54 research outputs found

    Contributos para o estudo da escola como organização aprendente: estudo empírico num agrupamento de escolas de Faro

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    Dissertação de mestrado, Gestão e Administração Escolar, Escola Superior de Educação e Comunicação, Universidade do Algarve, 2017Da área da gestão empresarial a conceção de organização aprendente passou para a escola, surgindo um novo domínio do conhecimento, a Escola Aprendente. A escola aprendente é a escola que promove o trabalho colaborativo, a experimentação integrada em processos de ação-reflexão, a inovação e mecanismos de autorregulação. É a escola que problematiza e que procura resolver os seus problemas com a participação de toda a comunidade educativa. A escola aprendente, pelas ações que gera, é uma organização que se projeta no futuro e que, pensa-se, surge como um modelo organizacional que responde aos desafios deste século. O estudo desenvolve-se em duas vertentes: uma teórico-concetual e outra empírica. A primeira assenta nos paradigmas e pressupostos de escola aprendente e nas concetualizações que contribuem para a caracterizar, bem como na análise dos estudos empíricos já realizados em Portugal. Esta parte do trabalho inclui também uma breve abordagem à investigação em educação e ao estudo da escola, pressupostos metodológicos e epistemológicos que direcionaram e sustentaram o estudo empírico. Na segunda parte analisa-se de forma crítica, a partir do modelo teórico-concetual construído, a estrutura da organização e a cultura de escola do objeto de estudo (um agrupamento de escolas em Faro) com recurso a metodologias diversificadas, destacando-se a abordagem qualitativa e o predomínio da entrevista e da observação

    Linear relationships between partition coefficients of different organic compounds and proteins in aqueous two-phase systems of various polymer and ionic compositions

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    Analysis of the partition coefficients of small organic compounds and proteins in different aqueous two-phase systems under widely varied ionic compositions shows that logarithms of partition coefficients for any three compounds or proteins or two organic compounds and one protein are linearly interrelated, although for protein(s) there are ionic compositions when the linear fit does not hold. It is suggested that the established interrelationships are due to cooperativity of different types of solute–solvent interactions in aqueous media. This assumption is confirmed by analysis of distribution coefficients of various drugs in octanol-buffer systems with varied ionic compositions of the buffer. Analysis of the partition coefficients characterizing distribution of variety of drugs between blood and different tissues of rats in vivo reported in the literature showed that the above assumption is correct and enabled us to identify the tissues with the components of which the drug(s) may engage in presumably direct interactions. It shows that the suggested assumption is valid for even complex biological systems.info:eu-repo/semantics/publishedVersio

    Hydrogen bond arrangement is shown to differ in coexisting phases of aqueous two-phase systems

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    Analysis by attenuated total reflection-Fourier transform infrared spectroscopy shows that each coexisting phase in aqueous two-phase systems has a different arrangement of hydrogen bonds. Specific arrangements vary for systems formed by different solutes. The hydrogen bond arrangement is shown to correlate with differences in hydrophobic and electrostatic properties of the different phases of five specific systems, four formed by two polymers and one by a single polymer and salt. The results presented here suggest that the arrangement of hydrogen bonds may be an important factor in phase separation.P.P.M. acknowledges University of Aveiro, CICECO-Aveiro Institute of Materials for funding in the framework of the project UIDB/5011/2020 and UIDP/50011/2020, financed by national funds through the FCT/MEC contract foreseen in the numbers 4, 5, and 6 of the article 23, of the Decree-Law 57/2016, of August 29, changed by Law 57/2017, of July 19.publishe

    Infecção natural por Trypanosoma cruzi em um cão na região central do Brasil: relato de caso

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    RESUMO Trypanosoma cruzi, infecta cerca de 10 milhões de pessoas, principalmente na América Latina e mais de 25 milhões apresentam-se em risco de adquirir a doença nas áreas endêmicas. Os cães são considerados importantes reservatórios representando fator de risco para a população humana. Este relato descreve caso de doença de Chagas em cão na cidade de Cuiabá. O diagnóstico foi feito a partir do exame direto, apresentando inúmeras formas tripomastigotas em esfregaço sanguíneo. Amastigotas foram visualizadas na microscopia de medula óssea, linfonodo, rins, fígado e cérebro. A infecção por T. cruzi (ZIII) foi confirmado através do sequenciamento de produtos amplificados pela PCR. O animal apresentou sinais multissistêmicos, evoluindo para óbito. Apesar da doença de Chagas aguda em humanos não ser descrita em Cuiabá, este é o primeiro relato de um caso canino nessa região, fato que, constitui alerta aos profissionais da saúde e autoridades sanitárias para a possibilidade da transmissão desta zoonose em Cuiabá.SUMMARY It is estimated that about 10 million people are infected with Trypanosoma cruzi worldwide, mostly in Latin America and more than 25 million are at risk of acquiring this infection in endemic areas. Dogs are an important reservoir for this pathogen and thus, considered a risk factor for human populations. This report describes one case of Chagas disease in a dog from Cuiabá, Mato Grosso State, Brazil. The diagnosis was obtained by direct examination of trypomastigote forms in blood smears. Amastigotes forms were visualized in microscopy of the bone marrow, lymph nodes, kidneys, liver and brain. The T. cruzi (ZIII) infection was confirmed by Polymerase Chain Reaction, and sequencing. The animal presented multisystemic failure and died. Although acute Chagas disease in humans is not reported in Cuiabá, this is the first report of a canine case in this region. This case represents a warning, to health professionals and authorities, to the possibility of transmission of this zoonosis in Cuiabá

    Rational design of HIV vaccines and microbicides: report of the EUROPRISE network annual conference 2010

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    Novel, exciting intervention strategies to prevent infection with HIV have been tested in the past year, and the field is rapidly evolving. EUROPRISE is a network of excellence sponsored by the European Commission and concerned with a wide range of activities including integrated developmental research on HIV vaccines and microbicides from discovery to early clinical trials. A central and timely theme of the network is the development of the unique concept of co-usage of vaccines and microbicides. This review, prepared by the PhD students of the network captures much of the research ongoing between the partners. The network is in its 5th year and involves over 50 institutions from 13 European countries together with 3 industrial partners; GSK, Novartis and Sanofi-Pasteur. EUROPRISE is involved in 31 separate world-wide trials of Vaccines and Microbicides including 6 in African countries (Tanzania, Mozambique, South Africa, Kenya, Malawi, Rwanda), and is directly supporting clinical trials including MABGEL, a gp140-hsp70 conjugate trial and HIVIS, vaccine trials in Europe and Africa
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