The {\alpha}-Decay Chains of the 287,288115^{287, 288}115 Isotopes using Relativistic Mean Field Theory

We study the binding energy, root-mean-square radius and quadrupole deformation parameter for the synthesized superheavy element Z = 115, within the formalism of relativistic mean field theory. The calculation is dones for various isotopes of Z = 115 element, starting from A = 272 to A = 292. A systematic comparison between the binding energies and experimental data is made.The calculated binding energies are in good agreement with experimental result. The results show the prolate deformation for the ground state of these nuclei. The most stable isotope is found to be 282115 nucleus (N = 167) in the isotopic chain. We have also studied Q{\alpha} and T{\alpha} for the {\alpha}-decay chains of $^{287, 288}$115.Comment: 12 Pages 6 Figures 3 Table

Biodegradable Poly-pentadecalactone (PDL) Synthesis via Synergistic Lipase and Microwave Catalysis

Abstract A large nu mber of currently used synthetic biodegradable polymers in bio med ical engineering applications are polyesters based materials and thus research on the synthesis, properties, manufacturing and processing of aliphatic polyesters continues to be of great importance. Poly -ω-pentadecalactone (PPDL) a lactone based ring opening polymer has good mechanical properties and the presence of hydrolysable ester linkages along the poly mer chain making it desirable as a biodegradable material for diversified bio med ical engineering applications. In this paper we report the formation of PPDL using the synergistic effects of lipase and microwave (MW) technology. The effect of reaction time on the PPDL poly mer chain growth has been investigated. PPDL have been formed using lipase and MW irradiation at varying reaction time intervals (30-240 mins). Synergistic MW and lipase catalyzed poly merization of PPDL gave a number average molecular weight (Mn) of 24,997 g/ mol and a polydispersity index (PDI) of 1.93 in 240 mins as compared to Mn of 8,060 g/mo l and PDI of 2.17 using lipase and tradit ional heating. Thermal characterizat ion of PPDL fo rmed using MW and lipase catalysis showed that MW did not have a detrimental effect on the thermal properties of the poly mer obtained

New record of a marine bivalve (Family: Pinnidae) from Chilika Lagoon, Bay of Bengal

1039-1044Present study describes the newly reported marine bivalve species Atrina serrata from the marine influenced region of Chilika lagoon. This is the first time ever to record an Atlantic bivalve species from the shallow coastal waters of Indian subcontinent. With the paucity of information, the study isn’t reached to any conclusion regarding the possible reason of occurrence, since multiple parameters are governing on the distribution of a species. However, this finding will help to understand the changed or changing benthic ecology of shallow water coastal ecosystem such as Chilika after opening of the lagoon inlets

Functionalisation of Ti6Al4V components fabricated using selective laser melting with a bioactive compound

Surface modification of an implant with a biomolecule is used to improve its biocompatibility and to reduce post-implant complications. In this study, a novel approach has been used to functionalise phosphonic acid monolayers with a drug. Ti6Al4V components fabricated using selective laser melting (SLM) were functionalised with Paracetamol (a pharmaceutically relevant biomolecule) using phosphonic acid based self-assembled monolayers (SAMs). The attachment, stability of the monolayers on the SLM fabricated surface and functionalisation of SAMs with Paracetamol were studied using X-ray photoelectron spectroscopy (XPS) and surface wettability measurements. The obtained results confirmed that SAMs were stable on the Ti6Al4V surface for over four weeks and then began to desorb from the surface. The reaction used to functionalise the phosphonic acid monolayers with Paracetamol was noted to be successful. Thus, the proposed method has the potential to immobilise drugs/proteins to SAM coated surfaces and improve their biocompatibility and reduce post-implant complications

Microneedles: A New Frontier in Nanomedicine Delivery

This review aims to concisely chart the development of two individual research fields, namely nanomedicines, with specific emphasis on nanoparticles (NP) and microparticles (MP), and microneedle (MN) technologies, which have, in the recent past, been exploited in combinatorial approaches for the efficient delivery of a variety of medicinal agents across the skin. This is an emerging and exciting area of pharmaceutical sciences research within the remit of transdermal drug delivery and as such will undoubtedly continue to grow with the emergence of new formulation and fabrication methodologies for particles and MN. Firstly, the fundamental aspects of skin architecture and structure are outlined, with particular reference to their influence on NP and MP penetration. Following on from this, a variety of different particles are described, as are the diverse range of MN modalities currently under development. The review concludes by highlighting some of the novel delivery systems which have been described in the literature exploiting these two approaches and directs the reader towards emerging uses for nanomedicines in combination with MN

Poly-lactic acid nanoparticles (PLA-NP) promote physiological modifications in lung epithelial cells and are internalized by clathrin-coated pits and lipid rafts

BackgroundPoly-lactic acid nanoparticles (PLA-NP) are a type of polymeric NP, frequently used as nanomedicines, which have advantages over metallic NP such as the ability to maintain therapeutic drug levels for sustained periods of time. Despite PLA-NP being considered biocompatible, data concerning alterations in cellular physiology are scarce.MethodsWe conducted an extensive evaluation of PLA-NP biocompatibility in human lung epithelial A549 cells using high throughput screening and more complex methodologies. These included measurements of cytotoxicity, cell viability, immunomodulatory potential, and effects upon the cells’ proteome. We used non- and green-fluorescent PLA-NP with 63 and 66 nm diameters, respectively. Cells were exposed with concentrations of 2, 20, 100 and 200 µg/mL, for 24, 48 and 72 h, in most experiments. Moreover, possible endocytic mechanisms of internalization of PLA-NP were investigated, such as those involving caveolae, lipid rafts, macropinocytosis and clathrin-coated pits.ResultsCell viability and proliferation were not altered in response to PLA-NP. Multiplex analysis of secreted mediators revealed a low-level reduction of IL-12p70 and vascular epidermal growth factor (VEGF) in response to PLA-NP, while all other mediators assessed were unaffected. However, changes to the cells’ proteome were observed in response to PLA-NP, and, additionally, the cellular stress marker miR155 was found to reduce. In dual exposures of staurosporine (STS) with PLA-NP, PLA-NP enhanced susceptibility to STS-induced cell death. Finally, PLA-NP were rapidly internalized in association with clathrin-coated pits, and, to a lesser extent, with lipid rafts.ConclusionsThese data demonstrate that PLA-NP are internalized and, in general, tolerated by A549 cells, with no cytotoxicity and no secretion of pro-inflammatory mediators. However, PLA-NP exposure may induce modification of biological functions of A549 cells, which should be considered when designing drug delivery systems. Moreover, the pathways of PLA-NP internalization we detected could contribute to the improvement of selective uptake strategies

Kinetics of Oxidation of Cyclopentanol, Cyclohexanol, Cycloheptanol & Cyclooctanol by Pyridinium Chloro-chromate (Corey’s Reagent) in Chlorobenzene-Nitro-benzene Mixture

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