Constraining the PopIII IMF with high-z GRBs

We study the possibility to detect and distinguish signatures of enrichment from PopIII stars in observations of PopII GRBs (GRBIIs) at high redshift by using numerical N-body/hydrodynamical simulations including atomic and molecular cooling, star formation and metal spreading from stellar populations with different initial mass functions (IMFs), yields and lifetimes. PopIII and PopII star formation regimes are followed simultaneously and both a top-heavy and a Salpeter-like IMF for pristine PopIII star formation are adopted. We find that the fraction of GRBIIs hosted in a medium previously enriched by PopIII stars (PopIII-dominated) is model independent. Typical abundance ratios, such as [Si/O] vs [C/O] and [Fe/C] vs [Si/C], can help to disentangle enrichment from massive and intermediate PopIII stars, while low-mass first stars are degenerate with regular PopII generations. The properties of galaxies hosting PopIII-dominated GRBIIs are not very sensitive to the particular assumption on the mass of the first stars.Comment: 9 pages, 4 figure

Neuronal mechanisms of epileptogenesis

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A cellular automaton for the factor of safety field in landslides modeling

Landslide inventories show that the statistical distribution of the area of recorded events is well described by a power law over a range of decades. To understand these distributions, we consider a cellular automaton to model a time and position dependent factor of safety. The model is able to reproduce the complex structure of landslide distribution, as experimentally reported. In particular, we investigate the role of the rate of change of the system dynamical variables, induced by an external drive, on landslide modeling and its implications on hazard assessment. As the rate is increased, the model has a crossover from a critical regime with power-laws to non power-law behaviors. We suggest that the detection of patterns of correlated domains in monitored regions can be crucial to identify the response of the system to perturbations, i.e., for hazard assessment.Comment: 4 pages, 3 figure

Changing, priming, and acting on values: Effects via motivational relations in a circular model

Circular models of values and goals suggest that some motivational aims are consistent with each other, some oppose each other, and others are orthogonal to each other. The present experiments tested this idea explicitly by examining how value confrontation and priming methods influence values and value-consistent behaviors throughout the entire value system. Experiment 1 revealed that change in 1 set of social values causes motivationally compatible values to increase in importance, whereas motivationally incompatible values decrease in importance and orthogonal values remain the same. Experiment 2 found that priming security values reduced the better-than-average effect, but priming stimulation values increased it. Similarly, Experiments 3 and 4 found that priming security values increased cleanliness and decreased curiosity behaviors, whereas priming self-direction values decreased cleanliness and increased curiosity behaviors. Experiment 5 found that priming achievement values increased success at puzzle completion and decreased helpfulness to an experimenter, whereas priming with benevolence values decreased success and increased helpfulness. These results highlight the importance of circular models describing motivational interconnections between values and personal goals

Population III stars and the Long Gamma Ray Burst rate

Because massive, low-metallicity population III (PopIII) stars may produce very powerful long gamma-ray bursts (LGRBs), high-redshift GRB observations could probe the properties of the first stars. We analyze the correlation between early PopIII stars and LGRBs by using cosmological N-body/hydrodynamical simulations, which include detailed chemical evolution, cooling, star formation, feedback effects and the transition between PopIII and more standard population I/II (PopII/I) stars. From the Swift observed rate of LGRBs, we estimate the fraction of black holes that will produce a GRB from PopII/I stars to be in the range 0.028<f_{GRB}<0.140, depending on the assumed upper metallicity of the progenitor. Assuming that as of today no GRB event has been associated to a PopIII star, we estimate the upper limit for the fraction of LGRBs produced by PopIII stars to be in the range 0.006<f_{GRB}<0.022. When we apply a detection threshold compatible with the BAT instrument, we find that the expected fraction of PopIII GRBs (GRB3) is ~10% of the full LGRB population at z>6, becoming as high has 40% at z>10. Finally, we study the properties of the galaxies hosting our sample of GRB3. We find that the average metallicity of the galaxies hosting a GRB3 is typically higher than the critical metallicity used to select the PopIII stars, due to the efficiency in polluting the gas above such low values. We also find that the highest probability of finding a GRB3 is within galaxies with a stellar mass <10^7 Msun, independently from the redshift.Comment: 8 pages,3 figures. Submitted to MNRAS, revised version after referee's comment

Parametric thermal analysis for the optimization of Double Walled Tubes layout in the Water Cooled Lithium Lead inboard blanket of DEMO fusion reactor

Within the roadmap that will lead to the nuclear fusion exploitation for electric energy generation, the construction of a DEMOnstration (DEMO) reactor is, probably, the most important milestone to be reached since it will demonstrate the technological feasibility and economic competitiveness of an industrial-scale nuclear fusion reactor. In order to reach this goal, several European universities and research centres have joined their efforts in the EUROfusion action, funded by HORIZON 2020 UE programme. Within the framework of EUROfusion research activities, ENEA and University of Palermo are involved in the design of the Water-Cooled Lithium Lead Breeding Blanket (WCLL BB), that is one of the two BB concepts under consideration to be adopted in the DEMO reactor. It is mainly characterized by a liquid lithium-lead eutectic alloy acting as breeder (lithium) and neutron multiplier (lead), as well as by subcooled pressurized water as coolant. Two separate circuits, both characterized by a pressure of 15.5 MPa and inlet/outlet temperatures of 295 °C/328 °C, are deputed to cool down the First Wall (FW) and the Breeder Zone (BZ). The former consists in a system of radial-toroidal-radial C-shaped squared channels where countercurrent water flow occurs while the latter relies in the use of bundles of poloidal-radial Double Walled Tubes (DWTs) housed within the breeder. A parametric thermal study has been carried out in order to assess the best DWTs' layout assuring that the structural material maximum temperature does not overcome the allowable limit of 550 °C and that the overall coolant thermal rise fulfils the design target value of 33 °C. The study has been performed following a theoretical-numerical approach based on the Finite Element Method (FEM) and adopting the quoted Abaqus FEM code. Main assumptions and models together with results obtained are herewith reported and critically discussed

Additive effect of non-alcoholic fatty liver disease on metabolic syndrome-related endothelial dysfunction in hypertensive patients

Metabolic syndrome (MS) is characterized by an increased risk of incident diabetes and cardiovascular (CV) events, identifying insulin resistance (IR) and endothelial dysfunction as key elements. Moreover, non-alcoholic fatty liver disease (NAFLD) is bidirectionally linked with MS as a consequence of metabolic and inflammatory abnormalities. We addressed the question if the evolution in NAFLD might worsen endothelium-dependent vasodilating response in MS hypertensives. We recruited 272 Caucasian newly-diagnosed never-treated hypertensive outpatients divided into three groups according to the presence/absence of MS alone or in combination with NAFLD. MS and NAFLD were defined according to the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATPIII) and non-invasive fatty liver index, respectively. We determined IR by using the homeostasis model assessment (HOMA) index. Vascular function, as forearm blood flow (FBF), was determined through strain-gauge plethysmography after intra-arterial infusion of acetylcholine (ACh) and sodium nitroprusside. MS+NAFLD+ group showed worse metabolic, inflammatory and vascular profiles compared with MS-NAFLD- and MS+NAFLD-. HOMA resulted in being the strongest predictor of FBF both in the MS+NAFLD- and in the MS+NAFLD+ groups, accounting for 20.5% and 33.2% of its variation, respectively. In conclusion, we demonstrated that MS+NAFLD+ hypertensives show a worse endothelium-dependent vasodilation compared with MS+NAFLD-, allowing for consideration of NAFLD as an early marker of endothelial dysfunction in hypertensives

Ketogenic diet-induced weight loss is associated with an increase in vitamin d levels in obese adults

Vitamin D is an important micronutrient involved in several processes. Evidence has shown a strong association between hypovitaminosis D and cardio-metabolic diseases, including obesity. A ketogenic diet has proven to be very effective for weight loss, especially in reducing fat mass while preserving fat-free mass. The aim of this study was to investigate the effect of a ketogenic diet-induced weight loss on vitamin D status in a population of obese adults. We enrolled 56 obese outpatients, prescribed with either traditional standard hypocaloric Mediterranean diet (SHMD) or very low-calorie ketogenic diet (VLCKD). Serum 25(OH)D concentrations were measured by chemiluminescence. The mean value of serum 25-hydroxyvitamin D (25(OH)D) concentrations in the whole population at baseline was 17.8 +/- 5.6 ng/mL, without differences between groups. After 12 months of dietetic treatment, in VLCKD patients serum 25(OH)D concentrations increased from 18.4 +/- 5.9 to 29.3 +/- 6.8 ng/mL (p &lt; 0.0001), vs 17.5 +/- 6.1 to 21.3 +/- 7.6 ng/mL (p = 0.067) in the SHMD group (for each kilogram of weight loss, 25(OH)D concentration increased 0.39 and 0.13 ng/mL in the VLCKD and in the SHMD groups, respectively). In the VLCKD group, the increase in serum 25(OH)D concentrations was strongly associated with body mass index, waist circumference, and fatty mass variation. In a multiple regression analysis, fatty mass was the strongest independent predictor of serum 25(OH)D concentration, explaining 15.6%, 3.3%, and 9.4% of its variation in the whole population, in SHMD, and VLCKD groups, respectively. We also observed a greater reduction of inflammation (evaluated by high-sensitivity C reactive protein (hsCRP) values) and a greater improvement in glucose homeostasis, confirmed by a reduction of HOMA values, in the VLCKD versus the SHMD group. Taken together, all these data suggest that a dietetic regimen, which implies a great reduction of fat mass, can improve vitamin D status in the obese