Recent Trends in SST, Chl-a, Productivity and Wind Stress in Upwelling and Open Ocean Areas in the Upper Eastern North Atlantic Subtropical Gyre

The global upper ocean has been warming during the last decades accompanied with a chlorophyll-a (Chl-a) and productivity decrease. Whereas subtropical gyres show similar trends, Eastern Boundary Upwelling Systems are thought to increase in productivity due to increased trade winds. This study analyzes recent trends in sea surface temperature (SST), Chl-a, net primary production (NPP) and meridional wind stress in the Eastern North Atlantic subtropical gyre (NASE) in order to examine if the global trends can be detected in open ocean and upwelling areas and how the ocean biota responds. Satellite data of such variables of the last 15–40 years were analyzed to calculate mean trends in upwelling areas in the Canary upwelling system and open ocean areas around the Azores, Madeira and the Canary Islands. Our results show significant warming in the area with a maximum of 2.7°C per century for the Azores. Moreover, a general decreasing trend for Chl-a and NPP seems to be more evident in the permanent upwelling areas, which will be responsible for a loss of 0.13% of the global NPP per century. Our results also highlight a significant expansion of the oceanic desert area of 10% with an increase in unproductive days of up to 84 days in the last 20 years. The competitive relationship of stratification and wind stress in the Canary upwelling system might be a more plausible explanation for the decrease in Chl-a and NPP in upwelling areas linked to the increase in upwelling favorable wind stress and the surface warming.En prens

Manejo de perforaciones, fugas y fístulas del tracto gastrointestinal con clip sobre el endoscopio. Experiencia de un centro oncológico Latinoamericano

Introducción. Las fístulas derivadas de enfermedades neoplásicas del tracto digestivo, así como las fugas posteriores a procedimientos quirúrgicos, no son infrecuentes y ocasionan una morbilidad importante cuando se manejan de forma quirúrgica. También durante los procedimientos endoscópicos se pueden presentar perforaciones y, si se logra un manejo no operatorio, se alcanza una adecuada recuperación. El objetivo de este estudio fue describir las características clínicas y los resultados de los pacientes con perforaciones, fístulas y fugas del tracto gastrointestinal, manejadas endoscópicamente con clip sobre el endoscopio. Métodos. Estudio descriptivo, retrospectivo, de pacientes con perforación, fuga o fístula postoperatoria, llevados a endoscopía digestiva con colocación de clip sobre el endoscopio, en el Instituto Nacional de Cancerología en Bogotá, D.C., Colombia, entre enero de 2016 y abril de 2020. Resultados. Se incluyeron 21 pacientes, 52,4 % de ellos mujeres. La mediana de edad fue de 66 años y del diámetro del defecto fue de 9 mm. En el 95 % se logró éxito técnico. Hubo éxito clínico temprano en el 85,7 % de los casos. El 76,1 % de los pacientes permanecieron sin síntomas a los 3 meses de seguimiento. Conclusiones. El manejo de perforaciones, fugas y fístulas con clip sobre el endoscopio parece ser factible y seguro. En la mayoría de estos pacientes se logró la liberación del clip y la identificación endoscópica del cierre inmediatamente después del procedimiento; sin embargo, en el caso de las fístulas, no se alcanzó el éxito clínico tardío en todos los casos

Can scenario-planning support community-based natural resource management? Experiences from three countries in latin america

Community Based Natural Resource Management (CBNRM) is a concept critical to managing socio-ecological systems, but whose implementation needs strengthening. Scenario-planning is one approach that may offer benefits relevant to CBNRM, but whose potential is not yet well understood. We therefore designed, trialled and evaluated a scenario-planning method intended to support CBNRM at three cases, located in Colombia, Mexico and Argentina. Implementing scenario-planning was judged as worthwhile in all three cases, although aspects of it could be challenging to facilitate. The benefits generated were relevant to strengthening CBNRM: encouraging the participation of local people and using their knowledge; enhanced consideration and adaption of future change; and supporting the development of systems thinking. Tracing exactly when and how these benefits arise is challenging, but two elements of the method seemed particularly useful. Firstly, using a systematic approach to discuss how drivers of change may affect local socio-ecological systems helped to foster systems thinking and identify connections between issues. Secondly, explicitly focusing on how to use and respond to scenarios helped identify specific practical activities ('response options') that would support CBNRM despite the pressures of future change. Discussions about response options also highlighted the need for support by other actors (e.g. policy groups): this raises the question of when and how other actors and other sources of knowledge should be involved in scenario-planning, so as to encourage their buy-in to actions identified by the process. We suggest other CBNRM initiatives may benefit from adapting and applying scenario-planning. However, these initiatives should be carefully monitored since further research is required to understand how and when scenario-planning methods may produce benefits, and their strengths and weaknesses versus other methods

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Meridional overturning transports at 7.5N and 24.5N in the Atlantic Ocean during 1992-93 and 2010-11

17 pages, 14 figures, 6 tablesTransatlantic hydrographic sections along latitudes 7.5N and 24.5N have been repeated with about 20. years difference, at the beginning of the 1990s and 2010s. For each period, an inverse model is applied to the closed box bound by both sections. The model imposes mass conservation for individual layers, defined by isoneutral surfaces, and the whole water column, using surface Ekman transport and several transport constraints for specific ranges of longitudes and depths. As a result, the velocities at the reference layer for each station pair and the dianeutral velocities between layers are estimated, and the horizontal velocity fields and the water, heat and freshwater transports are calculated; in particular, we find that mass transport per stratum at 24.5N in 2011 is in good agreement with the transport estimates from the RAPID-Watch array. During both realizations the dianeutral velocities downwell from the Upper North Atlantic Deep Water (UNADW) to the Lower North Atlantic Deep Water (LNADW) strata, resulting in the merging of the two southward flowing strata at 24.5N into one deep southward-moving stratum at 7.5N. At 24.5N, there is an increase in southward UNADW transport between 1992 and 2011, compensated by a decrease of southward LNADW transport; a descent in the upper limit of the Antarctic Bottom Water (AABW) from 1992 to 2011 is also inferred. The Atlantic Meridional Overturning Circulation (AMOC) is larger in 1992-93 than in 2010-11, decreasing from 24.7. ±. 1.7 to 20.1. ±. 1.4. Sv at 24.5N and from 29.2. ±. 1.7 to 16.9. ±. 1.5. Sv at 7.5N. Much of this decrease arises because of the northward flow of Antarctic Intermediate Water (AAIW), which was much more intense in 1992-93 than in 2010-11. As a consequence, heat transport at 24.5N is not significantly different in 1992 (1.4. ±. 0.1 PW) and 2011 (1.2. ±. 0.1 PW). The estimation of heat transport at 7.5N strongly depends on the magnitude of the North Brazil Current over the American continental platform. The freshwater flux into the box bounded by the two transoceanic sections decreases significantly from 1992-93 (-0.45. ±. 0.05. Sv) to 2010-11 (-0.36. ±. 0.3. Sv), meaning a decrease in net evaporation over this same area. © 2014 Elsevier Ltd.This work has been performed under the projects MOC2 (CTM2008-06438) and Malaspina (CSD2008-00077), funded by the Spanish Government and Feder. Part of this study was carried out when the first author spent a sabbatical at Scripps Institution of Oceanography with a grant from ‘‘el Programa Nacional de Movilidad de Recursos Humanos del Plan Nacional de I+D+I’’Peer Reviewe