The Global Networked Value Circle: A new model for best-in-class manufacturing

As companies face deflation, slowing production and declining prices, they will need to assess their entire value chain as they look for ways to keep costs low and improve efficiencies while continuing to innovate. To help address this challenge, this report reflects fresh research undertaken by Capgemini in collaboration with the University of Edinburgh into the ?Best-in-Class Global Manufacturing Value Chain?

Confined compression of collagen hydrogels

Reconstituted collagen hydrogels are often used for in vitro studies of cell-matrix interaction and as scaffolds for tissue engineering. Understanding the mechanical and transport behaviours of collagen hydrogels is therefore extremely important, albeit difficult due to their very high water content (typically > 99.5%). In the present study the mechanical behaviour of collagen hydrogels in confined compression was investigated using biphasic theory (J. Biomech. Eng. 102 (1980) 73), to ascertain whether the technique is sufficiently sensitive to determine differences in the characteristics of hydrogels of between 0.2% and 0.4% collagen. Peak stress, equilibrium stress, aggregate modulus and hydraulic permeability of the hydrogels exhibited sensitivity to collagen content, demonstrating that the technique is clearly able to discriminate between hydrogels with small differences in collagen content and may also be sensitive to factors that affect matrix remodelling. The results also offer additional insight into the deformation-dependent permeability of collagen hydrogels. This study suggests that confined compression, together with biphasic theory, is a suitable technique for assessing the mechanical properties of collagen hydrogels

Kolab: appropriation & improvisation in mobile tangible collaborative interaction

Current design guidelines for conventional tangible systems suggest that the representational significance of tangible tokens is an important consideration in the design of tangible interaction, especially in collaborative contexts. Such advice might be assumed to imply that nomadic tangible systems that employ improvised tokens are liable to have highly impaired usability. In this paper we describe a proof of concept experiment for Kolab, a nomadic tangible interaction system that permits any surface to be appropriated as a collaborative tabletop, and which affords the use of a wide range of appropriated artifacts as improvised tangibles. We demonstrate an approach for realizing the necessary interaction techniques combining tangibles and hand gestures using a fusion of image and depth sensing. We present the results of a user study showing that while users' choices of artifacts were seen to follow an unexpected pattern, various artifacts were appropriated and improvised as tangibles, and the system was found to be both usable and well able to support user collaboration

On columnar thin films as platforms for surface-plasmonic-polaritonic optical sensing: higher-order considerations

The ability to tailor the porosity and optical properties of columnar thin films (CTFs) renders them promising platforms for optical sensing. In particular, surface-plasmon-polariton (SPP) waves, guided by the planar interface of an infiltrated CTF and a thin layer of metal, may be harnessed to detect substances that penetrate the void regions in between the columns of a CTF. This scenario was investigated theoretically using a higher-order homogenization technique, based on an extended version of the second-order strong-permittivity-fluctuation theory, which takes into account the size of the component particles which make up the infiltrated CTF and the statistical distribution of these particles. Our numerical studies revealed that as the size of the component particles increases and as the correlation length that characterizes their distribution increases: (i) the phase speed of the SPP wave decreases and the SPP wave's attenuation increases; (ii) the SPP wave's penetration into the CTF decreases; (iii) the angle of incidence required to excite the SPP wave in a modified Kretschmann configuration increases; (iv) the sharpness of the SPP trough in the graph of reflectance versus angle of incidence increases; and (v) the sensitivity to changes in refractive index of the infiltrating fluid decreases

``Critical'' phonons of the supercritical Frenkel-Kontorova model: renormalization bifurcation diagrams

The phonon modes of the Frenkel-Kontorova model are studied both at the pinning transition as well as in the pinned (cantorus) phase. We focus on the minimal frequency of the phonon spectrum and the corresponding generalized eigenfunction. Using an exact decimation scheme, the eigenfunctions are shown to have nontrivial scaling properties not only at the pinning transition point but also in the cantorus regime. Therefore the phonons defy localization and remain critical even where the associated area-preserving map has a positive Lyapunov exponent. In this region, the critical scaling properties vary continuously and are described by a line of renormalization limit cycles. Interesting renormalization bifurcation diagrams are obtained by monitoring the cycles as the parameters of the system are varied from an integrable case to the anti-integrable limit. Both of these limits are described by a trivial decimation fixed point. Very surprisingly we find additional special parameter values in the cantorus regime where the renormalization limit cycle degenerates into the above trivial fixed point. At these ``degeneracy points'' the phonon hull is represented by an infinite series of step functions. This novel behavior persists in the extended version of the model containing two harmonics. Additional richnesses of this extended model are the one to two-hole transition line, characterized by a divergence in the renormalization cycles, nonexponentially localized phonons, and the preservation of critical behavior all the way upto the anti-integrable limit.Comment: 10 pages, RevTeX, 9 Postscript figure

A detailed binding free energy study of 2 : 1 ligand–DNA complex formation by experiment and simulation

In 2004, we used NMR to solve the structure of the minor groove binder thiazotropsin A bound in a 2 : 1 complex to the DNA duplex, d(CGACTAGTCG)2. In this current work, we have combined theory and experiment to confirm the binding thermodynamics of this system. Molecular dynamics simulations that use polarizable or non-polarizable force fields with single and separate trajectory approaches have been used to explore complexation at the molecular level. We have shown that the binding process invokes large conformational changes in both the receptor and ligand, which is reflected by large adaptation energies. This is compensated for by the net binding free energy, which is enthalpy driven and entropically opposed. Such a conformational change upon binding directly impacts on how the process must be simulated in order to yield accurate results. Our MM-PBSA binding calculations from snapshots obtained from MD simulations of the polarizable force field using separate trajectories yield an absolute binding free energy (-15.4 kcal mol-1) very close to that determined by isothermal titration calorimetry (-10.2 kcal mol-1). Analysis of the major energy components reveals that favorable non-bonded van der Waals and electrostatic interactions contribute predominantly to the enthalpy term, whilst the unfavorable entropy appears to be driven by stabilization of the complex and the associated loss of conformational freedom. Our results have led to a deeper understanding of the nature of side-by-side minor groove ligand binding, which has significant implications for structure-based ligand development

The realities of storing carbon dioxide - A response to CO2 storage capacity issues raised by Ehlig-Economides & Economides

In a recent publication, Ehlig-Economides & Economides (2010) have sought to demonstrate that carbon dioxide capture and storage (CCS) is not technically or economically feasible, based on a supposed lack of underground storage capacity. We consider this to be a serious misrepresentation of the scientific, engineering and operational facts surrounding CCS. Ehlig-Economides & Economides raise a number of storage related issues: reservoir boundaries, capacity, pressure management, storage integrity, dissolution and storage in depleted reservoirs. We take each one in turn, highlighting specific errors in the paper but also drawing attention to more general background issues. Finally, we discuss in more detail some inconsistencies in the paper surrounding the reservoir engineering calculations

Classical and Quantum Transport Through Entropic Barriers Modelled by Hardwall Hyperboloidal Constrictions

We study the quantum transport through entropic barriers induced by hardwall constrictions of hyperboloidal shape in two and three spatial dimensions. Using the separability of the Schrodinger equation and the classical equations of motion for these geometries we study in detail the quantum transmission probabilities and the associated quantum resonances, and relate them to the classical phase structures which govern the transport through the constrictions. These classical phase structures are compared to the analogous structures which, as has been shown only recently, govern reaction type dynamics in smooth systems. Although the systems studied in this paper are special due their separability they can be taken as a guide to study entropic barriers resulting from constriction geometries that lead to non-separable dynamics.Comment: 59 pages, 22 EPS figures

Solar Magnetic Carpet I: Simulation of Synthetic Magnetograms

This paper describes a new 2D model for the photospheric evolution of the magnetic carpet. It is the first in a series of papers working towards constructing a realistic 3D non-potential model for the interaction of small-scale solar magnetic fields. In the model, the basic evolution of the magnetic elements is governed by a supergranular flow profile. In addition, magnetic elements may evolve through the processes of emergence, cancellation, coalescence and fragmentation. Model parameters for the emergence of bipoles are based upon the results of observational studies. Using this model, several simulations are considered, where the range of flux with which bipoles may emerge is varied. In all cases the model quickly reaches a steady state where the rates of emergence and cancellation balance. Analysis of the resulting magnetic field shows that we reproduce observed quantities such as the flux distribution, mean field, cancellation rates, photospheric recycle time and a magnetic network. As expected, the simulation matches observations more closely when a larger, and consequently more realistic, range of emerging flux values is allowed (4e16 - 1e19 Mx). The model best reproduces the current observed properties of the magnetic carpet when we take the minimum absolute flux for emerging bipoles to be 4e16 Mx. In future, this 2D model will be used as an evolving photospheric boundary condition for 3D non-potential modeling.Comment: 33 pages, 16 figures, 5 gif movies included: movies may be viewed at http://www-solar.mcs.st-and.ac.uk/~karen/movies_paper1