21 research outputs found

    Sciatica (Gridhrasi) - An Ayurveda Perspective

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    Large number of population suffers from low back pain. Chronic low back pain (CLBP) prevalence increases linearly from the third decade of life on, until the 60 years of age, being more prevalent in women. Sciatica is the most common debilitating condition causes CLBP. Radiating leg pain and related disabilities are the observed in sciatica. Nearly 40% people experience sciatic pain at some point in their life. The diagnosis of sciatica and its management varies considerably within and between countries. Conventional Medicine and surgery are widely used in the management of sciatica. There is radical rise in the use of Complementary and Alternative Medicine (CAM) in patients with sciatica. Ayurveda is one of the widely used CAM in the recent past. Sciatica resembles the disease Gridharsi of Ayurveda. Gridharsi is one among the Vataja nanatmaja vyadhi, where dysfunction of Vata affect gridharsi nadi characterized by low back pain radiating to lower limbs, stiffness and pricking type of pain. It starts from kati- prishta (pelvic region and Lumbosacral) radiating to jangha paada (Thigh, Feets) with impairment of lifting the leg. The gait of the person is very similar to vulture (Gridhra) hence the name is given as Gridharsi. In this article, attempt has been made to review the Ayurvedic classics text and related literatures to understand the disease Gridharsi with emphasis on its samprapti on the basis of Kriyakala and role of Shodhana and Shamana chikitsa in the management of Gridharsi

    QCD and strongly coupled gauge theories : challenges and perspectives

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    We highlight the progress, current status, and open challenges of QCD-driven physics, in theory and in experiment. We discuss how the strong interaction is intimately connected to a broad sweep of physical problems, in settings ranging from astrophysics and cosmology to strongly coupled, complex systems in particle and condensed-matter physics, as well as to searches for physics beyond the Standard Model. We also discuss how success in describing the strong interaction impacts other fields, and, in turn, how such subjects can impact studies of the strong interaction. In the course of the work we offer a perspective on the many research streams which flow into and out of QCD, as well as a vision for future developments.Peer reviewe

    Purinergic signalling and immune cells

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    This review article provides a historical perspective on the role of purinergic signalling in the regulation of various subsets of immune cells from early discoveries to current understanding. It is now recognised that adenosine 5'-triphosphate (ATP) and other nucleotides are released from cells following stress or injury. They can act on virtually all subsets of immune cells through a spectrum of P2X ligand-gated ion channels and G protein-coupled P2Y receptors. Furthermore, ATP is rapidly degraded into adenosine by ectonucleotidases such as CD39 and CD73, and adenosine exerts additional regulatory effects through its own receptors. The resulting effect ranges from stimulation to tolerance depending on the amount and time courses of nucleotides released, and the balance between ATP and adenosine. This review identifies the various receptors involved in the different subsets of immune cells and their effects on the function of these cells

    Soft tissue infections with arcanobacterium haemolyticum: Report of three cases

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    We report here three polymicrobial wound infections associated with Arcanobacterium haemolyticum in rural patients aged between 60-65 years. In two patients, one with cellulitis and the other with postoperative wound infection following amputation of the limb, Arcanobacterium haemolyticum was isolated repeatedly along with β haemolytic streptococci (BHS). The BHS belonged to Lancefield′s group G and group C respectively. In another patient, who was a diabetic with chronic osteomyelitis, Arcanobacterium haemolyticum was isolated along with Proteus vulgaris . All the three isolates of Arcanobacterium haemolyticum isolated by us were uniformly resistant to cotrimoxazole and sensitive to penicillin, erythromycin, clindamycin, ciprofloxacin and gentamicin. Erythromycin alone or combined therapy of penicillin with erythromycin or penicillin with ciprofloxacin was effective in treating these infections
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