Doctoral dissertation management at the University of Granada

La Universidad de Granada (UGR) cuenta desde 2005 con el Proyecto DIGIBUG, un modelo que mejora la visibilidad y accesibilidad de su producción científica, con el objetivo de acercarla a los investigadores, doctorandos, estudiantes y a la sociedad en general, ofreciendo una nueva perspectiva de difusión, utilización, citación y seguimiento de las diferentes líneas de investigación existentes en la UGR.Since 2005 the University of Granada (UGR) has implemented the DIGIBUG Project, which aims to improve visibility of and access to its scientific output so as to bring it closer to researchers, doctorate and undergraduate students and society in general, providing a new way of disseminating, using, citing and following up the different lines of enquiry at the UGR

Análisis del abandono en los estudios de ingeniería y arquitectura en la Universidad Politécnica de Madrid

El abandono académico preocupa en todas las universidades y tiene especial incidencia en los estudios de Ingeniería y Arquitectura. En este trabajo se presentan los resultados de un estudio exhaustivo del abandono desarrollado en el marco de un proyecto transversal de Innovación Educativa, con la participación de más de 80 profesores de la Universidad Politécnica de Madrid (UPM), que pretende analizar los factores más influyentes en el abandono y, en particular, su relación con el absentismo académico. Se toma como población de estudio el colectivo de estudiantes de nuevo ingreso del curso 2010-11 en la UPM, que no se han matriculado en el curso 2011-12 en la misma carrera. Es lo que técnicamente se conoce como pre-abandono y que, en la inmensa mayoría de los casos, se convierte en abandono definitivo de la titulación iniciada.Se han usado dos metodologías: 1. Análisis de la información objetiva procedente de bases de datos de la UPM relativa a variables académicas (nota y opción de acceso, rendimiento académico, ...)y de componente social (sexo, nacionalidad, ...),así como de la información sobre absentismo solicitada a los profesores de las diferentes asignaturas, para la población de estudio. 2. Análisis de la información subjetiva recogida mediante trabajo de campo, a través de encuestas telefónicas(CATI) y entrevistasen profundidad, de los estudiantes en situación de pre-abandono. Entre las conclusiones más relevantes del estudio cabe señalar: En un porcentaje significativo el pre-abandono corresponde a un cambio para continuar estudios del mismo nivel en la misma u otra institución. El absentismo se identifica como predictor del abandono. El factor académico más relacionado con el abandono de una titulación es la nota de acceso. Los alumnos de la población de estudio tienen nota de acceso y rendimiento académico inferiores a los de los alumnos que continúan sus estudios. También presentan mayores índices de absentismo académico y menor participación en las actividades de aprendizaje y evaluación. Respecto a los factores de componente social y personal, se ha observado menor abandono entre las mujeres y mayor abandono entre los estudiantes extranjeros. En cuanto a la integración en la universidad y la relación con los compañeros, se ha detectado que los estudiantes de la población de pre-abandono perciben su integración en la comunidad universitaria como menos efectiva

Influence of immigration on tuberculosis transmission patterns in Castellón, Spain (2004–2007)

Objetivo Describir los patrones de transmisión de la tuberculosis en Castellón en un periodo de importantes cambios demográficos. Métodos Estudio prospectivo descriptivo de los pacientes con cultivo positivo en la provincia de Castellón entre 2004 y2007. Se describen los pacientes por año y nacionalidad, y se cotejan con los casos declarados a la Dirección General de Salud Pública (DGSP). Se estudia la población con patrón molecular disponible por RFLP (restriction fragment length polymorphism) y se analizan las variables de los pacientes agrupados (clusters) a partir de los datos de la DGSP y del Programa de Gestión del Laboratorio. Resultados Según la DGSP, la tasa global de tuberculosis por 100.000 habitantes en la provincia de Castellón fue de 15,7 en 2004, 19,9 en 2005, 18,2 en 2006 y 17,5 en 2007. En nuestro laboratorio se identificaron las cepas de 301 pacientes, que suponen el 77% (301/390) de los casos declarados y el 94% (301/321) aquellos con cultivo positivo. El porcentaje de tuberculosis en extranjeros aumentó hasta superar el 50% en 2007. Se disponía de estudio molecular en el 95% de los casos (286), con un 58% de españoles y un 42% de extranjeros. El porcentaje de agregación fue del 40%, con un 30% de clusters mixtos. Según el estudio convencional de contactos, el 85% de los pacientes en cluster habían sido considerados casos aislados. Conclusiones El aumento de la tasa de tuberculosis en Castellón se debe, principalmente, al creciente número de los casos en extranjeros. Disponer del estudio molecular de todos los pacientes con cultivo positivo nos ha permitido analizar cómo y dónde se transmite la tuberculosis. El 40% de los pacientes se agruparon en clusters, y eran mixtos un tercio de ellos, lo que indica una elevada integración de los inmigrantes.Background This study aimed to identify tuberculosis transmission patterns in Castellón in a period of major demographic changes. Methods A prospective study of patients with positive culture in the province of Castellon over a 4-year period (2004–2007) was carried out. Cases were described by year and nationality and were compared with those reported to the Department of Public Health. We studied the population with available molecular patterns, identified through restriction fragment length polymorphism (RFLP) and analyzed the variables from patient clusters, based on data collected in surveys of the Department of Health and the Laboratory Management Program. Results According to data from the Department of Public Health, the overall rate of tuberculosis per 100,000 inhabitants in the province of Castellón was 15.7 in 2004, 19.9 in 2005, 18.2 in 2006 and 17.5 in 2007. In our laboratory, strains were identified from 301 patients, representing 77% (301/390) of reported cases and 94% (301/321) of reported cases with a positive culture. The percentage of tuberculosis among foreigners increased with age, exceeding 50% in 2007. Molecular studies were available in 95% of patients (286); 58% were Spanish and 42% were foreigners, of whom 54% were Romanians. The cluster percentage was 40%, with 30% of mixed clusters. According to conventional contact studies, 85% of patients in clusters had been considered isolated cases. Conclusions The increased rate of tuberculosis in Castellón was mainly due to the increasing number of cases among foreigners, mostly Romanians. The availability of molecular studies in all patients with a positive culture allowed us to analyze how and where tuberculosis is transmitted in our province. Forty percent of the patients were grouped into clusters; of these, mixed clusters accounted for one third, indicating the high integration of immigrants in our area

Derivados de 1,3-dioxoperhidropirido[1,2-c]pirimidinas como antagonistas de colecistoquinina

Referencia OEPM: P9501857.-- Fecha de solicitud: 26/09/1995.-- Titulares: Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Navarra.Derivados de 1,3-dioxoperhidropirido[1,2-c]pirimidinas como antagonistas de colecistoquinina (ver figura en archivo de texto adjunto). La presente invención se refiere a derivados de 1,3- dioxoperhidropirido [1,2,-c] piriminas, e intermedios para su preparación de fórmula general (I). Dichos derivados son útiles como antagonistas de colecistoquinina (CCK) y por lo tanto como agentes activos sobre el sistema nervioso central y el periférico.Peer reviewe

Effect of rowing on mobility, functionality, and quality of life in women with and without breast cancer: a 4-month intervention

Purpose: Of the different modalities of rowing, dragon boat training is the most analyzed in breast cancer (BC). However, other types of boats, such as the felucca, use different biomechanical techniques, which have not been studied in the scientific literature. Consequently, in this study, we sought to determine the benefits of felucca rowing on the physical, psychological, and emotional well-being of patients with BC and healthy persons. Methods: A pre- and post-intervention, single-arm study without a control group with a 4-month intervention was carried out in Spain in 2019. The study sample included six women with BC and 15 healthy women. The following questionnaires were administered before and after the intervention: Disabilities of the Arm, Shoulder, and Hand (DASH), Constant-Murley score (CMS), and the European Quality of Life 5 Dimensions (EQ-5D, rate your health today). Differences were determined before and after the intervention using the paired t test. Results: Significant differences (p < 0.05) were found in the results of all the questionnaires for the women with BC and for the healthy women: DASH (- 13.8 BC and - 6.7 healthy), CMS (+ 12.0 BC and 9.2 healthy), and EQ-5D (+ 8.5 BC and 10.5 healthy). Conclusion: Felucca rowing showed benefits in health and quality of life in both women with BC and healthy women. In future studies with controlled design, values regarding clinical relevance, such as effect sizes/confidence intervals, are needed to corroborate our results

Multipactor radiation analysis within a waveguide region based on a frequency-domain representation of the dynamics of charged particles

A technique for the accurate computation of the electromagnetic fields radiated by a charged particle moving within a parallel-plate waveguide is presented. Based on a transformation of the time-varying current density of the particle into a time-harmonic current density, this technique allows the evaluation of the radiated electromagnetic fields both in the frequency and time domains, as well as in the near- and far-field regions. For this purpose, several accelerated versions of the parallel-plate Green’s function in the frequency domain have been considered. The theory has been successfully applied to the multipactor discharge occurring within a two metal-plates region. The proposed formulation has been tested with a particle-in-cell code based on the finite- difference time-domain method, obtaining good agreement.The authors would like to thank ESA/ESTEC for having funded this research activity through the Contract “RF Breakdown in Multicarrier Systems” ͑Contract No. 19918/06/NL/GLC͒

Massive presence of insertion sequences in the genome of SOPE, the primary endosymbiont of the rice weevil Sitophilus oryzae

Bacteria that establish an obligate intracellular relationship with eukaryotic hosts undergo an evolutionary genomic reductive process. Recent studies have shown an increase in the number of mobile elements in the first stage of the adaptive process towards intracellular life, although these elements are absent in ancient endosymbionts. Here, the genome of SOPE, the obligate mutualistic endosymbiont of rice weevils, was used as a model to analyze the initial events that occur after symbiotic integration. During the first phases of the SOPE genome project, four different types of insertion sequence (IS) elements, belonging to well-characterized IS families from γ-proteobacteria, were identified. In the present study, these elements, which may represent more than 20% of the complete genome, were completely characterized; their relevance as a source of gene inactivation, chromosomal rearrangements, and as participants in the genome reductive process are discussed herein.Gil Garcia, Rosario, [email protected] ; Belda Cuesta, Eugenio, [email protected] ; Gosalbes Soler, Maria Jose, [email protected] ; Delaye, Luis, [email protected] ; Silva Moreno, Francisco J., [email protected] ; Moya Simarro, Andres, [email protected] ; Latorre Castillo, Amparo, [email protected]

Incidence, hospitalization, mortality and risk factors of COVID-19 in long-term care residential homes for patients with chronic mental illness

Long-term care residential homes (LTCRH) for patients with chronic mental illness have suffered the enormous impact of COVID-19. This study aimed to estimate incidence, hospitalization, mortality, and risk factors of COVID-19 to prevent future epidemics. From March 2020 to January 2021 and before vaccination anti-SARS-CoV-2 begins, cumulate incidence rate (CIR), hospitalization rate (HR), mortality rate (MR), and risk factors of COVID-19 in the 11 LTCRH of two Health Departments of Castellon (Spain) were studied by epidemiological surveillance and an ecological design. Laboratory tests confirmed COVID-19 cases, and multilevel Poisson regression models were employed. All LTCRH participated and comprised 346 residents and 482 staff. Residents had a mean age of 47 years, 40% women, and suffered 75 cases of COVID-19 (CIR = 21.7%), five hospitalizations (HR = 1.4%), and two deaths (MR = 0.6%) with 2.5% fatality-case. Staff suffered 74 cases of the disease (CIR = 15.4%), one hospitalization (HR = 0.2%), and no deaths were reported. Risk factors associated with COVID-19 incidence in residents were private ownership, severe disability, residents be younger, CIR in municipalities where LTCRH was located, CIR in staff, and older age of the facilities. Conclusion: COVID-19 incidence could be prevented by improving infection control in residents and staff and modernizing facilities with increased public ownership