Supercritical carbon dioxide applications for energy conversion systems

In the present paper, the possibility of increasing the thermodynamic efficiency of an electric energy production plant, by using an advanced energy conversion system based on supercritical carbon dioxide (S-CO2) as working fluid, has been analyzed. Since the supercritical carbon dioxide cycles are being considered as a favorable candidate for the next generation of nuclear power plant energy conversion systems, a lead cooled fast reactor has been selected as reference in the present analyses. The main aim of the present study is to compare two different S-CO2 thermal cycles applied on the conversion system of a nuclear power plant. The reference Lead cooled Fast Reactor (LFR) used for the present analyses is the ALFRED reactor, which has a thermal power of 300 MW and it is considered the scaled down prototype of the industrial European Lead Fast Reactor (ELFR). Thermodynamic cycles selected for the present study are a Recompression Cycle and a Brayton Cycle with Regeneration. Each of them has been analyzed under several design conditions regarding the maximum pressure and the regeneration coefficient. Among different design conditions, the solution allowing the maximization of the overall efficiency has been identified. Thermodynamic analyses have been carried out with GateCycle™ v. 6.1.1, which is a General Electric software able to predict design and off-design performance of power plants

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An approach based on Support Vector Machines and a K-D Tree search algorithm for identification of the failure domain and safest operating conditions in nuclear systems

The safety of a Nuclear Power Plant (NPP) is verified by analyzing the system responses under normal and accidental conditions. This is done by resorting to a Best-Estimate (BE) Thermal-Hydraulic (TH) code, whose outcomes are compared to given safety thresholds enforced by regulation. This allows identifying the limit-state function that separates the failure domain from the safe domain. In practice, the TH model response is affected by uncertainties (both epistemic and aleatory), which make the limit-state function and the failure domain probabilistic. The present paper sets forth an innovative approach to identify the failure domain together with the safest plant operating conditions. The approach relies on the use of Reduced Order Models (ROMs) and K-D Tree. The model failure boundary is approximated by Support Vector Machines (SVMs) and, then, projected onto the space of the controllable variables (i.e., the model inputs that can be manipulated by the plant operator, such as reactor control-rods position, feed-water flow-rate through the plant primary loops, accumulator water temperature and pressure, repair times, etc.). The farthest point from the failure boundary is, then, computed by means of a K-D Tree-based nearest neighbor algorithm; this point represents the combination of input values corresponding to the safest operating conditions. The approach is shown to give satisfactory results with reference to one analytical example and one real case study regarding the Peak Cladding Temperature (PCT) reached in a Boiling Water Reactor (BWR) during a Station-Black-Out (SBO), simulated using RELAP5-3D

Candida albicans enhances meropenem tolerance of Pseudomonas aeruginosa in a dual-species biofilm

Background: Pseudomonas aeruginosa is an opportunistic bacterium that infects the airways of cystic fibrosis patients, surfaces of surgical and burn wounds, and indwelling medical devices. Patients are prone to secondary fungal infections, with Candida albicans being commonly co-isolated with P. aeruginosa. Both P. aeruginosa and C. albicans are able to form extensive biofilms on the surfaces ofmucosa and medical devices. Objectives: To determine whether the presence of C. albicans enhances antibiotic tolerance of P. aeruginosa in a dual-species biofilm. Methods: Single- and dual-species biofilms were established in microtitre plates and the survival of each species was measured following treatment with clinically relevant antibiotics. Scanning electron microscopy and confocal microscopy were used to visualize biofilm structure. Results: C. albicans enhances P. aeruginosa biofilm tolerance to meropenem at the clinically relevant concentration of 5 mg/L. This effect is specific to biofilm cultures and is dependent upon C. albicans extracellular matrix polysaccharides, mannan and glucan, with C. albicans cells deficient in glycosylation structures not enhancing P. aeruginosa tolerance tomeropenem. Conclusions: We propose that fungal mannan and glucan secreted into the extracellular matrix of P. aeruginosa/C. albicans dual-species biofilms play a central role in enhancing P. aeruginosa tolerance to meropenem, which has direct implications for the treatment of coinfected patients

Gender influence on professional satisfaction and gender issue perception among young oncologists. A survey of the Young Oncologists Working Group of the Italian Association of Medical Oncology (AIOM)

Background: The professional gender gap is increasingly recognised in oncology. We explored gender issues perception and gender influence on professional satisfaction/gratification among young Italian oncologists. Methods: Italian oncologists aged 6440 years and members of the Italian Association of Medical Oncology were invited to participate in an online survey addressing workload/burnout, satisfaction in professional abilities and relations, relevant factors for professional gratification, and gender barriers. \u3c72 test for general association or \u3c72 test for trend was used to analyse the data. Results: 201 young oncologists participated in the survey: 67% female, 71% aged 30-40 years, 41% still in training and 82% without children. Women and men were equally poorly satisfied by the relations with people occupying superior hierarchical positions. There was heterogeneity between women and men in current (p=0.011) and expected future (p=0.007) satisfaction in professional abilities: women were more satisfied by current empathy and relations with colleagues and were more confident in their future managerial and team leader skills. The most important elements for professional gratification indicated by all participants were, in general, work-life balance (36%) and intellectual stimulation/research (32%); specifically for women, work-life balance (48%) and intellectual stimulation/research (20%); and specifically for men, career (29%) and social prestige/recognition (26%). Heterogeneity within the same gender emerged. For example, the elements indicated by men as the most important were intellectual stimulation/research (39%) and work-life balance (21%) in general, versus social prestige/recognition (24%) and career (24%), respectively, specifically for men (p<0.0001). More women versus men perceived gender issue as an actual problem (60% vs 38%, p=0.03); men underestimated gender barriers to women's career (p=0.011). Conclusions: Satisfaction in professional abilities varied by gender. Work-life balance is important for both women and men. Stereotypes about gender issues may be present. Gender issue is an actual problem for young oncologists, mostly perceived by women

In vivo manipulation of the extracellular matrix induces vascular regression in a basal chordate.

We investigated the physical role of the extracellular matrix (ECM) in vascular homeostasis in the basal chordate Botryllus schlosseri, which has a large, transparent, extracorporeal vascular network encompassing an area &gt;100 cm2 We found that the collagen cross-linking enzyme lysyl oxidase is expressed in all vascular cells and that in vivo inhibition using β-aminopropionitrile (BAPN) caused a rapid, global regression of the entire network, with some vessels regressing &gt;10 mm within 16 h. BAPN treatment changed the ultrastructure of collagen fibers in the vessel basement membrane, and the kinetics of regression were dose dependent. Pharmacological inhibition of both focal adhesion kinase (FAK) and Raf also induced regression, and levels of phosphorylated FAK in vascular cells decreased during BAPN treatment and FAK inhibition but not Raf inhibition, suggesting that physical changes in the vessel ECM are detected via canonical integrin signaling pathways. Regression is driven by apoptosis and extrusion of cells through the basal lamina, which are then engulfed by blood-borne phagocytes. Extrusion and regression occurred in a coordinated manner that maintained vessel integrity, with no loss of barrier function. This suggests the presence of regulatory mechanisms linking physical changes to a homeostatic, tissue-level response