antibodies. Upon addition of a color-changing substrate, the samples provide a colorimetric signal that directly correlates to the targeted biomarker concentration. While ELISAs are effective for analyzing samples with high biomarker content, they lack the sensitivity required to analyze samples with low antigen levels. We hypothesized that the sensitivity of ELISAs could be enhanced by replacing freely delivered primary antibodies with antibody-nanoparticle conjugates that provide excess binding sites for detectible secondary antibodies, ultimately leading to increased signal. Here, we investigated the use of nanoshells (NS) decorated with antibodies specific to epidermal growth factor receptor (EGFR) as a model system (EGFR-NS). We incubated one healthy and two breast cancer cell lines, each expressing different levels of EGFR, with EGFR-NS, untargeted NS, or unconjugated EGFR antibodies, as well as detectable secondary antibodies. We found that EGFR-NS consistently increased signal intensity relative to unconjugated EGFR antibodies, with a substantial 13-fold enhancement from cells expressing high levels of EGFR. Additionally, 40x more unconjugated antibodies were required to detect EGFR compared to those conjugated to NS. Our results demonstrate that antibody-nanoparticle conjugates lower the detection limit of traditional ELISAs and support further investigation of this strategy with other antibodies and nanoparticles. Owing to their enhanced sensitivity, we anticipate that nanoparticle-modified ELISAs can be used to detect low levels of biomarkers found in various diseases, such as cancers, tuberculosis, and rheumatoid arthritis, and may ultimately enable earlier diagnosis, better prognostication, and improved treatment monitoring.</p></div