La biblioteca del MuVIM: seis años de gestión (2004-2010)

Se describe la gestión de la biblioteca del MuVIM desde su creación. Una biblioteca de museo especializada en el pensamiento ilustrado pero que, al mismo tiempo, busca en la materialidad de los libros una proyección de futuro que le permita encontrar un espacio en la sociedad

La Biblioteca General de la Diputación de Valencia: evolución histórica

La Diputación de Valencia, a lo largo de su historia, creó instituciones que potenciaron la cultura valenciana, además de apoyar y promocionar el libro valenciano, consciente de su papel como impulsora y difusora de su identidad local. La Biblioteca Provincial, creada en 1926, pretendió ser un espacio de difusión cultural, pero la falta de un espacio propio y la diversificación de proyectos impidieron que pudiera ser el germen de la futura biblioteca nacional valenciana

El caso MoviStar en medios: ¿cumple la tendencia transmedia?

El interés del tema que se trata en este artículo es el cambio y evolución que se observa, al estudiar la comunicación publicitaria de los últimos tiempos, un cambio del lenguaje debido a la revolución tecnológica, al desarrollo de nuevos canales y medios, y a la implicación de los ciudadanos en este desarrollo tecnológico. La adaptación a este nuevo entorno será clave para el éxito de las estrategias de medios de los anunciantes. Al analizar la estrategia de medios de la empresa Movistar utilizando el análisis de contenido se pretende ver si existe un cambio en la planificación de medios en España.The interest of the topic covered in this article is the fact that it is observed, studying the marketing communication of recent times, a change of language due to the technological revolution, the development of new channels and media, and the involvement of citizens in this technological development. Adapting to this new environment will be key to the success of media strategies advertisers. Researching media strategy company Movistar using content analysis is to see if there is a change in media planning in Spain

Aproximación al método de análisis estructural de los mensajes informativo-periodísticos

Grupo de Investigación en Estructura, Historia y Contenidos de la Comunicación. GREHCCO HUM61

Prensa sevillana, prensa regional, ¿y grupos de comunicación a partir de diarios editados en Sevilla? (1998): hacia el siglo XXI

Grupo de Investigación en Estructura, Historia y Contenidos de la Comunicación. GREHCCO HUM61

Gain modulation of synaptic inputs by network state in auditory cortex in vivo

The cortical network recurrent circuitry generates spontaneous activity organized into Up (active) and Down (quiescent) states during slow-wave sleep or anesthesia. These different states of cortical activation gain modulate synaptic transmission. However, the reported modulation that Up states impose on synaptic inputs is disparate in the literature, including both increases and decreases of responsiveness. Here, we tested the hypothesis that such disparate observations may depend on the intensity of the stimulation. By means of intracellular recordings, we studied synaptic transmission during Up and Down states in rat auditory cortex in vivo. Synaptic potentials were evoked either by auditory or electrical (thalamocortical, intracortical) stimulation while randomly varying the intensity of the stimulus. Synaptic potentials evoked by the same stimulus intensity were compared in Up/Down states. Up states had a scaling effect on the stimulus-evoked synaptic responses: the amplitude of weaker responses was potentiated whereas that of larger responses was maintained or decreased with respect to the amplitude during Down states. We used a computational model to explore the potential mechanisms explaining this nontrivial stimulus–response relationship. During Up/Down states, there is different excitability in the network and the neuronal conductance varies. We demonstrate that the competition between presynaptic recruitment and the changing conductance might be the central mechanism explaining the experimentally observed stimulus–response relationships. We conclude that the effect that cortical network activation has on synaptic transmission is not constant but contingent on the strength of the stimulation, with a larger modulation for stimuli involving both thalamic and cortical networks.Fil: Reig, Ramon. Institut d'Investigacions Biomèdiques August Pi i Sunyer; España. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Zerlaut, Yann. Centre National de la Recherche Scientifique; Francia. Unité de Neurosciences, Information et Complexité; FranciaFil: Vergara, Ramiro Oscar. Institut d'Investigacions Biomèdiques August Pi i Sunyer; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Acústica y Percepción Sonora; ArgentinaFil: Destexhe, Alain. Centre National de la Recherche Scientifique; Francia. Unité de Neurosciences, Information et Complexité; FranciaFil: Sánchez Vives, María V.. Institut d'Investigacions Biomèdiques August Pi i Sunyer; España. Institució Catalana de Recerca i Estudis Avancats; Españ

Multidisciplinary clinical approach to cancer patients with immune-related adverse events induced by checkpoint inhibitors

Immune-oncology is a major breakthrough in cancer treatment and has become the standard of care for a wide variety of solid organ malignancies. Unfortunately, manipulation of the immune system with checkpoint inhibitors may result in an immune-based attack of normal tissues which can lead to treatment discontinuation. These immune-related adverse events (irAEs) are diverse and affect several organs, constituting a new clinical challenge in the management of cancer patients. The complexity of this scenario requires a multidisciplinary approach that allows the early identification, diagnosis and treatment of specific irAE, ruling out other non-related adverse events. Hospital Clinic has a multidisciplinary team seeking to develop a coordinated strategy to facilitate the access of patients with suspected irAEs to specialised care resulting in harmonised management that guarantees the best patient care. The aim of the manuscript was to describe the current evidence on the management of irAEs reflecting a coordinated multidisciplinary approach to face this clinical challenge regardless of the immunotherapy indication

The teaching of reading and writing, with an emphasis on Synthetic Phonics

Synthetic phonics is the method used in British schools to teach reading and writing. Throughout the centuries different methodologies have appeared with the purpose of finding the best way for teaching to read and write in English. This research provides a general view of the different approaches and it is focused on Synthetic phonics, its theoretical framework and practical application

Circuit simulators for circuit analysis in graduate engineering courses

Circuit simulators are extensively used as an aid in many courses at the graduate level in many different engineering and applied sciences programs. SPICE (Simulation Program with Integrated Circuits Emphasis) based software programs have been used for long due to their traditional market position. If we focus on circuits analysis and linear systems subjects, the features that are required from a given simulator can be found in student/limited versions of commercial EDA (Electronic Design Automation) suites or in freeware/open source codes. In this contribution, we analyse and compare the most revelant characteristics of a representative set of the software packages that are commonly adopted in these courses, focusing on the Spanish University system. For this purpose, the analysis (transient, DC and AC) of a typical second order passive low-pass filter is approached making use of each one. Then, we give some comments and recommendations, based on our own expertise, always taking into account the particular circumstances within a given academic scenario.http://ocs.editorial.upv.es/index.php/HEAD/HEAD18Cubells-Beltrán, M.; Reig, C. (2018). Circuit simulators for circuit analysis in graduate engineering courses. Editorial Universitat Politècnica de València. https://doi.org/10.4995/HEAD18.2018.803