An Integrated Circuit for Signal Processing of the AMS RICH Photmultipliers Tubes

An analog integrated circuit has been designed, in a BiCMOS 0.8 micron technology, for the feasability study of the signal processing of the AMS RICH photomultiplier tubes. This low power, three channel gated integrator includes its own gate and no external analog delay is requiered. It processes PMT pulses over a dynamic range of more than 100. A logic output that indicates whether the analog charge has to be considered is provided. This gated integrator is used with a compact DSP based acquisition system in a 132 channels RICH prototype. The charge calibration of each channel is carried out using a LED. The pedestal measurement is performed on activation of a dedicated input. The noise contribution study of the input RC network and amplifiers is presented.Comment: IEEE symp. on Nucl. Sci. and Med. Imaging, Toront

TNF-α-induced E3 ligase, TRIM15 inhibits TNF-α-regulated NF-κB pathway by promoting turnover of K63 linked ubiquitination of TAK1

Ubiquitin E3-ligases are recruited at different steps of TNF-α-induced NF-κB activation; however, their role in temporal regulation of the pathway remains elusive. The study systematically identified TRIMs as potential feedback regulators of the TNF-α-induced NF-κB pathway. We further observed that TRIM15 is “late” response TNF-α-induced gene and inhibits the TNF-α-induced NF-κB pathway in several human cell lines. TRIM15 promotes turnover of K63-linked ubiquitin chains in a PRY/SPRY domain-dependent manner. TRIM15 interacts with TAK1 and inhibits its K63-linked ubiquitination, thus NF-κB activity. Further, TRIM15 interacts with TRIM8 and inhibits cytosolic translocation to antagonize TRIM8 modualted NF-κB. TRIM8 and TRIM15 also show functionally inverse correlation in psoriasis condition. In conclusion, TRIM15 is TNF-α-induced late response gene and inhibits TNF-α induced NF-κB pathway hence a feedback modulator to keep the proinflammatory NF-κB pathway under control

Electrochemical integration of graphene with light absorbing copper-based thin films

We present an electrochemical route for the integration of graphene with light sensitive copper-based alloys used in optoelectronic applications. Graphene grown using chemical vapor deposition (CVD) transferred to glass is found to be a robust substrate on which photoconductive Cu_{x}S films of 1-2 um thickness can be deposited. The effect of growth parameters on the morphology and photoconductivity of Cu_{x}S films is presented. Current-voltage characterization and photoconductivity decay experiments are performed with graphene as one contact and silver epoxy as the other

Quasiperiodic spin-orbit motion and spin tunes in storage rings

We present an in-depth analysis of the concept of spin precession frequency for integrable orbital motion in storage rings. Spin motion on the periodic closed orbit of a storage ring can be analyzed in terms of the Floquet theorem for equations of motion with periodic parameters and a spin precession frequency emerges in a Floquet exponent as an additional frequency of the system. To define a spin precession frequency on nonperiodic synchro-betatron orbits we exploit the important concept of quasiperiodicity. This allows a generalization of the Floquet theorem so that a spin precession frequency can be defined in this case too. This frequency appears in a Floquet-like exponent as an additional frequency in the system in analogy with the case of motion on the closed orbit. These circumstances lead naturally to the definition of the uniform precession rate and a definition of spin tune. A spin tune is a uniform precession rate obtained when certain conditions are fulfilled. Having defined spin tune we define spin-orbit resonance on synchro--betatron orbits and examine its consequences. We give conditions for the existence of uniform precession rates and spin tunes (e.g. where small divisors are controlled by applying a Diophantine condition) and illustrate the various aspects of our description with several examples. The formalism also suggests the use of spectral analysis to ``measure'' spin tune during computer simulations of spin motion on synchro-betatron orbits.Comment: 62 pages, 1 figure. A slight extension of the published versio

Evidence for Factorization in Three-body B --> D(*) K- K0 Decays

Motivated by recent experimental results, we use a factorization approach to study the three-body B --> D(*) K- K0 decay modes. Two mechanisms are proposed for kaon pair production: current-produced (from vacuum) and transition (from B meson). The Bbar0 --> D(*)+ K- K0 decay is governed solely by the current-produced mechanism. As the kaon pair can be produced only by the vector current, the matrix element can be extracted from e+ e- --> K Kbar processes via isospin relations. The decay rates obtained this way are in good agreement with experiment. Both current-produced and transition processes contribute to B- --> D(*)0 K- K0 decays. By using QCD counting rules and the measured B- --> D(*)0 K- K0 decay rates, the measured decay spectra can be understood.Comment: 17 pages, 6 figure

Solvothermal Synthesis of Ternary Sulfides of Sb2 − xBixS3(x = 0.4, 1) with 3D Flower-Like Architectures

Flower-like nanostructures of Sb2 − xBixS3(x = 0.4, 1.0) were successfully prepared using both antimony diethyldithiocarbamate [Sb(DDTC)3] and bismuth diethyldithiocarbamate [Bi(DDTC)3] as precursors under solvothermal conditions at 180 °C. The prepared Sb2 − xBixS3 with flower-like 3D architectures were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectrometry (EDS), high-resolution transmission electron microscopy (HRTEM), and selected area electron diffraction (SAED). The flower-like architectures, with an average diameter of ~4 μm, were composed of single-crystalline nanorods with orthorhombic structures. The optical absorption properties of the Sb2 − xBixS3 nanostructures were investigated by UV–Visible spectroscopy, and the results indicate that the Sb2 − xBixS3 compounds are semiconducting with direct band gaps of 1.32 and 1.30 eV for x = 0.4 and 1.0, respectively. On the basis of the experimental results, a possible growth mechanism for the flower-like Sb2 − xBixS3 nanostructures is suggested

PATRIC: The VBI PathoSystems Resource Integration Center

The PathoSystems Resource Integration Center (PATRIC) is one of eight Bioinformatics Resource Centers (BRCs) funded by the National Institute of Allergy and Infection Diseases (NIAID) to create a data and analysis resource for selected NIAID priority pathogens, specifically proteobacteria of the genera Brucella, Rickettsia and Coxiella, and corona-, calici- and lyssaviruses and viruses associated with hepatitis A and E. The goal of the project is to provide a comprehensive bioinformatics resource for these pathogens, including consistently annotated genome, proteome and metabolic pathway data to facilitate research into counter-measures, including drugs, vaccines and diagnostics. The project's curation strategy has three prongs: ‘breadth first’ beginning with whole-genome and proteome curation using standardized protocols, a ‘targeted’ approach addressing the specific needs of researchers and an integrative strategy to leverage high-throughput experimental data (e.g. microarrays, proteomics) and literature. The PATRIC infrastructure consists of a relational database, analytical pipelines and a website which supports browsing, querying, data visualization and the ability to download raw and curated data in standard formats. At present, the site warehouses complete sequences for 17 bacterial and 332 viral genomes. The PATRIC website () will continually grow with the addition of data, analysis and functionality over the course of the project

Intermediate-mass dilepton spectra and the role of secondary hadronic processes in heavy-ion collisions

We carry out a study of intermediate-mass (between 1 and 2.5 GeV) dilepton spectra from hadronic interactions in heavy-ion collisions. The processes considered are $\pi\pi\to l{\bar l}$, $\pi\rho\to l{\bar l}$, $\pi a_1\to l{\bar l}$, $\pi\omega\to l{\bar l}$, $K{\bar K}\to l{\bar l}$, and $K{\bar K^*}+c.c \to l{\bar l}$. The elementary cross sections for those are obtained from chiral Lagrangians involving pseudoscalar, vector, and axial-vector mesons. The respective electromagnetic form factors are determined by fitting to experimental data for the reverse processes of $e^+e^-\to hadrons$. Based on this input we calculate cross sections and thermal dilepton emission rates and compare our results with those from other approaches. Finally we use these elementary cross sections with a relativistic transport model and calculate dilepton spectra in S+W collisions at SPS energies. The comparison of our results with experimental data from the HELIOS-3 collaboration indicates the importance of the secondary hadronic contributions to the intermediate-mass dilepton spectra.Comment: 25 pages, including 20 postscript figure

Higher Order Spin Resonances in a 2.1 GeV/c Polarized Proton Beam

Spin resonances can depolarize or spin-flip a polarized beam. We studied 1st and higher order spin resonances with stored 2.1 GeV/c vertically polarized protons. The 1st order vertical ({\nu}y) resonance caused almost full spin-flip, while some higher order {\nu}y resonances caused partial depolarization. The 1st order horizontal ({\nu}x) resonance caused almost full depolarization, while some higher order {\nu}x resonances again caused partial depolarization. Moreover, a 2nd order {\nu}x resonance is about as strong as some 3rd order {\nu}x resonances, while some 3rd order {\nu}y resonances are much stronger than a 2nd order {\nu}y resonance. One thought that {\nu}y spin resonances are far stronger than {\nu}x, and that lower order resonances are stronger than higher order; the data do not support this.Comment: 5 pages, 5 figures Note that Fig. 5 did not appear in the PRL due to space limitation, but did appear in the March 2012 CERN Courier News Item "Results from SPIN@COSY may bode well for RHIC

Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV

A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7 TeV is presented. The data were collected at the LHC, with the CMS detector, and correspond to an integrated luminosity of 4.6 inverse femtobarns. No significant excess is observed above the background expectation, and upper limits are set on the Higgs boson production cross section. The presence of the standard model Higgs boson with a mass in the 270-440 GeV range is excluded at 95% confidence level.Comment: Submitted to JHE