Cross-linguistic Morphosyntactic Influence in Bilingual Speakers of Jamaican Creole and Jamaican English

Bilingualism in Jamaica is of considerable consequence, as most individuals are early bilinguals, speaking both a variety of Jamaican Creole (JC) from birth and having standardized English (sE) as the language of instruction in education. Immigrants from Jamaica to the United States are an ideal population to examine how cross-linguistic influence (CLI) impacts morphosyntax as JC and sE differ in morphosyntactic constructions, including verb tense- marking, subject-verb agreement, and copula use. While much of the work in the field of CLI has examined spoken language pairs with varying degrees of similarity (or difference) between the languages, examining CLI in a language paired with a creole lexified from that language has yet to be investigated. This study investigated whether CLI of morphosyntax, including verb tense-marking, subject-verb agreement, and copula inclusion, is bidirectional; that is, whether CLI can be observed between the L1 (Jamaican Creole) to the L2 (standardized English, sE) in both directions. We examined sentences and narratives for two groups of bilingual speakers—an Immigrant group residing in the U.S. and a Non-immigrant group residing in Jamaica—to analyze morphosyntactic production. We also investigated which internal and external factors contribute to bidirectional CLI. Evaluating language samples collected from bilingual speakers on controlled and less controlled tasks, we reasoned, provides a unique opportunity to observe how these two languages might influence each other in the same speaker. Our findings show bidirectional CLI in both groups, with the Immigrant group exhibiting more cross-linguistic influence from the L2 to the L1. By contrast, the Non-immigrant group exhibited greater L1 to L2 CLI than the Immigrant group, possibly as a result of greater use of the L1. Sociolinguistic factors were analyzed and indicated that variables linked to increased language use in either the L1 or L2 resulted in more CLI from that language. This study provides valuable information about the variation in both Jamaican Creole and Jamaican English. This information is crucial to understanding how healthy adult bilingual speakers of Jamaican Creole and Jamaican English produce morphosyntax, which will benefit our understanding of what occurs in adults with acquired language disorders

Stem cell transplantation in traumatic spinal cord injury:a systematic review and meta-analysis of animal studies

Spinal cord injury (SCI) is a devastating condition that causes substantial morbidity and mortality and for which no treatments are available. Stem cells offer some promise in the restoration of neurological function. We used systematic review, meta-analysis, and meta-regression to study the impact of stem cell biology and experimental design on motor and sensory outcomes following stem cell treatments in animal models of SCI. One hundred and fifty-six publications using 45 different stem cell preparations met our prespecified inclusion criteria. Only one publication used autologous stem cells. Overall, allogeneic stem cell treatment appears to improve both motor (effect size, 27.2%; 95% Confidence Interval [CI], 25.0%-29.4%; 312 comparisons in 5,628 animals) and sensory (effect size, 26.3%; 95% CI, 7.9%-44.7%; 23 comparisons in 473 animals) outcome. For sensory outcome, most heterogeneity between experiments was accounted for by facets of stem cell biology. Differentiation before implantation and intravenous route of delivery favoured better outcome. Stem cell implantation did not appear to improve sensory outcome in female animals and appeared to be enhanced by isoflurane anaesthesia. Biological plausibility was supported by the presence of a dose-response relationship. For motor outcome, facets of stem cell biology had little detectable effect. Instead most heterogeneity could be explained by the experimental modelling and the outcome measure used. The location of injury, method of injury induction, and presence of immunosuppression all had an impact. Reporting of measures to reduce bias was higher than has been seen in other neuroscience domains but were still suboptimal. Motor outcomes studies that did not report the blinded assessment of outcome gave inflated estimates of efficacy. Extensive recent preclinical literature suggests that stem-cell-based therapies may offer promise, however the impact of compromised internal validity and publication bias mean that efficacy is likely to be somewhat lower than reported here

Pathogenetics of alveolar capillary dysplasia with misalignment of pulmonary veins.

Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a lethal lung developmental disorder caused by heterozygous point mutations or genomic deletion copy-number variants (CNVs) of FOXF1 or its upstream enhancer involving fetal lung-expressed long noncoding RNA genes LINC01081 and LINC01082. Using custom-designed array comparative genomic hybridization, Sanger sequencing, whole exome sequencing (WES), and bioinformatic analyses, we studied 22 new unrelated families (20 postnatal and two prenatal) with clinically diagnosed ACDMPV. We describe novel deletion CNVs at the FOXF1 locus in 13 unrelated ACDMPV patients. Together with the previously reported cases, all 31 genomic deletions in 16q24.1, pathogenic for ACDMPV, for which parental origin was determined, arose de novo with 30 of them occurring on the maternally inherited chromosome 16, strongly implicating genomic imprinting of the FOXF1 locus in human lungs. Surprisingly, we have also identified four ACDMPV families with the pathogenic variants in the FOXF1 locus that arose on paternal chromosome 16. Interestingly, a combination of the severe cardiac defects, including hypoplastic left heart, and single umbilical artery were observed only in children with deletion CNVs involving FOXF1 and its upstream enhancer. Our data demonstrate that genomic imprinting at 16q24.1 plays an important role in variable ACDMPV manifestation likely through long-range regulation of FOXF1 expression, and may be also responsible for key phenotypic features of maternal uniparental disomy 16. Moreover, in one family, WES revealed a de novo missense variant in ESRP1, potentially implicating FGF signaling in the etiology of ACDMPV

Systematic review and meta-analysis of therapeutic hypothermia in animal models of spinal cord injury

Therapeutic hypothermia is a clinically useful neuroprotective therapy for cardiac arrest and neonatal hypoxic ischemic encephalopathy and may potentially be useful for the treatment of other neurological conditions including traumatic spinal cord injury (SCI). The pre-clinical studies evaluating the effectiveness of hypothermia in acute SCI broadly utilise either systemic hypothermia or cooling regional to the site of injury. The literature has not been uniformly positive with conflicting studies of varying quality, some performed decades previously.In this study, we systematically review and meta-analyse the literature to determine the efficacy of systemic and regional hypothermia in traumatic SCI, the experimental conditions influencing this efficacy, and the influence of study quality on outcome. Three databases were utilised; PubMed, ISI Web of Science and Embase. Our inclusion criteria consisted of the (i) reporting of efficacy of hypothermia on functional outcome (ii) number of animals and (iii) mean outcome and variance in each group.Systemic hypothermia improved behavioural outcomes by 24.5% (95% CI 10.2 to 38.8) and a similar magnitude of improvement was seen across a number of high quality studies. The overall behavioural improvement with regional hypothermia was 26.2%, but the variance was wide (95% CI -3.77 to 56.2). This result may reflect a preponderance of positive low quality data, although a preferential effect of hypothermia in ischaemic models of injury may explain some of the disparate data. Sufficient heterogeneity was present between studies of regional hypothermia to reveal a number of factors potentially influencing efficacy, including depth and duration of hypothermia, animal species, and neurobehavioural assessment. However, these factors could reflect the influence of earlier lower quality literature.Systemic hypothermia appears to be a promising potential method of treating acute SCI on the basis of meta-analysis of the pre-clinical literature and the results of high quality animal studies

Meta-analysis of pre-clinical studies of early decompression in acute spinal cord injury:a battle of time and pressure

The use of early decompression in the management of acute spinal cord injury (SCI) remains contentious despite many pre-clinical studies demonstrating benefits and a small number of supportive clinical studies. Although the pre-clinical literature favours the concept of early decompression, translation is hindered by uncertainties regarding overall treatment efficacy and timing of decompression.We performed meta-analysis to examine the pre-clinical literature on acute decompression of the injured spinal cord. Three databases were utilised; PubMed, ISI Web of Science and Embase. Our inclusion criteria consisted of (i) the reporting of efficacy of decompression at various time intervals (ii) number of animals and (iii) the mean outcome and variance in each group. Random effects meta-analysis was used and the impact of study design characteristics assessed with meta-regression.Overall, decompression improved behavioural outcome by 35.1% (95%CI 27.4-42.8; I(2)=94%, p<0.001). Measures to minimise bias were not routinely reported with blinding associated with a smaller but still significant benefit. Publication bias likely also contributed to an overestimation of efficacy. Meta-regression demonstrated a number of factors affecting outcome, notably compressive pressure and duration (adjusted r(2)=0.204, p<0.002), with increased pressure and longer durations of compression associated with smaller treatment effects. Plotting the compressive pressure against the duration of compression resulting in paraplegia in individual studies revealed a power law relationship; high compressive forces quickly resulted in paraplegia, while low compressive forces accompanying canal narrowing resulted in paresis over many hours.These data suggest early decompression improves neurobehavioural deficits in animal models of SCI. Although much of the literature had limited internal validity, benefit was maintained across high quality studies. The close relationship of compressive pressure to the rate of development of severe neurological injury suggests that pressure local to the site of injury might be a useful parameter determining the urgency of decompression

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Ageing as a Confound in Language Attrition Research: Lexical Retrieval, Language Use, and Cognitive and Neural Changes

Adult-onset native-language attrition most often occurs following a move to an environment where a non-native language is spoken. To date, the focus of attrition research has been in identifying what aspects of language are lost and which factors are crucial for the retention or attrition of the native language. Attrition is a gradual and fairly subtle process with no clear beginning or end. To best assess the effects of attrition, researchers tend to choose study participants who have lived in a non-native environment for a decade or longer (e.g., de Bot & Clyne, 1994; Schmid, 2002). The assumption is that the longer they have been removed from the native-language environment, the greater the degree of language attrition that should be observable. However, this principle regarding length of time and its relationship to language use overlaps with another, largely ignored, phenomenon: language changes associated with ageing. Are language changes due to long-term disuse conflated with age-related language changes in older adults who experience language attrition? This chapter explores changes to the adult lexicon as a result of attrition and ageing since the lexicon is considered a vulnerable part of the language system in both attrition and ageing. We consider neurophysiological changes that may play a role in language attrition and in non-pathological ageing to speculate whether the neurobiological sources of these two processes are similar or different. If attrition and ageing exert independent effects on lexical retrieval decline, we must consider the effects of each of these factors for word retrieval for older adult bilinguals immersed in a non-native-language environment

Geochemistry of Carboniferous peralkaline felsic volcanic rocks, central New Brunswick, Canada: examination of uranium potential

Felsic volcanic rocks from the ca. 335 Ma Cumberland Hill Formation of southern New Brunswick consist of peralkaline rhyolite and trachyte. These rocks are interpreted to have undergone extensive fractional crystallization from an alkali basaltic magma, although their different geochemical signatures indicate that the rhyolite was not derived from the trachyte via continuous fractional crystallization. The rhyolite is highly enriched in incompatible trace elements including uranium (up to ca. 20 ppm). Cumberland Hill peralkaline rhyolite suggests that a potentially economic source of uranium exists in the basin, based on the elevated uranium concentrations and high potential for remobilization into surrounding sedimentary units. RÉSUMÉ Les roches volcaniques felsiques de la Formation de Cumberland Hill, au sud du Nouveau-Brunswick, dont l’origine remonte à quelque 335 Ma se composent de rhyolite et de trachyte hyperalcalines. On estime que ces roches ont subi une cristallisation fractionnée intense à partir d’un magma de basalte alcalin, même si leurs diverses signatures géochimiques indiquent que la rhyolite n’est pas issue de la trachyte par un processus permanent de cristallisation fractionnée. La rhyolite est fortement enrichie d’éléments traces incompatibles, au nombre duquel se trouve de l’uranium (concentration qui peut atteindre environ 20 ppm). Si l’on se fie aux fortes concentrations d’uranium et à la grande possibilité de remobilisation dans les unités sédimentaires environnantes, la présence de la rhyolite hyperalcaline dans la Formation de Cumberland Hill porte à croire que le bassin pourrait contenir une source d’uranium vraisemblablement rentable.[Traduit par la redaction

Primary Progressive Aphasias in Bilinguals and Multilinguals

Primary progressive aphasia (PPA) is the result of neurodegeneration affecting language abilities that continue to decline as the disease progresses. There are three main variants of PPA: non‐fluent, semantic, and logopenic. Deficits may occur in different areas of language, such as lexical retrieval, auditory comprehension, syntactic structure, processing morphological components, and repetition abilities. However, the impact on language is not comparable across all individuals with PPA; rather it differs for each of the different variants based on the underlying pattern of neural change. In bilinguals or multilinguals with PPA, the language decline has an added layer of complexity. Decline may occur across the different languages in parallel, or differentially, and a number of factors may affect the pattern of decline. Recognizing the factors that most affect language decline in bilinguals and multilinguals with PPA, along with identifying the neural changes occurring in the brain, can increase our understanding of language organization in the bilingual or multilingual brain. It should be noted that language decline is not the only decline associated with PPA, as changes in cognition and behaviour have also been observed, particularly in the later stages (e.g. Rosen et al. 2006). However, language is the most salient decline in PPA so we focus on language in this chapter