Implication of Higgs at 125 GeV within Stochastic Superspace Framework

We revisit the issue of considering stochasticity of Grassmannian coordinates in N=1 superspace, which was analyzed previously by Kobakhidze {\it et al}. In this stochastic supersymmetry(SUSY) framework, the soft SUSY breaking terms of the minimal supersymmetric Standard Model(MSSM) such as the bilinear Higgs mixing, trilinear coupling as well as the gaugino mass parameters are all proportional to a single mass parameter \xi, a measure of supersymmetry breaking arising out of stochasticity. While a nonvanishing trilinear coupling at the high scale is a natural outcome of the framework, a favorable signature for obtaining the lighter Higgs boson mass $m_h$ at 125 GeV, the model produces tachyonic sleptons or staus turning to be too light. The previous analyses took $\Lambda$, the scale at which input parameters are given, to be larger than the gauge coupling unification scale $M_G$ in order to generate acceptable scalar masses radiatively at the electroweak scale. Still this was inadequate for obtaining $m_h$ at 125 GeV. We find that Higgs at 125 GeV is highly achievable provided we are ready to accommodate a nonvanishing scalar mass soft SUSY breaking term similar to what is done in minimal anomaly mediated SUSY breaking (AMSB) in contrast to a pure AMSB setup. Thus, the model can easily accommodate Higgs data, LHC limits of squark masses, WMAP data for dark matter relic density, flavor physics constraints and XENON100 data. In contrast to the previous analyses we consider $\Lambda=M_G$, thus avoiding any ambiguities of a post-grand unified theory physics. The idea of stochastic superspace can easily be generalized to various scenarios beyond the MSSM . PACS Nos: 12.60.Jv, 04.65.+e, 95.30.Cq, 95.35.+dComment: LaTex, 35 pages, 7 figures. Minor changes in text. B-physics constraints updated with no change in conclusion. Version to be published in PR

In vitro antioxidant and antimicrobial activity of carotenoid pigment extracted from Sporobolomyces sp. isolated from natural source

The aim of the present study was to isolate and study about the antioxidant and antibacterial activity of carotenoid pigment. Sporobolomyces sp. isolated from the phyllosphere surface of rice plant has found to produce carotenoid pigment. The present investigation was carried out for antioxidant assays viz., DPPH, iron reducing and metal chelating activity. A steady increase in the antioxidant activities was observed in the carotenoid pigment with raising the pigment concentration. In the present study, the maximum antioxidation characteristics of carotenoid by DPPH, iron reducing and metal chelating assays (75.04 %, 1.88 % and 59.32 %) were achieved by pigmentation of Sporobolomyces sp. at the concentration of 100 ?g ml-1. The antibacterial activity was studied on several organisms like Enterococcus sp., Staphylococcus aureus, Streptococcus faecalis, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa. Among the six pathogens, the pigment was found to be more effective against E. coli (2.9 cm) and S. aureus (2.6 cm). This study revealed that yeast carotenoid pigment was a potential source for its use in food and pharmaceutical applications

Effect of Implant Height Differences on the Retention and Wear Behaviour of Ball Attachment System in Mandibular Two-Implant Over Dentures: An In Vitro Study

PURPOSE: The purpose of this study was to evaluate in vitro, the effect of implant height differences on the retention and wear behaviour of ball attachment system in mandibular two-implant over dentures. MATERIALS AND METHODS: 22 wax blocks were fabricated and out of these, 2 were used as master blocks and 20 were used as prosthetic blocks. 2 implant analogs were placed in each master wax block with same height in one block and with different height in the other block. Both the master and prosthetic wax blocks were then heat cured. The attachments were placed in the master block and transferred to the prosthetic block by Direct Pick up technique. Group I had test samples placed at same height and Group II at different height. The retention force was tested from baseline to 1440 cycles with 3 time intervals simulating 1 year of clinical use, using Universal testing machine. The data obtained were then subjected to statistical analysis using ‘t’-test. The surface wear was qualitatively evaluated using Stereo microscope. RESULTS: The mean retention force for Group I and II at baseline, 360, 720, 1080, and after 1440 cycles were 24.73N, 23.49N, 22.46N, 21.07N, 19.28N and 27.13N, 25.80N, 24.16N, 22.73N and 21.85N respectively. Group II showed statistically higher retention force than Group I. Both the groups showed significant retention loss over a period of 1 year and wear on the surface of the attachments evaluated. CONCLUSION: Within the limitations of the study, the retention values obtained from the implant analogs placed at different height was significantly higher than that of at same height. But both the values were higher from the value considered minimal for overdenture stability

Chemoenzymatic Probes for Detecting and Imaging Fucose-α(1-2)-galactose Glycan Biomarkers

The disaccharide motif fucose-α(1-2)-galactose (Fucα(1-2)Gal) is involved in many important physiological processes, such as learning and memory, inflammation, asthma, and tumorigenesis. However, the size and structural complexity of Fucα(1-2)Gal-containing glycans have posed a significant challenge to their detection. We report a new chemoenzymatic strategy for the rapid, sensitive detection of Fucα(1-2)Gal glycans. We demonstrate that the approach is highly selective for the Fucα(1-2)Gal motif, detects a variety of complex glycans and glycoproteins, and can be used to profile the relative abundance of the motif on live cells, discriminating malignant from normal cells. This approach represents a new potential strategy for biomarker detection and expands the technologies available for understanding the roles of this important class of carbohydrates in physiology and disease

Spontaneous R-Parity Violation, A4A_4 Flavor Symmetry and Tribimaximal Mixing

We explore the possibility of spontaneous R parity violation in the context of $A_4$ flavor symmetry. Our model contains $SU(3)_c \times SU(2)_L \times U(1)_Y$ singlet matter chiral superfields which are arranged as triplet of $A_4$ and as well as few additional Higgs chiral superfields which are singlet under MSSM gauge group and belong to triplet and singlet representation under the $A_4$ flavor symmetry. R parity is broken spontaneously by the vacuum expectation values of the different sneutrino fields and hence we have neutrino-neutralino as well as neutrino-MSSM gauge singlet higgsino mixings in our model, in addition to the standard model neutrino- gauge singlet neutrino, gaugino-higgsino and higgsino-higgsino mixings. Because all of these mixings we have an extended neutral fermion mass matrix. We explore the low energy neutrino mass matrix for our model and point out that with some specific constraints between the sneutrino vacuum expectation values as well as the MSSM gauge singlet Higgs vacuum expectation values, the low energy neutrino mass matrix will lead to a tribimaximal mixing matrix. We also analyze the potential minimization for our model and show that one can realize a higher vacuum expectation value of the $SU(3)_c \times SU(2)_L \times U(1)_Y$ singlet sneutrino fields even when the other sneutrino vacuum expectation values are extremely small or even zero.Comment: 18 page

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Phototoxic aptamers selectively enter and kill epithelial cancer cells

The majority of cancers arise from malignant epithelial cells. We report the design of synthetic oligonucleotides (aptamers) that are only internalized by epithelial cancer cells and can be precisely activated by light to kill such cells. Specifically, phototoxic DNA aptamers were selected to bind to unique short O-glycan-peptide signatures on the surface of breast, colon, lung, ovarian and pancreatic cancer cells. These surface antigens are not present on normal epithelial cells but are internalized and routed through endosomal and Golgi compartments by cancer cells, thus providing a focused mechanism for their intracellular delivery. When modified at their 5′ end with the photodynamic therapy agent chlorin e6 and delivered to epithelial cancer cells, these aptamers exhibited a remarkable enhancement (>500-fold increase) in toxicity upon light activation, compared to the drug alone and were not cytotoxic towards cell types lacking such O-glycan-peptide markers. Our findings suggest that these synthetic oligonucleotide aptamers can serve as delivery vehicles in precisely routing cytotoxic cargoes to and into epithelial cancer cells