Modelos de control quimioterapéutico contra Fasciola hepatica en ganado bovino en pastoreo en clima cálido húmedo

2 páginas.-- Trabajo presentado al XIII Congreso Latinoamericano de Parasitología ( La Habana, Cuba, 11 al 23 de Noviembre, 1997).La fasciolosis en bovinos en el estado de Veracruz, México, tiene una alta prevalencia, por lo que se considera una necesidad generar información sobre modelos de control. Con el objetivo de evaluar 3 modelos de tratamientos fasciolicidas aplicados de manera estratégica en base a las condiciones climatológicas locales, se emplearon 3 grupos de 23 vacunos cada uno, hembras cruces de cebú con suizo pardo, homogéneos en las cantidades de huevos de 5 g de heces. Se utilizó el triclabendazol a dosis de 12 mg/kg. El grupo 1 fue tratado en enero, el 2 en enero y junio, y el 3 en enero, junio y octubre. Cada 45 días se les practicaron exámenes coprológicos cuantitativos (hpg) por la técnica de sedimentación durante un año. Los bovinos se encontraban localizados en una finca situada en el municipio de Nautla, Estado de Veracruz. Se encontró en el grupo 1 la prevalencia al inicio de 100%, en los siguientes 5 muestreos fue de 21.7 a 91.3 % y en el resto de 100%, mientras que el x de hpg al inicio fue de 13.23.14 se redujo en 5 muestreos de 0.560.26 a 12.12.02 mientras que en 4 se incrementó de 14.63.87 a 21.1 3.06 con diferencia (P0.01) entre el primer muestreo y los siguientes. En el grupo 2 la prevalencia al inicio fue de 100%, posteriormente se redujo en 8 muestreos de 8.6% a 95.6%, mientras que el último muestreo fue de 100%, el x de hpg al inicio fue de 15.043.62 se redujo en 8 muestreos de 0.170.13 a 14.102.13 mientras que el penúltimo muestreo fue de 15.733.07 con diferencia entre el primer muestreo hasta el 8, pero sin diferencia con el 9 y el 10 (P0.01). En el grupo 3 la prevalencia al inicio fue de 100% en los siguientes muestreos se redujo de 15.07% a 94.4%, mientras el x de hpg al inicio fue de 13.132.24 disminuyó en los subsecuentes muestreos 0.270.13 a 11.554.56 se encontró que hubo diferencia entre el primer muestreo con todos los subsecuentes (P0.01). Al comparar entre grupos mediante la prueba de Kruskall-Wallis se encontró que hay diferencia (P0.01) del muestreo 8 al 10.Peer reviewe

Transmission of Calicophoron daubneyi and Fasciola hepatica in Galicia (Spain): Temporal follow-up in the intermediate and definitive hosts

Background Paramphistomosis caused by Calicophoron daubneyi and fasciolosis caused by Fasciola hepatica are common parasitic diseases of livestock animals. Transmission of the diseases depends on the presence of intermediate hosts, i.e. freshwater gastropods such as lymnaeids. We carried out a 2-year-long study of the dynamics of the snail population acting as the intermediate host for these parasites, considering the population structure in terms of size/age and infection status. In addition, we determined the kinetics of trematode egg excretion in grazing cows. Generalized Additive Models (GAMs) were used to analyze the associations between different response variables and snail size, sampling month and weather-related variables. Results Of the molluscan species examined, Galba truncatula, Radix peregra, Anisus (Anisus) leucostoma and Pisidium casertanum (n = 2802), only G. truncatula was infected with C. daubneyi or F. hepatica, at prevalence rates of 8.2% and 4.4% respectively. The probability of infection with C. daubneyi or F. hepatica was linearly related to snail size, although in different ways (negative for C. daubneyi and positive for F. hepatica). The total snail population increased in winter, when specimens of all size classes were found. Infected snails were more abundant during spring-autumn. Mature cercariae of both parasites were found in most seasons. In the statistical models, the sampling month accounted for a high percentage (71.9–78.2%) of the observed variability in snail abundance. The inclusion of climatic variables in the models moderately increased the percentage of deviance explained (77.7–91.9%). Excretion of C. daubneyi eggs in cow faeces was always higher than that of F. hepatica eggs. Conclusions Particular care should be taken to prevent pastures and the surrounding environment being contaminated with parasite eggs during winter-spring, when the number of snails susceptible to miracidial infections is maximal. This is therefore the optimal time for treating grazing animals. Nevertheless, control of trematodosis based only on chemotherapy is difficult in an area such as the study area, where environmental factors favour the regular appearance of snail populations harbouring mature cercariaeThe present study was financially supported by the Ministerio de Economía y Competitividad (AGL2011-30563-C03-03). The funders did not have any role in the study design, data collection and analyses, decision to publish or preparation of the manuscriptS

Prescripción potencialmente inadecuada en personas mayores. Una revisión actualizada

El aumento de la esperanza de vida hace que haya un incremento de dependencia y discapacidad en el proceso de envejecimiento. Las personas mayores son un grupo heterogéneo, en el que a menudo coexisten múltiples enfermedades para las que se prescribe un elevado número de medicamentos clasificados como potencialmente inapropiados, que contribuyen al aumento de efectos adversos frente a su beneficio clínico en esta población, existen distintas herramientas para detectar la prescripción potencialmente inadecuada (PPI), siendo los criterios de Beers y STOPP-START (screeening tool of older people´s prescriptions/ screening tool alert to right treatment) los más utilizados en Europa.<br /

Programa de educación para la prevención de la vigorexia en adolescentes

Los medios de comunicación tienen gran peso en nuestra sociedad, influenciándola con la imagen de una figura inalcanzable y aumentando la insatisfacción corporal, esto se exacerba aùn más en los adolescentes, aumentando las cifras año a año de los trastornos mentales como la vigorexia. Es de suma importancia la educación sanitaria, siendo la base para la prevención de estos tipos de trastornos.<br /

Evaluation of molecular methods for the field study of the natural history of Dicrocoelium dendriticum

There is a need for improved methods for the study of the impacts of climatic and livestock management change on the epidemiology of production-limiting helminth parasitic diseases. In this study we report the application of molecular methods to describe the natural history of the small lancet fluke, Dicrocoelium dendriticum on Machair pastures on the Inner Hebridean Isle of Coll. Our results build upon those of the only previous historic field study of D. dendriticum in the British Isles that had been undertaken on the same study site. We demonstrate the value of combining conventional parasitological methods with PCR amplification of a mitochondrial DNA fragment for the detection of D. dendriticum in ants and snails, and PCR amplification of ITS2 and 28S ribosomal DNA fragments to support the species identity of the intermediate hosts, to improving understanding of the epidemiology of D. dendriticum. We report the presence of D. dendriticum infection in cattle, sheep and rabbits grazing on Machair pastures. D. dendriticum infection was identified in a high percentage of the snails, identified as Cochlicella acuta and Cernuella virgata, and in a high percentage of Formica fusca and Myrmica ruginoides ants that were collected from, or clinging to, the tops of flowers. We have identified the involvement of different intermediate host species and higher prevalences of snail and ant infection than previously reported, in part reflecting differences between the sensitivity and specificity of morphological and molecular speciation methods. Overall, our results highlight the complex life history of dicrocoeliosis and illustrate the parasite’s generalist host strategy that confers potential to exploit new niches created by climatic change or grazing management for habitat conservation

Paramphistomosis bovina en Galicia

Las paramphistomosis son infecciones producidas por trematodos de la familia Paramphistomidae Fischoeder, 1901, que incluye diferentes géneros y especies que parasitan el tracto gastrointestinal de rumiantes. Los animales se infectan al ingerir pastos contaminados con metacercarias producidas tras el enquistamiento de las fases larvarias emitidas por moluscos que actúan como hospedadores intermediarios. En Galicia, donde también se han detectado explotaciones con altas prevalencias de infección, se desconocían aspectos básicos sobre la epidemiología de estas parasitosis. En consecuencia, se ha realizado un amplio estudio en el que se han abordado muchos aspectos

Calicophoron daubneyi (Paramphistomidae) in slaughtered cattle in Castilla y León (Spain)

The prevalence and aetiology of natural paramphistomosis was investigated in cattle slaughtered in the Castilla y León region (Spain) over a 3 year-period. The overall prevalence of positive animals was 6.20%. The parasite burden per animal ranged from 8 to 8005 (median = 144) and the ruminal atrium had the highest parasite burden whereas the ruminal dorsal sac the lowest. The prevalence and parasite burden increased with age while these parameters were lower in cattle under intensive management. Calicophoron daubneyi was the only Paramphistomidae species identified using morphoanatomical, histological and molecular methods in the studied animals.This work was supported by grant LE023A10-2 fromJunta de Castilla y León (JCyL). A.M. Martínez-Ibeas was supported by the JCyL andthe European Social Funds (ESF) and J. Benavides by theJAE-Doc programme (CSIC-ESF).Peer Reviewe

Elucidating compositional factors of maize cell walls contributing to stalk strength and lodging resistance

Lodging is one of the causes of maize (Zea mays L.) production losses worldwide and, at least, the resistance to stalk lodging has been positively correlated with stalk strength. In order to elucidate the putative relationship between cell wall, stalk strength and lodging resistance, twelve maize inbreds varying in rind penetration strength and lodging resistance were characterized for cell wall composition and structure. Stepwise multiple regression indicates that H lignin subunits confer a greater rind penetration strength. Besides, the predictive model for lodging showed that a high ferulic acid content increases the resistance to lodging, whereas those of diferulates decrease it. These outcomes highlight that the strength and lodging susceptibility of maize stems may be conditioned by structural features of cell wall rather than by the net amount of cellulose, hemicelluloses and lignin. The results presented here provide biotechnological targets in breeding programs aimed at improving lodging in maize.This work was funded by Projects AGL2014−58126-R and RTC-2016−5816-2 from the Spanish Ministry of Science, Innovation and Universities. This work was also supported by the CERCA Program and the SGR program (SGR-710) from the Generalitat de Catalunya. We acknowledge financial support from the Spanish Ministry of Economy and Competitiveness, through the “Severo Ochoa Program for Centres of Excellence in R&D” 2016–2019 (SEV‐2015‐0533)”. Alba Manga-Robles’s contract was granted by the Junta de Castilla y León and the Fondo Social Europeo through “Sistema Nacional de Garantía Juvenil” Program, Universidad de León and Junta de Castilla y León predoctoral Programs. Rogelio Santiago acknowledges a postdoctoral contract “Ramón y Cajal” financed by the Ministry of Economy and Competitiveness of Spain (RYC-2012-10603).Peer reviewe

Training in values through Research as a Pedagogical Strategy in school

La educación ha presentado cambios significativos a lo largo del siglo XXI, donde el rol del docente y las estrategias pedagógicas que este utilice en el aula son elementos fundamentales que favorecen el proceso enseñanza – aprendizaje. En este artículo se buscó fomentar la formación en valores mediante la Investigación como Estrategia Pedagógica en educación básica. Se realizó un estudio de tipo descriptivo, de campo y transaccional, para escoger la muestra se ejecutó un muestreo por conveniencia donde se seleccionaron ciento ochenta (180) estudiantes de la IED Buenos Aires, sede San Martin en cursos comprendidos entre primero y quinto de primaria, donde se plantearon actividades de acuerdo al grado de escolaridad y edad. En la actualidad se evidencia dificultades a nivel de convivencias escolar en sus estudiantes, conflictos en el aula, que impiden el desarrollo oportuno de las clases, se observan con mayor frecuencia en la institución educativa Buenos Aires, por tal razón, se hace imperante diseñar un proyecto educativo encaminado a fomentar la formación de valores mediante la investigación como estrategia pedagógica IEP, para fomentar en los estudiantes relaciones efectivas, que aporten a la mejora de las relaciones interpersonales.Education has presented significant changes during the 21st century, where the role of the teacher and the teaching strategies that use this in the classroom are key elements that favour the process of teaching - learning. This article sought to promote training in values through research as a pedagogical strategy in basic education. A study of descriptive type, field and transactional, to choose the sample executed a sampling by convenience were selected where one hundred and eighty (180) students of the IED Buenos Aires, San Martin-based courses included between first and fifth grade, where activities according to the level of schooling and age were raised. Today there is evidence of difficulties at the level of school coexistence in its students, conflict in the classroom, that prevent the timely development of classes, are seen more frequently in school Buenos Aires, for this reason, it is prevailing design an educational project aimed at nurturing values through research as a pedagogical strategy IEP, to foster effective relationships, contributing to the improvement of interpersonal relationships in students

Predicting the Current and Future Potential Distributions of Lymphatic Filariasis in Africa Using Maximum Entropy Ecological Niche Modelling

Modelling the spatial distributions of human parasite species is crucial to understanding the environmental determinants of infection as well as for guiding the planning of control programmes. Here, we use ecological niche modelling to map the current potential distribution of the macroparasitic disease, lymphatic filariasis (LF), in Africa, and to estimate how future changes in climate and population could affect its spread and burden across the continent. We used 508 community-specific infection presence data collated from the published literature in conjunction with five predictive environmental/climatic and demographic variables, and a maximum entropy niche modelling method to construct the first ecological niche maps describing potential distribution and burden of LF in Africa. We also ran the best-fit model against climate projections made by the HADCM3 and CCCMA models for 2050 under A2a and B2a scenarios to simulate the likely distribution of LF under future climate and population changes. We predict a broad geographic distribution of LF in Africa extending from the west to the east across the middle region of the continent, with high probabilities of occurrence in the Western Africa compared to large areas of medium probability interspersed with smaller areas of high probability in Central and Eastern Africa and in Madagascar. We uncovered complex relationships between predictor ecological niche variables and the probability of LF occurrence. We show for the first time that predicted climate change and population growth will expand both the range and risk of LF infection (and ultimately disease) in an endemic region. We estimate that populations at risk to LF may range from 543 and 804 million currently, and that this could rise to between 1.65 to 1.86 billion in the future depending on the climate scenario used and thresholds applied to signify infection presence