Píldoras Educativas para la Elaboración del Trabajo Final de Grado en Estudios Ingleses (Lengua y Lingüística).

Este proyecto plantea elaborar un módulo, estructurado en píldoras educativas (o mini-videos didácticos), para dar una visión general a los estudiantes del último curso de grado de cómo abordar la escritura del TFG

Biomarkers of Venous Thromboembolism Recurrence after Discontinuation of Low Molecular Weight Heparin Treatment for Cancer-Associated Thrombosis (HISPALIS-Study)

The most appropriate duration of anticoagulant treatment for cancer-associated venous thromboembolism (CAT) remains unclear. We have conducted a prospective multicenter study in CAT patients with more than 6 months of anticoagulant treatment to predict the risk of venous thromboembolism (VTE) recurrence after anticoagulation discontinuation. Blood samples were obtained when patients stopped the anticoagulation, at 21 days and at 90 days. In each sample we assessed different coagulation-related biomarkers: D-dimer (DD), high-sensitivity C-reactive protein (hs-CRP), P-selectin (PS), phospholipids, soluble tissue factor, factor VIII and the thrombin generation test. It was evaluated 325 CAT patients and 166 patients were included in the study, mean age 64 ± 17 years. VTE recurrence until 6 months after stopping anticoagulation treatment was 9.87% [95% confidence interval (CI): 6–15]. The biomarkers sub-distribution hazard ratios were 6.32 for ratio DD basal/DD 21 days > 2 (95% CI: 1.82–21.90), 6.36 for hs-CRP > 4.5 (95% CI: 1.73–23.40) and 5.58 for PS > 40 (95% CI: 1.46–21.30) after 21 days of stopping anticoagulation. This is the first study that has identified the DD ratio, hs-CRP and PS as potential biomarkers of VTE recurrence in cancer patients after the discontinuation of anticoagulation treatment. A risk-adapted strategy may allow the identification of the optimal time to withdraw the anticoagulation in each CAT patientmThis research was funded by Instituto de Salud Carlos III, grant number (PI15/01085; PI18/01640, PI20/00075), Sociedad Española de Trombosis y Hemostasia; Fundación Respira, grant number (140/2013), Fundación Neumosur, grant number (5/2013) and the LEO Pharma Research Foundation. Partial funding for open access charge: Universidad de Málaga

Desarrollo de estrategias discursivas de posicionamiento en los trabajos científicos universitarios (TFGs, TFMs, TDs, y AC): Análisis de los géneros discursivos, propuestas para la formación y elaboración de píldoras educativas

El presente proyecto reúne a docentes e investigadoras de dos grupos de investigación UCM consolidados del Departamento de Estudios Ingleses, “Discurso y comunicación en lengua inglesa: estudios de lingüística cognitiva y funcional” (DISCOM-COGFUNC) (930160) y “Lingüística funcional (ingles-español) y sus aplicaciones (FUNCAP)”, que imparten asignaturas afines. Todas las integrantes del equipo han formado parte al menos de uno de los dos proyectos de innovación previos, Innova-2015-188 e Innova-2016-123, sobre Objetos de Aprendizaje Reutilizable (OARs), como son las píldoras educativas, dando así muestra de una continuidad del trabajo en la innovación educativa en el campo de la docencia de lengua y lingüística inglesas. Los objetivos generales propuestos en la solicitud del proyecto han sido la formación de estudiantes y profesores en el uso y desarrollo de estrategias discursivas de posicionamiento en: (a) los trabajos científicos universitarios (TFGs, TFMs, TDs), y (b) los artículos de investigación de los docentes. Se trataba de llevar a cabo el análisis de estos géneros discursivos, realizar propuestas para la formación en el uso de estrategias discursivas, y elaborar materiales y píldoras educativas adecuadas a cada contexto de aprendizaje

Extended treatment of cancer-associated thrombosis

Venous thromboembolism (VTE) is a growing concern in patients with cancer. Current guidelines recommend that cancer patients with VTE should receive anticoagulation for at least 3–6 months. However, the question as to whether anticoagulants should be continued after 3 to 6 months of treatment remains open. In presence of an active malignancy, physicians should weigh the benefits and burdens of ongoing anticoagulation taking into account the clinical status, patient expectations, and the risk of bleeding. As the length of time from the index event increases, the available evidence is not conclusive. The most critical unresolved issues include the decision to continue or discontinue anticoagulation and the selection of the most appropriate anticoagulant agent. On this background, our article provides an overview of the available studies focusing on extended (i.e., >6 months) anticoagulation treatment in cancer-associated thrombosis, with the ultimate goal of refining real-world clinical decision-making in this patient population

A continuous-flow catalytic process with natural hematite-alginate beads for effective water decontamination and disinfection: Peroxymonosulfate activation leading to dominant sulfate radical and minor non-radical pathways

[EN] A natural, ferruginous material, Hormuz Red Soil (HRS), was used as a catalyst for decontamination and disinfection via PMS activation. The HRS was fully characterized (morphological, structural, chemical properties) and was mainly comprised of alpha-Fe2O3. Complete degradation and 88.6% mineralization of Diclofenac (DCF) was achieved in the HRS/PMS process (10 mg/L HRS, 75 mg/L PMS) within 8 min at neutral pH, while sulfate and chloride did not inhibit the process. E. coli and Enterococcus sp. were rapidly inactivated in shorter timeframe than DCF. The rapid purification was attributed to SO4 center dot-, less to O-1(2) and almost insignificant HO center dot participation; the degradation mechanisms and transformation pathways were fully elucidated by scavenging tests/EPR, and LC/MS, respectively. Considering potential applications, HRS was supported on alginate beads (HRSB), maintaining high activity and high reusability (x5 reuse). Finally, a continuous-flow, packed-bed process with HRSB/PMS was assessed, where DCF degradation and mineralization was reached within 2 min HRT.This work was technically and financially supported by the Tarbiat Modares University, Iran, under the Research Group Grant No. IG39801, the National Institute for Medical Research Development (NIMAD), Iran, under Elite's Grant No. 987616, and the Spanish Ministry of Science, Innovation and Universities via Projects PID2019110441RB-C32 and PID2019-110441RB-C33. Also, Stefanos Giannakis would like to acknowledge the Spanish Ministry of Science, Innovation and Universities (MICIU) for the Ram on y Cajal Fellowship (RYC2018024033-I).Mohammadi, S.; Moussavi, G.; Shekoohiyan, S.; Marín García, ML.; Bosca Mayans, F.; Giannakis, S. (2021). A continuous-flow catalytic process with natural hematite-alginate beads for effective water decontamination and disinfection: Peroxymonosulfate activation leading to dominant sulfate radical and minor non-radical pathways. Chemical Engineering Journal. 411:1-21. https://doi.org/10.1016/j.cej.2020.127738S12141

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population