College of Business, Business Career Accelerator, Qualitative Research Study on Student Involvement in Professional Development Activities

The creation and execution of this project began by analyzing the honors project specifications, to design a project that met the Honors College criteria. To meet these criteria, a market research study was conducted to assist the College of Business’s Business Career Accelerator management in understanding the student market of the College of Business. In addition, the study’s goal is to make recommendations utilizing marketing and education frameworks to maintain and increase student usage of the center. The project was executed using traditional market research frameworks, which required conducting in-depth interviews of College of Business students to determine student attitudes and behaviors towards professional development and usage of the Business Career Accelerator. The College of Business student market was then segmented based on typical usage behaviors. A ‘validity check’ was also conducted with management of the Business Career Accelerator, which compared management’s understanding of student attitudes and behaviors with the student responses received from the in-depth interviews. After conducting the in-depth interviews, several barriers to student participation in the Business Career Accelerator were identified. These barriers were identified and analyzedby applying relevant marketing and education frameworks identified by interviewing College of Education faculty and industry professionals at Root Inc., a center which focuses on implementing strategic change in organizations. Following marketing and education methods, tentative recommendations were made based on the education frameworks, to address the barriers to student participation that were identified in the qualitative interviews. Feedback was then sought on these recommendations, by conducting a focus group with a group of senior level College of Business students. The focus group sought student feedback that would help to adapt or further refine these career development suggestions. Following the focus group, the career development suggestions were adapted to reflect student input. Finally, the results of this study were presented to a market research course of approximately fifty students. Students attending the presentation provided more feedback on the recommendations prior to the development of this report, and its presentation to the Honors College and Business Career Accelerator’s management for implementation

Fertility, Belief, and Sexuality

The human ovulatory cycle lasts an average of 28 days and is highly variable both within and among women, making ovulation and the fertile window difficult to estimate in humans. Commonly used methods for estimating fertility assume length consistency during various cycle phases, an assumption that often miscategorizes women as fertile when not and vice versa. This experiment analyzes several of the common methods used to estimate fertility, including forwards and backwards-counting methods and actuarial methods, and compares them against hormonal testing to determine the most accurate method for fertility identification. Additionally, we used hormonal ovulation tests combined with daily journaling reports to determine the degree to which fertility affects sexual desire, likely sexual engagement, and general happiness, as well as a woman’s belief that she is fertile. We hypothesize that women will not be able to accurately predict their fertility and will show increased sexual interest and general happiness during the fertile window. We also hypothesize that estimation methods will have different results than those using confirmed fertility, but that the closest estimation will be backward counting methods estimating fertility as the six-day window ending at thirteen days from the start of menses

Tuft-cell-intrinsic and -extrinsic mediators of norovirus tropism regulate viral immunity

Murine norovirus (MNoV) is a model for human norovirus and for interrogating mechanisms of viral tropism and persistence. We previously demonstrated that the persistent strain MNo

Quantum hydrodynamics

Quantum hydrodynamics in superfluid helium and atomic Bose-Einstein condensates (BECs) has been recently one of the most important topics in low temperature physics. In these systems, a macroscopic wave function appears because of Bose-Einstein condensation, which creates quantized vortices. Turbulence consisting of quantized vortices is called quantum turbulence (QT). The study of quantized vortices and QT has increased in intensity for two reasons. The first is that recent studies of QT are considerably advanced over older studies, which were chiefly limited to thermal counterflow in 4He, which has no analogue with classical traditional turbulence, whereas new studies on QT are focused on a comparison between QT and classical turbulence. The second reason is the realization of atomic BECs in 1995, for which modern optical techniques enable the direct control and visualization of the condensate and can even change the interaction; such direct control is impossible in other quantum condensates like superfluid helium and superconductors. Our group has made many important theoretical and numerical contributions to the field of quantum hydrodynamics of both superfluid helium and atomic BECs. In this article, we review some of the important topics in detail. The topics of quantum hydrodynamics are diverse, so we have not attempted to cover all these topics in this article. We also ensure that the scope of this article does not overlap with our recent review article (arXiv:1004.5458), "Quantized vortices in superfluid helium and atomic Bose--Einstein condensates", and other review articles.Comment: 102 pages, 29 figures, 1 tabl

Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly.

International audienceThe genetic causes of malformations of cortical development (MCD) remain largely unknown. Here we report the discovery of multiple pathogenic missense mutations in TUBG1, DYNC1H1 and KIF2A, as well as a single germline mosaic mutation in KIF5C, in subjects with MCD. We found a frequent recurrence of mutations in DYNC1H1, implying that this gene is a major locus for unexplained MCD. We further show that the mutations in KIF5C, KIF2A and DYNC1H1 affect ATP hydrolysis, productive protein folding and microtubule binding, respectively. In addition, we show that suppression of mouse Tubg1 expression in vivo interferes with proper neuronal migration, whereas expression of altered γ-tubulin proteins in Saccharomyces cerevisiae disrupts normal microtubule behavior. Our data reinforce the importance of centrosomal and microtubule-related proteins in cortical development and strongly suggest that microtubule-dependent mitotic and postmitotic processes are major contributors to the pathogenesis of MCD

Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034

Crystal structures of protease/inhibitor complexes guided optimization of the buried nonpolar surface area thereby maximizing hydrophobic binding. The resulting potent tripeptide inhibitor is in clinical trials

A Search for Technosignatures Around 11,680 Stars with the Green Bank Telescope at 1.15-1.73 GHz

We conducted a search for narrowband radio signals over four observing sessions in 2020-2023 with the L-band receiver (1.15-1.73 GHz) of the 100 m diameter Green Bank Telescope. We pointed the telescope in the directions of 62 TESS Objects of Interest, capturing radio emissions from a total of ~11,680 stars and planetary systems in the ~9 arcminute beam of the telescope. All detections were either automatically rejected or visually inspected and confirmed to be of anthropogenic nature. In this work, we also quantified the end-to-end efficiency of radio SETI pipelines with a signal injection and recovery analysis. The UCLA SETI pipeline recovers 94.0% of the injected signals over the usable frequency range of the receiver and 98.7% of the injections when regions of dense RFI are excluded. In another pipeline that uses incoherent sums of 51 consecutive spectra, the recovery rate is ~15 times smaller at ~6%. The pipeline efficiency affects calculations of transmitter prevalence and SETI search volume. Accordingly, we developed an improved Drake Figure of Merit and a formalism to place upper limits on transmitter prevalence that take the pipeline efficiency and transmitter duty cycle into account. Based on our observations, we can state at the 95% confidence level that fewer than 6.6% of stars within 100 pc host a transmitter that is detectable in our search (EIRP > 1e13 W). For stars within 20,000 ly, the fraction of stars with detectable transmitters (EIRP > 5e16 W) is at most 3e-4. Finally, we showed that the UCLA SETI pipeline natively detects the signals detected with AI techniques by Ma et al. (2023).Comment: 22 pages, 9 figures, submitted to AJ, revise

Recyclable transmission line (RTL) and linear transformer driver (LTD) development for Z-pinch inertial fusion energy (Z-IFE) and high yield.

Z-Pinch Inertial Fusion Energy (Z-IFE) complements and extends the single-shot z-pinch fusion program on Z to a repetitive, high-yield, power plant scenario that can be used for the production of electricity, transmutation of nuclear waste, and hydrogen production, all with no CO{sub 2} production and no long-lived radioactive nuclear waste. The Z-IFE concept uses a Linear Transformer Driver (LTD) accelerator, and a Recyclable Transmission Line (RTL) to connect the LTD driver to a high-yield fusion target inside a thick-liquid-wall power plant chamber. Results of RTL and LTD research are reported here, that include: (1) The key physics issues for RTLs involve the power flow at the high linear current densities that occur near the target (up to 5 MA/cm). These issues include surface heating, melting, ablation, plasma formation, electron flow, magnetic insulation, conductivity changes, magnetic field diffusion changes, possible ion flow, and RTL mass motion. These issues are studied theoretically, computationally (with the ALEGRA and LSP codes), and will work at 5 MA/cm or higher, with anode-cathode gaps as small as 2 mm. (2) An RTL misalignment sensitivity study has been performed using a 3D circuit model. Results show very small load current variations for significant RTL misalignments. (3) The key structural issues for RTLs involve optimizing the RTL strength (varying shape, ribs, etc.) while minimizing the RTL mass. Optimization studies show RTL mass reductions by factors of three or more. (4) Fabrication and pressure testing of Z-PoP (Proof-of-Principle) size RTLs are successfully reported here. (5) Modeling of the effect of initial RTL imperfections on the buckling pressure has been performed. Results show that the curved RTL offers a much greater buckling pressure as well as less sensitivity to imperfections than three other RTL designs. (6) Repetitive operation of a 0.5 MA, 100 kV, 100 ns, LTD cavity with gas purging between shots and automated operation is demonstrated at the SNL Z-IFE LTD laboratory with rep-rates up to 10.3 seconds between shots (this is essentially at the goal of 10 seconds for Z-IFE). (7) A single LTD switch at Tomsk was fired repetitively every 12 seconds for 36,000 shots with no failures. (8) Five 1.0 MA, 100 kV, 100 ns, LTD cavities have been combined into a voltage adder configuration with a test load to successfully study the system operation. (9) The combination of multiple LTD coaxial lines into a tri-plate transmission line is examined. The 3D Quicksilver code is used to study the electron flow losses produced near the magnetic nulls that occur where coax LTD lines are added together. (10) Circuit model codes are used to model the complete power flow circuit with an inductive isolator cavity. (11) LTD architectures are presented for drivers for Z-IFE and high yield. A 60 MA LTD driver and a 90 MA LTD driver are proposed. Present results from all of these power flow studies validate the whole LTD/RTL concept for single-shot ICF high yield, and for repetitive-shot IFE

The NANOGrav 15-year Data Set: Evidence for a Gravitational-Wave Background

We report multiple lines of evidence for a stochastic signal that is correlated among 67 pulsars from the 15-year pulsar-timing data set collected by the North American Nanohertz Observatory for Gravitational Waves. The correlations follow the Hellings-Downs pattern expected for a stochastic gravitational-wave background. The presence of such a gravitational-wave background with a power-law-spectrum is favored over a model with only independent pulsar noises with a Bayes factor in excess of $10^{14}$, and this same model is favored over an uncorrelated common power-law-spectrum model with Bayes factors of 200-1000, depending on spectral modeling choices. We have built a statistical background distribution for these latter Bayes factors using a method that removes inter-pulsar correlations from our data set, finding $p = 10^{-3}$ (approx. $3\sigma$) for the observed Bayes factors in the null no-correlation scenario. A frequentist test statistic built directly as a weighted sum of inter-pulsar correlations yields $p = 5 \times 10^{-5} - 1.9 \times 10^{-4}$ (approx. $3.5 - 4\sigma$). Assuming a fiducial $f^{-2/3}$ characteristic-strain spectrum, as appropriate for an ensemble of binary supermassive black-hole inspirals, the strain amplitude is $2.4^{+0.7}_{-0.6} \times 10^{-15}$ (median + 90% credible interval) at a reference frequency of 1/(1 yr). The inferred gravitational-wave background amplitude and spectrum are consistent with astrophysical expectations for a signal from a population of supermassive black-hole binaries, although more exotic cosmological and astrophysical sources cannot be excluded. The observation of Hellings-Downs correlations points to the gravitational-wave origin of this signal.Comment: 30 pages, 18 figures. Published in Astrophysical Journal Letters as part of Focus on NANOGrav's 15-year Data Set and the Gravitational Wave Background. For questions or comments, please email [email protected]