The Contribution of Universities to Growth: Empirical Evidence for Italy

New entrepreneurial ventures may represent a viable and effective mechanism to transform academic knowledge into regional economic growth. We test this notion for the Italian provinces between 2001 and 2006. We evaluate three outputs of academic activities: teaching, research and Intellectual Property Rights (IPR) activities management. New ventures may be able to transform the mentioned outputs into improved economic performance. The findings show that the effects of academic outputs on provincial economic growth (all sectors) are appreciable when they are associated with sustained entrepreneurial activities in the province. It suggests that academic inquiry may provide new ventures with valuable commercial opportunities overseen by established companies.

Phytochemical and antioxidant characterization of Hypericum perforatum alcoholic extracts

The antioxidant potentials of a total ethanolic extract of Hypericum perforatum (TE) and fractions were evaluated and correlated with their phenolic contents. The extracts were fully characterised by HPLC-DAD-MS-MS. Kaempferol 3-rutinoside and rutin-acetyl were identified for the first time in TE extracts. The free radical-scavenging properties of TE (EC50=21 [mu]g dwb/ml) and fractions were studied using DPPH. Fractions containing flavonoids and/or caffeoylquinic acids were found to be the main contributors to the free radical-scavenging activity of the TE. Lipid peroxidation, induced with ascorbate/Fe2+, was significantly reduced in the presence of the TE (EC50=26 [mu]g dwb/ml) and fractions containing flavonoids and/or caffeoylquinic acids. The fraction containing flavonoid aglycones was found to be responsible for a major part of the TE protection against lipid peroxidation. Hypericins and hyperforins made no significant contributions to the antioxidant properties of TE. Human consumption of H. perforatum extract or fractions could be beneficial.http://www.sciencedirect.com/science/article/B6T6R-4CG2JK5-3/1/ae503f0537dcaaab2ede0770605a66c

Optical detection of scopolamine and ketamine with a BODIPY-Phen conjugate and Cu(II)

[EN] Chemical submission is becoming a global growing threat. Therefore, the development of fast and reliable methods for detecting the presence of chemical submission drugs in drinks is of great interest. For this purpose, a new BODIPY-Phen conjugate consisting of a 1,10-phenanthroline moiety connected through its 4-position to the meso position of a BODIPY dye has been synthesized and characterized by NMR, UV-vis spectroscopy and by single-crystal X-ray diffraction. BODIPY-Phen in combination with Cu(II) was used as a probe for the fluorescent and colorimetric detection of scopolamine and ketamine, two of the drugs used in cases of chemical submission. The determined limits of detection in water were 3 mu M for scopolamine and 2.88 mu M for ketamine. Selectivity of the probe in the presence of other drugs and some possible interferents that could be found in beverages has also been tested. The detection process seems to be due to a reduction of the Cu(II) ion to Cu(I) followed by coordination of Cu(I) to the BODIPY-Phen conjugate, which results in quenching of its fluorescence together with a visible color change. The probe is able to detect by the unaided eye the presence of scopolamine in real soft drinks and alcoholic beverages spiked with the drug.The authors gratefully acknowledge grant PID2021-126304OB-C42 funded by the Spanish MCIN/AEI/10.13039/501100011033 and by "ERDF A way of making Europe, EU", and grant PDC2022-133576-C22 funded by the Spanish MCIN/AEI/10.13039/501100011033 and by the European Union "NextGenerationEU"/PRTR". SCSIE (Universidad de Valencia) is gratefully acknowledged for all the equipment employed. NMR was registered at the U26 facility of ICTS "NAMBIOSIS" at the Universitat of Valencia.Hernandez-Contreras, J.; Madrigal, P.; Arroyo, P.; Liu-González, M.; Gil, S.; Parra, M.; Sáez José A.... (2024). Optical detection of scopolamine and ketamine with a BODIPY-Phen conjugate and Cu(II). Dyes and Pigments. 221. https://doi.org/10.1016/j.dyepig.2023.11180622

Resultados de la enseñanza de estrategias de lectura y escritura en la alfabetización temprana de niños con riesgo social

Introducción: La evidencia científica reciente destaca la importancia de la alfabetización temprana como fundamento del aprendizaje lector posterior, especialmente en niños en riesgo social, pero no existen las condiciones adecuadas para alcanzar su desarrollo. El objetivo del estudio fue evaluar los resultados de una intervención focalizada en el aprendizaje temprano de la lectura y la escritura de niños con riesgo social (5 años 3 meses promedio). Material y Métodos: Se evaluaron 339 niños(as) (132 grupo intervención/207 grupo comparación), al inicio y al fin del año escolar. Los profesores del grupo de intervención participaron en un programa de desarrollo profesional de un año que incluyó capacitación y acompañamiento para la aplicación de estrategias de enseñanza de la alfabetización temprana. Resultados: Se observó un resultado positivo en el conocimiento del alfabeto, la escritura emergente y el reconocimiento visual de palabras, no en comprensión oral. Discusión: Se contrastan los resultados con otros programas de intervención en niños con riesgo social, resaltando la importancia de la capacitación y el acompañamiento a los educadores

Salts of 5-amino-2-sulfonamide-1,3,4-thiadiazole, a structural and analog of acetazolamide, show interesting carbonic anhydrase inhibitory properties, diuretic, and anticonvulsant action

Three salts of 5-amino-2-sulfonamide-1,3,4-thiadiazole (Hats) were prepared and characterized by physico-chemical methods. The p-toluensulfonate, the methylsulfonate, and the chlorhydrate monohydrate salts of Hats were evaluated as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors (CAIs) and as anticonvulsants and diuretics, since many CAIs are clinically used as pharmacological agents. The three Hats salts exhibited diuretic and anticonvulsant activities with little neurotoxicity. The human (h) isoforms hCA I, II, IV, VII, IX, and XII were inhibited in their micromolar range by these salts, whereas pathogenic beta and gamma CAs showed similar, weak inhibitory profiles.Fil: Diaz, Jorge R. A.. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Área Química General e Inorgánica; ArgentinaFil: Camí, Gerardo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; ArgentinaFil: Liu González, Malva. Universidad de Valencia; EspañaFil: Vega, Daniel Roberto. Comisión Nacional de Energía Atómica. Gerencia del Área de Investigaciones y Aplicaciones no Nucleares. Gerencia de Física (Centro Atómico Constituyentes); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vullo, Daniela. Università degli Studi di Firenze; ItaliaFil: Juárez, Américo. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Pedregosa, Jose Carmelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; ArgentinaFil: Supuran, Claudiu T.. Università degli Studi di Firenze; Itali

Individual Differences, Economic Stability, and Fear of Contagion as Risk Factors for PTSD Symptoms in the COVID-19 Emergency

On January 30th 2020, the World Health Organization (WHO) declared the COVID-19 pandemic a Public Health Emergency of International Concern (PHEIC). Italy has been one of the most affected countries in the world. To contain further spread of the virus, the Italian government has imposed an unprecedented long-period lockdown for the entire country. This dramatic scenario may have caused a strong psychological distress, with potential negative long-term mental health consequences. The aim of the present study is to report the prevalence of high psychological distress due to the COVID-19 pandemic on the general population, especially considering that this aspect is consistently associated with PTSD symptoms. Furthermore, the present study aims to identify the risk factors for high PTSD symptoms, including individual differences and subjective perception of both economic and psychological aspects. We administered an online survey to 1253 participants during the peak period of the contagion in Italy. A logistic regression on the Impact of Event Scale – Revised (IES-R) scores was used to test the risk factors that predict the possibility to develop PTSD symptoms due to the COVID-19 pandemic. Gender (female), lower perceived economic stability, higher neuroticism, and fear and consequences of contagion were predictors of high PTSD symptomatology. The results, highlighted in the present study, extend our understanding of the COVID-19 pandemic’s impact on the population’s mental health, by identifying individuals at high-risk of developing PTSD. This may help with the implementation of specific protocols to prevent the possibility of developing symptoms of PTSD in target populations

Functional Properties of Meat in Athletes’ Performance and Recovery

Physical activity (PA) and sport play an essential role in promoting body development and maintaining optimal health status both in the short and long term. Despite the benefits, a long-lasting heavy training can promote several detrimental physiological changes, including transitory immune system malfunction, increased inflammation, and oxidative stress, which manifest as exercise-induced muscle damages (EIMDs). Meat and derived products represent a very good source of bioactive molecules such as proteins, lipids, amino acids, vitamins, and minerals. Bioactive molecules represent dietary compounds that can interact with one or more components of live tissue, resulting in a wide range of possible health consequences such as immune-modulating, antihypertensive, antimicrobial, and antioxidative activities. The health benefits of meat have been well established and have been extensively reviewed elsewhere, although a growing number of studies found a significant positive effect of meat molecules on exercise performance and recovery of muscle function. Based on the limited research, meat could be an effective post-exercise food that results in favorable muscle protein synthesis and metabolic performance

Competencias de pensamiento científico y resolución de problemas de genética simulados computacionalmente. su contribución al aprendizaje de la Biología

Esta investigación se relaciona con las implicancias didácticas de la incorporación de las simulaciones computacionales a la enseñanza de la genética escolar. Específicamente, se identifican y caracterizan competencias de pensamiento científico (CPC) que desarrollan estudiantes de secundaria, al momento de enfrentarse a la resolución de problemas de genética simulados mediante un software. Los resultados indican que los estudiantes abordan los distintos problemas científicos a través de diversas competencias de pensamiento científico, con distintas frecuencia y tipología. Además, las vinculaciones conceptuales, establecidas son principalmente de tipo explicativo-causal, lo que aparentemente estaría condicionado por las orientaciones metodológicas y las finalidades teóricas del software utilizado

Effect of Hypoproteic and High-Fat Diets on Hippocampal Blood-Brain Barrier Permeability and Oxidative Stress

Worldwide, millions of people are exposed to dietary imbalance that impacts in health and quality of life. In developing countries, like in Brazil, in poor settings, dietary habits, traditionally hypoproteic, are changing rapidly to western-type high-fat foods. These rapidly changing dietary habits are imposing new challenges to human health and there are many questions in the field that remain to be answered. Accordingly, we currently do not know if chronic consumption of hypoproteic (regional basic diet, RBD) or high-fat diets (HFD) may impact the brain physiology, contributing to blood-brain barrier (BBB) dysfunction and neuroinflammatory events. To address this issue, mice were challenged by breastfeeding from dams receiving standard, RBD or HFD from suckling day 10 until weaning. Immediately after weaning, mice continued under the same diets until post-natal day 52. Herein, we show that both RBD and HFD cause not only a peripheral but also a consistent central neuroinflammatory response, characterized by an increased production of Reactive Oxygen Species (ROS) and pro-inflammatory cytokines. Additionally, BBB hyperpermeability, accounted by an increase in hippocampal albumin content, a decrease in claudin-5 protein levels and collagen IV immunostaining, was also observed together with an upregulation of vascular cell adhesion molecule 1 (VCAM-1). Interestingly, we also identified a significant astrogliosis, manifested by upregulation of GFAP and S100β levels and an intensification of arbor complexity of these glial cells. In sum, our data show that dietary imbalance, related with hypoproteic or high-fat content, impairs BBB properties potentially favoring the transmigration of peripheral immune cells and induces both a peripheral and central neuroinflammatory status. Noteworthy, neuroinflammatory events in the hippocampus may cause neuronal malfunction leading to cognitive deficits and long-term persistence of this phenomenon may contribute to age-related neurodegenerative diseases

Modulation of subventricular zone oligodendrogenesis: a role for hemopressin?

Neural stem cells (NSCs) from the subventricular zone (SVZ) have been indicated as a source of new oligodendrocytes to use in regenerative medicine for myelin pathologies. Indeed, NSCs are multipotent cells that can self-renew and differentiate into all neural cell types of the central nervous system. In normal conditions, SVZ cells are poorly oligodendrogenic, nevertheless their oligodendrogenic potential is boosted following demyelination. Importantly, progressive restriction into the oligodendrocyte fate is specified by extrinsic and intrinsic factors, endocannabinoids being one of these factors. Although a role for endocannabinoids in oligodendrogenesis has already been foreseen, selective agonists and antagonists of cannabinoids receptors produce severe adverse side effects. Herein, we show that hemopressin (Hp),a modulator of CB1 receptors, increased oligodendroglial differentiation in SVZ neural stem/progenitor cell cultures derived from neonatal mice. The original results presented in this work suggest that Hp and derivates may be of potential interest for the development of future strategies to treat demyelinating diseases