Construcción y calibración de un Modelo de Drenaje Pluvial del sector Este del Recinto Universitario Rubén Darío de la UNAN-Managua, utilizando el Software EPA SWMM

La presente investigación monográfica tiene como finalidad la construcción y calibración de un modelo de drenaje pluvial del Sector Este del Recinto Universitario Rubén Darío de la UNAN-Managua, se construyó un Modelo Hidrológico de la red de drenaje, utilizando software de gestión de aguas pluviales EPA SWMM, el cual permite simular eventos hidrológicos y obtener resultados que pueden ser calibrados y corroborados, los cuales pueden ser utilizados posteriormente en proyectos o investigaciones. Para la construcción del modelo es necesario tener definida la red de drenaje y las características topográficas que la componen, de igual manera las características de los conductos, parámetros de impermeabilidad, entre otros, así mismo la tasa de infiltración que se determinó por el método de infiltración de Horton, Green Ampt y Número de Curva. La calibración del modelo se hizo utilizando la lluvia registrada el día 14 de octubre del 2021, la cual fue aforada en dos puntos estratégicos del Recinto Universitario Rubén Darío de secciones uniformes, en estas secciones se midieron los caudales de referencia, para después hacer la comparación y ajustes con los caudales que registra el modelo de EPA SWMM. Utilizando los valores referenciales del coeficiente de Nash-Sutcliffe se encontró que los resultados de referencia o medidos en el área de estudio, para el primer aforo se ajustan con un coeficiente en un rango Bueno, mientras que para el segundo aforo se ajusta de manera Satisfactoria respecto a los resultados que simula el modelo de EPA SWM

A Hybrid Metaheuristic-Based Approach for the Aerodynamic Optimization of Small Hybrid Wind Turbine Rotors

This work presents a novel framework for the aerodynamic design and optimization of blades for small horizontal axis wind turbines (WT). The framework is based on a state-of-the-art blade element momentum model, which is complemented with the XFOIL 6.96 software in order to provide an estimate of the sectional blade aerodynamics. The framework considers an innovative nested-hybrid solution procedure based on two metaheuristics, the virtual gene genetic algorithm and the simulated annealing algorithm, to provide a near-optimal solution to the problem. The objective of the study is to maximize the aerodynamic efficiency of small WT (SWT) rotors for a wide range of operational conditions. The design variables are (1) the airfoil shape at the different blade span positions and the radial variation of the geometrical variables of (2) chord length, (3) twist angle, and (4) thickness along the blade span. A wind tunnel validation study of optimized rotors based on the NACA 4-digit airfoil series is presented. Based on the experimental data, improvements in terms of the aerodynamic efficiency, the cut-in wind speed, and the amount of material used during the manufacturing process were achieved. Recommendations for the aerodynamic design of SWT rotors are provided based on field experience

Dengue virus infection induces chromatin remodeling at locus AAEL006536 in the midgut of Aedes aegypti

Objective. To identify and characterize Aedes aegypti’s AAEL006536 gene proximal upstream cis-regulatory sequences activated by dengue virus infection. Materials and methods. A. aegypti Rockefeller strain mosquitoes were blood fed or infected with dengue virus 2. Open chromatinprofiling was then carried out in pools of midguts from each group of mosquitoes. Results. The proximal upstream region does not contain open chromatin sites in the midguts of blood-fed mosquitoes as detected by FAIRE-qPCR. In contrast, two cis-regulatory sites were identified in the same upstream region of dengue virus-infected mosquito midguts. The distal sequence contains STAT-, REL- and C/EBP-type transcription factor binding sites. Conclusion. The activation of two proximal cis-regulatory sequences, induced by dengue virus infection, is mediated by chromatin remodeling mechanisms. Binding sites suggest a dengue virus infectioninduced participation of immunity transcription factors in the up-regulation of this gene. This suggests the participation of the AAEL006536 gene in the mosquito’s antiviral innate immune response

Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial

This study assessed the effect of 12-week aerobic exercise on arterial stiffness (primary outcome), inflammation, oxidative stress, and cardiorespiratory fitness (secondary outcomes) in women with systemic lupus erythematosus (SLE). In a non-randomized clinical trial, 58 women with SLE were assigned to either aerobic exercise (n = 26) or usual care (n = 32). The intervention comprised 12 weeks of aerobic exercise (2 sessions X 75 min/week) between 40–75% of the individual’s heart rate reserve. At baseline and at week 12, arterial stiffness was assessed through pulse wave velocity (PWV), inflammatory (i.e., high-sensitivity C-reactive protein [hsCRP], tumor necrosis factor alpha [TFN- α], and inteleukin 6 [IL-6]) and oxidative stress (i.e., myeloperoxidase [MPO]) markers were obtained from blood samples, and cardiorespiratory fitness was assessed (Bruce test). There were no between-group differences in the changes in arterial stiffness (median PWV difference -0.034, 95% CI -0.42 to 0.36 m/s; p = 0.860) or hsCRP, TNF-α, IL-6, and MPO (all p > 0.05) at week 12. In comparison to the control group, the exercise group significantly increased cardiorespiratory fitness (median difference 2.26 minutes, 95% CI 0.98 to 3.55; p = 0.001). These results suggest that 12 weeks of progressive treadmill aerobic exercise increases cardiorespiratory fitness without exacerbating arterial stiffness, inflammation, or oxidative stress in women with SLE.This work was supported by Fundación para la Investigación Biosanitaria de Andalucía Oriental (grant number: PI-0525-2016) and the Ilustre Colegio Oficial de Médicos de Granada (Premios de Investigación 2017). BG-C was supported by the Spanish Ministry of Education (FPU15/00002)

Association of objectively measured physical activity and sedentary time with arterial stiffness in women with systemic lupus erythematosus with mild disease activity

Objectives To examine the association of objectively measured physical activity (PA) intensity levels and sedentary time with arterial stiffness in women with systemic lupus erythematosus (SLE) with mild disease activity and to analyze whether participants meeting the international PA guidelines have lower arterial stiffness than those not meeting the PA guidelines. Methods The study comprised 47 women with SLE (average age 41.2 [standard deviation 13.9]) years, with clinical and treatment stability during the 6 months prior to the study. PA intensity levels and sedentary time were objectively measured with triaxial accelerometry. Arterial stiffness was assessed through pulse wave velocity, evaluated by Mobil-O-Graph® 24h pulse wave analysis monitor. Results The average time in moderate to vigorous PA in bouts of 10 consecutive minutes was 135.1±151.8 minutes per week. There was no association of PA intensity levels and sedentary time with arterial stiffness, either in crude analyses or after adjusting for potential confounders. Participants who met the international PA guidelines did not show lower pulse wave velocity than those not meeting them (b = -0.169; 95% CI: -0.480 to 0.143; P = 0.280). Conclusions Our results suggest that PA intensity levels and sedentary time are not associated with arterial stiffness in patients with SLE. Further analyses revealed that patients with SLE meeting international PA guidelines did not present lower arterial stiffness than those not meeting the PA guidelines. Future prospective research is needed to better understand the association of PA and sedentary time with arterial stiffness in patients with SLE.This work was supported by Fundación para la Investigación Biosanitaria de Andalucia Oriental, Grant numbers: PI-0525-2016 (http:// www.fibao.es/; http://www.ibsgranada.es/) to JAVH. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Hábitos de consumo de vino en Canarias: Frenos e impulsores al consumo de vinos canarios

El objetivo general con el que se plantea este estudio consiste en, partiendo del conocimiento de los hábitos de consumo, evaluar y caracterizar la intención de consumo de vino local.Instituto Canario de Calidad Agroalimentaria del Gobierno de Canaria

COVID-19 mRNA Based Vaccine Immune-Response Assessment in Nursing Home Residents for Public Health Decision

Nursing home residents (NHR) have been targeted as a vaccination priority due to their higher risk of worse outcome after COVID-19 infection. The mRNA-based vaccine BTN2b2 was first approved in Europe for NHRs. The assessment of the specific vaccine immune response (both humoral and cellular) at long term in NHRs has not been addressed yet. A representative sample of 624 NHR subjects in Northern region of Spain was studied to assess immune response against full vaccination with BTN2b2. The anti-S1 antibody levels and specific T cells were measured at two and six months after vaccination. 24.4% of NHR had a previous infection prior to vaccination. The remaining NHR were included in the full vaccination assessment group (FVA). After two months, a 94.9% of the FVA presented anti-S1 antibodies, whereas those seronegative without specific cellular response were 2.54%. At long-term, the frequency of NHR within the FVA group with anti-S1 antibodies at six months were 88.12% and the seronegative subjects without specific cellular response was 8.07%. The cellular immune assays complement the humoral test in the immune vaccine response assessment. Therefore, the cellular immune assessment in NHRs allows for the fine tuning of those seronegative subjects with potential competent immune responses against the vaccine