Dressing the Giant Magnon II

We extend our earlier work by demonstrating how to construct classical string solutions describing arbitrary superpositions of scattering and bound states of dyonic giant magnons on S^5 using the dressing method for the SU(4)/Sp(2) coset model. We present a particular scattering solution which generalizes solutions found in hep-th/0607009 and hep-th/0607044 to the case of arbitrary magnon momenta. We compute the classical time delay for the scattering of two dyonic magnons carrying angular momenta with arbitrary relative orientation on the S^5.Comment: 13 pages, harvma

Quasi Stable Black Holes at the Large Hadron Collider

We adress the production of black holes at LHC and their time evolution in space times with compactified space like extra dimensions. It is shown that black holes with life times of hundred fm/c can be produced at LHC. The possibility of quasi-stable remnants is discussed.Comment: 4 pages, 3 figures, typos removed, omitted factors included, accepted for publicatio

On the Strong Coupling Scaling Dimension of High Spin Operators

We give an exact analytic solution of the strong coupling limit of the integral equation which was recently proposed to describe the universal scaling function of high spin operators in N = 4 gauge theory. The solution agrees with the prediction from string theory, confirms the earlier numerical analysis and provides a basis for developing a systematic perturbation theory around strong coupling.Comment: 26 pages, 2 figure

Two-level system with a thermally fluctuating transfer matrix element: Application to the problem of DNA charge transfer

Charge transfer along the base-pair stack in DNA is modeled in terms of thermally-assisted tunneling between adjacent base pairs. Central to our approach is the notion that tunneling between fluctuating pairs is rate-limited by the requirement of their optimal alignment. We focus on this aspect of the process by modeling two adjacent base pairs in terms of a classical damped oscillator subject to thermal fluctuations as described by a Fokker-Planck equation. We find that the process is characterized by two time scales, a result that is in accord with experimental findings.Comment: original file is revtex4, 10 pages, three eps figure

Oral Angiotensin-(1–7) prevented obesity and hepatic inflammation by inhibition of resistin/TLR4/MAPK/NF-κB in rats fed with high-fat diet

AbstractObesity is characterized by a pro-inflammatory state commonly associated with type 2 diabetes and fat-liver disease. In the last few years, different studies pointed out the role of Angiotensin (Ang)-(1–7) in the metabolic regulation. The aim of the present study was to evaluate the effect of oral-administration of Ang-(1–7) in metabolism and inflammatory state of high-fat feed rats. Twenty-four male Sprague Dawley rats were randomized into three groups: High Fat Diet (HFD); Standard Diet (ST); High Fat Diet+Angiotensin-(1–7) [HFD+Ang-(1–7)]. Glycemic profile was evaluated by glucose tolerance and insulin sensitivity tests, plasmatic glucose and insulin. Cholesterol, HDL and triglycerides analyses presented lipidic profile. RT-PCR evaluated mRNA expression to ACE, ACE2, resistin, TLR4, IL-6, TNF-α and NF-κB genes. The main results showed that oral Ang-(1–7) decreased body weight and abdominal fat-mass. In addition, HFD+Ang-(1–7) treated rats presented enhanced glucose tolerance, insulin-sensitivity and decreased plasma-insulin levels, as well as a significant decrease in circulating lipid levels. These alterations were accompanied by a marked decreased expression of resistin, TLR4, ACE and increased ACE2 expression in liver. Furthermore, Ang-(1–7) decreases phosphorylation of MAPK and increases NF-κB expression. These alterations diminished expression of interleukin-6 and TNF-α, ameliorate inflammatory state in liver. In summary, the present study showed that oral-treatment with Ang-(1–7) in high-fat feed rats improved metabolism down-regulating resistin/TLR4/NF-κB-pathway

Virasoro operators in the continuous basis of string field theory

In this work we derive two important tools for working in the \kappa basis of string field theory. First we give an analytical expression for the finite part of the spectral density \rho_{fin}. This expression is relevant when both matter and ghost sectors are considered. Then we calculate the form of the matter part of the Virasoro generators L_n in the \kappa basis, which construct string field theory's derivation Q_{BRST}. We find that the Virasoro generators are given by one dimensional delta functions with complex arguments.Comment: 16 page

Unconstrained Hamiltonian Formulation of SU(2) Gluodynamics

SU(2) Yang-Mills field theory is considered in the framework of the generalized Hamiltonian approach and the equivalent unconstrained system is obtained using the method of Hamiltonian reduction. A canonical transformation to a set of adapted coordinates is performed in terms of which the Abelianization of the Gauss law constraints reduces to an algebraic operation and the pure gauge degrees of freedom drop out from the Hamiltonian after projection onto the constraint shell. For the remaining gauge invariant fields two representations are introduced where the three fields which transform as scalars under spatial rotations are separated from the three rotational fields. An effective low energy nonlinear sigma model type Lagrangian is derived which out of the six physical fields involves only one of the three scalar fields and two rotational fields summarized in a unit vector. Its possible relation to the effective Lagrangian proposed recently by Faddeev and Niemi is discussed. Finally the unconstrained analog of the well-known nonnormalizable groundstate wave functional which solves the Schr\"odinger equation with zero energy is given and analysed in the strong coupling limit.Comment: 20 pages REVTEX, no figures; final version to appear in Phys. Rev. D; minor changes, notations simplifie

Semiclassical Quantization of the Giant Magnon

Solitons in field theory provide a window into regimes not directly accessible by the fundamental perturbative degrees of freedom. Motivated by interest in the worldsheet S-matrix of string theory in AdS_5 x S^5 in the limit of infinite worldsheet volume we consider the semiclassical quantization of a particular soliton of this theory: the Hofman-Maldacena `giant magnon' spinning string. We obtain explicit formulas for the complete spectrum of bosonic and fermionic fluctuations around the giant magnon. As an application of these results we confirm that the one-loop correction to the classical energy vanishes as expected.Comment: 20 pages, JHEP3 style; v2: minor typos fixed and references adde

Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue

We report the development of a combined confocal Raman spectroscopy (CRS) and optical coherence tomography (OCT) instrument (CRS-OCT) capable of measuring analytes in targeted biological tissues with sub-100-micron spatial resolution. The OCT subsystem was used to measure depth-resolved tissue morphology and guide the acquisition of chemically-specific Raman spectra. To demonstrate its utility, the instrument was used to accurately measure depth-resolved, physiologically-relevant concentrations of Tenofovir, a microbicide drug used to prevent the sexual transmission of HIV, in ex vivo tissue samples

Application of non-HDL cholesterol for population-based cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium.

BACKGROUND: The relevance of blood lipid concentrations to long-term incidence of cardiovascular disease and the relevance of lipid-lowering therapy for cardiovascular disease outcomes is unclear. We investigated the cardiovascular disease risk associated with the full spectrum of bloodstream non-HDL cholesterol concentrations. We also created an easy-to-use tool to estimate the long-term probabilities for a cardiovascular disease event associated with non-HDL cholesterol and modelled its risk reduction by lipid-lowering treatment. METHODS: In this risk-evaluation and risk-modelling study, we used Multinational Cardiovascular Risk Consortium data from 19 countries across Europe, Australia, and North America. Individuals without prevalent cardiovascular disease at baseline and with robust available data on cardiovascular disease outcomes were included. The primary composite endpoint of atherosclerotic cardiovascular disease was defined as the occurrence of the coronary heart disease event or ischaemic stroke. Sex-specific multivariable analyses were computed using non-HDL cholesterol categories according to the European guideline thresholds, adjusted for age, sex, cohort, and classical modifiable cardiovascular risk factors. In a derivation and validation design, we created a tool to estimate the probabilities of a cardiovascular disease event by the age of 75 years, dependent on age, sex, and risk factors, and the associated modelled risk reduction, assuming a 50% reduction of non-HDL cholesterol. FINDINGS: Of the 524 444 individuals in the 44 cohorts in the Consortium database, we identified 398 846 individuals belonging to 38 cohorts (184 055 [48·7%] women; median age 51·0 years [IQR 40·7-59·7]). 199 415 individuals were included in the derivation cohort (91 786 [48·4%] women) and 199 431 (92 269 [49·1%] women) in the validation cohort. During a maximum follow-up of 43·6 years (median 13·5 years, IQR 7·0-20·1), 54 542 cardiovascular endpoints occurred. Incidence curve analyses showed progressively higher 30-year cardiovascular disease event-rates for increasing non-HDL cholesterol categories (from 7·7% for non-HDL cholesterol <2·6 mmol/L to 33·7% for ≥5·7 mmol/L in women and from 12·8% to 43·6% in men; p<0·0001). Multivariable adjusted Cox models with non-HDL cholesterol lower than 2·6 mmol/L as reference showed an increase in the association between non-HDL cholesterol concentration and cardiovascular disease for both sexes (from hazard ratio 1·1, 95% CI 1·0-1·3 for non-HDL cholesterol 2·6 to <3·7 mmol/L to 1·9, 1·6-2·2 for ≥5·7 mmol/L in women and from 1·1, 1·0-1·3 to 2·3, 2·0-2·5 in men). The derived tool allowed the estimation of cardiovascular disease event probabilities specific for non-HDL cholesterol with high comparability between the derivation and validation cohorts as reflected by smooth calibration curves analyses and a root mean square error lower than 1% for the estimated probabilities of cardiovascular disease. A 50% reduction of non-HDL cholesterol concentrations was associated with reduced risk of a cardiovascular disease event by the age of 75 years, and this risk reduction was greater the earlier cholesterol concentrations were reduced. INTERPRETATION: Non-HDL cholesterol concentrations in blood are strongly associated with long-term risk of atherosclerotic cardiovascular disease. We provide a simple tool for individual long-term risk assessment and the potential benefit of early lipid-lowering intervention. These data could be useful for physician-patient communication about primary prevention strategies. FUNDING: EU Framework Programme, UK Medical Research Council, and German Centre for Cardiovascular Research