Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report.

We identified a PSEN1 (presenilin 1) mutation carrier from the world's largest autosomal dominant Alzheimer's disease kindred, who did not develop mild cognitive impairment until her seventies, three decades after the expected age of clinical onset. The individual had two copies of the APOE3 Christchurch (R136S) mutation, unusually high brain amyloid levels and limited tau and neurodegenerative measurements. Our findings have implications for the role of APOE in the pathogenesis, treatment and prevention of Alzheimer's disease

robotica2013.dvi

RESUMEN PIRATE es un observatorio de investigación y enseñanza de 0.43m de la Open University en Reino Unido. Desde 2010 ha estado reservado durante varios meses para enseñar astronomía bajo el programa de pregrado de la OU. Dado que los estudiantes en este curso operan PIRATE remotamente, en vez de viajar al observatorio en sí, decidimos investigar si el aprendizaje efectivo era afectado adversamente por la ausencia de una experiencia práctica más tradicional. Discutimos las perspectivas de los estudiantes respecto a las tecnologías utilizadas (por ejemplo: investigaciones remotas y virtuales), el impacto queéstas han tenido sobre el resultado de los cursos y consideramos las implicaciones para enseñanza y divulgación futura ABSTRACT PIRATE is a 0.43m semi-autonomous research and teaching observatory owned by The Open University, UK. Since 2010, it has been reserved for several months of each year for teaching astronomy in the OU's undergraduate programme. As students in these courses operate PIRATE remotely rather than travelling to the observatory itself, we chose to investigate whether effective learning was adversely affected by the absence of a more traditional 'hands on' experience. We discuss student perspectives on the technologies employed (i.e., remote and virtual investigations), the impact these had on perceived course outcomes, and consider implications for future teaching and outreach

DICOM-Based Multidisciplinary Platform for Clinical Decision Support: Needs and Direction

Multi-disciplinary platform is created to store and integrate DICOM objects from various clinical disciplines. With artificial intelligence, clinical decision support system is built to assess risk of disease complications using the features extracted from the DICOM objects and their interrelationship. Diabetes Mellitus is considered as the disease of interest and the risks of its complications are assessed based on the extracted features. The synergy of the DICOM-based multi-disciplinary platform and the clinical decision support system provides promising functions for extracting and interrelating consistent features of clinical information

Characterization and use of an unprecedentedly bright and structurally non-perturbing fluorescent DNA base analogue

This article presents the first evidence that the DNA base analogue 1,3-diaza-2-oxophenoxazine, tCO, is highly fluorescent, both as free nucleoside and incorporated in an arbitrary DNA structure. tCO is thoroughly characterized with respect to its photophysical properties and structural performance in single- and double-stranded oligonucleotides. The lowest energy absorption band at 360 nm ({varepsilon} = 9000 M–1 cm–1) is dominated by a single in-plane polarized electronic transition and the fluorescence, centred at 465 nm, has a quantum yield of 0.3. When incorporated into double-stranded DNA, tCO shows only minor variations in fluorescence intensity and lifetime with neighbouring bases, and the average quantum yield is 0.22. These features make tCO, on average, the brightest DNA-incorporated base analogue so far reported. Furthermore, it base pairs exclusively with guanine and causes minimal perturbations to the native structure of DNA. These properties make tCO a promising base analogue that is perfectly suited for e.g. photophysical studies of DNA interacting with macromolecules (proteins) or for determining size and shape of DNA tertiary structures using techniques such as fluorescence anisotropy and fluorescence resonance energy transfer (FRET