Реализация «габсбургского мифа» в трагедии Ф. Нрильпарцера «Либуша»

Трагедия «Либуша» (1847) занимает особое место в творческом наследии Ф.Грильпарцера: воплощая в себе эстетические и социально-политические взгляды зрелого художника, она является кульминацией развития его творческого метода – мифологизации и одновременно итогом авторской реализации мифологизма

Marie-Hélène Froeschlé-Chopard, Tourrettes-sur-Loup au xviiie siècle. Hérésie et scandale au village

Marie-Hélène Froeschlé-Chopard présente un ouvrage de micro-histoire sur un village qui l’a vue naître en 1942. Fontenaisienne, agrégée d’histoire, directeur de recherches honoraire au CNRS, l’auteure est membre du Centre de recherches historiques (EHESS). Elle est bien connue des historiens modernistes par ses travaux: La religion populaire en Provence orientale (1980), Atlas de la réforme pastorale en France de 1550 à 1790 (1986), Espace et sacré en Provence (xvie-xxe siècles). Cultes, imag..

Impacts of meso-to submeso-scale features on the ocean circulation in the Coral Sea

International audienceAs part of the South Pacific subtropical gyre, the encounter of the South Equatorial Current (SEC)with the complex bottom topography and numerous islands of the southwest tropical Pacific resultsinto a series of zonal jets, flowing mainly westward off the tip of archipelagos. Moreover, themesoscale activity at basin scale is dominated by westward-propagating nonlinear eddies, with astrong impact on the ocean circulation, the mixing of water masses and tracers' distribution. Eddy-jet interactions are studied here with the data collected in September 2012 during theBIFURCATION cruise in the Coral Sea, under the auspices of SPICE (Southwest PacIfic OceanCirculation and Climate Experiment). We analyze and explain in situ data with the help of satellite-based remote sensing data (altimetry, SSS, SST, ocean color), and we estimate the mass transportbudget within the Coral Sea. We show that the mesoscale activity is a significant contributor to the0-600m transport estimates (5-10 Sv) and is essential for the interpretation of hydrologicalobservations. A specific mesoscale eddy is identified as responsible for the connection between theNorth Vanuatu Jet (NVJ) and the North Caledonian Jet (NCJ). By using a Lagrangian technique, weare able to confirm the long-term connection between the NVJ and the NCJ through mesoscaleactivity. At a smaller scale, our analysis shows that surface temperature and salinity gradients can beassociated with hydrodynamical submesoscale features depicted by Finite Size LyapunovExponents (FSLE). These structures can also be linked to the presence of diazotroph species, incontrast with the general oligotrophy of the area. This study offers interesting outlooks for the useof FSLE to study the distribution of biogeochemical elements

The Influence of Conjugated Polymer Side Chain Manipulation on the Efficiency and Stability of Polymer Solar Cells

The stability of polymer solar cells (PSCs) can be influenced by the introduction of particular moieties on the conjugated polymer side chains. In this study, two series of donor-acceptor copolymers, based on bis(thienyl)dialkoxybenzene donor and benzo[c][1,2,5]thiadiazole (BT) or thiazolo[5,4-d]thiazole (TzTz) acceptor units, were selected toward effective device scalability by roll-coating. The influence of the partial exchange (5% or 10%) of the solubilizing 2-hexyldecyloxy by alternative 2-phenylethoxy groups on efficiency and stability was investigated. With an increasing 2-phenylethoxy ratio, a decrease in solar cell efficiency was observed for the BT-based series, whereas the efficiencies for the devices based on the TzTz polymers remained approximately the same. The photochemical degradation rate for PSCs based on the TzTz polymers decreased with an increasing 2-phenylethoxy ratio. Lifetime studies under constant sun irradiance showed a diminishing initial degradation rate for the BT-based devices upon including the alternative side chains, whereas the (more stable) TzTz-based devices degraded at a faster rate from the start of the experiment upon partly exchanging the side chains. No clear trends in the degradation behavior, linked to the copolymer structural changes, could be established at this point, evidencing the complex interplay of events determining PSCs’ lifetime

Connexins and pannexins in liver damage

Connexins and pannexins are key players in the control of cellular communication and thus in the maintenance of tissue homeostasis. Inherent to this function these proteins are frequently involved in pathological processes. The present paper reviews the role of connexins and pannexins in liver toxicity and disease. As they act both as sensors and effectors in these deleterious events connexins and pannexins could represent a set of novel clinical diagnostic biomarkers and drug targets

Inhibition of connexin hemichannels alleviates non-alcoholic steatohepatitis in mice

While gap junctions mediate intercellular communication and support liver homeostasis, connexin hemichannels are preferentially opened by pathological stimuli, including inflammation and oxidative stress. The latter are essential features of non-alcoholic steatohepatitis. In this study, it was investigated whether connexin32 and connexin43 hemichannels play a role in non-alcoholic steatohepatitis. Mice were fed a choline-deficient high-fat diet or normal diet for 8 weeks. Thereafter, TAT-Gap24 or TAT-Gap19, specific inhibitors of hemichannels composed of connexin32 and connexin43, respectively, were administered for 2 weeks. Subsequently, histopathological examination was carried out and various indicators of inflammation, liver damage and oxidative stress were tested. In addition, whole transcriptome microarray analysis of liver tissue was performed. Channel specificity of TAT-Gap24 and TAT-Gap19 was examined in vitro by fluorescence recovery after photobleaching analysis and measurement of extracellular release of adenosine triphosphate. TAT-Gap24 and TAT-Gap19 were shown to be hemichannel-specific in cultured primary hepatocytes. Diet-fed animals treated with TAT-Gap24 or TAT-Gap19 displayed decreased amounts of liver lipids and inflammatory markers, and augmented levels of superoxide dismutase, which was supported by the microarray results. These findings show the involvement of connexin32 and connexin43 hemichannels in non-alcoholic steatohepatitis and, simultaneously, suggest a role as potential drug targets in non-alcoholic steatohepatitis

Investigation of an international water polo tournament in Czechia as a potential source for early introduction of the SARS-CoV-2 Omicron variant into Belgium, Switzerland and Germany, November 2021

Background: The earliest recognised infections by the SARS-CoV-2 Omicron variant (Pango lineage B.1.1.529) in Belgium and Switzerland suggested a connection to an international water polo tournament, held 12-14 November 2021 in Brno, Czechia.AimTo study the arrival and subsequent spread of the Omicron variant in Belgium and Switzerland, and understand the overall importance of this international sporting event on the number of infections in the two countries. Methods: We performed intensive forward and backward contact tracing in both countries, supplemented by phylogenetic investigations using virus sequences of the suspected infection chain archived in public databases. Results: Through contact tracing, we identified two and one infected athletes of the Belgian and Swiss water polo teams, respectively, and subsequently also three athletes from Germany. In Belgium and Switzerland, four and three secondary infections, and three and one confirmed tertiary infections were identified. Phylogenetic investigation demonstrated that this sporting event played a role as the source of infection, but without a direct link with infections from South Africa and not as a superspreading event; the virus was found to already be circulating at that time in the countries involved. Conclusion: The SARS-CoV-2 Omicron variant started to circulate in Europe several weeks before its identification in South Africa on 24 November 2021. Accordingly, it can be assumed that travel restrictions are usually implemented too late to prevent the spread of newly detected SARS-CoV-2 variants to other regions. Phylogenetic analysis may modify the perception of an apparently clear result of intensive contact tracing

Search for physics beyond the standard model in events with τ leptons, jets, and large transverse momentum imbalance in pp collisions at [Formula: see text].

A search for physics beyond the standard model is performed with events having one or more hadronically decaying τ leptons, highly energetic jets, and large transverse momentum imbalance. The data sample corresponds to an integrated luminosity of 4.98 fb-1 of proton-proton collisions at [Formula: see text] collected with the CMS detector at the LHC in 2011. The number of observed events is consistent with predictions for standard model processes. Lower limits on the mass of the gluino in supersymmetric models are determined