A simulation study of single cell inside an integrated dual nanoneedle-microfludic system

Electrical properties of living cells have been proven to play significant roles in understanding of various biological activities including disease progression both at the cellular and molecular levels. Analyzing the cell’s electrical states especially in single cell analysis (SCA) lead to differentiate between normal cell and cancer cell. This paper presents a simulation study of micro-channel and nanoneedle structure, fluid manipulation and current flow through HeLa cell inside a microfluidic channel. To perform electrical measurement, gold dual nanoneedle has been utilized. The simulation result revealed, the cell penetration occurs at microchannel dimension and solution flow rate is 22 µm x 70 µm x 25 µm (width x length x height) and 0.396 pL/min, respectively. The purposed device has capability to characterize the electrical property of single cells can be used as a novel method for cell viability detection in instantaneous manner

Implementation of Single Minutes of Exchange Die (SMED) in Malaysia Metal Stamping Industry: A Case Study

Downtime loss due to long set-up time will lead to shorter actual production time. This situation will result in a loss to the company because they could not produce their products as planned. Therefore, set-up time needs to be reduced to maximize the resources invested by the company. The most popular approach to is an approach to improve setup time is Single Minutes of Exchange Die (SMED), developed by Shigeo Shingo in early 1960s. Setup operations were divided by into fundamental types; Internal setup and External setup. By Converting Internal setup to External setup, the company can reduced the setup time and thus, lead to longer actual production time. This paper presents an afford of a Malaysia’s metal stamping company in implementing SMED in their company. The company is a supplier of passenger car’s components to Malaysia’s major car makers. The implementation was carried out by separating Internal and External Setup, converting Internal to External Setup and finally streamlining all aspects of the setup operation. After implemented SMED approach, the company managed to reduce their set-up time from 32 minutes to 12 minutes. However, the company still working hard to achieve the objective of SMED, which is to complete all changeovers are in a single number of minutes or less than 10 minutes

Dual element MIMO planar inverted-F antenna for 5G millimeter wave application

This work presents a 28 GHz Dual Element Multiple Input Multiple Output (MIMO) Planar Inverted-F Antenna for millimeter wave 5G mobile terminal. The antenna design employs PIFA design concept as it is a common antenna type use for mobile phone as it provides wide bandwidth and good performance. The antenna design begins with a characterization of the single element PIFA design and then extended to Dual Element MIMO PIFA design. The single element PIFA design is enhanced to MIMO design by extending the ground plane and locate the second PIFA at the other end. Isolation between the antenna elements of the MIMO PIFA is analyzed by varying the gap distance between the antenna elements. The result for Envelope Correlation Coefficient, Diversity Gain and Multiplexing Efficiency is also presented. The simulation computed using Computer Simulation Technology (CST) Microwave Studio software

Mechanical performance of roselle/sugar palm fiber hybrid reinforced polyurethane composites

The effect of sugar palm fiber (SPF) loading was studied relative to the mechanical properties of roselle (RF)/SPF/thermoplastic polyurethane (TPU) hybrid composites. RF/SPF/TPU hybrid composites were fabricated at different weight ratios (100:0, 75:25, 50:50, 25:75, and 0:100) by melt mixing and hot compression. The mechanical (tensile, flexural, and impact test) and morphological properties of tensile fractured samples were examined using a universal testing machine, impact machine, and scanning electron microscope. It was found that the hybridization of RF/SPF increased its impact strength corresponding to the increases in the SPF content of the composites. The tensile and flexural properties of the hybrid composites decreased due to poor interfacial bonding between the fiber and matrix. Scanning electron micrographs of the tensile fractured surface of the RF/SPF hybrid composites revealed fiber pullouts and poor adhesion bonding. In conclusion, the hybridization of SPF with RF/TPU composites enhanced its impact strength while decreasing the tensile and flexural strength

The Novel Digital Image Correlation Technique in Predicting Behaviour and Failure of Hybrid Composite

This paper presents a technique in measuring deformation occurs on in-plane hybrid composite CFRP/GFRP. The challenging task of extracting mechanical properties of the hybrid composite is assisted with the use of Digital Image Correlation (DIC) technique. DIC is an innovative technique which able to capture full field deformation of tensile deformation. The complex deformation captured for hybrid composite in-plane tensile deformation and behavior using Digital Image Correlation (DIC) under static loading is a new area of study in literature. Generally, hybrid composite consists of more than one reinforcing sections or multiple reinforcing or multiple matrix sections or single reinforcing phase with multiple matrix phases. As a result of a compromise between the materials within the hybrid composite, the deformation and stress analysis are to be evaluated and tailored as each constituent of material carry their own desired mechanical properties according to a performance requirement. It is found in relation of stress-strain relationship of hybrid composite under tensile loading via DIC, the modulus of elasticity is found to record value around 92-97GPa which in theoretical benchmark located in between value of Modulus of Elasticity, E1 for CFRP(120GPa) and GFRP(42GPa) which proves the occurrence of the hybrid effect. It is a new research area in utilizing digital image correlation (DIC) technique on hybrid composite rather than conventional composite in material characterization

Dielectric study of electrolyzed rubber

Rubber was produced by placing rubber latex between two electrodes between which an external voltage was maintained. The thickness of the rubber deposited on the anode was measured as a function of time of electrolysis, voltage applied across the electrodes and distance between the electrodes. Based on the observed dielectric responses of rubber obtained through the electrolysis process, an electrical model of conductance and complex capacitance elements linked in parallel is proposed, indicating the additive nature of the individual responses in the system. Electrical representation of rubber obtained by simple drying however showed two different models. Natural rubber was found to have all the elements connected in parallel while that of vulcanized rubber was found to have a series connection of a pair of parallel connected conductance and capacitance elements

Thermal Diffusivity of Silver Metallic Nanoparticles in Clay Matrix

In this work, we have applied thermal lens (TL) technique to measure thermal diffusivity of clay suspensions containing metallic silver nanoparticles (Ag-NPs) prepared by chemical reduction method in different concentration. This study carried out with diode laser (wavelength 514 nm, power 80mW) as the excitation source and intensity stabilized He-Ne laser as a probe beam. The results show that thermal diffusivity of fluid increases when Ag-NPs concentrations increase

Knowledge management to boost productivity in manufacturing

Data are the crucial element for productivity improvement and the evaluation or measurement process in the manufacturing sector because the data can tell the real situation about the production site. The dataare useful for productivity improvement by using certain lean manufacturing’s tools such as Value Stream Mapping (VSM), Single Minutes of Exchange Die (SMED), Total Productive Maintenance (TPM), and others. The data are also necessary for performance measurement. In this paper, we discuss the necessary data that should be included in a knowledge repository for manufacturing where the data then will be used by an assessment tool. The assessment tool is an important factor because knowledge management has a deep relationship with performance evaluation and measurement. Data Management to boost productivity in manufacturing can be divided into five phase and consists of in fourteen steps

Aerodynamics of harmonically oscillating aerofoil at low Reynolds number

Two-dimensional flows over harmonically oscillating symmetrical aerofoil at reduced frequency of 0.1 were investigated for a Reynolds number of 135,000, with focus on the unsteady aerodynamic forces, pressure and vortex dynamics at post-stall angles of attack. Numerical simulations using ANSYS® FLUENT CFD solver, validated by wind tunnel experiment, were performed to study the method of sliding mesh employed to control the wing oscillation. The transport of flow was solved using incompressible, unsteady Reynolds-Averaged Navier-Stokes equations. The 2-equation k-ε realizable turbulence model was used as turbulence closure. At large angle of attack, complex flows structure developed on the upper surface of the aerofoil induced vortex shedding from the activity of separated flows and interaction of the leading edge vortex with the trailing edge one. This interaction at some stage promotes the generation of lift force and delays the static stall. In this investigation, it was found that the sliding mesh method combined with the k-ε realizable turbulence model provides better aerodynamic loads predictions compared to the methods reported in literature

The opportunity of magnetic induction tomography modality in breast cancer detection

The needs for non-invasive technique in breast cancer detection could enhance and preserve the future of medical field in Malaysia as well as countries around the world. Breast cancer has become the main concern nowadays not only for women but for man as well. In overall, the risk of women getting breast cancer is higher than man due to the denser tissue of breast in women compare to man. Beside the unawareness for the disease, the reason which contributes to this increasing number of breast cancer reported is also due to the limitations arising from modalities such as MRI, Mammography, ultrasound and other modalities. An alternative to current technologies should be improved for early detection and treatment which causes no physical harm to patients if possible. Thus, non-invasive and better technology in detecting breast cancer is very much needed in the current market. This paper will be discussing the insights of Magnetic Induction Tomography techniques in breast cancer detection