278 research outputs found
Sensorial Intermedialities in Roman Letters: Cicero, Horace, and Ovid
In recent years, much progress has been made towards elucidating the function of ekphrasis in Roman epistolography, especially with relation to the writings of Seneca and Pliny. Following on from these precedents, this article mines the epistles of three prominent Roman letter-writers, Cicero, Horace, and Ovid, for their intermedial elements. The motifs of oral quotations, handwriting, and human tear stains, which interweave the sources analysed, are shown not only to straddle the borders between distinct media, but also to engage with multiple senses as a result of their multiple medialities. Oral quotations integrate speech into written texts and thus necessitate both sight and hearing. Handwriting likewise consists of both a ‘basic mediality’ – the visual – and a ‘qualified mediality’ of chirographic distinctiveness, and thus necessitates not only perception via sight but also recognition. Tear stains, which range from the actual smudges in Cicero’s missives to metaphorical ones in Tears don’t feature in Horace’s letters. Ovid’s epistles, are in turn geared both towards sight and touch, since they simultaneously alter the letter’s appearance and surface. However, these intermedial connections have different effects in prose and poetry epistles: they enable the former to transcend the very category of ‘letter’, but confine the latter within the epistolary genre by characterising them in material terms
Dynamics of multi-kinks in the presence of wells and barriers
Sine-Gordon kinks are a much studied integrable system that possesses
multi-soliton solutions. Recent studies on sine-Gordon kinks with
space-dependent square-well-type potentials have revealed interesting dynamics
of a single kink interacting with wells and barriers. In this paper, we study a
class of smooth space-dependent potentials and discuss the dynamics of one kink
in the presence of different wells. We also present values for the critical
velocity for different types of barriers. Furthermore, we study two kinks
interacting with various wells and describe interesting trajectories such as
double-trapping, kink knock-out and double-escape.Comment: 17 pages, 7 figure
Identifying clustering at high redshift through actively star-forming galaxies
Identifying galaxy clustering at high redshift (i.e. z > 1) is essential to
our understanding of the current cosmological model. However, at increasing
redshift, clusters evolve considerably in star-formation activity and so are
less likely to be identified using the widely-used red sequence method. Here we
assess the viability of instead identifying high redshift clustering using
actively star-forming galaxies (SMGs associated with over-densities of
BzKs/LBGs). We perform both a 2- and 3-D clustering analysis to determine
whether or not true (3D) clustering can be identified where only 2D data are
available. As expected, we find that 2D clustering signals are weak at best and
inferred results are method dependant. In our 3D analysis, we identify 12 SMGs
associated with an over-density of galaxies coincident both spatially and in
redshift - just 8% of SMGs with known redshifts in our sample. Where an SMG in
our target fields lacks a known redshift, their sightline is no more likely to
display clustering than blank sky fields; prior redshift information for the
SMG is required to identify a true clustering signal. We find that the strength
of clustering in the volume around typical SMGs, while identifiable, is not
exceptional. However, we identify a small number of highly clustered regions,
all associated with an SMG. The most notable of these, surrounding
LESSJ033336.8-274401, potentially contains an SMG, a QSO and 36 star-forming
galaxies (a > 20sig over-density) all at z~1.8. This region is highly likely to
represent an actively star-forming cluster and illustrates the success of using
star-forming galaxies to select sites of early clustering. Given the increasing
number of deep fields with large volumes of spectroscopy, or high quality and
reliable photometric redshifts, this opens a new avenue for cluster
identification in the young Universe.Comment: 24 pages, 14 figures, accepted MNRA
Immunity to self co-generates regulatory T cells
Immune responses to self are kept in check by tolerance mechanisms, including suppression by regulatory T cells (Tregs). The defective generation of Tregs specific for self-antigens may lead to autoimmune disease. We identified a novel population of human CD4^+^ Tregs, characterized by high surface expression of CD52, which is co-generated in response to autoantigen. Blood CD4^+^CD52^hi^ T cells were generated preferentially in response to low-dose autoantigen and suppressed proliferation and interferon-[gamma] production by other T cells. Depletion of resting CD4^+^CD52^hi^ T cells enhanced the T-cell response to autoantigen. CD4^+^CD52^hi^ Tregs were neither derived from nor distinguished by markers of conventional resting CD4^+^CD25^+^ Tregs. In response to the pancreatic islet autoantigens glutamic acid decarboxylase, the generation of CD4^+^CD52^hi^ Tregs was impaired in individuals with and at-risk for type 1 diabetes, compared to healthy controls and individuals with type 2 diabetes. CD4^+^CD52^hi^ Tregs co-generated to self-antigen may therefore contribute to immune homeostasis and protect against autoimmune disease
Galaxy and Mass Assembly (GAMA): Panchromatic data release (far-UV–far-IR) and the low-z energy budget
We present the Galaxy And Mass Assembly (GAMA) Panchromatic Data Release (PDR) constituting over 230 deg2 of imaging with photometry in 21 bands extending from the farUV to the far-IR. These data complement our spectroscopic campaign of over 300k galaxies, and are compiled from observations with a variety of facilities including: GALaxy Evolution eXplorer, Sloan Digital Sky Survey, Visible and Infrared Telescope for Astronomy (VISTA), Wide-field Infrared Survey Explorer, and Herschel, with the GAMA regions currently being surveyedbyVLTSurveyTelescope(VST)andscheduledforobservationsbyAustralianSquare Kilometer Array Pathfinder (ASKAP). These data are processed to a common astrometric solution, from which photometry is derived for ∼221373 galaxies with r < 19.8 mag. Online tools are provided to access and download data cutouts, or the full mosaics of the GAMA regions in each band. We focus, in particular, on the reduction and analysis of the VISTA VIsta Kilo-degree INfrared Galaxy data, and compare to earlier data sets (i.e. 2MASS and UKIDSS) before combining the data and examining its integrity. Having derived the 21-band photometric catalogue, we proceed to fit the data using the energy balance code MAGPHYS. These measurements are then used to obtain the first fully empirical measurement of the
0.1–500 μm energy output of the Universe. Exploring the cosmic spectral energy distribution
across three time-intervals (0.3–1.1, 1.1–1.8, and 1.8–2.4 Gyr), we find that the Universe is currently generating (1.5 ± 0.3) × 1035 h70 W Mpc−3, down from (2.5 ± 0.2) × 1035 h70 W Mpc−3 2.3 Gyr ago. More importantly, we identify significant and smooth evolution in the integrated photon escape fraction at all wavelengths, with the UV escape fraction increasing from 27(18) per cent at z= 0.18 in NUV(FUV) to 34(23) per cent at z= 0.06. The GAMA PDR can be found at: http://gama-psi.icrar.org/
Limits on dust emission from z~5 LBGs and their local environments
We present 1.2mm MAMBO-2 observations of a field which is over-dense in Lyman
Break Galaxies (LBGs) at z~5. The field includes seven
spectroscopically-confirmed LBGs contained within a narrow (z=4.95+/-0.08)
redshift range and an eighth at z=5.2. We do not detect any individual source
to a limit of 1.6 mJy/beam (2*rms). When stacking the flux from the positions
of all eight galaxies, we obtain a limit to the average 1.2 mm flux of these
sources of 0.6mJy/beam. This limit is consistent with FIR imaging in other
fields which are over-dense in UV-bright galaxies at z~5. Independently and
combined, these limits constrain the FIR luminosity (8-1000 micron) to a
typical z~5 LBG of LFIR<~3x10^11 Lsun, implying a dust mass of Mdust<~10^8 Msun
(both assuming a grey body at 30K). This LFIR limit is an order of magnitude
fainter than the LFIR of lower redshift sub-mm sources (z~1-3). We see no
emission from any other sources within the field at the above level. While this
is not unexpected given millimetre source counts, the clustered LBGs trace
significantly over-dense large scale structure in the field at z = 4.95. The
lack of any such detection in either this or the previous work, implies that
massive, obscured star-forming galaxies may not always trace the same
structures as over-densities of LBGs, at least on the length scale probed here.
We briefly discuss the implications of these results for future observations
with ALMA.Comment: 10 pages, 6 figures, MNRAS Accepte
HLA-B*27:05 alters immunodominance hierarchy of universal influenza-specific CD8+ T cells
Seasonal influenza virus infections cause 290,000–650,000 deaths annually and severe morbidity in 3–5 million people. CD8+ T-cell responses towards virus-derived peptide/human leukocyte antigen (HLA) complexes provide the broadest cross-reactive immunity against human influenza viruses. Several universally-conserved CD8+ T-cell specificities that elicit prominent responses against human influenza A viruses (IAVs) have been identified. These include HLA-A*02:01-M158-66 (A2/M158), HLA-A*03:01-NP265-273, HLA-B*08:01-NP225-233, HLA-B*18:01-NP219-226, HLA-B*27:05-NP383-391 and HLA-B*57:01-NP199-207. The immunodominance hierarchies across these universal CD8+ T-cell epitopes were however unknown. Here, we probed immunodominance status of influenza-specific universal CD8+ T-cells in HLA-I heterozygote individuals expressing two or more universal HLAs for IAV. We found that while CD8+ T-cell responses directed towards A2/M158 were generally immunodominant, A2/M158+CD8+ T-cells were markedly diminished (subdominant) in HLA-A*02:01/B*27:05-expressing donors following ex vivo and in vitro analyses. A2/M158+CD8+ T-cells in non-HLA-B*27:05 individuals were immunodominant, contained optimal public TRBV19/TRAV27 TCRαβ clonotypes and displayed highly polyfunctional and proliferative capacity, while A2/M158+CD8+ T cells in HLA-B*27:05-expressing donors were subdominant, with largely distinct TCRαβ clonotypes and consequently markedly reduced avidity, proliferative and polyfunctional efficacy. Our data illustrate altered immunodominance patterns and immunodomination within human influenza-specific CD8+ T-cells. Accordingly, our work highlights the importance of understanding immunodominance hierarchies within individual donors across a spectrum of prominent virus-specific CD8+ T-cell specificities prior to designing T cell-directed vaccines and immunotherapies, for influenza and other infectious diseases
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