Correlación entre mielo cultivos y hemocultivos para el diagnóstico de salmonelosis en el Hospital Militar Central 2008 - 2010

La salmonelosis es una enfermedad infectocontagiosa, invasiva, generalizada, del sistema retículo-endotelial producida por enterobacterias del género Salmonella. Comprende un conjunto de cuadros clínicos cuya principal manifestación es la gastroenteritis aguda, una de las intoxicaciones alimentarias más comunes causadas por agua y alimentos contaminados, especialmente carnes. Esta es una causa importante de morbilidad y mortalidad alrededor del mundo, se estima que esta entidad causa más de 16 millones de casos nuevos y 600.000 muertes por año. Dadas las variadas manifestaciones clínicas de la salmonelosis, la confirmación del diagnóstico de estas infecciones, requiere de métodos microbiológicos que permitan el aislamiento o identificación del agente causal o de pruebas serológicas que facilitan reconocer anticuerpos específicos presentes en el suero de los paciente

Representation of non-semibounded quadratic forms and orthogonal additivity

In this article we give a representation theorem for non-semibounded Hermitean quadratic forms in terms of a (non-semibounded) self-adjoint operator. The main assumptions are closability of the Hermitean quadratic form, the direct integral structure of the underlying Hilbert space and orthogonal additivity. We apply this result to several examples, including the position operator in quantum mechanics and quadratic forms invariant under a unitary representation of a separable locally compact group. The case of invariance under a compact group is also discussed in detail

Coarse-Grained Simulations of Release of Drugs Housed in Flexible Nanogels: New Insights into Kinetic Parameters

Funding: This research was funded by “Consejería de Economía, Conocimiento, Empresas y Universidad, Junta de Andalucía, Programa Operativo FEDER Andalucía 2014-2020”, grant number P20_00138 as well as “Ministerio de Ciencia e Innovación”, grant numbers PID2020-116615RA-I00 and PGC2018-098770-B-I00.The diffusion-controlled release of drugs housed in flexible nanogels has been simulated with the help of a coarse-grained model that explicitly considers polymer chains. In these in silico experiments, the effect of its flexibility is assessed by comparing it with data obtained for a rigid nanogel with the same volume fraction and topology. Our results show that the initial distribution of the drug can exert a great influence on the release kinetics. This work also reveals that certain surface phenomena driven by steric interactions can lead to apparently counterintuitive behaviors. Such phenomena are not usually included in many theoretical treatments used for the analysis of experimental release kinetics. Therefore, one should be very careful in drawing conclusions from these formalisms. In fact, our results suggest that the interpretation of drug release curves in terms of kinetic exponents (obtained from the Ritger–Peppas Equation) is a tricky question. However, such curves can provide a first estimate of the drug diffusion coefficient.Consejería de Economía, Conocimiento, Empresas y Universidad, Junta de Andalucía, Programa Operativo FEDER Andalucía 2014-2020, grant number P20_00138Ministerio de Ciencia e Innovación, grant numbers PID2020-116615RA-I00 and PGC2018-098770-B-I0

A low-power reconfigurable ADC for biomedical sensor interfaces

This paper presents a 12-bit low-voltage low-power reconfigurable Analog-to-Digital Converter (ADC). The design employs Switched Capacitor (SC) techniques and implements a Successive Approximation (SA) algorithm. The ADC can be tuned to handle a large variety of biopotential signals, with digitally selectable resolution and input signal amplitude. It achieves 10.4-bit of effective resolution sampling at 56kS/s, with a power consumption below 3μW from a 1V voltage supply.Ministerio de Educación y Ciencia TEC2006-03022Junta de Andalucía TIC-0281

A self-calibration circuit for a neural spike recording channel

This paper presents a self-calibration circuit for a neural spike recording channel. The proposed design tunes the bandwidth of the signal acquisition Band-Pass Filter (BPF), which suffers from process variations corners. It also performs the adjustment of the Programmable Gain Amplifier (PGA) gain to maximize the input voltage range of the analog-to-digital conversion. The circuit, which consists on a frequency-controlled signal generator and a digital processor, operates in foreground, is completely autonomous and integrable in an estimated area of 0.026mm 2 , with a power consumption around 450nW. The calibration procedure takes less than 250ms to select the configuration whose performance is closest to the required one.Ministerio de Ciencia e Innovación TEC2009-08447Junta de Andalucía TIC-0281

El papel de la función de extensión de la Universidad de Cundinamarca en el desarrollo regional durante el periodo 2005-2008

No cabe duda que existe una relación dialéctica entre la sociedad y la Universidad, pero esta relación puede tener matices diferenciados en función de distintos momentos y contextos, con lo cual podemos encontrar Universidades profundamente enraizadas en la vida de la comunidad, donde no solo se satisfacen demandas sino también e atienden necesidades, hasta otras encerradas en si mismas, alejadas del contexto, sin respuestas concretas al medio, a excepción de la masificación de coberturas y producción de profesionales

Fractionation and fluxes of metals and radionuclides during the recycling process of phosphogypsum wastes applied to mineral CO2 sequestration

The industry of phosphoric acid produces a calcium-rich by-product known as phosphogypsum, which is usually stored in large stacks of millions of tons. Up to now, no commercial application has been widely implemented for its reuse because of the significant presence of potentially toxic contaminants. This work confirmed that up to 96% of the calcium of phosphogypsum could be recycled for CO2 mineral sequestration by a simple two-step process: alkaline dissolution and aqueous carbonation, under ambient pressure and temperature. This CO2 sequestration process based on recycling phosphogypsum wastes would help to mitigate greenhouse gasses emissions. Yet this work goes beyond the validation of the sequestration procedure; it tracks the contaminants, such as trace metals or radionuclides, during the recycling process in the phosphogypsum. Thus, most of the contaminants were transferred from raw phosphogypsum to portlandite, obtained by dissolution of the phosphogypsum in soda, and from portlandite to calcite during aqueous carbonation. These findings provide valuable information for managing phosphogypsum wastes and designing potential technological applications of the by-products of this environmentally-friendly proposal.Junta de Andalucía P10-RNM-6300, P12- RNM-226

On the theory of self-adjoint extensions of symmetric operators and its applications to quantum physics

This is a series of five lectures around the common subject of the construction of self-adjoint extensions of symmetric operators and its applications to Quantum Physics. We will try to offer a brief account of some recent ideas in the theory of self-adjoint extensions of symmetric operators on Hilbert spaces and their applications to a few specific problems in Quantum Mechanics

Power Efficient ADCs for Biomedical Signal Acquisition

Open Access.Peer reviewe