CIARD Activities in the CGIAR: Final Report on activities, outputs and lessons from the implementation of the CIARD grant to the CGIAR

CIARD activities for the CGIAR have been led by the CGIAR ICT-KM program, which has worked closely with scientists, researchers, research managers and information and communication specialists across the CGIAR: Centers, Programs and projects. This document reports on activities implemented by the CGIAR ICT-KM program through a grant (PO245548) from FAO, originally from the DFID CIARD grant, but is based on activities being undertaken by Centres, Programs and projects of the CGIAR. Special acknowledgement and appreciation is given to ILRI for hosting the CIARD CGIAR grant coordinator and its great support to learning, documentation and promotion of CIARD principles and pathways

Agricultural Research

Besemer H, Addison C, Pelloni F, Porcari EM, Manning-Thomas N. Agricultural Research. In: Meier zu Verl C, Horstmann W, eds. Studies on Subject-Specific Requirements for Open Access Infrastructure. Bielefeld: Universitätsbibliothek; 2011: 19-68.Agricultural science combines amongst others applied socioeconomic disciplines, applied plant animal physiology and environmental sciences (soil science, hydrology, erosion/geomorphology). Research workflows, like for other applied sciences, depend on the disciplines and methods that are applied, as well as on the way that the organisation that does the research is embedded in the agricultural sector. This chapter was written from the perspective of the Consultative Group on International Agricultural Research (CGIAR), a global partnership that unites organisations engaged in research for sustainable development with funders, including governments, foundations and international and regional organisations. CGIAR's mission implies working for international development, but many of the processes apply to national agricultural research organisations as well. As it impossible to give a general framework for research workflows in our field, we will present case studies from the CIAGR to illustrate the diversity

Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders.

International audienceSHANK3 (also known as ProSAP2) regulates the structural organization of dendritic spines and is a binding partner of neuroligins; genes encoding neuroligins are mutated in autism and Asperger syndrome. Here, we report that a mutation of a single copy of SHANK3 on chromosome 22q13 can result in language and/or social communication disorders. These mutations concern only a small number of individuals, but they shed light on one gene dosage-sensitive synaptic pathway that is involved in autism spectrum disorders

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Giving young people a chance in agricultural research and development

Keynote presentation made at the CGIAR Gender and Diversity Program?s Annual Networking Event on ?What do young people expect from their research institution?? held at the CGIAR Annual General Meeting, Maputo, Mozambique, 30 November 200