34 research outputs found
Performance of a proteomic preterm delivery predictor in a large independent prospective cohort
- Author
- Baxter Jason K.
- Boggess Kim A.
- Boniface J. Jay
- Burchard Julja
- Coonrod Dean V.
- Critchfield Gregory C.
- Crockett Amy H.
- Fleischer Tracey C.
- Fox Angela C.
- Grobman William A.
- Haas David M.
- Hawk Angela F.
- Heyborne Kent D.
- Lam Garrett K.
- Laurent Louise C.
- Longo Sherri
- Major Carol A.
- Markenson Glenn R.
- Pereira Leonardo M.
- Polpitiya Ashoka
- Saade George R.
- Schoen Corina N.
- Su Emily J.
- Sullivan Scott A.
- Wheeler Sarahn M.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/08/2020
- Field of study
Get PDFBackground
Preterm birth remains a common and devastating complication of pregnancy. There remains a need for effective and accurate screening methods for preterm birth. Using a proteomic approach, we previously discovered and validated (Proteomic Assessment of Preterm Risk study, NCT01371019) a preterm birth predictor comprising a ratio of insulin-like growth factor-binding protein 4 to sex hormone-binding globulin.
Objective
To determine the performance of the ratio of insulin-like growth factor-binding protein 4 to sex hormone-binding globulin to predict both spontaneous and medically indicated very preterm births, in an independent cohort distinct from the one in which it was developed.
Study Design
This was a prospective observational study (Multicenter Assessment of a Spontaneous Preterm Birth Risk Predictor, NCT02787213) at 18 sites in the United States. Women had blood drawn at 170/7 to 216/7 weeks’ gestation. For confirmation, we planned to analyze a randomly selected subgroup of women having blood drawn between 191/7 and 206/7 weeks’ gestation, with the results of the remaining study participants blinded for future validation studies. Serum from participants was analyzed by mass spectrometry. Neonatal morbidity and mortality were analyzed using a composite score by a method from the PREGNANT trial (NCT00615550, Hassan et al). Scores of 0–3 reflect increasing numbers of morbidities or length of neonatal intensive care unit stay, and 4 represents perinatal mortality.
Results
A total of 5011 women were enrolled, with 847 included in this planned substudy analysis. There were 9 preterm birth cases at <320/7 weeks’ gestation and 838 noncases at ≥320/7 weeks’ gestation; 21 of 847 infants had neonatal composite morbidity and mortality index scores of ≥3, and 4 of 21 had a score of 4. The ratio of insulin-like growth factor-binding protein 4 to sex hormone-binding globulin ratio was substantially higher in both preterm births at <320/7 weeks’ gestation and there were more severe neonatal outcomes. The ratio of insulin-like growth factor-binding protein 4 to sex hormone-binding globulin ratio was significantly predictive of birth at <320/7 weeks’ gestation (area under the receiver operating characteristic curve, 0.71; 95% confidence interval, 0.55–0.87; P=.016). Stratification by body mass index, optimized in the previous validation study (22<body mass index≤37 kg/m2), resulted in an area under the receiver operating characteristic curve of 0.76 (95% confidence interval, 0.59–0.93; P=.023). The ratio of insulin-like growth factor-binding protein 4 to sex hormone-binding globulin ratio predicted neonatal outcomes with respective area under the receiver operating characteristic curve of 0.67 (95% confidence interval, 0.57–0.77; P=.005) and 0.78 (95% confidence interval, 0.63–0.93; P=.026) for neonatal composite morbidity and mortality scores of ≥3 or 4. In addition, the ratio of insulin-like growth factor-binding protein 4 to sex hormone binding globulin significantly stratified neonates with increased length of hospital stay (log rank P=.023).
Conclusion
We confirmed in an independent cohort the ratio of insulin-like growth factor-binding protein 4 to sex hormone-binding globulin ratio as a predictor of very preterm birth, with additional prediction of increased length of neonatal hospital stay and increased severity of adverse neonatal outcomes. Potential uses of the ratio of insulin-like growth factor-binding protein 4 to sex hormone-binding globulin predictor may be to risk stratify patients for implementation of preterm birth preventive strategies and direct patients to appropriate levels of care
Micromechanical Properties of Injection-Molded Starch–Wood Particle Composites
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- Abukurah A.
- Acharya M.
- Agarwal A.
- Ahmad S.
- Al-Bander H.
- Al-Saghir F.
- Alas E.
- Albertazzi A.
- Alcázar de La Ossa J.
- Alfred H.
- Almeida F.
- Altobelli V.
- Alvarez Sandoval E.
- Amatya A.
- Anashkin V.
- Andrusev A.
- Andrés Ribes E.
- Ang K.
- Anger M.
- Aranda Verástegui F.
- Araújo S.
- Arbeit L.
- Arfeen S.
- Arias I.
- Arif F.
- Arkossy O.
- Arrieta J.
- Arruda J.
- Ashfaq A.
- Assefi A.
- Auricchio M.
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- Ayodeji O.
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- Baer H.
- Balkarova O.
- Bannister K.
- Bastos M.
- Batista P.
- Batlle D.
- Becker B.
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- Bentkowski W.
- Beresan H.
- Bernardo M.
- Berta K.
- Bhandari K.
- Bhatia D.
- Bidas K.
- Billiouw J.
- Block G.
- Block Geoffrey A.
- Blumenthal S.
- Bochicchio-Ricardelli T.
- Bolasco P.
- Borbas B.
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- Bouman K.
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- Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) Trial Investigators
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- Field of study
Get PDFThe micromechanical properties of injection molded starch–wood particle composites were investigated as a function of particle content and humidity conditions.
The composite materials were characterized by scanning electron microscopy and X-ray diffraction methods. The microhardness
of the composites was shown to increase notably with the concentration of the wood particles. In addition,creep behavior under the indenter and temperature dependence
were evaluated in terms of the independent contribution of the starch matrix and the wood microparticles to the hardness value. The influence of drying time on the density
and weight uptake of the injection-molded composites was highlighted. The results revealed the role of the mechanism of water evaporation, showing that the dependence of water uptake and temperature was greater for the starch–wood composites than for the pure starch sample. Experiments performed during the drying process at 70°C indicated that
the wood in the starch composites did not prevent water loss from the samples.Peer reviewe
Corruption Manual for Beginners: 'Corruption Techniques' in Public Procurement with Examples from Hungary
- Author
- ---
- ---
- A Korm�ny
- A Lakos
- Ase Grodeland
- Charles Kenny
- David Jancsics
- Decio Coviello
- Denis Audet
- Eitan Goldman
- Emmanuelle Auriol
- Fidesz
- Glenn T Ware
- Gustavo Piga
- Guszt�v B�ger
- Gy V�rday
- G�bor Papanek
- Hm-Es Tr�kk�s
- Ian Byatt
- Istvvn JJnos TTth
- Istv�n T�th
- Ivar Strand
- Jessica Schultz
- J�l Van
- Kari K Heggstad
- Khi V Thai
- Lawrence P. King
- Major Dezs�rin�
- Meagher Patrick
- Mihaly Fazekas
- Mih�ly Fazekas
- Miriam A Golden
- Nf�-S Vezet? Egykori Egy
- Nicholas Charron
- O?iven�
- Oecd
- Oriana Bandiera
- Projektiroda-Vezet? Lett
- Richard Rose
- Sorin Ionita
- Sue Arrowsmith
- Tina Soreide
- Titkos�tott�k A Ludovika
- Vito Tanzi
- William E Kovacic
- Yvan Lengwiler
- Zolt�n Sz�nt�
- �va P�link�
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2013
- Field of study
Full text linkFinishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
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- Adams Charles Q.
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- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
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- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
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- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
- Baker Andrew
- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
- Banda Michael
- Banerjee Ruby
- Bao Jingyue
- Bao Qiyu
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- Barbe Valérie
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- Barker Darren
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- Barlow Karen
- Baron Laurent
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- Boukhgalter Boris
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- Brimhall Angela K.
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- Brottier Philippe
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- Bryant Jennifer E.
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- Buatsi Delali
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- Buckle Veronica
- Buczek Donald
- Budd Claire
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- Bunker Nathan
- Burberry Jill
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- Burford Deborah
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- Burkhart-Schultz Karolyn
- Burrell Kevin L.
- Burrill Wayne
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- Hancock Julie
- Harbes Brandy A.
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- Hitchens Matthew Edward
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- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
Get PDFThe sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
The Association of Genetic Predisposition to Depressive Symptoms with Non-suicidal and Suicidal Self-Injuries
- Author
- A Alaräisänen
- A Demirkan
- A Dumais
- A Koyanagi
- A Okbay
- A Schosser
- Abdel Abdellaoui
- AC Heath
- AC Heath
- American Psychiatric Association
- Andrew C. Heath
- AP Chioqueta
- BL Hankin
- Brendan P. Zietsch
- C Durrett
- C Haw
- C Haw
- CC Minică
- Converge Consortium
- CR Glenn
- D Tidemalm
- DF Maciejewski
- Dixie J. Statham
- DM Dougherty
- DM Fergusson
- Dominique F. Maciejewski
- EA Selby
- F Dudbridge
- G Kiekens
- GH Lubke
- GK Brown
- Grant Montgomery
- H Galfalvy
- IR Rockett
- J Csorba
- J Linker
- J Sareen
- JL Ayuso-Mateos
- K Hawton
- K Hek
- K Keenan
- Karin J.H. Verweij
- KK Bucholz
- KS Kendler
- KS Kendler
- L Claes
- Lauren R. Few
- M Bernal
- M Hesselbrock
- M Prinstein
- M Sokolowski
- M Voracek
- Major Depressive Disorder Working Group of the Psychiatric GC
- Miguel E. Renteria
- MK Nock
- MK Nock
- MP Thompson
- MS Mc Closkey
- N Mullins
- Nicholas G. Martin
- NR Wray
- NR Wray
- P Qin
- Pamela A.F. Madden
- PF Sullivan
- PM Lewinsohn
- PR Casey
- S Purcell
- S van der Sluis
- Sarah E. Medland
- Scott D. Gordon
- SE Medland
- SV Swannell
- Timothy J. Trull
- TP Sokero
- VL Willour
- VS Knopik
- WJ Peyrot
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Full text linkThe activated human met gene encodes a protein tyrosine kinase
- Publication venue
- 'Elsevier BV'
- Publication date
- 15/12/1986
- Field of study
Get PDFWe have raised antibodies against a synthetic dodecapeptide corresponding to the carboxyl terminus of the predicted met gene product. Phosphorylation of 60 kDa and 65 kDa proteins on tyrosine residues was observed when immunoprecipitates of cells containing the activated human met gene were incubated with [γ-32P]ATP. Phosphoproteins with the same molecular masses could be immunoprecipitated from cells metabolically labelled with [32P]orthophosphate. When considered together, these observations indicate that the activated human met gene encodes 60 kDa and 65 kDa proteins that can catalyse autophosphorylation on tyrosine residues
The universality of immuno-PCR for ultrasensitive antigen detection
- Publication venue
- 'Portland Press Ltd.'
- Publication date
- Field of study
No full text14: Enhanced preterm delivery predictors: verification in a large independent prospective cohort
- Author
- Amy Crockett
- Angela Fox
- Angela Hawk
- ashoka polpitiya
- Carol Major
- Corina N. Schoen
- David M. Haas
- Dean Coonrod
- Emily Su
- Garrett K. LAM
- George R. Saade
- Glenn Markenson
- Greg C. Critchfield
- J.Jay Boniface
- Jason Baxter
- Julja Burchard
- Kent Heyborne
- Kim Boggess
- leonardo Pereira
- Louise C. Laurent
- Sarahn M. Wheeler
- scott sullivan
- Sherri Longo
- Tracey Fleischer
- William A. Grobman
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
No full text9: Performance of a proteomic preterm delivery predictor in a large independent prospective cohort
- Author
- Amy Crockett
- Angela Fox
- Angela Hawk
- Carol Major
- Corina N. Schoen
- David M. Haas
- Dean Coonrod
- Emily Su
- Garrett K. LAM
- George R. Saade
- Glenn Markenson
- Greg C. Critchfield
- J.Jay Boniface
- Jason Baxter
- Julja Burchard
- Kent Heyborne
- Kim Boggess
- leonardo Pereira
- Louise C. Laurent
- paul Kearney
- Sarahn M. Wheeler
- scott sullivan
- Sherri Longo
- Tracey Fleischer
- William A. Grobman
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
No full text
